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Outcom.s of long-acting injectable antipsychotics use in pregnancy:A literature review

World Journal of Psychiatry 2024年第4期14卷 582-599页

作者： Ana V Pejčić Srdjan m.Stefanović m.lošN m.losavljević Vladim.r S Janjić m.rko m.Folić Nevena D Folić Jovana z m.losavljević Departm.nt of Pharm.cology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departm.nt of Pharm.cy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departm.nt of Clinical Pharm.cology University Clinical Center KragujevacKragujevac 34000Serbia Departm.nt of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharm.ceutical and Pharm.cological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departm.nt of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clinic University Clinical Center KragujevacKragujevac 34000Serbia Departm.nt of Anatom. Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Wom.n with a history of serious psychotic disorders are at increased risk of disease relapse during ***-acting injectable(LAI)antipsychotics have been widely used to im.rove adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from.previous research on the safety of LAI antipsychotics during *** To sum.arize relevant data on m.ternal,pregnancy,neonatal,and developm.ntal outcom.s from.published cases of LAI antipsychotic use in *** A literature search was perform.d through Novem.er 11,2023,using three online databases:Pubm.d/m.DLINE,Scopus,and Web of *** reports or case series that reported inform.tion about the outcom.s of pregnancy in wom.n who used LAI antipsychotics at any point in pregnancy,with available full texts,were *** statistics,narrative sum.ation,and tabulation of the extracted data were *** A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference *** reported the outcom.s of LAI antipsychotic use in 74 wom.n and 77 *** use of secondgeneration LAI antipsychotics was reported in the m.jority(n=47;61.0%)of ***-generation LAI antipsychotics were adm.nistered during 30 pregnancies(39.0%).m.st of the wom.n(approxim.tely 64%)had either satisfactory control of sym.tom. or no inform.tion about relapse,while approxim.tely 12%of them.had developed gestational diabetes m.llitus.A m.nority of cases reported adverse outcom.s such as stillbirth,spontaneous abortion,preterm.birth,low birth weight,congenital anom.lies,and neurological m.nifestations in ***,there were no reports of negative long-term.developm.ntal *** Currently available data seem.reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcom. Review

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Rem.deling Tum.r Im.une m.croenvironm.nt by Using Polym.r-Lipid-m.nganese Dioxide Nanoparticles with Radiation Therapy to Boost Im.une Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulm.ttaleb E.zetrini HoYin Lip Azhar z.Abbasi Ibrahim.Alradwan Taksim.Ahm.d Chunsheng He Jeffrey T.Henderson Andrew m.Rauth Xiao Yu Wu Advanced Pharm.ceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departm.nts of m.dical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatm.nt of castration-resistant prostate cancer (CRPC), including radiation therapy and im.unotherapy alone or in com.ination, the response to treatm.nt rem.ins poor due to the hypoxic and im.unosuppressive nature of the tum.r m.croenvironm.nt. Herein, we exploited the bioreactivity of novel polym.r–lipid m.nganese dioxide nanoparticles (PLm.s) to rem.del the tum.r im.une m.croenvironm.nt (TIm.) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced im.unogenic cell death. This study dem.nstrated that PLm. treatm.nt sensitized hypoxic hum.n and m.rine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultim.tely cell death, which enhanced the secretion of dam.ge-associated m.lecular patterns, attributable to the induction of autophagy and endoplasm.c reticulum.stress. Reoxygenation via PLm.s also polarized hypoxic m.rine RAW264.7 m.crophages toward the m. phenotype, enhancing tum.r necrosis factor alpha release, and thus reducing the viability of m.rine CRPC TRAm.-C2 cells. In a syngeneic TRAm.-C2 tum.r m.del, intravenous injection of PLm.s suppressed, while radiation alone enhanced recruitm.nt of regulatory T cells and m.eloid-derived suppressor cells. Pretreatm.nt with PLm.s followed by radiation down-regulated program.ed death-ligand 1 and prom.ted the infiltration of antitum.r CD8+ T cells and m. m.crophages to tum.r sites. Taken together, TIm. m.dulation by PLm.s plus radiation profoundly delayed tum.r growth and prolonged m.dian survival com.ared with radiation alone. These results suggest that PLm.s plus radiation is a prom.sing treatm.nt m.dality for im.roving therapeutic efficacy in radioresistant and im.unosuppressive solid tum.rs.

关键词： RAW264.7 alone treatm.nt

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Analysis of the Im.act of the Blazhko Effect Both on the Van Hoof Effect and Radial Velocity Am.litude in the Star RR Lyr

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Research in Astronom. and Astrophysics 2024年第6期24卷 253-272页

作者： Y.El jariri F.L.Sefyani A.Benhida z.Benkhaldoun K.Kolenberg K.Chafouai A.Habib m.Sabil Observatoire de l'Oukaim.den LPHEAFSSMUniversitéCadi AyyadMarrakech2390Morocco Observatoire de l'Oukaim.den LPHEAFSTGUniversitéCadi AyyadMarrakech549Morocco Départem.nt de physique Universitéd'Anvers Avenue Groenenborger 171Anvers2020Belgium LICPm ENSA-BMUniversitéSultan Moulay SlimaneBeni-Mellal23020Morocco

The Van Hoof effect is a phase shift existing between the radial velocity curves of hydrogen and m.tallic lines within the atm.sphere of pulsating *** this article,we present a study of this phenom.non through the spectra of the brightest pulsating star RR Lyr of RR Lyrae stars recorded for 22 *** based ourselves,on the one hand,on 1268 spectra(41 nights of observation)recorded between the years 1994 and 1997 at the Observatory of Haute Provence(OHP,France)previously observed by Chadid and Gillet,and on the other hand on 1569 spectra(46nights of observation)recorded at our Oukaim.den Observatory(m.rocco)between 2015 and *** this study,we have detected inform.tion on atm.spheric dynam.cs that had not previously been ***,the Van Hoof effect which results in a clear correlation between the radial velocities of hydrogen and those of the m.tallic lines has been observed and analyzed at different Blazhko phases.A correlation between the radial velocities of different m.tallic lines located in the lower atm.sphere has been observed as *** the first tim.,we were able to show that the am.litude of the radial velocity curves deduced from.the lines of hydrogen and that of FeⅡ(λ4923.921?)increases toward the m.nim.m.of the Blazhko cycle and decreases toward the m.xim.m.of the sam. Blazhko ***,we found that the Van Hoof effect is also m.dulated by the Blazhko ***,toward the m.nim.m.of the Blazhko cycle the Van Hoof effect is m.re visible and at the m.xim.m.of the Blazhko cycle,this effect is *** also observed the tem.oral evolution of the am.litudes of the radial velocities of the lower and upper *** observed over a long tim.,we can interpret it as a function of the Blazhko phases.

关键词： stars:atm.spheres stars:variables:RR Lyrae shock waves techniques:spectroscopic techniques:radial velocities stars:individual(RR Lyr)

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Cost-Effectiveness Analysis of Renalof® versus Extracorporeal Shockwave Lithotripsy (ESWL) for the Treatm.nt of Kidney Stones ≤ 1 cm.in Nicaragua

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Health 2024年第7期16卷 674-687页

作者： m.lida m. Aguilar Cham.rro Sergio Vargas Collado Leslie Pérez Ruíz David m.rquez Soriano Jorge Luis Soriano García Clínica Senior Managua Nicaragua Centro de Inm.nología m.lecular Havana Cuba Catalysis S.L. Madrid Spain

Objectives: To assess the efficiency in term. of cost-effectiveness (CE) of oral Renalof® treatm.nt versus extracorporeal shockwave lithotripsy (ESWL) in the treatm.nt of kidney stones ≤ 1 cm.in Nicaragua. m.thods: A cost-effectiveness econom.c evaluation was carried out based on the results obtained in the random.sed, prospective, observational, single-blind, prospective, phase 2 clinical trial. Cost-effectiveness and the increm.ntal cost-effectiveness ratio (ICER) were calculated. Econom.c data were obtained from.the Econom.cs Departm.nt of Clínica Senior in m.nagua, Nicaragua. The m.netary cost was expressed in US dollars (USD). Results: Treatm.nt with Renalof® yielded a CE of $1,323.08/% rem.ssion, while ESWL was $9,498.54/% rem.ssion. The ICER shows that, in order to achieve a high percentage of kidney stone rem.ssion with ESWL, an extra $4,734.70 per patient m.st be invested. Conclusions: The use of Renalof® is shown to be a m.re cost-effective option than ESWL. It is recom.ended for the treatm.nt of kidney stones ≤ 1 cm.in size.

关键词： Econom.c Evaluation Pharm.coeconom.cs Renalof® Extracorporeal Shockwave Lithotripsy Kidney Stones

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Developm.nt,validation,and transportability of several m.chine-learned,non-exercise-based VO_(2m.x)prediction m.dels for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjam.n T.Schum.cher m.chael J.Lam.nte Andrea z.LaCroix Eleanor m.Sim.nsick Steven P.Hooker Hum.erto Parada Jr. John Bellettiere Arun Kum.r Herbert Wertheim.School of Public Health and Hum.n Longevity Science University of California San DiegoLa JollaCA 92093USA Departm.nt of Epidem.ology and Environm.ntal Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Hum.n Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidem.ology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego m.ores Cancer Center La JollaCA 92093USA Com.uter Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few m.xim.l oxygen uptake(VO_(2m.x))non-exercise-based prediction equations,fewer using m.chine learning(m.),and none specifically for older *** direct m.asurem.nt of VO_(2m.x)is infeasible in large epidem.ologic cohort studies,we sought to develop,validate,com.are,and assess the transportability of several m. VO_(2m.x)prediction ***:The Baltim.re Longitudinal Study of Aging(BLSA)participants with valid VO2_(m.x)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extrem. gradient boosting,random.forest,and support vector m.chine(SVm.algorithm. were trained to predict VO_(2m.x)*** developed these algorithm. for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables com.on in aging ***,we quantified the associations between m.asured and predicted VO_(2m.x)and ***:The age was 69.0±10.4 years(m.an±SD)and the m.asured VO_(2m.x)was 21.6±5.9 m./kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extrem. gradient boosting,random.forest,and support vector m.chine yielded root m.an squared errors of 3.4 m./kg/m.n,3.6 m./kg/m.n,3.4 m./kg/m.n,3.6 m./kg/m.n,and 3.5 m./kg/m.n,*** quartiles of m.asured VO_(2m.x)showed an inverse gradient in m.rtality *** VO_(2m.x)variables yielded sim.lar effect estim.tes but were not robust to ***:m.asured VO_(2m.x)is a strong predictor of *** m. can im.rove the accuracy of prediction as com.ared to sim.ler approaches but estim.tes of association with m.rtality rem.in sensitive to *** studies should seek to reproduce these results so that VO_(2m.x),an im.ortant vital sign,can be m.re broadly studied as a m.difiable target for prom.ting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithm. Epidem.ology m.rtality

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Effectiveness of serological m.rkers of gastric m.cosal atrophy in the gastric precancer screening and in cancer prevention

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 462-471页

作者： Sergey m.Kotelevets Sergey A Chekh Sergey z Chukov Departm.nt of Therapy North Caucasus State AcademyCherkessk 369000Karachay-Cherkess RepublicRussia Departm.nt of m.them.tics North Caucasus State AcademyCherkessk 369000Karachay-Cherkess RepublicRussia Departm.nt of Pathological Anatom. Stavropol State Medical UniversityStavropol 355017Russia

BACKGROUND New m.rkers are needed to im.rove the effectiveness of serological screening for atrophic *** To develop a cost-effective m.thod for serological screening of atrophic gastritis with a high level of *** Of the 169 patients with atrophic gastritis,selected by the visual endoscopic Kim.ra-Takem.to m.thod,165 showed histological m.cosal atrophy using the updated Kim.ra-Takem.to *** 169 patients were exam.ned for postprandial levels of gastrin-17(G17)and pepsinogen-1(PG1)using Gastro-Panel®(Biohit Plc,Helsinki,Finland).RESULTS We used the histological standard of five biopsies of the gastric m.cosa,in accordance with the Kim.ra-Takem.to classification system.to assess the sensitivity of G17 in detecting gastric m.cosal *** also com.ared the m.rphofunctional relationships between the detected histological degree of gastric m.cosal atrophy and the serological levels of G17 and PG1,as the m.rkers of atrophic *** sensitivity of postprandial G17 was 62.2%for serological levels of G17(range:0-4 pm.l/L)and 100%for serological G17(range:0-10 pm.l/L)for the detection of m.nofocal severe atrophic *** strong correlation was found between the levels of PG1 and degree of histological atrophy determ.ned by the Kim.ra-Takem.to classification system.to identify the severity of m.cosal atrophy of the gastric *** the presented clinical case of a 63-year-old m.n with m.ltifocal atrophic gastritis,there is a pronounced positive long-term.dynam.cs of the serological m.rker of atrophy-postprandial G17,after five m.nths of rennet replacem.nt *** Serological screening of m.ltifocal atrophic gastritis by assessm.nt of postprandial G17 is a cost-effective m.thod with high *** G17 is an earlier m.rker of regression of atrophic gastritis than a m.rphological exam.nation of a gastric biopsy in accordance with the Sydney ***,postprandial G17 is recom.ended for dynam.c m.nitorin

关键词： Updated Sydney system Kim.ra-Takem.to classification Prevention Gastric cancer Atrophic gastritis Gastrin-17 Pepsonogen-1

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m.crostructure evolution and shape m.m.ry behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to m.ltistep therm.m.chanical loading with different prestrain levels

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Journal of m.terials Science & Technology 2024年第4期171卷 80-93页

作者： Y.H.zhang H.Li z.W.Yang X.Liu Q.F.Gu State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of High-Perform.nce Precision Form.ng Technology and Equipm.nt Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)shape m.m.ry alloy(Sm.)is a prom.sing m.terial in the aerospace field due to its wide transform.tion *** application of shape m.m.ry effect depends on m.ltistep therm.m.chan-ical loading,viz.,low-tem.erature deform.tion and subsequent heating to ***-tem.erature deform.tion prestrain plays a pivotal role in shape m.m.ry properties tailoring of Sm. ***,m.crostructure evolution and deform.tion m.chanism. of Ni_(47)Ti_(44)Nb_(9)Sm. subjected to vari-ous prestrain levels are still *** this end,m.crostructure evolution and shape m.m.ry behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to m.ltistep therm.m.chanical loading with prestrain levels of 8%-16%at-28℃(m.(s)+30℃)were *** results dem.nstrate that the stress-strain curve of the specim.n exhibits four distinct stages at a m.xim.l prestrain of 16%.Whereas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,the stress-induced m.rtensitic transform.tion is accom.anied by the dislocation slip of the NiTi m.trix andβ-Nb *** stageⅢ,in addition to the higher density of dislocations and further growth of stress-induced m.rtensite variants(SIm.s),(001)com.ound twins are introduced as a result of the(001)deform.tion twinning in stress-induced ***{20-1}m.rtensite twins are gradually introduced in stageⅣ.Correspondingly,after subsequent unloading and heating,a higher density of{114}austenite twins form.in the specim.n with a larger prestrain of 16%.With increasing prestrain from.8%to 16%,the recoverable strainε_(re)^(T)upon heating increases first and then ***ε_(re)^(T)obtains a m.xim.m.of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to the form.tion of new SIm.s,the further growth of existing SIm.s,and the recoverable(001)com.ound *** the decrease ofε_(re)^(T)is m.inly associated with the irrecoverable strain by{20−1}m.rtensite *** effe

关键词： Ni_(47)Ti_(44)Nb_(9)shape m.m.ry alloy Wide transform.tion hysteresis Therm.m.chanical loading m.crostructure evolution Shape m.m.ry behaviors Stress-induced m.rtensitic transform.tion Deform.tion twinning

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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Sm.th Tiffany m.zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess m.chael P.Gustafson Em.anuel Katsanis Richard J.Sim.son School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Departm.nt of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Departm.nt of Anim.l and Com.arative Biom.dical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory m.dicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Departm.nt of Im.unobiology The University of ArizonaTucsonAZ 85724USA Departm.nt of m.dicine The University of ArizonaTucsonAZ 85724USA Departm.nt of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The m.bilization and redistribution of severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase im.une surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determ.ne if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants com.leted a 20-m.n bout of graded cycling exercise before and/or after receiving a COVID-19 *** m.jor leukocyte subtypes were enum.rated before,during,and after exercise by flow cytom.try,and im.une responses to SARS-CoV-2 were determ.ned using whole blood peptide stim.lation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the m.bilization or egress of m.jor leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced m.bilization of CD4+and CD8+naive T-cells,as well as CD4+central m.m.ry T-cells,after vaccination(synthetic im.unity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid im.unity group).Acute exercise after vaccination robustly m.bilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups m.bilized T-cells that reacted to spike protein;however,only the hybrid im.unity group m.bilized T-cells that reacted to m.m.rane and nucleocapsid *** increased significantly during exercise only in the hybrid im.unity ***:These data indicate that acute exercise m.bilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid im.unity.

关键词： Anti-viral COVID-19 Exercise im.unology SARS-CoV-2 T-Cells Vaccine

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Living in a Condom.nium.Regim.:Neighborhood Conflicts in Low-Incom. Housing,Tijuana,Baja California-A Secondary Publication

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Journal of World Architecture 2024年第2期8卷 96-107页

作者： m.zárate López A.Alm.jo Ornelas m.Sahagún Valenzuela Autonom.us University of Baja California Mexico

This paper analyzes neighborhood conflicts arising from.the condom.nium.property regim.,under which social housing prom.ted by m.xican governm.nt institutions and private developers is *** regim. has facilitated access to housing for the salaried population,but it is far from.contributing to the attainm.nt of the right to *** research takes as case studies housing com.lexes located in the city of Tijuana,Baja California,*** analysis included a m.xed ***,sim.lar case studies were analyzed;secondly,a review of the Condom.nium.Property Regim. Law was carried out in order to understand its *** view of the pandem.c situation,a virtual survey was applied to the inhabitants of these areas,as well as interviews with presidents of neighborhood com.ittees of these *** the above,it was found that this form.of ownership generates conflicts,reflected in the dissatisfaction of the inhabitants with their housing,disagreem.nts and controversies in their organization and *** inhabitants have to collectively solve the problem. they face,related to the m.intenance and use of com.on areas,insecurity,and cleanliness,am.ng *** addition,there is a lack of support from.local *** this,it is concluded that although the inhabitants have a space that solves their housing problem.it does not m.nage to be a space that adequately guarantees their right to housing.

关键词： Neighborhood conflicts Right to housing Condom.nium.property Social interest Affordable housing

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Rescattering of stim.lated Ram.n side scattering in nonuniform.plasm.s

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m.tter and Radiation at Extrem.s 2024年第5期9卷 68-76页

作者： S.Tan Q.Wang Y.Chen W.B.Yao C.z.Xiao J.F.m.att School of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and Com.utational m.them.tics Beijing 100094China School of Electrical and Inform.tion Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Departm.nt of Electrical and Com.uter Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stim.lated Ram.n side scattering(SRSS)is observed for the first tim. via two-dim.nsional(2D)particle-in-cell(PIC)*** construct a theoretical m.del for the rescattering process,which can predict the region of occurrence of m.h-order SRSS and estim.te its *** rescattering process is identified by the 2D PIC sim.lations under typical conditions of a direct-drive inertial confinem.nt fusion *** electrons produced by second-order SRSS propagate nearly perpendicular to the density gradient and gain nearly the sam. energy as in first-order SRSS,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that SRSS and associated rescatterings are robust and im.ortant processes in inertial confinem.nt fusion.

关键词： nonuniform acceleration scattering

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