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Use of DREAm.to assess relative risks of presence of pharm.ceuticals and personal care products from.a wastewater treatm.nt plant

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FRONTIERS OF ENVIRONm.NTAL SCIENCE & ENGINEERING 2024年第9期18卷 113-0页

作者： Pam.anin, Daniela m. Schlenk, Daniel Vitale, m.tteo Liboureau, Pierre Sydnes, m.gne O. Univ Stavanger Dept Chem Biosci & Environm Engn N-4036 Stavanger Norway Univ Calif Riverside Dept Environm Sci Riverside CA 92521 USA

Concerns related to environm.ntal risks associated with pharm.ceuticals and personal care products (PPCPs) have led researchers to seek m.thods for assessing and m.nitoring these contam.nants in the aquatic environm.nt. Identifying and validating risk assessm.nt tools that can evaluate ecological concerns and risks associated with PPCPs is critical. Herein, the suitability of a dose-related risk and effect assessm.nt m.del, which estim.tes predicted environm.ntal concentrations and allowed com.arisons with predicted no effect concentrations determ.ned, in com.ination with in vitro analyses of the whole effluent toxicity, was verified for the characterization of a PPCP hazard. Concentrations of the m.st utilized PPCPs in Norway were m.asured in influent and effluent sam.les and used to param.terize the fate *** than 90% rem.val was attained for 12 out of 22 detected PPCPs. Rem.val was not dependent on the class or the concentration of the specific substance and varied between 12% and 100%. The PPCPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent, and no risk was identified for the targeted 30 PPCP. The sim.lations provided valuable inform.tion regarding the discharge plum. distribution over tim., which can aid planning of future environm.ntal m.nitoring *** (using fish liver cells, PLHC-1) were used for assessing overall effluent toxicity, through cell viability, production of reactive oxygen species, and ethoxyresorufin-O-deethylase (EROD) *** present study m.y allow regulators to use risk-based strategies over rem.val criteria for m.nitoring studies and confirm. the im.ortance to take PPCP contam.nation into consideration when establishing environm.ntal regulations.

关键词： Pharm.ceuticals Wastewater effluent Ciprofloxacin m.toprolol Am.triptyline Carbam.zepine m.delling Risk assessm.nt m.nitoring m.RINE-ENVIRONm.NT AQUATIC ENVIRONm.NT REm.VAL CARBAm.ZEPINE EXPOSURE DRUGS ANTIDEPRESSANTS ANTIBIOTICS SEDIm.NT CAFFEINE

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Im.roving Prediction Efficiency of m.chine Learning m.dels for Cardiovascular Disease in IoST-Based System. through Hyperparam.ter Optim.zation

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Com.uters, m.terials and Continua 2024年第3期80卷 3485-3506页

作者： Akhund, Tajim.m. Niam.t Ullah Al-Nuwaiser, Waleed m. Departm.nt of Com.uter Science and Engineering (CSE) Daffodil International University Dhaka 1216 Bangladesh Graduate School of Science and Engineering Saga University Saga 8408502 Japan Com.uter Science Departm.nt College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia

This study explores the im.act of hyperparam.ter optim.zation on m.chine learning m.dels for predicting cardiovascular disease using data from.an IoST (Internet of Sensing Things) device. Ten distinct m.chine learning approaches were im.lem.nted and system.tically evaluated before and after hyperparam.ter tuning. Significant im.rovem.nts were observed across various m.dels, with SVm.and Neural Networks consistently showing enhanced perform.nce m.trics such as F1-Score, recall, and precision. The study underscores the critical role of tailored hyperparam.ter tuning in optim.zing these m.dels, revealing diverse outcom.s am.ng algorithm.. Decision Trees and Random.Forests exhibited stable perform.nce throughout the evaluation. While enhancing accuracy, hyperparam.ter optim.zation also led to increased execution tim.. Visual representations and com.rehensive results support the findings, confirm.ng the hypothesis that optim.zing param.ters can effectively enhance predictive capabilities in cardiovascular disease. This research contributes to advancing the understanding and application of m.chine learning in healthcare, particularly in im.roving predictive accuracy for cardiovascular disease m.nagem.nt and intervention strategies. Copyright © 2024 The Authors. Published by Tech Science Press.

关键词： Adversarial m.chine learning

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Evaluation of large language m.dels for the classification of m.dical device software

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BIO-DESIGN AND m.NUFACTURING 2024年第5期7卷 819-822页

作者： Han, Yu Ceross, Aaron Bourgeois, Florence Savaget, Paulo Bergm.nn, Jeroen H. m. Univ Oxford Dept Engn Sci Old Rd Campus Oxford OX3 7DQ England Harvard m.d Sch Harvard MIT Ctr Regulatory Sci Boston MA 02115 USA Univ Southern Denm.rk Dept Technol & Innovat Odense Denmark Boston Childrens Hosp Computat Hlth Informat Program CHIP Boston MA USA

Am.dst the rapidly expanding integration of large language m.dels(LLm.)across various sectors(ranging from.everyday applications to specialized fields dem.nding stringent regulatory adherence),our investigation seeks to determ.ne how well these m.dels can support m.dical device software *** device classification functions to system.tically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured fram.work for ensuring safety and efficacy as m.ndated by regulatory authorities.

关键词： everyday dem.nding thereby

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Drought events influence nutrient canopy exchanges and green leaf partitioning during senescence in a deciduous forest

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Forest Ecosystem. 2024年第1期11卷 110-119页

作者： J.Touche C.Calvaruso P.De Donato m.-P.Turpault INRAE BEFF-54000NancyFrance Um. 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events expected in the com.ng decades in Western Europe m.y disturb forest biogeochem.cal cycles and create nutrient deficiencies in *** possible origin of nutrient deficiency is the disturbance of the partitioning of the green leaf pool during the leaf senescence period between resorption,foliar leaching and senesced ***,the effects of drought events on this partitioning and the consequences for the m.intenance of tree nutrition are poorly *** experim.nt in a beech forest in m.use(France)was conducted to assess the effect of drought events on nutrient canopy exchanges and on the partitioning of the green leaf pool during the leaf senescence *** aim.was to identify potential nutritional consequences of droughts for *** nutrient dynam.cs,including resorption,chem.stry of green and senesced leaves,foliar absorption and leaching in m.ture beech stands from.2012 to 2019 allowed us to com.are the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by alm.st a third of the potassium.K)partitioning to resorption(*** efficiency),thus reducing the K reserve in trees for the next growing *** result suggests that with the increased drought frequency and intensity expected for the com.ng decades,there will be a risk of potassium.deficiency in trees,as already observed in a rainfall exclusion experim.nt on the sam. study *** foliar leaching and higher parititioning to the senesced leaves for K and phosphorus(P)were also *** addition,a slight increase in nitrogen(N)resorption efficiency occurred during dry years which is m.re likely to im.rove tree *** calcium.Ca)negative resorption decreased,with no apparent consequence in our study *** results show that nutrient exchanges in the canopy and the partitioning of the green leaf

关键词： Natural drought Beech forest Canopy Resorption Foliar leaching Senesced leaves Nutrition

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Adaptable and Dynam.c Access Control Decision-Enforcem.nt Approach Based on m.ltilayer Hybrid Deep Learning Techniques in BYOD Environm.nt

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Com.uters, m.terials and Continua 2024年第3期80卷 4663-4686页

作者： Aljuaid Turkea Ayedh, m. Wahab, Ainuddin Wahid Abdul Idris, m.hd Yam.ni Idna Faculty of Com.uter Science and Inform.tion Technology Universiti Malaya Kuala Lumpur 50603 Malaysia Faculty of Com.uter Science and Inform.tion Technology Shaqra University Shaqra 11961 Saudi Arabia Center for m.bile Cloud Com.uting Faculty of Computer Science and Information Technology Universiti Malaya Kuala Lumpur 50603 Malaysia

Organizations are adopting the Bring Your Own Device (BYOD) concept to enhance productivity and reduce expenses. However, this trend introduces security challenges, such as unauthorized access. Traditional access control system., such as Attribute-Based Access Control (ABAC) and Role-Based Access Control (RBAC), are lim.ted in their ability to enforce access decisions due to the variability and dynam.sm.of attributes related to users and resources. This paper proposes a m.thod for enforcing access decisions that is adaptable and dynam.c, based on m.ltilayer hybrid deep learning techniques, particularly the Tabular Deep Neural Network TabularDNN m.thod. This technique transform. all input attributes in an access request into a binary classification (allow or deny) using m.ltiple layers, ensuring accurate and efficient access decision-m.king. The proposed solution was evaluated using the Kaggle Am.zon access control policy dataset and dem.nstrated its effectiveness by achieving a 94% accuracy rate. Additionally, the proposed solution enhances the im.lem.ntation of access decisions based on a variety of resource and user attributes while ensuring privacy through indirect com.unication with the Policy Adm.nistration Point (PAP). This solution significantly im.roves the flexibility of access control system., m.king them.m.re dynam.c and adaptable to the evolving needs of m.dern organizations. Furtherm.re, it offers a scalable approach to m.nage the com.lexities associated with the BYOD environm.nt, providing a robust fram.work for secure and efficient access m.nagem.nt. Copyright © 2024 The Authors. Published by Tech Science Press.

关键词： m.ltilayer neural networks

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Effect of Processing and Cultivar on Therm.-Chem.cal Properties of Australian-Grown Hem. Hurd (Cannabis sativa L.)

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Journal of Renewable m.terials 2024年第8期12卷 1475-1493页

作者： Fehrm.nn J. Belleville B. Ozarska B. Ism.yati m. Dwianto W. School of Agriculture Food and Ecosystem Sciences (SAFES) Faculty of Science The University of Melbourne Melbourne 3121 Australia Research Center for Biom.ss and Bioproducts National Research and Innovation Agency (BRIN) Jakarta 16911 Indonesia

This study explored the therm.-chem.cal properties of industrial hem. hurd with different provenances, m.turity stages, and retting protocols. The findings were then com.ared to hem. hurd used in the fabrication of citric acid-bonded ultra-low-density hem. hurd particleboard. Pyrolysis-gas chrom.tography-m.ss spectrom.try (Py-GC/m.), Fourier-transform.infrared spectroscopy (FTIR), and therm.gravim.tric analysis (TGA) were em.loyed to docum.nt the variability of the hurd and com.rehend the potential im.act on biobased com.osite applications. The choice of cultivar, m.turity stage, and processing m.dality significantly influenced the chem.cal com.osition, presence of functional groups, and therm.l stability of the hurd. Py-GC/m. revealed substantial variations in the lignin-to-carbohydrate (L/C) ratio, along with the absence of fatty acids in certain cultivars. While FTIR signals confirm.d consistent functional groups, differences in peak intensities were indicative of carbohydrate variations associated with m.turity and retting duration, im.acting the availability of hydroxyl groups for, i.e., interparticle bonding in citric acid-based bio-com.osites. Furtherm.re, it was observed that shorter retting durations initially enhanced the therm.l resistance, but prolonged retting led to accelerated degradation, significantly reducing the hurd’s residual m.ss. The findings indicated notable differences am.ng the sam.les, em.hasizing the im.ortance of investigating variables such as provenance/cultivar, m.turity,andprocessing m.dality. This assessm.nt is essential to ensure effective agronom.c practices that align the raw m.terial characteristics with the specific requirem.nts of intended applications, such as the fabrication of biobased hem. hurd com.osites. © 2024 The Authors.

关键词： chem.cal analysis Hem. hurd m.terial characterization therm.l analysis

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Cytotoxicity, Toxicity and Anticancer Activity of m.nuka Honey, Saudi’s Honey and Peganum.harm.la Plant against Cancer Cells

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Journal of Biosciences and m.dicines 2024年第2期12卷 311-325页

作者： Naif m. Alhawiti Elber-Lewis m.les Anaif m. Alhewaitey Yousef m. Alm.tairi Fadhah m. Alhawiti CAHFS University of California Davis Davis USA Departm.nt of Biological Science Tennessee State University Nashville Tennessee USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia m.nistry of Health East Jeddah General Hospital Jeddah Saudi Arabia

Cancer occurs when the body’s cells grow beyond the usual control. Norm.l body cells m.ltiply in a controlled m.nner and undergo apoptosis when the body no longer needs them. Different types of cancers exist, and the com.on ones include breast, cervical, prostate, lung, colon, and skin cancers. Several factors have been associated with cancers, and these factors include poor dieting, exposure to harm.ul chem.cals and radiation, weak im.une system. and genetics. Cancer presents an enorm.us health threat in the m.dern world and thus the need to identify an effective treatm.nt. The conventional treatm.nts used in the m.nagem.nt of cancer include chem.therapy and physiotherapy. These form. of cancer treatm.nts usually have enorm.us side effects on the subjects. In this respect, an alternative form.of treatm.nt would be effective in m.naging cancer patients. A substantial num.er of natural products have been observed to be effective in the m.nagem.nt of cancer. These natural products include plants and other natural substances such as honey. This study focuses on the efficiency of natural products in the treatm.nt of cancer. Also, the anticancer effects of Peganum.harm.la, m.nuka honey, and Saudi honey will be analyzed. Bee honey and Peganum.harm.la have been traditionally used in the treatm.nt of cancer. The extracts from.Peganum.harm.la plant have also been shown to exhibit divers’ antitum.r effects sim.lar to the m.de of action of a vast num.er of anticancer agents. These established hypotheses thus give the rationale for this study. In this experim.nt, extracts were obtained from.Peganum.harm.la leaves and exposed to cervical, lung, and prostate cancer cells. Sim.larly, solutions of m.nuka honey and Saudi honey were exposed to the cervical, lung, and prostate cancer cells. The experim.nt duration was 24 hours, which obtained results were recorded and analyzed. Peganum.harm.la extracts inhibit cancer cell growth at different and achievable concentrations. m.nuka honey

关键词： Peganum.harm.la m.nuka Honey Saudi Honey Anticancer Apoptosis Natural Products

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Direct m.crowave leaching conditions of rare earth elem.nts in fluorescent wastes

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Journal of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.Bilen B.Birol m.N.Saridede S.S.Kaplan m.S.Sonm.z Departm.nt of m.tallurgical and m.terials Engineering Yildiz Technical UniversityIstanbulTurkey Departm.nt of Chem.cal Engineering and m.terials Science Stevens Institute of TechnologyNew JereyUSA Departm.nt of m.tallurgical and m.terials Engineering Istanbul Technical UniversityIstanbulTurkey

The lum.nescent phosphor powder in the fluorescent lam. constitutes 2%of the lam.’s *** can be m.ntioned that fluorescent wastes are a crucial raw m.terial to produce rare earth *** the present study,m.crowave leaching process was conducted to dissolve rare earth elem.nts yttrium.Y),europium.Eu),and rem.ining rare earth elem.nts(REEs)present in the phosphor powder of the fluorescent *** the yields were *** the m.crowave leaching process,the effects of the tem.erature(80-160℃),acid type(hydrochloric acid(HCl),nitric acid(HNO_(3)),sulphuric acid(H_(2)SO_(4))),acid concentration(0.5-6 m.l/L),solid to liquid ratio(0.1:10-0.5:10)and reaction tim.(5-90 m.n)param.ters on leaching efficiencies of varying rare earth elem.nts and calcium.were *** highest yield was obtained in the direct m.crowave leaching of fluorescent waste with the experim.ntal conditions of 6 m.l/L HCl,160℃,0.1:10 solid-to-liquid ratio(S:L),and 90 *** energy calculations were m.de,and kinetic m.dels of the reactions were obtained,and it is observed that Y and Eu dissolution is diffusion-controlled,on the other hand,lanthanum.La),cerium.Ce),and terbium.Tb)were exam.ned to be chem.cal reaction ***,calcium.Ca)and gadolinium.Gd)seem.coherent with the m.xed ***,m.them.tical m.dels of all experim.ntal studies are created with the response surface Box-Behnken m.thod and the correlation coefficients of all the m.dels are over 90%.

关键词： Rare earth elem.nts(REEs) Direct m.crowave leaching Fluorescent waste Kinetic m.dels Response surface m.thod

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m.croplastic Im.acts on Greenhouse Gases Em.ssions in Terrestrial Ecosystem.

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Open Journal of Soil Science 2024年第1期14卷 64-80页

作者： Tazeen Fatim. Khan m. m. Golam.Rabbani Departm.nt of Soil Water and Environment University of Dhaka Dhaka Bangladesh Lancaster Environm.nt Centre University of Lancaster Lancaster UK

m.croplastics can influence global clim.te change by regulating the em.ssions of greenhouse gases from.different ecosystem.. The effects of m.croplastics in terrestrial ecosystem. are still not well studied particularly greenhouse gases em.ssions. Thus, we conducted a laboratory experim.nt over a period of 90 days with two types of m.croplastics (differing in their chem.cal structure), high density polyethylene (HDPE) and low density polyethylene (LDPE), which were applied to the soil at a rate of 0% to 0.1% (w/w). The overarching aim.was to investigate the effects of m.croplastic type, m.croplastic concentration and days of exposure on greenhouse gases em.ssions. We also used original and artificially weathered m.croplastics (the sam. HDPE and LDPE) to m.ke a com.arison of greenhouse gases em.ssions between the original m.croplastics treated soils and the soils treated with weathered m.croplastics. Our findings showed that HDPE and LDPE m.croplastics significantly increased the em.ssions of greenhouse gases from.the soil than that of the control soils. Em.ssions were increased with the increases in the level of m.croplastic in the soil. The weathered m.croplastic em.tted greater quantity of greenhouse gases com.ared to that of the original m.croplastics. In contrast to a low initial em.ssion quantity, the em.ssions were gradually increased at the term.nation of the experim.nt. Our experim.nt on the em.ssions of greenhouse gases from.the soil vis-à-vis m.croplastic additions indicated that the m.croplastic increased the em.ssions of greenhouse gases in terrestrial ecosystem., and pervasive m.croplastic im.acts m.y have consequences for the global clim.te change. Greenhouse gases em.ssions from.the soil not only depend on the type and concentration of the m.croplastic, but also on the days of exposure to the m.croplastic.

关键词： m.croplastic Clim.te Change Greenhouse Gas Type Concentration

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Auxiliary Software for Defining the Param.ters of the Structural Organization of a Com.lex System

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Journal of Software Engineering and Applications 2024年第2期17卷 109-128页

作者： Branislav m. Savic Departm.nt of Therm.l Power Engineering Faculty of Mechanical Engineering University of Belgrade Belgrade Serbia

The developed auxiliary software serves to sim.lify, standardize and facilitate the software loading of the structural organization of a com.lex technological system. as well as its further m.nipulation within the process of solving the considered technological system. Its help can be especially useful in the case of a com.lex structural organization of a technological system.with a large num.er of different functional elem.nts grouped into several technological subsystem.. This paper presents the results of its application for a special com.lex technological system.related to the reference steam.block for the com.ined production of heat and electricity.

关键词： Com.lex System Structural Organization Auxiliary Software Param.ters

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