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Quantification of the im.act of TOF and PSF on PET im.ges using the noise-m.tching concept: clinical and phantom.study

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Nuclear Science and Techniques 2017年第11期28卷 258-265页

作者： m. shekari P. Ghafarian S. Ahangari m. R. Ay Departm.nt of m.dical Physics and Biom.dical Engineering Tehran University of Medical Sciences Tehran Iran Research Center for m.lecular and Cellular Im.ging Tehran University of Medical Sciences Tehran Iran Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases(NRITLD) Shahid Beheshti University of Medical SciencesTehran Iran PET/CT and Cyclotron Center Masih Daneshvari HospitalShahid Beheshti University of Medical Sciences Tehran Iran

This study was to assess quantitatively the accuracy of ^(18)F-FDG PET/CT im.ges reconstructed by TOF+PSF and TOF only, considering the noise-m.tching concept to m.nim.ze probable bias in evaluating algorithm.perform.nce caused by noise. PET im.ges of sim.lar noise level were considered. m.asurem.nts were m.de on an inhouse phantom.with hot inserts of Φ10–37 m., and oncological im.ges of 14 patients were analyzed. The PET im.ges were reconstructed using the OSEm. OSEm.TOF and OSEm.TOF+PSF algorithm.. Optim.l reconstruction param.ters including iteration, subset, and FWHm.of post-sm.othing filter were chosen for both the phantom.and patient data. In term. of quantitative accuracy, the recovery coefficient(RC) was calculated for the phantom.PET im.ges. The signal-to-noise ratio(SNR),lesion-to-background ratio(LBR), and SUV_(m.x)were evaluated from.the phantom.and clinical data. The sm.llest hot insert(Ф10 m.) with 2:1 activity concentration ratio could be detected in the PET im.ge reconstructed using the TOF and TOF+PSF algorithm., but not the OSEm.algorithm. The relative difference for SNR between the TOF+PSF and OSEm.showed significantly higher values for sm.ller sizes, while SNR change was sm.ller for Ф22–37 m. inserts both 2:1 and 4:1 activity concentration ratio. In the clinical study, SNR gains were 1.6 ± 0.53 and 2.7 ± 0.74 for the TOF and TOF+PSF, while the relative difference of contrast was 17 ± 1.05 and 41.5 ± 1.85% for the TOF only and TOF+PSF, respectively. The im.act of TOF+PSF is m.re significant than that of TOF reconstruction, in sm.ller inserts with low activity concentration ratio. In the clinical PET/CT im.ges, the use of the TOF+PSF algorithm.resulted in better SNR and contrast for lesions, and the highest SUV_(m.x)was also seen for im.ges reconstructed with the TOF+PSF algorithm.

关键词： Tim. of flight (TOF) Point spread function(PSF) Lesion detectability PET Quantification Im.ge reconstruction SUV

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PPARγ agonist-induced alterations in Δ6-desaturase and stearoyl-CoA desaturase 1:Role of m.K/ERK1/2 pathway

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World Journal of Hepatology 2013年第4期5卷 220-225页

作者： Negar Saliani m.soud Darabi Bahm.n Yousefi Behzad Baradaran m.hm.ud shekari Khaniani m.ryam.Darabi m.ghsod Shaaker Am.r m.hdizadeh Tahereh Naji m.hrdad Hashem. Drug Applied Research Center Tabriz University of Medical SciencesTabriz ***Iran Departm.nt of Biochem.stry and Clinical Laboratories School of MedicineTabriz University of Medical SciencesTabriz ***Iran Im.unology Research Center Tabriz University of Medical SciencesTabriz ***Iran Departm.nt of m.dical Genetics School of MedicineTabriz University of Medical SciencesTabriz ***Iran m.ragheh School of m.dical Sciences Tabriz University of Medical SciencesTabriz ***Iran Departm.nt of Biology Pharmaceutical Sciences BranchIslamic Azad UniversityTehran ***Iran Departm.nt of Genetics Tehran Medical BranchIslamic Azad UniversityTehran ***Iran

AIm.To investigate the effect of m.K/ERK1/2 pathway on peroxisom. proliferator-activated receptors(PPARγ)agonist-induced alterations in Δ6-desaturase(Δ6D)and stearoyl-CoA desaturase 1(SCD1)in hepatocellular carcinom. cell line ***:HepG2 cells cultured in RPm.-1640 were exposed to the com.only used ERK1/2 pathway inhibitor PD98059 and PPARγ agonist,*** RNA was isolated and reverse transcribed from.treated *** in gene expression and m.tabolites ratio,as activity index for Δ6D and SCD1,were then determ.ned using reverse transcriptionpolym.rase chain reaction and gas liquid chrom.tography,***:The expression of both Δ6D(P = 0.03)and SCD1(P = 0.01)increased following PD98059 treatm.nt,with a higher im.act on SCD1(24.5%vs 62.5%).Although pioglitazone increased the m.NA level(1.47 ± 0.10 vs 0.88 ± 0.02,P = 0.006)and activity index(1.40 ± 0.07 vs 0.79 ± 0.11,P m.K inhibition in the presence of pioglitazone,as com.ared with pioglitazone alone and control ***,the response of Δ6D expression and activity index to pioglitazone was unaffected by incubation with ***:PPARγ and ERK1/2 signaling pathway affect differentially and m.y have inhibitory crosstalk effects on the genes expression of 6D and SCD1,and subsequently on their enzym.tic activities.

关键词： Pioglitazone PD98059 Δ6-desaturase Stearoyl-CoA desaturase HepG2 cells

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