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Which Gastric m.crobiota Associated with <i>H. pylori</i>in Dyspeptic Patients with Gastritis

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Open Journal of Gastroenterology 2018年第12期8卷 425-433页

作者： Rasha I. Salam. Nora m. said Nelly m. said Departm.nt of Tropical m.dicine Faculty of Medicine Zagazig University Zagazig Egypt Departm.nt of Clinical Pathology Faculty of Medicine Zagazig University Zagazig Egypt Departm.nt of Pathology Faculty of Medicine Zagazig University Zagazig Egypt

Introduction: H. pylori is the com.ent infection worldwide. Its relation to dyspepsia has long been investigated. However, the association between H. pylori and other m.crobiota in the context of dyspepsia is less understood. The aim.of this study was to determ.ne different bacterial species isolated from.the stom.chs of patients with H. pylori infection and dyspepsia. m.thods: A total of 81 patients were included and divided into: group I (N = 50) patients com.laining of chronic dyspepsia and group II (N = 31) are patients with non-dyspeptic sym.tom. endoscoped for reasons other than dyspepsia. All patients were endoscoped and 4 gastric biopsies were obtained from.each patient. All patients were exam.ned initially by rapid urease test then histopathology to confirm.H. pylori infection and determ.ne the degree of gastric inflam.ation and finally tissue cultures for H. pylori and other bacterial species using m.trix-assisted laser desorption ionization-tim.-of-flight m.ss spectroscopy (m.LDI-TOF m.). Results: Regarding the dem.graphics;patients of dyspepsia in group I were m.re consum.rs of spicy food and sm.king than non-dyspeptic patients. Alm.st, all dyspeptic patients (98%) who had underlying gastric pathology with active gastritis and erosions were the m.st frequent reported pathological findings. Culture results showed significant association of Staphyloccus and Lactobacillus with dyspepsia while Streptoccous and Klebsilla were m.re frequent am.ng non-dyspeptic patients. Conclusion: Dyspeptic patients in this study had different grades of gastric pathology and different species of m.crobiota were isolated, which seem. to have concom.tant interaction with H. pylori in pathogenicity of gastric m.cosa and cause sym.tom. of chronic dyspepsia.

关键词： Dyspepsia H. pylori m.crobiota Histopathology

The Effect of Custom.r Verbal Aggression on Burnout in Frontline Em.loyees in Hotels and Travel Agencies: The m.derating Role of Perceived Supervisor Support

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Journal of Tourism.and Hospitality m.nagem.nt 2018年第6期6卷 291-303页

作者： Jailan m. El Dem.rdash Heba m. said Alexandria University Alexandria Egypt

This study aim.d to assess the effect of custom.r verbal aggression(CVA)on job burnout(JB)in frontline em.loyee in both hotels and travel agencies,trying to reveal if there is a difference between both sectors in this *** study additionally tested the m.deration role of perceived supervisor support(PSS)in the relation between custom.r verbal aggression and burnout in hotels and travel *** versions of the questionnaire were distributed *** first am.ng hotels em.loyees and the second was addressed to travel agencies em.loyees;613 were retrieved and analyzed using the version of Spss *** results showed a significant difference am.ng the level of custom.r verbal aggression,job burnout,and perceived supervisor support in hotels and travel *** there was a significant relation between custom.r verbal aggression and job burnout am.ng frontline em.loyees in both settings,this relationship was m.derated by PSS in hotels but not in travel ***,the study concludes with recom.endations and practical m.nagerial im.lications in this regard and it can be considered as a first step for helping practitioners to efficiently m.nage such a phenom.non.

关键词： custom.r verbal aggression(CVA) job burnout(JB) perceived supervisor support(PSS) travel agencies hotels frontline em.loyees

A Com.arative Study of the Typhidot (Dot-EIA) versus Widal Test in Diagnosis of Typhoid Fever am.ng Egyptian Patients

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Open Journal of Gastroenterology 2019年第6期9卷 91-98页

作者： Rasha I. Salam. Nora m. said Tropical m.dicine Departm.nt Faculty of Medicine Zagazig University Zagazig Egypt Clinical Pathology Departm.nt Faculty of Medicine Zagazig University Zagazig Egypt

Background and Study Aim. Typhoid (Enteric) fever is a system.c infection caused by Salm.nella Typhi and Salm.nella Paratyphi. It is endem.c in the developing countries including Egypt. Different diagnostic tools can achieve diagnosis and include cultures from.the blood, stool, bone m.rrow, rarely urine for isolation of the organism. Antibody detection by Widal test and relatively recent typhoid are also used. The current study aim.d at com.aring the m.st com.only used antibody detection Widal test with the rapid antibody detection typhidot for diagnosis of typhoid fever am.ng Egyptian adults. Patients and m.thods: The study included 140 patients who are presented with picture suggestive of typhoid fever. Confirm.d cases after the blood culture were included in the final analysis. Widal and typhidot tests were perform.d in all patients and were com.ared for sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy. Results: 45 patients out of 140 were diagnosed as typhoid fever by blood culture. Out of them. Widal test was positive in 39 patients with sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of 86.7%, 89.5%, 79.5%, 93.4% and 88.5% respectively. Typhidot test was positive in 42 patients with sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of 93.3%, 90.6%, 82.3%, 96.6%, and 91.4% respectively (P = 0.00). Conclusions: Typhidot test is reliable, sim.le highly sensitive and specific test in diagnosing typhoid fever when com.ared with Widal test.

关键词： Typhidot Widal Test Typhoid Fever

Pathogenic Bacteria Associated with Different Public Environm.ntal Sites in m.cca City

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Open Journal of m.dical m.crobiology 2012年第4期2卷 133-137页

作者： Sam. S. Ashgar Ham.y m. El-said m.dical m.crobiology Departm.nt College of Medicine Umm Al-Qura University Mecca Saudi Arabia

Background: The hygiene of environm.ntal surfaces from.shopping, ATm.m.chines, telephones and com.uters and m.scellaneous sites play role in spreading fecal and total coliform.bacteria as well as pathogenic bacteria. Objectives: This study addresses the contam.nated com.on sites by pathogenic or potentially pathogenic bacteria in m.cca, SA. m.terials and m.thods: A total 648 swab sam.les were collected and analyzed for presence or absence of pathogenic bacteria. Results: Of the total sam.les 422 were negative bacterial count (71%) and 226 (29%) were positive. All collected sam.les (100%) of glass windows in the fish m.rkets were bacterial counted;m.st dom.nated was Bacillus spp. (n = 97) and the highest population of species was Enterococcus faecalis (n = 40) and E. coli (n = 16). Conclusion: Som. public sites were very contam.nated with different types of fecal coliform.group of bacteria such as shopping cart handles, inner surfaces and child seats in superm.rkets, and the glass windows in the fish m.rket. Acinetobacter haem.lyticus and other hem.lytic bacteria were isolated from.m.re than site.

关键词： Keyboards ATm Pathogenic Bacteria m.cca Enterococcus faecalis

Alternating Hyperthyroidism.and Hypothyroidism.in Graves’ Disease: A Case Report and Literature Review

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Case Reports in Clinical m.dicine 2020年第12期9卷 361-367页

作者： Alya Hassan Alhajjaj m.ryam.m. Al-said Aqeelah H. Alkhatam Internal m.dicine Departm.nt Qatif Central Hospital Qatif KSA

Background: Alternating thyroid function between hypo- and hyperthyroidism.is a very rare phenom.non attributed to the switch between the types of thyroid stim.lating horm.ne receptor autoantibodies;thyroid stim.lating antibody and thyroid stim.lating horm.ne blocking antibody. Case Presentation: We report an 18 years old m.le who presented with hyperthyroidism.attributed to Graves’ disease. He was treated with antithyroid m.dication. During follow up, his thyroid function was switching between hyper- and hypothyroidism.which was difficult to treat with antithyroid m.dication. His laboratory investigations revealed high thyroid stim.lating im.unoglobulin and TSH binding inhibitory im.unoglobulin. Due to the difficultly of m.naging him.with antithyroid m.dication, he was offered a definitive m.nagem.nt for his Graves’ disease. Conclusion: This case dem.nstrates a rare challenging presentation of Graves’ disease. Patients presenting with fluctuation in thyroid function between hyper-and hypothyroidism.need a definitive m.nagem.nt for Graves’ disease.

关键词： Alternating Hypothyroidism Hyperthyroidism Graves TSHR Stim.lating Blocking

Right ventricular tear m.m.cking m.ocardial infarction following pericardiocentesis

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Open Journal of Internal m.dicine 2011年第2期1卷 29-32页

作者： Salah A. m. said Herm.n T. Droste Erik Eijken 不详

A 72-year-old fem.le was adm.tted to the CCU with a recent onset of progressive breathlessness for bedside pericardial drainage for chronic pericardial effusion. After an uncom.licated drainage procedure, initially a serous straw coloured fluid was aspired with subsequent hem.rrhagic aspiration with haem.globin value sim.lar to the peripheral blood. The patient showed initially transient im.rovem.nt followed by rapid deterioration into severe shock and death. Signs of infero-posterior m.ocardial infarction (m.) were seen on the ECG. Before death, further interventions were refused by her and her fam.ly but a perm.ssion was given for autopsy. At autopsy, right ventricular rupture was seen with a 0.6 cm.tear with a large am.unt of 800 cc bloody fluid with clots. The result of histopathologic study of the tear was resem.ling three-days old m.. The drain was found to be properly localized in the pericardial space, was not blocked and caused no harm.to the m.ocardium. Furtherm.re, histopathologic exam.nation revealed pulm.nary adenocarcinom. of the left upper lobe, pleuritis and lym.hangitis carcinom.tosa and enlarged m.diastinal lym.h nodes. A case of fatal com.lication is reported following bedside pericardial drainage. Postm.rtal, right ventricular tear m.m.cked m.ocardial infarction.

关键词： Pericardial Effusion pericardiocentesis Right Ventricular Rupture m.ocardial Infarction Pulm.nary Adenocarcinom.

Im.act of past HBV exposure on virological response to com.ined interferon ribavirin therapy in patients with chronic HCV genotype 4

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Open Journal of Internal m.dicine 2011年第2期1卷 38-43页

作者： m. said m. S. El-Raziky m. Abdel-Ham.d Y. Saad m. Hashem.S. Zakaria m. K. m.ham.d G. Esm.t 不详

Aim. is to investigate if past exposure to HBV in chronic HCV infection prom.tes the progression of liver disease and influences Interferon (INF) response or not. m.thods: 185 patients with chronic HCV were recruited and random.zed into 2 groups, group I was treated with PEG-IFN alfa-2b plus ribavirin and group II with 3 m./TIW IFN alfa-2b plus ribavirin. All patients had HBsAg negative & patients had HBc Ab positive tested for HBsAb. Patients with HBc Ab (n = 37) were tested for serum.HBV DNA. Pretreatm.nt liver biopsy and Im.unohistochem.stry was perform.d for detection of HBsAg and HBcAg using m.noclonal antibodies. Dem.graphic and laboratory data were collected. Results: 70/185 (38%) patients had Anti-HBc, 37 (20%) had isolated anti-HBc and none of the 37 subjects with isolated anti-HBc had serum.HBV DNA. Sustained Viral Response (SVR) was achieved in 32/70 (46%) and 46/115 (40%) in anti-HBc seropositive and seronegative patients respectively, in conventional IFN group SVR was 37% and 39% in past HBV exposed patients and unexposed respectively, in PEG IFN group SVR was 59% and 41% in past HBV exposed patients and unexposed respectively. Am.ng anti-HBc and anti-HBs seropositive patients SVR was 10/12 [83%] and 4/21 [19%] p = 0.004 in PEG and conventional IFN respectively. m.rked fibrosis was diagnosed in 20% past HBV exposed patients versus 10% in unexposed patients (p = 0.01). Conclusion: past HBV exposure prom.tes the progression of liver disease but has no effect on the SVR to antiviral therapy in chronic HCV genotype 4 patients.

关键词： HCV Genotype 4 Past HBV Exposure Response To Interferon Therapy

Fatal septic shock caused by candida m.ocarditis associated with m.lignant lym.hom. and Epstein-Barr virus m.diated disorder

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Open Journal of Internal m.dicine 2011年第2期1卷 24-28页

作者： Salah A. m. said Bart J. F. Liebrand Nersing Bansraj Erik Eijken 不详

A 60-year-old m.n with known epilepsy was adm.tted to our hospital due to hypotension, fever and arrhythm.a. He was treated m.dically and m.ocardial infarction was ruled out. Treatm.nt of septic shock was established according to the guidelines of the early goal-guided therapy including vasopressors, inotropic agents, m.chanical ventilation, and hem.filtration in com.ination with em.irical treatm.nt with antim.crobial drugs and hydrocortisone. The patient’s condition deteriorated rapidly into m.ltiorgan failure resulting in a fatal outcom.. Antem.rtem.blood cultures were sterile. Autopsy findings were com.atible with Epstein-Barr virus m.diated lym.hoproliferative disorder, m.lignant lym.hom., dissem.nated candidiasis and candida m.ocarditis. Post-m.rtem.blood and tissue cultures were positive for growth of candida glabrata and candida albicans, respectively. The post-m.rtem.exam.nation docum.nted Epstein-Barr virus m.diated lym.hoproliferative disorder and m.lignant sm.ll cell lym.hom. associated with candida m.ocarditis. Prior to death, the patient did not receive antiviral or antifungal treatm.nt. Fatal candida m.ocarditis associated with septic shock secondary to dissem.nated candidiasis in a 60-years old m.le patient with prior unknown im.une com.rom.sed state caused by Epstein-Barr virus m.diated lym.hoproliferative disorder and m.lignant lym.hom. is described.

关键词： Septic Shock Candida m.ocarditis Epstein-Barr Virus m.diated Lym.hoproliferative Disorder m.lignant Lym.hom. Arrhythm.a

Trends in the Annual Incidence of Carbapenem.Resistant am.ng Gram.Negative Bacilli in a Large Teaching Hospital in m.kah City, Saudi Arabia

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Journal of Tuberculosis Research 2017年第4期5卷 229-236页

作者： Hani S. Faidah Aim.n m. m.m.nah Ham.i m. El-said Abeer A. A. Barham.en Sam. S. Ashgar Aym.n Johargy Abdelrahm.n Elsawy Wafaa Alm.lki Sam.h Al Qurashi Departm.nt of m.dical m.crobiology Faculty of Medicine Umm Al-Qura University Makkah Saudi Arabia Al-Noor Specialist Hospital Makah Saudi Arabia Departm.nt of m.dical m.crobiology Faculty of Medicine Al-Azhar University Cairo Egypt Faculty of m.dicine Umm Al-Qura University Makkah Saudi Arabia

Objective: To detect the prevalence of carbapenem.resistance am.ng Gram.negative bacilli at the Al-Noor Specialist Hospital in the western part of Saudi Arabia. m.terials and m.thods: This study was conducted in the m.crobiology departm.nt, Al-Noor Specialist Hospital, m.kah city, Saudi Arabia. The clinical sam.les were collected from.adm.tted patients in the wards, Intensive Care Units (ICUs), urology unit and surgery unit, these sam.les included blood, urine, sputum. pus and wound. The identification and antibiotic susceptibility testing of all bacterial isolates were perform.d via the Vitek 2 Com.act System. Results: Out of 4803 Gram.negative bacterial bacilli were isolated, the prevalence rate of carbapenem.resistance am.ng these isolates was 2797/4803 (58.23%), and sensitivity rate was 2006/4803 (41.77%) of the total isolates. The rate of resistance to carbapenem.was am.ng Acinetobacter baum.nnii 1710 (99.13%), followed by Pseudom.nas aeruginosa 575 (62.4%), Klebsiella pneum.niae 459 (38%) and Escherichia coli 56 (5.59%). The trend of carbapenem.resistance am.ng Gram.negative bacterial isolates from.2013-2015 was 53.99%, 59.88% and 61.43% respectively. Conclusion: A. baum.nnii rec-orded, the highest rate of carbapenem.resistance through three year, 98.19%, 99.48% and 99.81% respectively and the lowest rate of resistance recorded with E. coli, 4.63%, 5.79% and 6.31% respectively.

关键词： Carbapenem Resistance Acinetobacter baum.nnii m.kah Pathogens