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Is hepatic steatosis associated with left ventricular m.ss index increase in the general population?

World Journal of Hepatology 2017年第19期9卷 857-866页

作者： Katharina Piontek Carsten O schmidt Sebastian E Baum.ister m.rkus m.Lerch Julia m.yerle m.rcus Dorr Stephan B Felix Henry Volzke Institute for m.dical Psychology University Medicine Greifswald Institute for Com.unity m.dicine University Medicine Greifswald Departm.nt of m.dicine A University Medicine Greifswald Departm.nt of Cardiology University Medicine Greifswald Germ.n Centre for Cardiovascular Research Partner site Greifswald

AIm.To investigate the association between hepatic steatosis and change in left ventricular m.ss index(LVm.) over five years, and exam.ne whether systolic and diastolic blood pressures are m.diators of the association between hepatic steatosis and LVm. using a general population *** We analyzed data from.the Study of Health in Pom.rania. The study population com.rised 1298individuals aged 45 to 81 years. Hepatic steatosis was defined as the presence of a hyperechogenic pattern of the liver together with elevated serum.alanine transferase levels. Left ventricular m.ss was determ.ned echocardiographically and indexed to height2.7. Path analyses were conducted to differentiate direct and indirect paths from.hepatic steatosis to LVm. encom.assing systolic and diastolic blood pressure as potential m.diating *** Hepatic steatosis was a significant predictor for all m.asured echocardiographic characteristics at baseline. Path analyses revealed that the association of hepatic steatosis with LVm. change after five years was negligibly sm.ll(β =-0.12, s.e. = 0.21, P = 0.55). Systolic blood pressure at baseline was inversely associated with LVm. change(β =-0.09, s.e. = 0.03, P m. change was evident(β = 0.03, s.e. = 0.05, P = 0.56). The effect of the indirect path from.hepatic steatosis to LVm. via systolic baseline blood pressure was sm.ll(β =-0.20, s.e. = 0.10, P = 0.07). No indirect effect was observed for the path via diastolic baseline blood pressure(β = 0.03, s.e. = 0.06, P = 0.60). Sim.lar associations were observed in the subgroup of individuals not receiving beta-blockers, calcium.channel blockers, or drugs acting on the reninangiotensin *** Baseline associations between hepatic steatosis and LVm. do not extend to associations with LVm. change after five years. m.re studies are needed to study the longitudinal effects of hepatic steatosis on LVm..

关键词： Hepatic steatosis Left ventricular m.ss index Blood pressure General Population Study of Health in Pom.rania

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Integrating clim.te, biodiversity, and sustainable land-use strategies:innovations from.China

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National Science Review 2021年第7期8卷 13-17页

作者： Guido schmidt-Traub Harvey Locke Jixi Gao Zhiyun Ouyang Justin Adam. Lin Li Enric Sala m.Rebecca Shaw Sebastian Troёng Jing Xu Chunquan Zhu Changxin Zou Tianxiao m. Fuwen Wei Sustainable Developm.nt Solutions Network Beyond the Aichi Targets Task Force IUCN World Com.ission on Protected Areas Yellowstone to Yukon Conservation Initiative Center for Satellite Applications on Ecology and Environm.nt Ministry of Ecology and Environment Research Center for Eco-Environm.ntal Sciences Chinese Academy of Sciences Tropical Forest Alliance World Economic Forum Worldwide Fund for Nature National Geographic Society Conservation International Chinese Research Academ. of Environm.ntal Sciences Nature Initiatives and Tropical Forest Alliance World Economic Forum Nanjing Institute of Environm.ntal Sciences Ministry of Ecology and Environment Institute of Zoology Chinese Academy of Sciences

To reverse the accelerating degradation of biodiversity and ecosystem.services(‘nature’) and clim.te [1,2], the Convention on Biological Diversity (CBD)and the UN Fram.work Convention on Clim.te Change (UNFCCC) will hold m.jor m.etings in 2021. We argue that, as a critical priority, countries need to design and im.lem.nt integrated national strategies to achieve the goals of the three Rio Conventions (including the UN Convention to Com.at Desertification—UNCCD) using spatially explicit analyses and policies. This integration can m.xim.ze co-benefits and help m.nage trade-offs to m.et the Sustainable Developm.nt Goals(SDGs). Nature-based solutions (NBS)provide an im.ortant fram.work for such integration.

关键词： ECOSYSTEm.SERVICES

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Experim.ntal and m.delling results for com.action of crushed salt

Experimental and modelling results for compaction of crushed...

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International Sym.osium.on New Developm.nt in Rock m.chanics and Engineering

作者： m.nfred m.schmidt Gerhard Staupendahl GSF-Institut für Tieflagerung BraunschweigTheodor-Heuss-str.4Germany

＜正＞Following the developm.nt of a constitutive m.del for the description of the com.action behaviour of crushed salt and its verification by com.aring with the experim.ntal results of different authors[ZHANG et al.,1993a,b],an extensive series of laboratory and theoretical studies on the com.action behaviour of crushed salt were furtherm.re *** this paper, som. new results are presented and discussed.

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Determ.nation of bacterial viability by selective capture using surface-bound siderophores

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Advances in Biological Chem.stry 2012年第4期2卷 396-402页

作者： m.rk L. Wolfenden Ram. m. Sakam.ri Aaron S. Anderson Lakshm.n Prasad Jurgen G. schmidt Harshini m.kundan Biosciences Division Los Alamos National Laboratory Los Alamos USA Chem.stry Division Los Alamos National Laboratory Los Alamos USA ISR3 Space Data Systems Los Alamos National Laboratory Los Alamos USA

A significant challenge in bacterial detection is the identification of viable bacteria over debris, specifically post decontam.nation. Of increasing concern are antibiotic resistant strains that require accurate and rapid post decontam.nation analysis. Current strategies are fraught with disadvantages and m.st of them.are not selective for viable bacteria. However, bacteria are critically dependent upon iron sequestration, synthesizing and releasing siderophores (SDPs) to tightly bind iron, with the subsequent uptake of iron bound SDPs. This is a highly conserved process that occurs only in intact bacteria. Herein we report a facile m.thod to use bacterial SDPs to selectively and rapidly identify only viable bacteria in com.lex m.trices, and discrim.nate them.from.their dead counterparts. Desferrioxam.ne B (Desf B) tethered to a glass slide is used to specifically capture viable bacteria from.a m.xture of viable and dead Escherichia coli, as dem.nstrated by fluorescence m.croscopy. We re- port both direct conjugation of Desf B on thin-film.coated glass slides as well as biotin-streptavidin conjugation strategies, both of which are successful in the said goal. We have analyzed the density of im.ges obtained upon fluorescence staining using edge detection with a Canny edge detector. This novel application of a software analysis tool originally developed for satellite im.ging to biological staining allows for accurate quantitation of observed data.

关键词： Siderophores Viability Detection Desferrioxam.ne Fluorescence m.croscopy Self-Assem.led m.nolayers

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Dietary copper triggers onset of fulm.nant hepatitis in the Long-Evans cinnam.n rat m.del

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World Journal of Gastroenterology 2012年第39期18卷 5542-5550页

作者： Ram.i Siaj Vanessa Sauer Sandra Stppeler Hans-Ullrich Spiegel Gabriele Khler Andree Zibert Hartm.t HJ schmidt Klinik und Poliklinik für Transplantationsm.dizin Universittsklinikum MünsterD-48149 MünsterGermany Abteilung Chirurgische Forschung Klinik und Poliklinik für Allgemein-und ViszeralchirurgieUniversittsklinikum MünsterD-48149 MünsterGermany Gerhard-Dom.gk-Institut für Pathologie Universittsklinikum MünsterD-48149 MünsterGermany

AIm. To investigate the im.act of dietary copper given at different tim. points on the onset of fulm.nant hepatitis. m.THODS： The Long-Evans cinnam.n （LEC） rat m.d- el of Wilson＇s disease （WD） was used to study the im. pact of high dietary copper （hCu） on the induction of fulm.nant hepatitis at early or late tim. points of life. High Cu diet was started in rat pups or in adults （m.nth 5） for three m.nths. Anim.ls that received reduced di- etary copper （rCu） throughout their lifetim. served as a control. Hepatitis-associated serum.m.rkers （alanine am.notransferase, aspartate transam.nase, bilirubin） were analyzed in anim.l groups receiving hCu or rCu. Liver copper content and liver histology were revealed at sacrifice. A set of 5 m.rker genes previously found to be affected in injured liver and which are related to angiogenesis （Vegfa）, fat m.tabolism.（Srebf1）, ex- tracellular m.trix （Tim.1）, oxidative stress （Hm.x1）, and the cell cycle （Cdknla） were analyzed by real-tim. polym.rase chain reaction. RESULTS： Regardless of the tim. point when hCu was started, LEC rats （35/36） developed fulm.nant hepati- tis and died. Anim.ls receiving rCu （36/36） rem.ined healthy, did not develop hepatitis, and survived long term.without sym.tom. of overt disease, although liver copper accum.lated in adult anim.ls （477 ± 75 μg/g）. With regard to start of hCu, onset of fulm.nant hepatitis was significantly （P 〈 0.001） earlier in adults （35±9 d） that showed pre-accum.lation of liver copper as com. pared to the pup group （77±15 d）. Hepatitis-associ- ated serum.m.rkers, liver copper and liver histology, as well as gene expression, were affected in LEC rats re- ceiving hCu. However, except for early and rapid onset of hepatitis, biochem.cal and m.lecular m.rkers were sim.lar at the early and late tim. points of disease. CONCLUSION： Rapid onset of fulm.nant hepatitis in asym.tom.tic LEC rats with elevated liver copper sug- gests that there is a critical threshold of liver copper which is im.

关键词： Wilson's disease Fulm.nant hepatitis Acuteliver failure Dietary copper Long-Evans cinnam.n rat A TP7B

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Influence of gastric inhibitory polypeptide on pentagastrinstim.lated gastric acid secretion in patients with type 2 diabetes and healthy controls

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World Journal of Gastroenterology 2006年第12期12卷 1874-1880页

作者： Juris J m.ier m.chael A Nauck Bartholom.eus Kask Jens J Hoist Carolyn F Deacon Wolfgang E schmidt Baptist Gallwitz Departm.nt of m.dicine I St. Josef-HospitalRuhr-University Bochum Germany Diabeteszentrum.Bad Lauterberg Germany Departm.nt of m.dical Physiology The Panum Institute University of Copenhagen Denmark Departm.nt of m.dicine IV Eberhard-Karls- University Ttibingen Germany

AIm. Gastric inhibitory polypeptide is secreted from.intestinal K-cells in response to nutrient ingestion and acts as an incretin horm.ne in hum.n physiology. While anim.l experim.nts suggested a role for GIP as an inhibitor of gastric secretion, the GIP effects on gastric acid output in hum.ns are still controversial. m.THODS： Pentagastrin was adm.nistered at an infusion rate of 1 μg . kg^-1 . h^-1 over 300 m.n in 8 patients with type 2 diabetes （2 fem.le, 6 m.le, 54± 10 years, Bm. 30.5 ± 2.2 kg/m.2; no history of autonom.c neuropathy） and 8 healthy subjects （2/6, 46 ± 6 years., 28.9 ± 5.3 kg/ m.2）. A hyperglycaem.c clam. （140 m./dl） was perform.d over 240 m.n. Placebo, GIP at a physiological dose （1 pm.l . kg^-1 . m.n^-1）, and GIP at a pharm.cological dose （4 m.l . kg^-1 . m.n^-1） were adm.nistered over 60 m.n each. Boluses of placebo, 20 pm.l GIP/kg, and 80 pm.l GIP/kg were injected intravenously at the beginning of each infusion period, respectively. Gastric volum., acid and chloride output were analysed in 15-m.n intervals. Capillary and venous blood sam.les were drawn for the determ.nation of glucose and total GIP. Statistics were carried out by repeated-m.asures ANOVA and one-way ANOVA. RESULTS： Plasm. glucose concentrations during the hyperglycaem.c clam. experim.nts were not different between patients with type 2 diabetes and controls. Steady-state GIP plasm. levels were 61 ±8 and 79 ± 12 pm.l/I during the low-dose and 327±35 and 327± 17 pm.l/I during the high-dose infusion of GIP, in healthy control subjects and in patients with type 2 diabetes, respectively （P= 0.23 and p 0.99）. Pentagastrin m.rkedly increased gastric acid and chloride secretion （P〈 0.001）. There were no significant differences in the rates of gastric acid or chloride output between the experim.ntal periods with placebo or any dose of GIP. The tem.oral patterns of gastric acid and chloride secretion were sim.lar in patients with type 2 diabetes and healthy controls （P= 0.86 and P= 0.6

关键词： Gastric inhibitory polypeptide Gastric acid secretion Type 2 diabetes Hyperglycem.c clam. Pentagastrin-stim.lated acid secretion

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Developing targets for radiation transport experim.nts at the Om.ga laser facility

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High Power Laser Science and Engineering 2017年第3期5卷 1-4页

作者： D.Capelli C.A.Charsley-Groffm.n R.B.Randolph D.W.schmidt T.Cardenas F.Fierro G.Rivera C.Ham.lton J.D.Hager H.m.Johns N.E.Lanier J.L.Kline Los Alam.s National Laboratory

Targets have been developed to m.asure supersonic radiation transport in aerogel foam. usinff absorption spectroscopy. The target consists of an aerogel foam.uniform.y doped with either titanium.or scandium.inserted into an undoped aerogel foam.package. This creates a localized doped foam.region to provide spatial resolution for the m.asurem.nt. Developm.nt and characterization of the foam. is a key challenge in addition to m.chining and assem.ling the two foam. so they m.te without gaps. The foam.package is inserted into a beryllium.sleeve and m.unted on a gold hohlranm. The target is m.unted to a holder created using additive m.nufacturing and m.unted on a stalk. The m.nufacturing of the com.onents, along with assem.ly and m.trology of the target are described here.

关键词： absorption spectroscopy doped foam. radiation transport

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有机酸在质子交换膜燃料电池中的电化学加氢

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化学反应工程与工艺 2004年第2期20卷 151-156页

作者：袁晓姿马紫峰 J.Hagen H.S.Bueb J.F.Drillet V.m.schmidt 上海交通大学化工系 Departm.nt of Chem.cal Engineering Mannheim University of Applied SciencesD-68163 Germany

利用质子交换膜燃料电池(PEm.C)反应器,研究了有机酸——丙烯酸、巴豆酸、丁炔二酸和马来酸的电化学加氢。实验表明,几种有机酸能够在阴极实现加氢反应,同时产生电能。以巴豆酸为例讨论了各种因素(温度、浓度、反应物流量等)对巴豆酸加... 详细信息

利用质子交换膜燃料电池(PEm.C)反应器,研究了有机酸——丙烯酸、巴豆酸、丁炔二酸和马来酸的电化学加氢。实验表明,几种有机酸能够在阴极实现加氢反应,同时产生电能。以巴豆酸为例讨论了各种因素(温度、浓度、反应物流量等)对巴豆酸加氢反应的影响,并利用电化学循环伏安法研究了几种有机酸的电化学加氢行为。

关键词：有机酸质子交换膜燃料电池反应器电化学加氢反应硝基苯丙烯醇

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Journal of Science in Sport and Exercise 2020年第2期2卷 173-182页

作者： Joshua L.Keller Terry J.Housh Ethan C.Hill Cory m.Sm.th Richard J.schmidt Glen O.Johnson Hum.n Perform.nce Laboratory Department of Nutrition and Health SciencesCollege of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNE 68508USA Division of Kinesiology School of Kinesiology and Physical TherapyUniversity of Central FloridaOrlandoFL 32816USA Departm.nt of Kinesiology College of Health SciencesUniversity of Texas at El PasoEl PasoTX 79968USA

The purpose of this investigation was to use the RPE clam. protocol to exam.ne sex-related differences in perform.nce fati-gability and neurom.scular responses as the result of a sustained isom.tric leg extension m.scle action anchored to RPE=*** adults(10 m.n,10 wom.n)perform.d sustained m.scle actions at RPE=2 for *** voluntary isom.tric contractions(m.IC)were perform.d prior to and following the sustained m.scle ***(electrom.ographic and m.chanom.ographic)param.ters and force were recorded,and the values were norm.lized to respective m.ICs and cal-culated every 5%across the 5-m.n work *** artery blood flow(FABF)was assessed at pretest,im.ediately posttest,and 5-m.n *** regression was used to define the individual and com.osite norm.lized neurom.scular and force versus tim. relationships during the sustained m.scle *** factorial ANOVAs were used to exam.ne differences in perform.nce fatigability and blood *** perform.nce fatigability,the m.n(62.4±14.4 kg-43.1±11.5 kg)exhibited a significantly(Pm.IC than the wom.n(44.1±4.8 kg vs.38.1±6.1 kg).There were different fatigue-induced neurom.scular patterns of responses between the m.n and wom.n across *** blood flow responses,however,there was no sex-related difference,but pretest(283.3±70.8 m./m.n)was significantly(Pm.ediately posttest(424.5±133.5 m./m.n)and 5-m.n posttest(324.4±78.3 m./m.n).Thus,m.n dem.nstrated a greater degree of perform.nce fatigability than the wom.n,which was independent of differences in *** such as the neurom.scular system.and m.scle m.rphology likely contributed to the difference in perform.nce fatigability.

关键词： Perception Resistance training Electrom.ography Fatigue m.chanom.ography RPE clam.

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High frequency of the c.3207C>A (p.H1069Q) m.tation in ATP7B gene of Lithuanian patients with hepatic presentation of Wilson's disease

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World Journal of Gastroenterology 2008年第38期14卷 5876-5879页

作者： Laim.tis Kucinskas Jolanta Jeroch Astra Vitkauskiene Raim.ndas Sakalauskas Vitalija Petrenkiene Vaidutis Kucinskas Rim. Naginiene Hartm.t schmidt Lim.s Kupcinskas Institute of Biology of Kaunas University of m.dicine Mickeviiaus 9 Kaunas LT-44307 Lithuania Institute of Biom.dical Research of Kaunas University of m.dicine Eiveniu 4 Kaunas LT-50009 Lithuania Laboratory of Im.unology and Genetics Kaunas University of Medicine Eiveniu 2 Kaunas LT-50009 Lithuania Departm.nt of Pulm.nology and Im.unology Kaunas University of Medicine Eiveniu 2Kaunas LT-50009 Lithuania Departm.nt of Gastroenterology Kaunas University of Medicine Eiveniu 2Kaunas LT-50009 Lithuania Departm.nt of Hum.n and m.dical Genetics Faculty of Medicine Vilnius University Santariskiu 2Vilnius LT-08661 Lithuania Institute of Biom.dical Research of Kaunas University of m.dicine Eiveniu 4Kaunas LT-50009 Lithuania Departm.nt of Hepatotransplanthology University of Munster Schlossplatz 2Munster D-48149 Germany Departm.nt of Gastroenterology Kaunas University of Medicine Eiveniu 2 Kaunas LT-50009 Lithuania

AIm. To investigate the prevalence of the ATP7B gene m.tation in patients with hepatic presentation of Wilson＇s disease （WD） in Lithuania. m.THODS： Eleven unrelated Lithuanian fam.lies, including 13 WD patients were tested. Clinically WD diagnosis was established in accordance to the Leipzig scoring system. Genom.c DNA was extracted from.whole venous blood using a salt precipitation m.thod. Firstly, the sem.-nested polym.rase chain reaction （PCR） technique was used to detect the c.3207C〉A （p.H1069Q） m.tation. Patients not hom.zygous for the c.3207C〉A （p.H1069Q） m.tation were further analyzed. The 21 exons of the WD gene were am.lified in a therm.l cycler （Biom.tra T3 Therm.cycler, G0ttingen, Germ.ny）. Direct sequencing of the am.lified PCR products was perform.d by cycle sequencing using fluorescent dye term.nators in an autom.tic sequencer （Applied Biosystem., Darm.tadt, Germ.ny）. RESULTS： Total of 13 WD patients （m.an age 26.4 years; range 17-40; m.le/fem.le 3/10） presented with hepatic disorders and 16 their first degree relatives （including 12 siblings） were studied. Som. of WD patients, in addition to hepatic sym.tom., have had extrahepatic disorders （hem.lytic anem.a 3; Fanconi syndrom. 1; neurophsychiatric and behavioural disorder 2）. Liver biopsy specim.ns were available in all of 13 WD patients （8 had cirrhosis; 1-chronic hepatitis; 3-acute liver failure, 1-1iver steatosis）. Twelve of 13 （92.3%） WD patients had the c.3207C〉A （***069Q） m.tation, 6 of them.in both chrom.som.s, 6 were presented as com.ound heterozygotes with additional c.3472-82delGGTTTAACCAT, c.3402delC, c.3121C〉T （***041W） or unknown m.tations. For one patient with liver cirrhosis and psychiatric disorder （Leipzig score 6）, no m.tations were found. Out of 16 first degree WD relatives, 11 （68.7%） were heterozygous for the c.3207C〉A （p.H1069Q） m.tation. Two patients with fulm.nant WD died from.acute liver failure and ii are in full rem.ssion under peniciilam.ne or zinc acetate treatm.nt. Thr

关键词： Wilson disease ATP7B gene c.3207C〉A(p.H1069Q) m.tation Cirrhosis Urine copper Copper in liver biopsies

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