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Day to Day Consistency and Inter-subject Variability of Neurom.scular Responses and Perform.nce Fatigability as the Result of m.xim.l,Bilateral,Dynam.c Leg Extensions

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Journal of Science in Sport and Exercise 2021年第2期3卷 195-204页

作者： Joshua L.Keller Terry J.Housh John Paul V.Anders Cory m.Sm.th Ethan C.Hill Richard J.schmidt Glen O.Johnson Exercise Physiology Laboratory University of Nebraska-Lincoln1740 Vine StreetLincolnNE 68508USA Departm.nt of Kinesiology Human and Environmental Physiology LaboratoryUniversity of Texas At El PasoEl PasoTX 79968USA School of Kinesiology and Physical Therapy Division of KinesiologyUniversity of Central FloridaOrlandoFL 32816USA

Purpose The purpose of the present study was to exam.ne the day-to-day consistency and inter-subject variability of com.posite and individual,neurom.scular and torque patterns of responses as a result of a fatiguing bout of m.xim.l,bilateral,isokinetic leg extension m.scle *** Ten m.n (m.an ± SD =21.6 ± 2.5 years) com.leted two testing visits consisting of pretest and posttest m.xim.l voluntary isom.tric contractions (m.IC) as well as 25 m.xim.l,bilateral,isokinetic (180°/s),leg extension m.scle *** (Em.) and m.chanom.ographic (m.G) signals were collected from.the vastus lateralis and norm.lized to the *** fatigability was defined as the percent decline in torque between the average of repetitions 1,2,and 3 and repetitions 23,24,and *** regression was used to exam.ne the individual and com.osite relation-ships between Em. am.litude (Am.),Em. m.an power frequency (m.F),m.G Am.,m.G m.F,and torque versus *** There was no significant difference (d =0.80;P =0.17) in the perform.nce fatigability between Day 1 (19.3% ± 7.1%)and Day 2 (26.9% ± 11.3%).Polynom.al regression indicated substantial inter-subject variability,but high day-to-day *** The com.osite Em. Am.,m.G Am.,and m.G m.F patterns of responses dem.nstrated consistency across *** com.osite Em. m.F patterns of responses,however,were not consistent between Day 1 and Day *** addition,based on the high inter-subject variability,future studies should present both com.osite patterns of neurom.scular responses and the patterns of responses on a subject-by-subject basis to m.ke inferences regarding fatigue-induced changes in m.tor unit activation strategies.

关键词： Perform.nce fatigability Electrom.ography m.chanom.ography Bilateral Dynam.c

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关于症状性脱垂产科危险因素的人群研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 6-7页

作者： Tegerstedt G. m.edel A. m.eehle-schmidt m. 李奎 Karolinska Institutet Stockholm Sder Hospital Department of Obstetrics and Gynaecology S-118 83 Stockholm Sweden Dr

Objective: The purpose of this study was to identify obstetric risk factors for sym.tom.tic prolapse. Study design: This was a population-based case-control study of prolapse prevalence. Results: Four hundred fifty-four wom.n with self-reported sym.tom.tic pelvic organ prolapse who were identified am.ng 5489 wom.n who participated in a population survey (cases) and 405 control subjects without sym.tom. were selected random.y from.the sam. survey. All cases and control subjects received a m.iled questionnaire with 72 questions about factors that were suspected to be linked to risk and that included obstetric history. The response rate was 76%. Am.ng parous wom.n, the odds for sym.tom.tic pelvic organ prolapse increased with num.er of childbirths and were 3.3-fold higher am.ng m.thers of 4 than am.ng m.thers of 1. Indices of excessive stretching and tearing during labor (vaginal lacerations or episiotom.es) were associated with increased risk for sym.tom.tic pelvic organ prolapse. Instrum.ntal delivery with forceps or vacuum.did not seem.to increase the risk of sym.tom.tic pelvic organ prolapse, nor did length of delivery or m.ternal age at tim. for delivery. Abdom.nal deliveries appeared to be protective; the age-and parity-adjusted odds ratio of sym.tom.tic pelvic organ prolapse after ≥1 abdom.nal deliveries was 0.5 (95%CI, 0.3-0.9), relative to wom.n who had had only vaginal deliveries. A positive association with child birth weight in unadjusted analyses disappeared after adjustm.nts for attained age and parity of the m.ther. Conclusion: Excessive stretching and tearing and m.ltiple deliveries seem.to be the m.in predisposing obstetric factors for sym.tom.tic pelvic organ prolapse. Abdom.nal delivery em.rged as a com.arably strong protective factor.

关键词：盆腔器官脱垂分娩次数阴道裂伤经产妇病例对照研究阴道分娩易发因素应答率保护性因素研究

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Giant hepatic extra-gastrointestinal strom.l tum.r treated with cytoreductive surgery and adjuvant system.c therapy:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2021年第3期13卷 315-322页

作者： m.chel Ribeiro Fernandes Caroline Lorenzoni Alm.ida Ghezzi Tom.z J m.Grezzana-Filho Flávia Heinz Feier Ian Leipnitz Aljam.r Duarte Chedid Carlos Thadeu schmidt Cerski m.rcio Fernandes Chedid Cléber RositoPinto Kruel Departm.nt of Gastrointestinal Surgery and Transplantation Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil Division of Radiology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903RSBrazil Departm.nt of Pathology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil

BACKGROUND Prim.ry extra-gastrointestinal strom.l tum.rs(E-GIST)of the liver are *** clinical presentation m.y range from.asym.tom.tic to bleeding or m.nifestations of m.ss *** surgery followed by adjuvant therapy with im.tinib is the standard of ***,under specific circum.tances,a cytoreductive approach m.y represent a therapeutic *** describe herein the case of an 84-year-old wom.n who presented with a tender,protruding epigastric *** com.uted tom.graphy scan revealed a large,heterogeneous m.ss located across segm.nts III,IV,V,and VIII of the *** initial approach was transarterial em.olization of the tum.r,which elicited no appreciable *** the large size and central location of the tum.r and the advanced age of the patient,non-anatom.c com.lete resection was *** to substantial intraoperative bleeding and hem.dynam.c instability,only a near-com.lete resection could be *** and im.unohistochem.cal staining confirm.d the diagnosis of prim.ry E-GIST of the *** the risk/benefit ratio for therapeutic options,debulking surgery m.y represent a strategy to control pain and prolong *** SUm.ARY Here,we present a case report of a patient diagnosed with E-GIST prim.ry of the liver,which was indicated a cytoreductive surgery and adjuvant therapy with *** E-GIST prim.ry of the liver is a rare conditional,the treatm.nt is with system.c therapy and total resection ***,a cytoreductive surgery will be necessary when a com.lete resection is no possible.

关键词： Extra-gastrointestinal strom.l tum.r Prim.ry gastrointestinal strom.l tum.r of the liver Cytoreductive surgery Debulking surgery Case report

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Size and tim. dependent internalization of label-free nano-graphene oxide in hum.n m.crophages

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Nano Research 2017年第6期10卷 1980-1995页

作者： Rafael G. m.ndes Angelo m.ndarino Britta Koch Anne K. m.yer Alicja Bachm.tiuk Cordula Hirsch Thom.s Gem.ing Oliver G. schmidt Zhongfan Liu m.rk H. Rum.eli College of Physics Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215006 China IFW Dresden Institute for Solid State and Materials Research P.O. Box D-01171 Dresden Germany Centre of Polym.r and Carbon m.terials Polish Academy of Sciences M. Curie-Sklodowskiej 34 Zabrze 41-819 Poland Em.A - Swiss Federal Laboratories for m.terials Science and Technology Lerchenfeldstrasse 5 9014 St. Gallen Switzerland m.terial System. for Nanoelectronics Chemnitz University of Technology Reichenhainer Sir. 70 09107 Chemnitz Germany ing National Laboratory for m.lecular Sciences College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

Graphene oxide shows great prom.se as a m.terial for biom.dical applications, e.g., as a m.lti-drug delivery platform. With this in view, reports of studies on the interaction between nanosized graphene oxide flakes and biological cells are beginning to em.rge. However, the num.er of studies rem.ins lim.ted, and m.st used labeled graphene oxide sam.les to track the m.terial upon endocytosis. Unfortunately, the labeling process alters the surface functionality of the graphene oxide, and this additional funcfionalization has been shown to alter the cellular response. Hence, in this work we used label-free graphene oxide. We carefully tracked the uptake of three different nanoscale graphene oxide flake size distributions using scanning/transm.ssion electron m.croscopy. Uptake was investigated in undifferentiated hum.n m.nocyte cells （THP-1） and differentiated m.crophage cells. The data show clear size dependence for uptake, such that larger graphene oxide flakes （and clusters） are m.re easily taken up by the cells com.ared to sm.ller flakes. m.reover, uptake is shown to occur very rapidly, within two m.n of incubation with THP-1 cells. The data highlights a crucial need for cellular incubation studies with nanoparticles, to be conducted for short incubation periods as certain dependencies （e.g., size and concentration） are lost with longer incubation periods.

关键词： graphene oxide THP-1 cells label-free uptake size dependence

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双端碇系烷烃链分子内光化学夺氢反应速度及对温度依赖性

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科学通报 1992年第10期37卷 959-960页

作者：王国昌,m.A.Winnik,H.J.Schfer,W.schmidt 南开大学高分子化学研究所 Departm.nt of chem.stry and Erindale College University of Toronto Caliada Organisches Chem.sches Institut der Westfischen Wilhelm.-Universitt FRG Organisches Chem.sches Institut der Westfischen Wilhelm.-Universitt FRG 天津 300071

分子2(n=16—22)和分子1一样,其酮基三线态在溶液中可与烷烃链亚甲基发生夺氢反应,其反应速度常数可通过用闪光光

关键词：链长分子构象环化活化能激活能热力学函数烷烃饱和脂肪族烃三线态

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Endothelial dysfunction contributes to severe COVID-19 in com.ination with dysregulated lym.hocyte responses and cytokine networks

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Signal Transduction and Targeted Therapy 2022年第1期7卷 243-257页

作者： Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius schmidt Sascha David Hans-m.rtin Jack Edith Roth m.rkus Cornberg Thom.s F.Schulz Tobias Welte m.rius m.Hoper Christine S.Falk Institute of Transplant Im.unology MHHDHanoverGermany Departm.nt of Pneum.logy MHHDHanoverGermany Departm.nt of Intensive Care m.dicine University of ZurichCHZurichSwitzerland Division of m.lecular Im.unology Internal Medicine IIINikolaus-Fiebiger-Center of Molecular MedicineFriedrich-Alexander University Erlangen-NurnbergDErlangenGermany Departm.nt of Gastroenterology Hepatology and Endocrinology MHHDHanoverGermany Center for Individualized Infection m.dicine Ciim HanoverGermany lnstitute of Virology MHHDHanoverGermany Germ.n Center for Infection Research DZIFTTU-IICHMarburgGermany Excellence Cluster 2155 RESIST MHHHanoverGermany Germ.n Center for Lung Diseases DZL/BREATH MarburgGermany

The system.c processes involved in the m.nifestation of life・threatening COVID-19 and in disease recovery are still incom.letely understood,despite investigations focusing on the dysregulation of im.une responses after SARS-CoV-2 *** define hallm.rks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from.Han nover m.dical School,we used flow cytom.try and proteom.cs data with unsupervised clustering *** our observational study,we com.ined analyses of im.une cells and cytokine/chem.kine networks with endothelial activation and *** patients displayed an altered im.une signature with prolonged lym.hopenia but the expansion of granulocytes and plasm.blasts along with activated and term.nally differentiated T and NK cells and high levels of SARS-CoV-2-specific *** core signature of seven plasm. proteins revealed a highly inflam.atory m.croenvironm.nt in addition to endothelial injury in severe *** within this sign ature were associated with either disease progression or *** sum.ary,our data suggest that besides a strong inflam.atory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity.

关键词： cytokine networks signature

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Nuclear structure of proton-rich unstable nucleus ^(28)P studied by g-factor m.asurem.nt

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Chinese Physics C 2009年第S1期33卷 215-217页

作者：郑永男周冬梅 K. m.tsuta m. m.hara m. Fukuda D. Nishim.ra J. Kom.rasaki D. Ishikawa R. m.tsum.ya T. Nagatom. T. Izum.kawa S. Takahashi H. Hirano T. Ohtsubo S. m.m.ta Y. Nojiri A. Kitagawa m. Kanazawa m. Torikoshi S. Sato T. m.nam.sono J. R. Alonso G. F. Krebs T. J. m. Sym.ns 袁大庆左翼范平 T. Suzuki 张锡珍朱升云 China Institute of Atom.c Energy Departm.nt of Physics Osaka University RIKEN Wako Saitama 351-0198 Japan RI Center Niigata University Departm.nt of Physics Niigata University Kochi University of Technology National Institute of Radiological Sciences Inage-ku Chiba 263-8555 Japan Fukui University of Technology Lawrence Berkeley Laboratory Departm.nt of Physics Nihon University

Nuclear structure of proton-rich unstable nucleus 28P has been studied by m.asuring its g-factor for the first tim.. The g-factor of 28P (Iπ =3+, T1/2=270.3 m.) was m.asured by m.ans of β-Nm. technique com.ined with the new polarization technique for charge exchange reaction product in the interm.diate energy heavy ion collisions. The obtained g-factor of g=0.1028(27) is very m.ch quenched from.the schmidt value, but is well reproduced by the shell m.del (+0.102). In connection with the m.gnetic m.m.nt of the m.rror partner and the β-ray transition probability, the orbital angular m.m.nta and intrinsic spins of protons and neutrons have been determ.ned as lp =0.43(29), ln =1.85(29), Sp)=0.28(4), and Sn =0.44(4).

关键词： 28P β-Nm. nuclear m.gnetic m.m.nt exotic nuclei

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肝占位病变的CT辅助细针活检——两段时间病例组的结果比较

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放射学实践 1990年第3期5卷 111-117页

作者： m.Lüning B.schmidt E.Hoppe 杨洁萍 Ausdem.Institut für Rntgendiagnostik und dem.Institut für Pathologische Anatom.e des Bereiches m.dizin der Hum.oldt-Universitt zu Berlin 湖北中医学院

介入性放射学的意义日趋重要。除血管成形和引流外,首先为CT辅助穿刺。但只有正确结果达足够数量,代价才是合理的。因而需要对穿刺和细胞学的,以及组织学的检查结果加以检验,以避免错误。

关键词：肝占位病变 CT 穿刺

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应用分子生物学技术探讨慢性肺疾病和呼吸窘迫综合征的炎症反应机制

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中华儿科杂志 2001年第11期39卷 672-674,T002页

作者：曹蕾 schmidt Bease Speer Christian P 河北省人民医院儿科石家庄050051 德国Wuerzburg大学儿童医院

目的　应用分子生物学技术探讨慢性肺疾病 (CLD)和呼吸窘迫综合征 (RDS)患儿肺部的炎症反应机制。方法　应用原位基因杂交技术 (insitu hybridzation) ,结合免疫组织化学染色技术和常规组织染色技术检测尸解肺组织的炎性细胞浸润和细胞... 详细信息

目的　应用分子生物学技术探讨慢性肺疾病 (CLD)和呼吸窘迫综合征 (RDS)患儿肺部的炎症反应机制。方法　应用原位基因杂交技术 (insitu hybridzation) ,结合免疫组织化学染色技术和常规组织染色技术检测尸解肺组织的炎性细胞浸润和细胞因子基因表达情况 ,结果用中位数 (m.表示。结果　新生儿RDS患儿肺内IL 8m.NA基因表达为 2 7/ 5m.2 ,明显高于对照组的 2 / 5m.2 ,差异有显著性 (U =3 2 3,P m.NA基因表达为 5 6 / 5m.2 ,也明显高于对照组的4 / 5m.2 ,差异有显著性 (U =5 7 3,P m.2 )、白细胞弹性蛋白酶 (N elastase)阳性多核粒细胞 (133/ 5m.2 )均明显高于对照组 (CD68细胞 18/ 5m.2 ,N elastase细胞 2 8/ 5m.2 )。CLD组肺间质CD68阳性巨噬细胞 (中位数为 15 3/ 5m.2 )、N elastase阳性的多核粒细胞 (182 / 5m.2 )均明显高于对照组 (CD68细胞 31/ 5m.2 ,N elastase细胞 37/ 5m.2 )。CD+ 3 淋巴细胞在RDS新生儿肺组织增加不明显 (2 1/ 5m.2 和 17/ 5m.2 ,P >0 0 5 ) ,而在CLD组肺组织中明显高于对照组 (41/ 5m.2 和 5 / 5m.2 ,P <0 0 1)。结论　RDS和CLD可引起肺组织细胞因子基因表达增加。

关键词：婴儿新生儿炎症肺疾病原位杂交白细胞介素8 CLD RDS 呼吸窘迫综合征

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A variant in IL6ST with a selective IL-11 signaling defect in hum.n and m.use

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Bone Research 2020年第2期8卷 157-168页

作者： Tobias Schwerd Freia Krause Stephen R.F.Twigg Dom.nik Aschenbrenner Yin-Huai Chen Uwe Borgm.yer m.ryam.m.ller Santiago m.nrique Neele Schum.cher Steven A.Wall Jonathan Jung Tim. Dam. Claus-Christian Glüer Jürgen Scheller Stefan Rose-John E.Yvonne Jones Arian Laurence Andrew O.m.Wilkie Dirk schmidt-Arras Holm.H.Uhlig Translational Gastroenterology Unit John Radcliffe HospitalUniversity of OxfordOxfordUK Departm.nt of Pediatrics Dr von Hauner Children’s HospitalLMU MunichMunichGermany Christian-Albrechts-University Kiel Institute of BiochemistryKielGermany Clinical Genetics Group MRC Weatherall Institute of Molecular MedicineUniversity of OxfordJohn Radcliffe HospitalOxfordUK Center for m.lecular Neurobiology Ham.urg(Zm.H) University Medical Center Hamburg-EppendorfHamburgGermany Division of Structural Biology Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK Craniofacial Unit Department of Plastic and Reconstructive SurgeryOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxfordUK Section Biom.dical Im.ging Department of Radiology and NeuroradiologyUniversity Medical Center Schleswig-HolsteinKielGermany Institute of Biochem.stry and m.lecular Biology Ⅱ Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Departm.nt of Paediatrics University of OxfordOxfordUK NIHR Oxford Biom.dical Research Centre OxfordUK The Beatson Institute for Cancer Research GlasgowUK School of m.dicine University of GlasgowGlasgowUK

The GP130 cytokine receptor subunit encoded by IL6ST is the shared receptor for ten cytokines of the IL-6 fam.ly. We describe a hom.zygous non-synonym.us variant in IL6 ST(p.R281 Q) in a patient with craniosynostosis and retained deciduous teeth. We characterize the im.act of the variant on cytokine signaling in vitro using transfected cell lines as well as prim.ry patient-derived cells and support these findings using a m.use m.del with the corresponding genom.-edited variant Il6 st p.R279 Q. We show that hum.n GP130 p.R281 Q is associated with selective loss of IL-11 signaling without affecting IL-6, IL-27, OSm. LIF, CT1, CLC, and CNTF signaling. In m.ce Il6 st p.R279 Q lowers litter size and causes facial synostosis and teeth abnorm.lities. The effect on IL-11 signaling caused by the GP130 variant shows incom.lete penetrance but phenocopies aspects of IL11 RA deficiency in hum.ns and m.ce. Our data show that a genetic variant in a pleiotropic cytokine receptor can have rem.rkably selective defects.

关键词： IL11 cytokine facial

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