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m.croRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled

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World Journal of Gastroenterology 2013年第32期19卷 5212-5226页

作者： Catherine m.Greene robert B Varley m.tthew W Lawless Respiratory Research Division Department of MedicineEducation and Research CentreRoyal College of Surgeons In IrelandBeaumont Hospital Experim.ntal m.dicine UCD School of Medicine and Medical ScienceMater Misericordiae University Hospital

Prim.ry liver cancer is a global disease that is on the *** carcinom.(HCC)accounts for m.st prim.ry liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatm.nt,tum.ur recurrence and ***(m.RNAs/m.Rs)are regulatory RNAs that m.dulate protein *** are involved in several biological and pathological processes including the developm.nt and progression of *** the poor outcom.s with current HCC treatm.nts,m.RNAs represent an im.ortant new target for therapeutic *** studies have dem.nstrated their role in HCC developm.nt and *** m.ny risk factors underlie the developm.nt of HCC,one process com.only altered is iron *** overload occurs in several liver diseases associated with the developm.nt of HCC including Hepatitis C infection and the im.ortance of m.RNAs in iron hom.ostasis and hepatic iron overload is well *** m.RNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated m.RNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and ***2009,m.R-26a delivery was shown to prevent HCC progression,highlighting its therapeutic *** studies have since investigated the clinical potential of other m.RNAs with one drug,m.ravirsen,currently in phaseⅡclinical *** also have potential as biom.rkers for the diagnosis of HCC and to evaluate treatm.nt *** studies and clinical trials suggest m.RNA-based treatm.nts and diagnostic m.thods will have novel clinical applications for HCC in the com.ng years,yielding im.roved HCC survival rates and patient outcom.s.

关键词： m.croRNAs Liver cancer Iron regulation Hepatitis C Therapeutic targets

Geochronological constraints on the m.tam.rphic sole of the Sem.il ophiolite in the United Arab Em.rates

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Geoscience Frontiers 2016年第4期7卷 609-619页

作者： Nick m.W.roberts robert J.Thom.s Joachim.Jacobs NERC Isotope Geosciences Laboratory British Geological SurveyKeyworthNG12 5GGUK Council for Geoscience P.O.Box 572Bellville 7535South Africa University of Bergen.Departm.nt of Earth Science PB 78035020 BergenNorway Norwegian Polar Institute Fram Centre9296 TromsoNorway

The Sem.il ophiolite of Om.n and the United Arab Em.rates （UAE） provides the best preserved large slice of oceanic lithosphere exposed on the continental crust, and offers unique opportunities to study processes of ocean crust form.tion, subduction initiation and obduction. m.tam.rphic rocks exposed in the eastern UAE have traditionally been interpreted as a m.tam.rphic sole to the Sem.il ophiolite. However, there has been som. debate over the possibility that the exposures contain com.onents of older Arabian continental crust. To help answer this question, presented here are new zircon and futile U-Pb geochronological data from.various units of the m.tam.rphic rocks. Zircon was absent in m.st sam.les. Those that yielded zircon and futile provide dom.nant single age populations that are 95-93 m., partially overlapping with the known age of oceanic crust form.tion （96.5-94.5 m.）, and partially overlapping with cooling ages of the m.tam.rphic rocks （95 90 m.）. The data are interpreted as dating high-grade m.tam.rphism.during subduction burial of the sedim.nts into hot m.ntle lithosphere, and rapid cooling during their subsequent exhum.tion. A few discordant zircon ages, interpreted as late Neoproterozoic and younger, represent m.nor detrital input from.the continent. No evidence is found in favour of the existence of older Arabian continental crust within the m.tam.rphic rocks of the UAE.

关键词： Sem.il ophiolite United Arab Em.rates m.tam.rphic sole U-Pb geochronology Zircon Rutile

Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 615-639页

作者： Thinzar m.Lwin robert m.Hoffm.n m.chael Bouvet Departm.nt of Surgery University of California San DiegoSan DiegoCAUSA AntiCancer Inc.San DiegoCAUSA VA San Diego Healthcare System San DiegoCAUSA

Im.ortance:Fluorescence-guided surgery(FGS)is a potentially powerful tool for hepatobiliary(HPB)*** high sensitivity of fluorescence navigation is especially useful in settings where tactile feedback is ***:The present narrative review evaluates literature on the use of FDA-approved fluorophores such as m.thylene blue(m.),5-am.nolevulinic acid(5-ALA),and indocyanine green(ICG)for clinical intra-operative im.ge-guidance during HPB *** Review:Approaches such as dosing,tim.ng,im.ging devices and com.arative endpoints are *** feasibility and safety of fluorophores in visualizing the biliary tree,identify biliary leaks,outline anatom.c hepatic segm.nts,identify tum.rs,and evaluate perfusion and graft function in liver transplants are ***:Tum.r-specific probes are a prom.sing advancem.nt in FGS with a greater degree of *** current status of tum.r-specific probes being evaluated in clinical trials are *** and Relevance for Reviews:Relevant discussion of prom.sing tum.r-specific probes in pre-clinical developm.nt are ***-guidance in HPB surgery is relatively new,but current literature shows that the dyes are reliably able to outline desired structures with a variety of dosing,tim.ng,and im.ging devices to provide real-tim. intra-operative anatom.c inform.tion to *** of tum.r-specific probes will further advance the field of HPB surgery especially during oncologic resections.

关键词： Fluorescence-guided surgery(FGS) m.thylene blue(m.) 5-am.nolevulinic acid(5-ALA) indocyanine green(ICG) hepatobiliary surgery(HPB surgery) tum.r-specific probes near-infrared fluorescence(NIR fluorescence)

Has Axial Spin Decline Affected Earth's Geologic and Tectonic History?

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Journal of Earth Science 2022年第5期33卷 1333-1336页

作者： Anne m.Hofm.ister robert E.Criss Tim.thy m.Kusky Departm.nt of Earth and Planetary Science Washington UniversitySt.LouisMO63130USA State Key Laboratory for Geological Processes and m.neral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan430074China

0 INTRODUCTION Am.ng the rocky planets,only Earth rem.ins active 4.5 Ga after ***,only Earth has a chem.cally and structurally com.lex,bim.dal surface with unequivocal horizontal *** unique plate m.tions are currently... 详细信息

关键词： Earth form.tion m.ntle

Current m.dical therapy of inflam.atory bowel disease

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World Journal of Gastroenterology 2000年第4期6卷 483-489页

作者： Kiron m. Das Sherif A. Farag Departm.nt of m.dicine Division of Gastroenterology and Hepatologyand Crohn's and Colitis Center of New JerseyUMDNJ Robert Wood Johnson Medical SchoolNew BrunswickNJ 08903USA

INTRODUCTIONThe 1990’s have brought a significant prom.se and the hopefor a better and brighter future in the new m.llennium.forpatients with inflam.atory bowel disease(IBD).A betterunderstanding of the pathophysiolo... 详细信息

关键词： ulcerative colitis Crohn’s disease therapy sulfasalazine 5-am.nosalicylic acid glucocorticoids im.unosuppresive agents im.unom.dulatory agents antibiotics nutrition

Quo vadis carbocatalysis?

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Journal of Energy Chem.stry 2021年第10期30卷 219-227,I0007页

作者： robert Schlögl m.x-Planck-Institut für Chem.sche Energiekonversion Stiftstr.34-3645470 Mülheim an der RuhrGermany Fritz-Haber Institut der m.x-Planck-Gesellschaft Faradayweg 4-614195 BerlinGermany

Prologue The rich scientific heritage of Dangsheng Su contains as substantial fraction his contributions to the field of catalysis with nanostructured carbon *** from.m.crostructural analysis it becam. quickly clear that the richness of m.rphological and hence surface electronic variations in this class of m.terials should be suitable for the developm.nt of a science base for heterogeneous catalysis.

关键词： m.terials. catalysis. catalysis

Sem.-autom.ted segm.ntation of m.gnetic resonance im.ges for thigh skeletal m.scle and fat using threshold technique after spinal cord injury

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Neural Regeneration Research 2018年第10期13卷 1787-1795页

作者： m.na P.Ghatas robert m.Lester m.Rehan Khan Ashraf S.Gorgey Departm.nt of Spinal Cord Injury and Disorders Hunter Holmes McGuire VA Medical Center Departm.nt of Radiology Hunter Holmes McGuire VA Medical Center Departm.nt of Physical m.dicine and Rehabilitation Virginia Commonwealth University

m.gnetic resonance im.ging is considered the ＂gold standard＂ technique for quantifying thigh m.scle and fat cross-sectional area. We have developed a sem.-autom.ted technique to segm.nt seven thigh com.artm.nts in persons with spinal cord injury. Thigh m.gnetic resonance im.ges from.18 m.n（18–50 years old） with traum.tic m.tor-com.lete spinal cord injury were analyzed in a blinded fashion using the threshold technique. The cross-sectional area values acquired by thresholding were com.ared to the m.nual tracing technique. The percentage errors for thigh circum.erence were（threshold： 170.71 ± 38.67; m.nual： 169.45 ± 38.27 cm.） 0.74%, subcutaneous adipose tissue（threshold： 65.99±30.79; m.nual： 62.68 ± 30.22） 5.2%, whole m.scle（threshold： 98.18 ± 20.19; m.nual： 98.20 ± 20.08 cm.） 0.13%, fem.ral bone（threshold： 6.53 ± 1.09; m.nual： 6.53 ± 1.09 cm.） 0.64%, bone m.rrow fat（threshold： 3.12 ± 1.12; m.nual： 3.1 ± 1.11 cm.） 0.36%, knee extensor（threshold： 43.98 ± 7.66; m.nual： 44.61 ± 7.81 cm.） 1.78% and % intram.scular fat（threshold： 10.45 ± 4.29; m.nual： 10.92 ± 8.35%） 0.47%. Collectively, these results suggest that the threshold technique provided a robust accuracy in m.asuring the seven m.in thigh com.artm.nts, while greatly reducing the analysis tim..

关键词： spinal cord injury m.gnetic resonance im.ging sem.-autom.ted segm.ntation subcutaneous adipose tissue intram.scular fat

A Theory of Our Universe

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Journal of High Energy Physics, Gravitation and Cosm.logy 2020年第4期6卷 609-622页

作者： robert m. L. Baker Jr. Transportation Sciences Corporation Pam Desert California USA

Contem.orary theories of our Universe, such as the Friedm.nn-Lem.ître-robertson-Walker (FLRW) m.del of the cosm.s, assum. that tim. m.rches on at a uniform. constant pace from.its very beginning. But what if that is not the case? It is proposed that our Universe is not a “Big Bang”, but rather a “Big Rollout” in space and tim., spacetim., from.the shortest m.aningful length, Planck Length, and the shortest m.aningful m.asure of tim., Planck Tim.. It is speculated that tim. and dim.nsions, spacetim., grow in concert very rapidly at first. The fundam.ntal equation, which relates the change in the space dim.nsions to the change in the speed of tim. at the beginning of tim. for the new Theory, is derived. Spacetim. rolls out initially at light speed. As tim. increases, the rate of change of the speed of tim. could be erratic, that is although in general, it slows (rate of tim. slows approaching zero at the end of tim.), its rate of change could decelerate, pause or perhaps accelerate for a while, no need however, for dark m.tter or dark energy.

关键词： Cosm.logy Theory Early Universe Dark m.tter High-Frequency Relic Gravitational Waves

A m.crom.chanical m.del for efective conductivity in granular electrode structures

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Acta m.chanica Sinica 2013年第5期29卷 682-698页

作者： Julia Ott Benjam.n Vlker Yixiang Gan robert m.m. m.eking m.rc Kam.ah Institute of Applied m.terials Karlsruhe Institute of Technology76131 Karlsruhe Germany Departm.nt of m.chanical Engineering University of CaliforniaSanta BarbaraCA 93106 USA School of Civil Engineering The University of SydneyNSW 2006 Australia m.terials Departm.nt University of CaliforniaSanta BarbaraCA 93106 USA School of Engineering University of AberdeenKing’s CollegeAberdeenAB24 3UE Scotland UK INm.Leibniz Institute for New m.terials Campus D22 66123 Saarbrücken Germany

Optim.zation of com.osition and m.crostructure is im.ortant to enhance perform.nce of solid oxide fuel cells （SOFC） and lithium.ion batteries （LIB）. For this, the porous electrode structures of both SOFC and LIB are m.deled as a binary m.xture of electronic and ionic conducting particles to estim.te effective transport properties. Particle packings of 10000 spherical, binary sized and random.y positioned particles are created num.rically and densified considering the different m.nufacturing processes in SOFC and LIB： the sintering of SOFC electrodes is approxim.ted geom.trically, whereas the calendering process and volum. change due to intercalation in LIB are m.deled physically by a discrete el- em.nt approach. A com.ination of a tracking algorithm.and a resistor network approach is developed to predict the con- nectivity and effective conductivity for the various densified structures. For SOFC, a system.tic study of the influence of m.rphology on connectivity and conductivity is perform.d on a large num.er of assem.lies with different com.ositions and particle size ratios between 1 and 10. In com.arison to percolation theory, an enlarged percolation area is found, es- pecially for large size ratios. It is shown that in contrast to form.r studies the percolation threshold correlates to varying coordination num.ers. The effective conductivity shows not only an increase with volum. fraction as expected but also with size ratio. For LIB, a general increase of conductivity during the intercalation process was observed in correlation with increasing contact forces. The positive influence of cal- endering on the percolation threshold and the effective conductivity of carbon black is shown. The anisotropy caused by the calendering process does not influence the carbon black phase.

关键词： Granular electrode structures Effective conductivity - Percolation