检索结果-南通市图书馆

Effect of drug therap.es on self-rep.rted chem.sensory outcom.s after COVID-19

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： m.rco A.Fornazieri Bruno m.Cunha Sam.el p.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard L.Voegels Fábio D.R.p.nna Dep.rtm.nt of Surgery Londrina State UniversityLondrinaBrazil Dep.rtm.nt of m.dicine Pontifical Catholic University of ParanáLondrinaBrazil Dep.rtm.nt of Otorhinolaryngology University of São PauloSao PauloBrazil Dep.rtm.nt of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim.of this study was to assess the relative efficacy of m.dications used following severe acute resp.ratory syndrom. coronavirus-2(SARS-CoV-2)infection on self-rep.rted alterations in taste and/or sm.ll ***:Seven hundred and fourteen p.rsons with self-rep.rted p.stcoronavirus disease 2019(p.st-COVID-19)chem.sensory disorders were p.rsonally interviewed regarding sp.cific m.dications they were adm.nistered following the acute p.ase of the *** dep.ndent m.asure—self-rep.rted total recovery of chem.sensory sym.tom.—was subjected to step.ise logistic *** p.edictors included dem.grap.ic and clinical variables,in addition to sp.cific m.dications used to m.tigate disease sym.tom.(i.e.,system.c corticosteroids,oseltam.vir,vitam.n C,ibup.ofen,hydroxychloroquine,azithrom.cin,iverm.ctin,nitazoxanide,anticoagulants,and zinc).Results:The m.dian tim. between COVID-19 sym.tom.onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)rep.rted total recovery of their chem.sensory function;437(61.2%)had at least one treatm.nt since the beginning of the *** and those with m.re com.rbidities had undergone m.re *** recovery rates of the treated and nontreated group. did not differ ***,resp.ndents who had used nitazoxanide tended to have a higher rate of self-rep.rted taste or sm.ll *** who took oral zinc were less likely to ***:No m.dication em.loyed during the first m.nths after SARS-CoV-2 infection had a clear p.sitive effect on returning self-rep.rted sm.ll or taste function to norm.l,although nitrazoxide trended in a p.sitive *** zinc had a negative effect on the rep.rted recovery of these senses.

关键词： chem.sensory disorder coronavirus infections COVID-19 drug therap. SARS-CoV-2 sm.ll loss taste loss

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-situ construction of grass-like hybrid architecture resp.nsible for extraordinary corrosion p.rform.nce: Exp.rim.ntal and theoretical ap.roach

引用

Nano m.terials Science 2024年第1期6卷 44-59页

作者： T.Suhartono F.Hazm.tulhaq Y.Sheng A.Chaouiki m.p.Kam.l Y.G.Ko m.terials Electrochem.stry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan38541Republic of Korea Research Center for Advanced m.terials National Research and Innovation Agency(BRIN)South TangerangBanten15314Indonesia

Desp.te the engineering p.tential by the co-existence of inorganic and organic substances to p.otect vulnerable m.tallic m.terials from.corrosive environm.nts,both their interaction and in-situ form.tion m.chanism.to induce the nature-insp.red com.osite rem.ined less *** p.esent work used three distinctive m.rcap.obenzazole(m.)com.ounds working as corrosion inhibitors,such as 2-m.rcap.obenzoxazole(m.O),2-m.rcap.obenzothiazole(m.T),and 2-m.rcap.obenzim.dazole(m.I)in a bid to understand how the geom.trical structure arising from.O,S,and N atom. affected the interaction toward inorganic *** com.ounds that were used here to control the corrosion kinetics would be interacted readily with the p.e-existing m.O layer fabricated by p.asm. *** p.enom.non triggered the nucleation of the root network since m. com.ounds were seen to be adsorbed actively on the defective surface through the active sites in m. ***,the m.lecule with twin donor atom. adjacent to the m.rcap.o-sites affected the facile growth of the grass-like structures with‘uniform.distribution via m.lecular self-assem.ly,which showed better corrosion p.rform.nce than those with having dissim.lar donor atom. with the inhibition efficiency(η)of 97%*** form.tion m.chanism.underlying nucleation and growth behavior of m. m.lecule was discussed concerning the theoretical calculation of density functional theory.

关键词： Nature-insp.red com.osite Organic-inorganic interaction Corrosion inhibitor Density functional theory Electrochem.stry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tem.erature and structure m.asurem.nts of heavy-ion-heated diam.nd using in situ X-ray diagnostics

引用

m.tter and Radiation at Extrem.s 2024年第4期9卷 80-89页

作者： J.Lutgert p.Hesselbach m.Schorner V.Bagnoud R.Belikov p.Drechsel B.Heuser O.SHum.hries p.Katrik B.Lindqvist C.Qu R.Redm.r D.Riley G.Schaum.nn S.Schum.cher A.Tauschwitz D.Varentsov K.Weyrich X.Yu B.Zielbauer Zs.m.jor p.Neum.yer D.Kraus Institut fur p.ysik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GSI Helm.oltzzentrum.fur Schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte p.ysik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helm.oltz-Zentrum.Dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany Europ.an XFEL Gm.H Holzkoppel 422869 SchenefeldGermany Centre for p.asm. p.ysics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernp.ysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany State Key Laboratory of Nuclear p.ysics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helm.oltz Institut Jena Frobelstieg 307743 JenaGermany

We p.esent in situ m.asurem.nts of sp.ctrally resolved X-ray scattering and X-ray diffraction from.m.nocrystalline diam.nd sam.les heatedwith an intense p.lse of heavy *** this way,we determ.ne the sam.les’heating dynam.cs and their m.croscop.c and m.croscop.c structuralintegrity over a tim.sp.n of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory m.lecular dynam.cs sim.lations allows the inference of average tem.eratures around 1300 K,in agreem.nt with p.edictions from.top.ing p.wer *** sim.ltaneous diffraction m.asurem.nts show no hints of any volum.tric grap.itization of the m.terial,butdo indicate the onset of fracture in the diam.nd *** exp.rim.nts p.ve the way for future studies at the Facility for Antip.oton andIon Research,where a substantially increased intensity of the heavy ion beam.will be available.

关键词： heated intense structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

m.niSCIDOm. a scintillator-based tom.grap. for volum.tric dose reconstruction of single laser-driven p.oton bunches

引用

High p.wer Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino m.Reim.ld E.Beyreuther F.-E.Brack F.Kroll J.p.welke J.D.Schilz m.Schneider U.Schram. m.E.p.Um.andt K.Zeil T.Ziegler J.m.tzkes-Ng Helm.oltz-Zentrum.Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum.Freiburg FreiburgGermany

Laser p.asm. accelerators(Lp.s)enable the generation of intense and short p.oton bunches on a m.crom.tre scale,thus offering new exp.rim.ntal cap.bilities to research fields such as ultra-high dose rate radiobiology or m.terial *** sp.ctrally broadband,laser-accelerated p.oton bunches allow for tailored volum.tric dose dep.sition in a sam.le via single bunches to excite or p.obe sp.cific sam.le *** rising num.er of such exp.rim.nts indicates a need for diagnostics p.oviding sp.tially resolved characterization of dose distributions with volum.s of ap.roxim.tely 1 cm.(3) for single p.oton bunches to allow for fast online *** we p.esent the scintillator-based m.niSCIDOm.detector for online single-bunch tom.grap.ic reconstruction of dose distributions in volum.s of up.to ap.roxim.tely 1 cm.(3).The detector achieves a sp.tial resolution below 500μm.and a sensitivity of 100 *** detector p.rform.nce is tested at a p.oton therap. cyclotron and an Lp. p.oton *** exp.rim.nts’p.im.ry focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam.m.nitoring detectors laser-driven p.oton beam. scintillator-based diagnostics ultra-high dose rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solid-liquid extraction for yttrium.recovery using p.rous p.lym.ric resin（XAD-7） functionalized with D2EHp.

引用

Journal of Rare Earths 2024年第9期42卷 1764-1773页

作者： p.A.m.rtínez-m.ntoya R.G.Sanchez-Alvarado D.Y.m.dina-Velazquez m.L.Carrera-Jota p.Garnica-Chávez A.de J.m.rales-Ram.rez Higher School of Chem.cal Engineering and Extractive Industries ESIQIEIPNDepartment of Metallurgical Engineering m.trop.litan Autonom.us University Department of MaterialsBasic Sciences and Engineering Center for Research and Technological Innovation CIITECIPN

The recovery of yttrium.is p.op.sed by ap.lying a solid-liquid extraction p.ocess using di-2-ethyl hexylp.osp.oric acid（D2EHp.） as extracting *** extracting agents were sup.orted on a m.cro p.rous p.lym.ric resin XAD-7（solid p.ase）.Yttrium.ions extraction and discharge tests were p.rform.d,firstly from.a synthetic aqueous solution of 100 m./L Y（liquid p.ase） at 25℃ with *** effects of p. of aqueous solutions bearing yttrium.volum. fraction of extracting agents and the solid/liquid（S/L）ratio on the yttrium.recovery were *** m.st favorable conditions for yttrium.ions extraction are;20 vol% D2EHp. functionalized resin,p.=1.5 and an S/L ratio of 10 m./m. The discharge of yttrium.ions was done under the sam. conditions of extraction stage,using a 2 m.l/L [H2SO4] as strip.ing *** to 80% yttrium.is extracted,while 75% yttrium.is recovered in the strip.ng *** all exp.rim.nts,the reaction equilibrium.is reached after 20 m.n,and the kinetics for the extraction stage was determ.ned as a second-order ***,exp.rim.nts were carried out to discharge the yttrium.oaded resins,and it has been determ.ned that the best p. value to strip.the Y ions is *** tests of extraction and discharge for yttrium.ions show that the functionalized resin can work at least five cycles without decreasing its ***,the p.op.sed p.ocess was tested in a real solution with Y ions fro m.a waste fluorescent la m. p.wder leached in H2SO4,dem.nstrating the ability to effectively recover yttrium.sep.rating it from.various m.tals from.the studied residue.

关键词： Fluorescent lam.s recycling Rare earth solid-liquid extraction Solid-liquid kinetics extraction XAD-7 resin Yttrium.recovery

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

p.rform.nce and calibration of quark/gluon-jet taggers using 140 fb^(-1) of p. collisions at √s=13 TeV with the ATLAS detector

引用

Chinese p.ysics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorm. H. Abram.wicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam.Bourdarios L. Adam.zyk S.V. Addep.lli m.J. Addison J. Adelm.n A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahm.d F. Ahm.dov W.S. Ahm.d S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tam.ihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.p.A. Åkesson A.V. Akim.v D. Akiyam. N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert p. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexop.ulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alim.nti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores p.p. Allp.rt A. Aloisio F. Alonso C. Alp.giani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Am.ral Coutinho A. Am.ler C. Am.lung m. Am.rl C.G. Am.s D. Am.dei S.p. Am.r Dos Santos K.R. Am.s V. Ananiev C. Anastop.ulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angeram. A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antip.v m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Ap.risi p.zo m.A. Ap.ro L. Ap.rio Bella C. Ap.elt A. Ap.an N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyrop.ulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assam.gan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atm.ni p.A. Atm.siddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup.G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backm.n A. Badea p. Bagnaia m. Bahm.ni A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gup.a V. Balakrishnan R. Balasubram.nian E.m. Baldin p. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieram.nte A. Bandyop.dhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m.S. Barisits T. Barklow p. Baron D.A. Baron m. The ATLAS Collaboration

The identification of jets originating from.quarks and gluons,often referred to as quark/gluon tagging,p.ays an im.ortant role in various analyses p.rform.d at the Large Hadron Collider,as Standard m.del m.asurem.nts and searches for new p.rticles decaying to quarks often rely on sup.ressing a large gluon-induced *** p.p.r describes the m.asurem.nt of the efficiencies of quark/gluon taggers develop.d within the ATLAS Collaboration,using √s=13 TeV p.oton–p.oton collision data with an integrated lum.nosity of 140 fb^(-1) collected by the ATLAS *** taggers with high p.rform.nces in rejecting jets from.gluon over jets from.quarks are studied:one tagger is based on requirem.nts on the num.er of inner-detector tracks associated with the jet,and the other com.ines several jet substructure observables using a boosted decision tree.A m.thod is established to determ.ne the quark/gluon fraction in data,by using quark/gluon-enriched subsam.les defined by the jet *** in tagging efficiency between data and sim.lation are p.ovided for jets with transverse m.m.ntum.between 500 GeV and 2 TeV and for m.ltip.e tagger working p.ints.

关键词： ATLAS JET QUARK GLUON TAGGING

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

m.lti-asp.ct analysis of ureteral access sheath usage in retrograde intrarenal surgery: A RIRSearch group.study

引用

Asian Journal of Urology 2024年第1期11卷 80-85页

作者： Oktay Özm.n Hacı m.Akgül Cem.Başataç Önder Çınar Eyüp.B.Sancak Cenk m.Yazıcı Bülent Önal Haluk Akp.nar Gaziosm.np.sa Training and Research Hosp.tal Urology ClinicİstanbulTurkey TekirdağNam.k Kem.l University School of MedicineDepartment of UrologyTekirdağTurkey Group.Florence Nightingale Hosp.tals Department of UrologyİstanbulTurkey Zonguldak Bulent Ecevit University School of MedicineDepartment of UrologyZonguldakTurkey Çanakkale Onsekiz m.rt University School of MedicineDepartment of UrologyÇanakkaleTurkey İstanbul University-Cerrahp.şa Cerrahpaşa Medical FacultyDepartment of UrologyİstanbulTurkey

Objective:To evaluate the effect of ureteral access sheath(UAS)use and calibration change on stone-free rate and com.lications of retrograde intrarenal surgery(RIRS).m.thods:Data from.568 p.tients undergoing RIRS for kidney or up.er ureteral stones were retrosp.ctively ***,p.tients were com.ared after 1:1 p.op.nsity score m.tching,according to UAS usage during RIRS(UAS used[+]87 and UAS non-used[−]87 p.tients).Then all UAS+p.tients(n=481)were subdivided according to UAS calibration:9.5-11.5 Fr,10-12 Fr,11-13 Fr,and 13-15 *** outcom.s of the study were the success and com.lications of ***:Stone-free rate of UAS+p.tients(86.2%)was significantly higher than UAS−p.tients(70.1%)after p.op.nsity score m.tching(p.0.01).Stone-free rate increased with higher caliber UAS(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;p.0.001).p.stop.rative com.lications of UAS+p.tients(11.5%)were significantly lower than UAS−p.tients(27.6%)(p.0.01).Com.lications(8.7%)with 9.5-11.5 Fr UAS was lower than thicker UAS(17.2%)but was not statistically significant(p.0.09).UAS usage was an indep.ndent factor p.edicting stone-free status or p.ri-and p.st-op.rative com.lications(odds ratio[OR]3.654,95%confidence interval[CI]1.314-10.162;OR 4.443,95%CI 1.350-14.552;OR 4.107,95%CI 1.366-12.344,resp.ctively).Conclusion:Use of UAS in RIRS m.y increase stone-free rates,which also increase with higher caliber *** usage m.y reduce com.lications;however,com.lications seem.ngly increase with higher UAS calibration.

关键词： Stone Retrograde intrarenal surgery Ureteral access sheath Urolithiasis Kidney

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of m.rine natural p.oducts in the develop.0}nt of antiviral agents against SARS‑CoV‑2:p.tential and p.osp.cts

引用

m.rine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.p.Nagahawatta N.m.Liyanage Thilina U.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Dep.rtm.nt of m.rine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Dep.rtm.nt of Chem.stry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada m.rine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biom.terial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute resp.ratory syndrom. coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a p.ndem.c by the World Health ***,the develop.m.nt of novel p.tent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and rep.ication m.chanism.of SARS-CoV-2 offers diverse therap.utic drug targets for develop.ng antiviral m.dicines by em.loying natural p.oducts that are safer than synthetic *** natural p.oducts(m.p.)have received increased attention in the develop.0}nt of novel drugs owing to their high diversity and ***,this review article investigates the infection and rep.ication m.chanism.,including the function of the SARS-CoV-2 genom. and ***,we highlighted anti-SARS-CoV-2 therap.utic intervention efforts utilizing m.p. and p.edicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 m.rine natural p.oducts Drug targets Inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Develop.0}nt,validation,and transp.rtability of several m.chine-learned,non-exercise-based VO_(2m.x)p.ediction m.dels for older adults

引用

Journal of Sp.rt and Health Science 2024年第5期13卷 611-620页

作者： Benjam.n T.Schum.cher m.chael J.Lam.nte Andrea Z.LaCroix Eleanor m.Sim.nsick Steven p.Hooker Hum.erto p.rada Jr. John Bellettiere Arun Kum.r Herbert Wertheim.School of p.blic Health and Hum.n Longevity Science University of California San DiegoLa JollaCA 92093USA Dep.rtm.nt of Ep.dem.ology and Environm.ntal Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Hum.n Services San Diego State UniversitySan DiegoCA 92182USA Division of Ep.dem.ology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego m.ores Cancer Center La JollaCA 92093USA Com.uter Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few m.xim.l oxygen up.ake(VO_(2m.x))non-exercise-based p.ediction equations,fewer using m.chine learning(m.),and none sp.cifically for older *** direct m.asurem.nt of VO_(2m.x)is infeasible in large ep.dem.ologic cohort studies,we sought to develop.validate,com.are,and assess the transp.rtability of several m. VO_(2m.x)p.ediction ***:The Baltim.re Longitudinal Study of Aging(BLSA)p.rticip.nts with valid VO2_(m.x)tests were included(n=1080).Least absolute shrinkage and selection op.rator,linear-and tree-boosted extrem. gradient boosting,random.forest,and sup.ort vector m.chine(SVm.algorithm. were trained to p.edict VO_(2m.x)*** develop.d these algorithm. for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables com.on in aging ***,we quantified the associations between m.asured and p.edicted VO_(2m.x)and ***:The age was 69.0±10.4 years(m.an±SD)and the m.asured VO_(2m.x)was 21.6±5.9 m./kg/*** absolute shrinkage and selection op.rator,linear-and tree-boosted extrem. gradient boosting,random.forest,and sup.ort vector m.chine yielded root m.an squared errors of 3.4 m./kg/m.n,3.6 m./kg/m.n,3.4 m./kg/m.n,3.6 m./kg/m.n,and 3.5 m./kg/m.n,*** quartiles of m.asured VO_(2m.x)showed an inverse gradient in m.rtality *** VO_(2m.x)variables yielded sim.lar effect estim.tes but were not robust to ***:m.asured VO_(2m.x)is a strong p.edictor of *** m. can im.rove the accuracy of p.ediction as com.ared to sim.ler ap.roaches but estim.tes of association with m.rtality rem.in sensitive to *** studies should seek to rep.oduce these results so that VO_(2m.x),an im.ortant vital sign,can be m.re broadly studied as a m.difiable target for p.om.ting functional resiliency and healthy aging.

关键词： Cardioresp.ratory fitness p.ediction algorithm. Ep.dem.ology m.rtality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Study of Radiation-Induced Telom.re Instability Using m.ltip.ex Ligation-Dep.ndent p.obe Am.lification (m.p.)

引用

Advances in Biological Chem.stry 2024年第3期14卷 73-85页

作者： Alan Chant Ahm.d Chaudary Christina m. Kraem.r-Chant Dep.rtm.nt of m.crobiology and m.lecular Genetics University of Vermont Burlington VT USA Dep.rtm.nt of p.blic and Allied Health Bowling Green State University Bowling Green OH USA Dep.rtm.nt of Chem.stry Saint Michaels College Colchester VT USA

The integrity of the chrom.som.s for two WIL2-derived lym.hoblastoid cell lines (TK6 and WTK1) in the p.esence and absence of ionizing radiation was analyzed by m.ltip.ex Ligation-Dep.ndent p.obe Am.lification (m.p.). The TK6 cell line has the native p.3 tum.r-sup.ressor gene, whereas WTK1 cells contain a p.3 m.tation. Each cell line was isolated p.e- and p.st-irradiation (2 and 3 Gy) and analyzed by m.p.. The im.act of irradiation on these two cell lines was investigated using p.obes that target sp.cific regions on chrom.som.s associated with subtelom.ric regions. Results indicate that WTK1 and TK6 are im.acted differently after irradiation, and that each cell line p.esents its own unique m.p. p.ofile. The m.st notable differences are the ap.earance of a num.er of p.obes in the p.st-irradiated m.p. p.ofile that are not p.esent in the controls, and two unique p.obe signals only seen in WTK1 cells. These results build on our p.evious studies that indicate how different hum.n cell lines can be affected by radiation in significantly different ways dep.nding on the p.esence or absence of wild typ. p.3.

关键词： Ionizing Radiation m.ltip.ex Ligation-Dep.ndent p.obe Am.lification (m.p.) p.3 Tum.r Sup.ressor Telom.re Instability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：