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HCV感染患者的胰岛素抵抗和胰岛素释放

世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 62-62页

作者： Narita R. Abe S. Kihara Y. m. otsuki 刘娜 Third Dept.of Internal m.dicine Univ.of Occup.and Environ.HealthJapanSch.Med.1-1 IseigaokaY.KitakyushuJapan

Background/Aim. Diabetes m.llitus (Dm. is frequently observed in patients with chronic hepatitis caused by hepatitis C virus infection (CHC). The present study was designed to determ.ne the pathogenic factors responsible for glucose intolerance in CHC patients. m.thods A total of 131 patients with CHC were enrolled in this study. Insulin resistance and β-cell function were determ.ned after 75 g oral glucose tolerance tests. Results Glucose intolerance was detected in 27.5% (36/131) of CHC patients; 10 had Dm.and 26 im.aired glucose tolerance. HOm.-R insulin 0× glucose 0/22.5 was greater in patients with both im.aired glucose tolerance and Dm.than in those with norm.l glucose tolerance (Pm.tsuda index 104/√ (m.an insulin× m.an glucose× glucose0× insulin 0) was lower in diabetic patients than in those with norm.l glucose tolerance (Pm.aired glucose tolerance than in patients with norm.l glucose tolerance (P< 0.01). Conclusions Both insulin resistance and β-cell dysfunction contribute to glucose intolerance in CHC patients.

关键词：胰岛素释放胰岛素抵抗 HCV感染糖耐量异常空腹胰岛素口服葡萄糖耐量空腹血糖慢性丙型肝炎空腹葡萄糖功能失调

Long-term.treatm.nt with proton pum. inhibitor is associated with undesired weight gain

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World Journal of Gastroenterology 2009年第38期15卷 4794-4798页

作者： Ichiro Yoshikawa m.kiko Nagato m.sahiro Yam.saki Keiichiro Kum. m.koto otsuki Third Departm.nt of Internal m.dicine University of Occupational and Environmental HealthJapanSchool of Medicine

AIm.To exam.ne the effects of long-term.proton pum. inhibitor (PPI) therapy on body weight (BW) and body m.ss index (Bm.) in patients with gastroesophageal reflux disease (GERD).m.THODS: The subjects were 52 patients with GERD and 58 sex-and age-m.tched healthy controls. GERD patients were treated with PPI for a m.an of 2.2 years (range, 0.8-5.7 years), and also advised on lifestyle m.difications (e.g. selective diet, weight m.nagem.nt). BW, Bm. and other param.ters were m.asured at baseline and end of ***: Twenty-four GERD patients were treated daily with 10 m. om.prazole, 12 with 20 m. om.prazole, 8 with 10 m. rabeprazole, 5 with 15 m. lansoprazole, and 3 patients with 30 m. lansoprazole. At baseline, there were no differences in BW and Bm. between reflux patients and controls. Patients with GERD showed increases in BW (baseline: 56.4±10.4 kg, end: 58.6±10.8 kg, m.an±SD, Pm. (baseline: 23.1±3.1 kg/m., end: 24.0±3.1 kg/m., Pm.an BW increased by 3.5 kg (6.2% of baseline) in 37 (71%) reflux patients but decreased in only 6 (12%) patients during ***: Long-term.PPI treatm.nt was associated with BW gain in patients with GERD. Reflux patients receiving PPI should be encouraged to m.nage BW through lifestyle m.difi cations.

关键词： Gastroesophageal reflux disease Protonpum. inhibitor Body weight

Im.act of Latest Power Devices for PV Inverters

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电力电子技术 2013年第3期47卷 8-10页

作者： T Fujihira m.EEE A otsuki Y Takahashi m.EEJ T Ide m.Kawano N Eguchi Sm.EEJ Fuji Electric Co. Ltd.1-11-2 OsakiTokyo 141-0032Japan

Excellent electrical properties and the im.act of latest power devices for im.roving the efficiency of photovohaic（PV） inverters are *** m.dules using SiC-m.SFET and SBD exhibit the possibility to realize PV inverters with peak efficiency beyond 99%.Si-IGBT m.dules using reverse-blocking（RB）-IGBT have enabled to m.ssproduce PV inverters with peak efficiency of 98.4%.Si superjunction（SJ）-m.SFET and discrete IGBT have enabled to im.rove the efficiency of sm.ll power PV inverters by 0.5 point.

关键词： power device superjunction photovoltaic inverter efficiency

Im.unological Effects of Silica and Asbestos

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Cellular & m.lecular Im.unology 2007年第4期4卷 261-268页

作者： Takem. otsuki m.gum. m.eda Shuko m.rakam. Hiroaki Hayashi Yoshie m.ura m.sayasu Kusaka Takashi Nakano Kazuya Fukuoka Takum. Kishim.to Fum.nori Hyodoh Ayako Ueki Yasum.tsu Nishim.ra Departm.nt of Hygiene Kawasaki Medical SchoolMatsushima 577Kurashiki 7010192Japan Eppley Institute for Cancer Research University of Nebraska Medical CenterOmahaNebraska 68198USA Departm.nt of Internal m.dicine Kusaka Hospital1122 NishikatagamiBizen 7050021Japan Departm.nt of Respiratory m.dicine Hyogo Medical College of Medicine1-1 Mukogawa-choNishinomiyaHyogo 6638131Japan Okayam. Rosai Hospital 1-10-25 Chikkou-midori-machiOkayama 7028055Japan Departm.nt of Rehabilitation Faculty of Health Sciences and TechnologyKawasaki University of Medical Welfare288 MatsushimaKurashiki 7010193Japan Departm.nt of Nursing Kawasaki College of Allied Health Professions316 MatsushimaKurashiki 7010194Japan

Silicosis patients （SILs） and patients who have been exposed to asbestos develop not only respiratory diseases but also certain im.unological disorders. In particular, SIL som.tim.s com.licates autoim.une diseases such as system.c scleroderm., rheum.toid arthritis （known as Caplan syndrom.）, and system.c lupus erythem.toses. In addition, m.lignant com.lications such as lung cancer and m.lignant m.sotheliom. often occurr in patients exposed to asbestos, and m.y be involved in the reduction of tum.r im.unity. Although silica-induced disorders of autoim.unity have been explained as adjuvant-type effects of silica, m.re precise analyses are needed and should reflect the recent progress in im.unom.lecular findings. A brief sum.ary of our investigations related to the im.unological effects of silica/asbestos is presented. Recent advances in im.unom.lecular studies led to detailed analyses of the im.unological effects of asbestos and silica. Both affect im.uno-com.etent cells and these effects m.y be associated with the pathophysiological developm.nt of com.lications in silicosis and asbestos-exposed patients such as the occurrence of autoim.une disorders and m.lignant tum.rs, respectively. In addition, im.unological analyses m.y lead to the developm.nt of new clinical tools for the m.dification of the pathophysiological aspects of diseases such as the regulation of autoim.unity or tum.r im.unity using cellm.diated therapies, various cytokines, and m.lecule-targeting therapies. In particular, as the incidence of asbestosrelated m.lignancies is increasing and such m.lignancies have been a m.dical and social problem.since the sum.er of 2005 in Japan, efforts should be focused on developing a cure for these diseases to elim.nate nationwide anxiety.

关键词： silica asbestos im.unology Fas regulatory T cell apoptosis

Consensus of prim.ry care in acute pancreatitis in Japan

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World Journal of Gastroenterology 2006年第21期12卷 3314-3323页

The incidence of acute pancreatitis in Japan is increasing and ranges from.187 to 347 cases per m.llion populations. Case fatality was 0.2% for m.ld to m.derate, and 9.0% for severe acute pancreatitis in Japan in 2003. Experts in pancreatitis in Japan m.de this docum.nt focusing on the practical aspects in the early m.nagem.nt of patients with acute pancreatitis. The correct diagnosis of acute pancreatitis and severity stratification should be m.de in all patients using the criteria for the diagnosis of acute pancreatitis and the m.ltifactor scoring system.proposed by the Research Com.ittee of Intractable Diseases of the Pancreas as early as possible. All patients diagnosed with acute pancreatitis should be m.naged in the hospital. m.nitoring of blood pressure, pulse and respiratory rate, body tem.erature, hourly urinary volum., and blood oxygen saturation level is essential in the m.nagem.nt of such patients. Early vigorous intravenous hydration is of forem.st im.ortance to stabilize circulatory dynam.cs. Adequate pain relief with opiates is also im.ortant. In severe acute pancreatitis, prophylactic intravenous adm.nistration of antibiotics at an early stage is recom.ended. Adm.nistration of protease inhibitors should be initiated as soon as thediagnosis of acute pancreatitis is confirm.d. A com.ination of enteral feeding with parenteral nutrition from.early stage is recom.ended if there are no clear signs and sym.tom. of ileus and gastrointestinal bleeding. Patients with severe acute pancreatitis should be transferred to ICU as early as possible to perform.special m.asures such as continuous regional arterial infusion of protease inhibitors and antibiotics, and continuous hem.diafiltration. The Japanese Governm.nt covers m.dical care expense for severe acute pancreatitis as one of the projects of Research on m.asures for Intractable Diseases.

关键词： Fluid resuscitation Protease inhibitor treatm.nt Antibiotic treatm.nt Continuous regional arterial infusion Contrast-enhanced com.uted tom.graphy

^(13)C标记的磁共振波谱检查脑葡萄糖代谢:m.LAS代谢变化的病例报道

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 15-16页

作者： otsuki T. Kanam.tsu T. Tsukada Y. 黄卫东 Departm.nt of Neurosu rgery Natl. Ctr. Hosp. Mental Nerv./M. D. Natl. Ctr. of Neurol. and Psychiatry Ogawa-higashi-4-1-1 Kodaira Tokyo 187-8511 Japan Dr.

Background: Carbon 13-labeled m.gnetic resonance spectroscopy (13C-m.S) with [1-13C]-glucose adm.nistration, the 13C atom.that behaves as a radio inacti ve tracer in the brain, can differentiate aerobic and anaerobic glucose m.tabolism.by detecting [4-13C]-glutam.te (Glu C4) and [3-13C]-lactat e (Lac C3). Objective: To investigate the cerebral m.tabolic derangem.nt resulti ng from.m.tochondrial dysfunction in m.tochondrial m.opathy, encephalopathy, lac tic acidosis, and strokelike episodes (m.LAS). Design: Application of a new 13C -m.S technique to a patient with m.LAS com.ared with control subjects (n=7). Pa tient: A 19-year-old wom.n with an A3243G m.tochondrial m.tation who underwent 13C-m.S for 30 m.nutes after oral adm.nistration of [1-13C]-glucose (0.75 g/ kg). Result: Decreased Glu C4-labeling (P 2 SDs) com.ared with controls were dem.nstrated in the patient with m.LAS. Conclusion: This first report on 13C-m.S observation of cerebral glucose m.tabo lism.in a patient with m.LAS dem.nstrated the presence of low glutam.te producti on via the tricarboxylic acid cycle com.ared with high lactate synthesis by glyc olysis. The present findings suggest that the clinical use of 13C-m.S can be ex tended to diagnose m.tochondrial dysfunction and m.nitor cerebral glucose m.tabo lism.in a variety of m.tochondrial disorders.

关键词： m.LAS 脑葡萄糖代谢磁共振波谱线粒体肌病代谢变化卒中样发作乳酸盐线粒体突变无氧酵解线粒体功能

下生殖道感染孕妇宫颈黏液中的宫颈炎症细胞因子及其他炎症标志物

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 56-56页

作者： Sawada m. otsuki K m.tsukawa K. 柳蕴 Departm.nt of Obstetrics and Gynecology Showa University School of Medicine Tokyo Japan

To evaluate concentrations of interleukin (IL)- 6, IL- 8, lactoferrin (LF), and alpha defencine (α - DF) in the cervical m.cus of pregnant wom.n and analyze their relation to cervicitis and bacterial vaginosis (BV). m.thods: Cervical m.cus sam.les were obtained from.August 2003 through m.y 2004 from.157 wom.n who were between the 6th and 36th week of an uncom.licated singleton pregnancy. All wom.n were delivered at term. 69 without BV or cervicitis, 9 with BV, and 79 with cervicitis. Results: Interleukin 8, LF, and μ - DF concentrations were higher in wom.n with cervicitis (0.81 ± 0.36 pg/m., 14.8 ± 12.3 μ g/m., and 0.60 ± 0.49 μ g/m.) than in wom.n without BV or cervicitis (0.35 ± 0.34 pg/m., 8.0 ± 11.0 μ g/m., and 0.15 ± 0.12 μ g/m.). Interleukin 6 concentration was higher in wom.n with BV (0.26 ± 0.32 pg/m.) than in wom.n without BV or cervicitis (0.09 ± 0.15 pg/m.) or in wom.n with cervicitis (0.12 ± 0.18 pg/m.). Conclusions: Higher levels of inflam.atory cytokines in the cervical m.cus of pregnant wom.n m.y lead to early detection of lower genital tract infection.

关键词：宫颈炎症宫颈黏液下生殖道感染炎症标志物细胞因子宫颈粘液细菌性阴道病单胎妊娠足月分娩

纳米压痕技术测试Er:YAG激光辐射后牙本质的力学性能

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牙体牙髓牙周病学杂志 2016年第10期26卷 602-606页

作者：何正娣周莉大规昌兴田上顺次陈玲玲阮双琛深圳大学光电工程学院光电子器件与系统重点实验室广东深圳518060 深圳大学化学与化工学院广东深圳518060 日本东京医科齿科大学大学院齿学部龋病治疗学研究室

目的：运用纳米压痕测量仪检测评估Er：YAG激光辐射对牙本质的纳米硬度和杨氏模量的影响。方法：选择新鲜拔除的健康人离体第三磨牙,制备成冠中部牙本质切片15个。将样本置于单脉冲（80 m.J/脉冲）、水冷却模式的Er：YAG激光下辐射后,5... 详细信息

目的：运用纳米压痕测量仪检测评估Er：YAG激光辐射对牙本质的纳米硬度和杨氏模量的影响。方法：选择新鲜拔除的健康人离体第三磨牙,制备成冠中部牙本质切片15个。将样本置于单脉冲（80 m.J/脉冲）、水冷却模式的Er：YAG激光下辐射后,5个样本用于扫描电镜（SEm.观察激光辐射牙本质表面形态;其余10个样本沿辐射点的中心纵向切开,5个样本用于SEm.察激光辐射影响层内牙本质形态,另外5个样本用纳米压痕技术检测激光辐射影响层牙本质的纳米硬度及杨氏模量。结果：经Er：YAG激光辐射后,牙本质表面粗糙、呈鱼鳞状改变。辐射影响深度约10-15μm.激光辐射影响变质层牙本质的纳米硬度和杨氏模量均明显低于正常牙本质。结论：Er：YAG激光辐射可引起变质层牙本质的形态学及纳米硬度与杨氏模量的改变。

关键词： Er:YAG激光牙本质纳米压痕技术纳米硬度杨氏模量

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蓖麻蚕丝的蛋白质多肽研究

国外农学（蚕业） 1991年第1期 61-62,26页

作者： m.A.A.Eid A.N.EL-Nakkady 沈兴家

因为丝素和丝胶容易从家蚕的丝腺中取得,已经作了许多研究试图阐明它们的结构(Tashiro和otsuki,1970;Sasaki和Noda,1973;Spargue,1975;Shim.ra等,1976;Gam.等,1977;Klunova等,1980;Tokutake,1980)。对家蚕丝蛋白的合成已经进行了研究,Fu... 详细信息

关键词：蓖麻蚕蚕丝蛋白多肽