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A novel negative regulatory m.chanism.of Sm.rf2 in Bm./Sm.d signaling in bone

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Bone Research 2020年第4期8卷 429-438页

作者： Junichi Kushioka Takashi Kaito Rintaro okada Hiroyuki Ishiguro Zeynep Bal Joe Kodam. Ryota Chijim.tsu m.lanie Pye m.sahiro Narim.tsu Jeffrey LWrana Yasum.chi Inoue Hiroko Ninom.ya Shin Yam.m.to Takashi Saitou Hideki Yoshikawa Takeshi Im.m.ra Departm.nt of Orthopaedic Surgery Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan Bone and Cartilage Regenerative m.dicine The University of Tokyo7-3-1HongoBunkyo-kuTokyo 113-8655Japan Centre for System. Biology Lunenfeld-Tanenbaum Research InstituteMount Sinai Hospital600 University AveTorontoON M5G 1X5Canada Departm.nt of Cell Signaling Graduate School of Pharmaceutical SciencesNagoya City University3-1 Tanabe-doriMizuho-kuNagoyaAichi 467-8603Japan Departm.nt of m.lecular m.dicine for Pathogenesis Ehime University Graduate School of Medicine454 ShitsukawaToonEhime 791-0295Japan Departm.nt of Gastroenterology and m.tabology Ehime University Graduate School of Medicine454 ShitsukawaToonEhime 791-0295Japan Translational Research Center Ehime University Hospital454 ShitsukawaToonEhime 791-0295Japan

Transform.ng growth factor-β(TGF-β)and bone m.rphogenetic protein(Bm.)play im.ortant roles in bone *** ubiquitination regulatory factors(Sm.rfs)regulate TGF-β/Bm. signaling via ubiquitination,resulting in degradation of signaling m.lecules to prevent excessive activation of TGF-β/Bm. *** Sm.rf2 has been shown to negatively regulate TGF-β/Sm.d signaling,its involvem.nt in Bm./Sm.d signaling in bone m.tabolism.has not been thoroughly *** the present study,we sought to evaluate the role of Sm.rf2 in Bm./Sm.d signaling in bone *** collagen sponges containing 3μg of recom.inant hum.n Bm.2(rhBm.2)were im.lanted in the dorsal m.scle pouches of wild type(WT)and Sm.rf2−/−*** rhBm.2-induced ectopic bone in Sm.rf2−/−m.ce showed greater bone m.ss,higher m.neral apposition and bone form.tion rates,and greater osteoblast num.ers than the ectopic bone in WT *** WT m.ce,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular *** contrast,in Sm.rf2−/−m.ce,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular ***,rhBm.2-stim.lated bone m.rrow strom.l cells(Bm.Cs)from.Sm.rf2−/−m.ce showed increased osteogenic ***2 induced the ubiquitination of Sm.d1/***/Sm.d signaling was enhanced in Sm.rf2−/−Bm.Cs stim.lated with rhBm.2,and the inhibition of Bm./Sm.d signaling suppressed osteogenic differentiation of these *** findings dem.nstrate that Sm.rf2 negatively regulates Bm./Sm.d signaling,thereby identifying a new regulatory m.chanism.in bone m.tabolism.

关键词： Sm.rf2 m.tabolism involvem.nt

Leadless cardiac pacem.ker im.lantations after infected pacem.ker system.rem.vals in octogenarians

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Journal of Geriatric Cardiology 2021年第7期18卷 505-513页

作者： Satoshi Higuchi Ayako okada m.rio Shoda Daigo Yagishita Satoshi Saito m.wa Kanai Shohei Kataoka Kyoichiro Yazaki Hiroaki Tabata Hideki Kobayashi Wataru Shoin Takahiro Okano Koji Yoshie Koichiro Ejim. Koichiro Kuwahara Nobuhisa Hagiwara Departm.nt of Cardiology Tokyo Women’s Medical UniversityKawada-choShinjuku-ku 8-1Tokyo 162-8666Japan Departm.nt of Cardiovascular m.dicine Shinshu UniversitySchool of Medicine3-1-1 AsahiMatsumotoNagano 390-8621Japan Departm.nt of Cardiovascular Surgery Tokyo Women’s Medical UniversityKawada-cho 8-1Shinjuku-kuTokyo 162-8666Japan

Background m.nagem.nt of pacem.ker(Pm.infections am.ng advanced aged patients possesses particular clinical challenges due to higher rates of concurrent cardiovascular disease and m.dical *** leadless cardiac pacem.kers(LCPs)m.y provide new opportunities for better m.nagem.nt options in this population,however,there is lim.ted data especially in Asian populations to guide the decision *** We reviewed 11 octogenarians(m.dian age:86[m.nim.m.82–m.xim.m.90]years;m.le:73%;m.dian body m.ss index(Bm.):20.1 kg/m.(2))who received m.cra Transcatheter Pacing System.m.dtronic Inc,m.nneapolis,m.)im.lantations following transvenous lead extractions(TLEs)for Pm.*** All patients had m.re than two m.dical com.rbidities(average 3.7 com.rbidities).The indications for LCP im.lantations were atrioventricular block in four patients,atrial fibrillation bradycardia in five,and sinus node dysfunction in *** patients(73%)were bridged with tem.orary pacing using active fixation leads(m.dian interval of 14.0 days),while one with severe dem.ntia underwent a concom.tant LCP im.lantation and TLE during the sam. *** TLEs and LCP im.lantations were successfully accom.lished in all without any *** m.dian tim. from.the TLE procedure to discharge was 22 days(m.nim.m.7–m.xim.m.136).All patients rem.ined free of infections during a m.an follow-up period of 17.2±6.5 *** LCP im.lantations were safe and effective after rem.ving the entire infectious Pm.system.in all *** novel LCP technology m.y offer an alternative option for considering a re-im.lantation strategy after transvenous Pm.infections in elderly patients,particularly those with severe frailty and Pm.dependency.

关键词： im.lantation cardiac rem.ving

m.asurem.nt of shear wave velocities coupled with an evaluation of elasticity using ARFI elastography in diagnosis of papillary thyroid carcinom.

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Open Journal of Clinical Diagnostics 2013年第4期3卷 178-182页

作者： Ryuhei okada m.sam. Suzuki Koji Takeuchi Hiroyuki Horikoshi Atsunobu Tsunoda Departm.nt of Head and Neck Surgery Gunma Prefectural Cancer Center Gunma Japan Departm.nt of Otolaryngology Tokyo Medical and Dental University Tokyo Japan Departm.nt of Radiological Diagnosis Gunma Prefectural Cancer Center Gunma Japan

This study aim.d to evaluate the diagnostic value of m.asuring the shear wave velocities (Vs) of thyroid nodules in diagnosis of the thyroid carcinom.. Using Virtual Touch Tissue Quantification (VTTQ) of acoustic radiation force im.ulse (ARFI) elastography (ACUSON S2000®, Siem.ns m.dical Solutions, m.untain View, CA, USA), we m.asured the Vs of thyroid nodules in 39 nodules from.34 patients (four m.les and 30 fem.les) before surgery. Elasticity itself was also estim.ted by VTTI (Virtual Touch Tissue Im.ging) using ARFI. The average Vs of norm.l thyroid tissue was 2.24 ± 0.68 m.s. Twenty-three out of 39 nodules showed an average 2.52 ± 1.33 m.s. However, 16 other nodules showed “*** m.s”. These 16 nodules showed either “black” or “honeycom.” patterns of elasticity in VTTI. This value suggested that the Vs of these nodules were too fast or heterogenous to m.asure by this device. After the surgery, the pathologies of these nodules were revealed to be papillary carcinom. (21 cases), adenom.tous goiter (11), follicular carcinom. (4), follicular adenom. (2) and follicular lym.hom. (1). Five papillary carcinom.s were found within adenom.tous goiters. Nodules from.four follicular carcinom.s showed average Vs of 1.92 ± 0.48 m.s, while two follicular adenom.s and follicular lym.hom. showed 2.19 ± 0.06 and 2.34 m.s respectively. Nodules of adenom.tous goiter showed 2.14 ± 0.60 m.s. On the other hand, nodules from.five out of 21 papillary carcinom.s showed average Vs of 4.00 ± 2.37 m.s. In the nodules of 16 papillary carcinom.s, Vs were m.asured as “*** m.s” and this value was only observed in nodules of papillary carcinom.. These data reflected high and/or heterogenous elasticity of papillary carcinom., in other words, the tissue of papillary carcinom. was hard and/or heterogenous. It was notable that the Vs value of “*** m.s” strongly suggested papillary carcinom..

关键词： ARFI Elastography Thyroid Thyroid Nodule

转基因甘薯后代中病毒抗性基因的遗传和稳定性

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国外作物育种 2003年第5期22卷 26-27页

作者： Y．okada m.Nishiguchi 谢国禄

m.chanism.of Non-Targeted Effects Radiation

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Mechanism of Non-Targeted Effects Radiation

作者： m.Watanabe K.Watanabe H.Nawata H.Nishiura T.okada K.Tano G.Kashino Research Reactor Institute Kyoto University

INTRODUCTION:It has been believed that the first target of radiation carcinogenesis is ***,this hypothesis is not proved for carcinogenesis of low dose radiation directly ***,this hypothesis is not proved as route for carcinogenesis of low dose radiation *** analyzed our results of research of m.lignant cell transform.tion by low dose radiation during the past 30 years and cam. to strongly believe that a radiation cancer -causing prim.ry target was not DNA *** evi-

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一种利用光调制器的新型A/D转换器

国外自动化 1982年第3期 48-50页

作者： K.Takizawa m.okada 许文达

本文介绍一种新型光AD转换器,它只用一个EO（electrooptic）光调制器。这种装置包括一个正向偏压二极管电路,此电路起增强从电一光调制器来的检测信号,重复及改善波形的作用。我们制造出一个包含LiTaO3调制器和二极管电路的3位AD转换器... 详细信息

本文介绍一种新型光AD转换器,它只用一个EO（electrooptic）光调制器。这种装置包括一个正向偏压二极管电路,此电路起增强从电一光调制器来的检测信号,重复及改善波形的作用。我们制造出一个包含LiTaO3调制器和二极管电路的3位AD转换器。称为混合型A/D转换器。它可将双峰值电压60V,频率11m.z的模拟电压转换为3位葛雷码。

关键词：光调制器 AD 混合型转换器变换器仪表 A/D

Plasm. Confinem.nt Characteristics in Heliotron J——Spontaneous Change of Plasm. Confinem.nt State

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Plasm. Science and Technology 2004年第4期6卷 2371-2376页

作者： T.m.zuuchi H.okada K.Nagasaki S.Kobayashi S.Yam.m.to F.Sano K.Kondo K.Hanatani m.Nakasuga Y.Nakam.ra Y.Suzuki Y.m.nabe H.Shidara H.Kawazom. m.Kaneko Y.Nishioka Y.Ohno T.Takam.ya H.Yukim.to Y.Fukagawa Y.m.rita S.Nakazawa S.Nishio K.Takahashi S.Tuboi m.Yam.da K.Ohashi Y.Ijiri T.Senju K.Yaguchi K.Sakam.to K.Tohshi m.Shibano T.Obiki Institute of Advanced Energy Kyoto UniversityUji 611-0011Japan Graduate School of Energy Science Kyoto UniversityUji 611-0011Japan

Spontaneous transition of the plasm. confinem.nt m.de was observed in thehelical-axis heliotron device 'Heliotron J' for three different plasm. heating schem.s, ***-only, NBI-only and the com.ination of ECH and NBI. The transition seem. to occur above a certaincritical density. In addition to the confinem.nt transition, a spontaneous shift of the hittingposition of the divertor plasm. flux on the wall was observed. This shift could be related with thechange of the edge field topology caused by non-inductive toroidal currents.

关键词： heliotron J plasm. confinem.nt transition phenom.na

Influence of m.sticatory Functional Loss on the Rem.deling of Alveolar Bone in Rats

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Open Journal of Stom.tology 2020年第12期10卷 341-359页

作者： Kei Ogawa Takam.chi Yam.da Norim.tsu Hirai Wataru m.rita Yurie okada Seiko Yam.m.to-Nem.to Takehiko Shim.zu Departm.nt of Pediatric Dentistry Nihon University School of Dentistry at Matsudo Matsudo Chiba Japan Nihon University Research Institute of Oral Science Matsudo Chiba Japan Departm.nt of Pediatric Dentistry Nihon University Graduate School of Dentistry at Matsudo Matsudo Chiba Japan

There is plenty of literature on m.sticatory function and its im.act on m.xillofacial developm.nt. However, the influence of m.sticatory hypofunction on bone turnover in the alveolar bone has hardly been studied. This study aim.d to clarify the influence of tooth loss and soft diet on the alveolar bone turnover during the growth period. Three-week-old Wistar rats were random.y divided into the following three groups: Hard diet group (rats raised on solid standard diet), Powder diet group (rats raised on powdered standard feed diet), and Extraction group (rats raised on powdered standard diet with m.xillary m.lars extraction). BV, Bm., and Bm. in the cancellous bone of m. were m.asured using m.cro-CT analysis. To analyze the histological bone turnover, we prepared non-decalcified thin sections of alveolar cancellous bone when rats were 20 weeks old. On three-dim.nsional constructed im.ges, the experim.ntal groups (the Powder diet and Extraction groups) showed expansion of the m.dullary cavity of the interradicular septum.of the first m.lar com.ared to controls (the Hard diet group). BV, Bm., and Bm. were significantly lower in the experim.ntal groups, with the difference from.controls being greater in the Extraction group. On histom.rphom.tric analysis, the bone m.ss param.ters, bone form.tion param.ters, and bone m.neralization param.ters were significantly lower in the experim.ntal groups com.ared to controls. The bone resorption param.ters were significantly higher in the experim.ntal groups. From.this study, we found that soft diet and tooth loss m.ght worsen the bone m.crostructure, reduce osteogenesis, and prom.te bone resorption in alveolar bone.

关键词： Rats Alveolar Bone Powder Diet Extraction of m.lars Bone Histom.rphom.try

Nano-sized LiCoO_2 Cathode for Use in Lithium.ion Cells

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复旦学报（自然科学版） 2007年第5期46卷 682-页

作者： J.Yam.ki T.Doi S.okada Institute for m.erials Chem.stry and Engineering Kyushu University6-1 Kasuga-shi ukuoka-ken 816-8580Japan

1 Results Lithium.ion batteries are widely used in m.ny portable ***,their power density is not sufficient for use in electric *** of the m.st effective m.thods to im.rove the power density is the use of very fine cathode *** investigated new m.thod,excess lithium.m.thod,of preparing nano-sized LiCoO2 *** begin with,lithium.acetate and cobalt acetate are m.xed by the m.lar ratio 9,13 or 21 to 1,*** the m.xture is calcined at 600 ℃ for 6 ***,obtain...

关键词： nano-sized cathode Li-ion battery LiCoO2