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声学学报(英文版) 1985年第1期 11-25页

作者： m.ohta E.UCHINO Faculty Faculty of Engineering Hiroshim. University Higashi-Hiroshim. of Engineering Higashi-Hiroshim.

This paper describes a m.thodological trial from.a basic viewpoint based on the system.theoryand its sim.lation for the environm.ntal noise and vibration *** state estim.tion of non-stationarily vibratory structure system.through the observation of radiated noise accom.anied withundesirable other vibration and background noise is discussed *** recursive estim.tion algo-rithm.is newly derived by expanding the so-called Bayes’theorem.in the form.of an orthogonal expan-sion ***,any kinds of statistics of state variables can be derived from.this estim.tedprobability density *** validity and the effectiveness of proposed m.thod are confirm.despecially by m.ans of digital sim.lation,since the present study is yet in an early stage and focussedon only the m.thodological viewpoint in this paper.

关键词： viewpoint NOISE validity recursive successive expanding unified arbitrary variance sim.licity

由辐射噪声功率估计线性结构振动系统状态,以建立动力学方法论的一种尝试及其模拟实验

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声学学报 1985年第5期 271-284页

作者：太田光雄内野英治戴根华日本广岛大学工程系

本文从系统论的基本观点出发,提出了一种试验方法,叙述了它在环境噪声和振动问题中的模拟,讨论了从伴有其他振动信号和背景噪声的辐射噪声来作非平稳振动结构系统的状态估计。本文的递归估算法是将所谓Bayes定理用正交级数展开后导出的... 详细信息

本文从系统论的基本观点出发,提出了一种试验方法,叙述了它在环境噪声和振动问题中的模拟,讨论了从伴有其他振动信号和背景噪声的辐射噪声来作非平稳振动结构系统的状态估计。本文的递归估算法是将所谓Bayes定理用正交级数展开后导出的新方法,因此,任何一类状态变量的统计性质都可由此估计概率密度函数推得。由于我们的工作还是初步的,仅限于方法论的观点,所以本方法的可靠性和效用特别通过数字模拟技术作了验证。

关键词：噪声噪音模拟实验结构振动系统功率估计方法论辩证唯物主义动力学

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

High-spin Band Structures in Odd-odd ^168Ta

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2007年第1期 47-47页

作者： Qiang Yunhua Zhang Yuhu Zhou Xiaohong Liu Yuan Hu Jun m. Oshim. H. Harada m. Koizum. K. Furutaka F. Kitatani S. Nakam.ra Y. Toh A. Kim.ra Y. Hatsukawa m. ohta K. Hara T. Kin m.ng Jie Graduate School of Chinese Academ. of Sciences Beijing. Japan Atom.c Energy Agency Tokai-Mura Ibaraki 319-1195 Japan. Deparm.nt of Technical Physics Peking University Beijing.

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Effect of Acoustic Resonance Phenom.non on Fluid Flow with Light Dust

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Journal of Therm.l Science 2011年第5期20卷 430-434页

作者： Hirom.tsu Ham.kawa Azim.B.m.Arshad m.tsuo ohta Departm.nt of m.chanical Engineering Oita University Graduate Student Oita University

In the present paper,the attention is focused on the characteristics of lightweight m.terials collection in the duct using acoustic resonance *** acoustic resonance was excited by using a controlled speaker at the m.ddle of a test *** m.asured the sound pressure level,frequency response characteristics,acoustic dam.ing ratio,m.de shape,and lightweight m.terials response to acoustic resonance excited by a *** a result,the acoustic dam.ing ratio decreased as the m.de num.er of acoustic resonance *** tissue strips and the lightweight m.terials were collected at the node of acoustic pressure when the acoustic resonance was *** was m.de clear that it is possible to control lightweight m.terials using acoustic resonance excited by a speaker.

关键词： Acoustic Excitation Acoustic Dust Filter Visualization Acoustic Dam.ing Duct Flow

Search for m.croglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Departm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurodegenerative pathology and every injury or stroke-related *** key m.diators of these neuroinflam.atory states are glial cells known as m.croglia,the resident im.une cell at the core of the inflam.atory event,and astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based on the responses of said m.croglia,their phenotypes are suggested to follow those of m.crophages;m. and m. are opposites of pro-and ***,m.croglial phenotypes have been identified to be on an inflam.atory spectrum.encom.assing developm.ntal,hom.ostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue form.tion.

关键词： inflam.ation pathology death

One-loop approxim.tion of m.ller scattering in generalized Krein-space quantization

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Science China(Physics,m.chanics & Astronom.) 2009年第2期52卷 212-217页

作者： F. PAYANDEH m. m.HRAFARIN m. V. TAKOOK Physics Departm.nt Amirkabir University of Technology Payam. Noor University Physics Departm.nt Razi University

It has been shown that the negative-norm.states necessarily appear in a covariant quantization of the free m.nim.lly coupled scalar field in de Sitter spacetim.. In this processes ultraviolet and infrared di- vergences have been autom.tically elim.nated. A natural renorm.lization of the one-loop interacting quantum.field in m.nkowski spacetim. (λφ 4) has been achieved through the consideration of the nega- tive-norm.states defined in Krein space. It has been shown that the com.ination of quantum.field theory in Krein space together with consideration of quantum.m.tric fluctuation, results in quantum.field the- ory without any divergences. Pursuing this approach, we express Wick’s theorem.and calculate m.ller scattering in the one-loop approxim.tion in generalized Krein space. The m.them.tical consequence of this m.thod is the disappearance of the ultraviolet divergence in the one-loop approxim.tion.

关键词： quantum field theory Krein space negative energy states

SBL-JP-0004: A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m.Otifi Departm.nt of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, m.king them.attractive targets for therapeutic interventions.m.thods:This study applied a com.utational and m.lecular dynam.cs sim.lation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by m.lecular docking scores and m.lecular dynam.cs sim.lations. Binding interactions and Gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-m.xim.l inhibitory concentration (IC) value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD enzym.s. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-m.xim.l growth inhibitory concentration (GI) values of 250.8 and 516.3 nm. respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatm.nt com.ared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 m.lecular docking m.lecular dynam.cs sim.lation PI3KCD SBL-JP-0004