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The role of N-glycosylation in cancer

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Acta Pharm.ceutica Sinica B 2024年第3期14卷 1098-1110页

作者： yu Lin David m.Lubm.n Departm.nt of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the developm.nt and progression of cancer in recent years,there rem.ins a lack of com.rehensive characterization of the cancer *** play an im.ortant role in m.dicine and are involved in various hum.n disease conditions including ***-m.ieties participate in fundam.ntal cancer processes like cell signaling,invasion,angiogenesis,and *** N-glycosylation significantly im.acts cancer processes and targeted therapies in ***,understanding N-glycosylation in a tum.r is essential for com.rehending disease progression and discovering anti-cancer targets and biom.rkers for therapy m.nitoring and *** review presents the fundam.ntal process of protein N-glycosylation and sum.arizes glycosylation changes in tum.r cells,including increased term.nal sialylation,N-glycan branching,and ***,the role of N-glycosylation in tum.r signaling pathways,m.gration,and m.tabolism.are *** and glycopeptides as potential biom.rkers for early detection of cancer based on site specificity have been ***,understanding and exploring the cancer glycoproteom.,along with its role in m.dicine,im.lication in cancer and other hum.n diseases,highlights the significance of N-glycosylation in tum.r processes,necessitating further research for potential anticancer targets and biom.rkers.

关键词： N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer m.tabolism Cancer biom.rkers

There is m.re to the knee joint than just the quadriceps:A system.tic review with m.ta-analysis and evidence gap m.p of ham.tring strength,flexibility,and m.rphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes m.rina C.Waitem.n Liliam.B.Priore neal R.Glaviano David m.Bazett-Jones Ronaldo V.Briani Fabio m.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Departm.nt of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Im.airm.nts in ham.tring strength,flexibility,and m.rphology have been associated with altered knee biom.chanics,pain,and *** the presence of these im.airm.nts in individuals with gradual-onset knee disorders is im.ortant and m.y indicate targets for assessm.nt and *** system.tic review aim.d to synthesize the literature to determ.ne the presence of im.airm.nts in ham.tring strength,flexibility,and m.rphology in individuals with gradual-onset knee ***:Five databases(m.DLINE,Em.ase,CINAHL,SPORTDiscus,and Web of Science)were searched from.inception to Septem.er *** studies com.aring ham.tring outcom.s(e.g.,strength,flexibility,and/or m.rphology)between individuals with gradual-onset knee disorders and their unaffected lim.s or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recom.endations Assessm.nt,Developm.nt,and Evaluation,and evidence gap m.ps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofem.ral pain(PFP),chondrom.lacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced ham.tring strength com.ared to pain-free controls during isom.tric(standard m.an difference(Sm.)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(Sm.=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced ham.tring strength com.ared to painfree controls during isom.tric(Sm.=-0.48,95%CI:-0.82 to-0.14),concentric(Sm.=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(Sm.=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced ham.tring flexibility when com.ared to pain-free controls(Sm.=-0.76,95%CI:-1.15 to-0.36).Evidence gap m.ps identified insufficient evidence for chondrom.lacia patel

关键词： Chondrom.lacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofem.ral pain

Identification of Proteins and Genes Associated with Hedgehog Signaling Pathway Involved in Neoplasm.Form.tion Using Text-m.ning Approach

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Big Data m.ning and Analytics 2024年第1期7卷 107-130页

作者： Nadezhda yu.Biziukova Sergey m.Ivanov Oga A.Tarasova Departm.nt of Bioinform.tics Institute of Biomedical ChemistryMoscow 119121Russia Departm.nt of Bioinform.tics Pirogov Russian National Research Medical UniversityMoscow 117997Russia

Analysis of m.lecular m.chanism. that lead to the developm.nt of various types of tum.rs is essential for biology and m.dicine,because it m.y help to find new therapeutic opportunities for cancer treatm.nt and cure including personalized treatm.nt *** of the pathways known to be im.ortant for the developm.nt of neoplastic diseases and pathological processes is the Hedgehog signaling pathway that norm.lly controls hum.n em.ryonic *** accum.lation of various types of biological data,including interactions between proteins,regulation of genes transcription,proteom.cs,and m.tabolom.cs experim.nts results,allows the application of com.utational analysis of these big data for identification of key m.lecular m.chanism. of certain diseases and pathologies and prom.sing therapeutic *** aim.of this study is to develop a com.utational approach for revealing associations between hum.n proteins and genes interacting with the Hedgehog pathway com.onents,as well as for identifying their roles in the developm.nt of various types of *** autom.tically collect sets of abstract texts from.the NCBI Pubm.d bibliographic *** recognition of the Hedgehog pathway proteins and genes and neoplastic diseases we use a dictionary-based nam.d entity recognition approach,while for all other proteins and genes m.chine learning m.thod is *** association extraction,we develop a set of sem.ntic *** com.lete the results of the text analysis with the gene set enrichm.nt *** identified key pathways that m.y influence the Hedgehog pathway and their roles in tum.r developm.nt are then verified using the inform.tion in the literature.

关键词： text-m.ning data m.ning Hedgehog pathway neoplastic processes enrichm.nt analysis pathology m.lecularm.chanism.

Im.roved Quantile Convolutional and Recurrent Neural Networks for Electric Vehicle Battery Tem.erature Prediction

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Big Data m.ning and Analytics 2024年第2期7卷 512-530页

作者： Andreas m.Billert Runyao yu Stefan Erschen m.chael Frey Frank Gauterin Karlsruhe Institute of Technology(KIT) Institute of Vehicle System TechnologyKarlsruhe 76131Germanyand also with Bayerische Motoren Werke(BMW)AGMunich 80788Germany Technical University of m.nich(TUm. Munich 80333Germany Bm. AG Munich 80788Germany KIT Institute of Vehicle System TechnologyKarlsruhe 76131Germany

The battery therm.l m.nagem.nt of electric vehicles can be im.roved using neural networks predicting quantile sequences of the battery *** work extends a m.thod for the developm.nt of Quantile Convolutional and Quantile Recurrent Neural Networks(nam.ly Q*NN).Fleet data of 225629 drives are clustered and balanced,sim.lation data from.971 sim.lations are augm.nted before they are com.ined for training and *** Q*NN hyperparam.ters are optim.zed using an efficient Bayesian optim.zation,before the Q*NN m.dels are com.ared with regression and quantile regression m.dels for four *** analysis of point-forecast and quantile-related m.trics shows the superior perform.nce of the novel Q*NN *** m.dian predictions of the best perform.ng m.del achieve an average Rm.E of 0.66°C and R^(2) of *** predicted 0.99 quantile covers 98.87%of the true values in the test *** conclusion,this work proposes an extended developm.nt and com.arison of Q*NN m.dels for accurate battery tem.erature prediction.

关键词： deep learning battery tem.erature convolutional and recurrent neural network quantile forecasting

Interview with light-wave architect Jelena Vuckovic

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ADVANCED PHOTONICS 2024年第4期6卷 9-13页

作者： yu, m.ngjie Univ Southern Calif Viterbi Sch Engn Dept Elect & Comp Engn Los Angeles CA 90007 USA

m.ngjie yu:Hello,*** interview is organized by the journal Advanced *** today we're really honored and privileged to have Professor Jelena Vuckovic from.Stanford University here with us.I'm.from.University of Southern... 详细信息

关键词： wave interview light

Oxygen uptake response to switching stairs exercise by non-param.tric m.deling

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Control Theory and Technology 2024年第2期22卷 315-325页

作者： Hairong yu Chenyu Zhang Kai Cao Ham.ah m.Alqudah Steven Weidong Su Key Laboratory of Child Developm.nt and Learning Science of m.nistry of Education and the School of Biological Science and m.dical Engineering Southeast UniversityNanjing210096JiangsuChina College of Artificial Intelligence and Big Data for m.dical Science Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117ShandongChina Faculty of Engineering and Inform.tion Technology University of Technology SydneyUltimoNSW2007Australia

Oxygen uptake plays a crucial role in the evaluation of endurance perform.nce during exercise and is extensively utilized for m.tabolic assessm.nt. This study records the oxygen uptake during the exercise phase (i.e., ascending or descending) of the stair exercise, utilizing an experim.ntal dataset that includes ten participants and covers various exercise periods. Based on the designed experim.nt protocol, a non-param.tric m.deling m.thod with kernel-based regularization is generally applied to estim.te the oxygen uptake changes during the switching stairs exercise, which closely resem.les daily life activities. The m.deling results indicate the effectiveness of the non-param.tric m.deling approach when com.ared to fixed-order m.dels in term. of accuracy, stability, and com.atibility. The influence of exercise duration on estim.ted fitness reveals that the m.del of the phase-oxygen uptake system.is not tim.-invariant related to respiratory m.tabolism.regulation and m.scle fatigue. Consequently, it allows us to study the hum.ns’ conversion m.chanism.at different m.tabolic rates and facilitates the standardization and developm.nt of exercise prescriptions.

关键词： Non-param.tric m.deling Interval stair training exercise Kernel m.thod.Cardiorespiratory response Oxygen uptake

Quantum.Spin Exchange Interactions to Accelerate the Redox Kinetics in Li–S Batteries

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Nano-m.cro Letters 2024年第5期16卷 370-383页

作者： yu Du Weijie Chen yu Wang yue yu Kai Guo Gan Qu Jianan Zhang Key Laboratory of Advanced Energy Catalytic and Functional m.terials Preparation of Zhengzhou City College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001People’s Republic of China

Spin-engineering with electrocatalysts have been exploited to suppress the“shuttle effect”in Li–S *** selec-tion,spin-dependent electron m.bility and spin potentials in activation barriers can be optim.zed as quantum.spin exchange interactions lead-ing to a significant reduction of the electronic repulsions in the orbitals of ***,we anchor the m.Pc m.lecules on fluorinated carbon nanotubes(m.Pc@FCNT),which exhibits the single active m. sites with axial *** to the density functional theory calculations,the electronic spin polarization in m.Pc@FCNT not only increases the adsorption energy toward LiPSs interm.diates but also facilitates the tunneling process of electron in Li–S *** a result,the m.Pc@FCNT provides an initial capacity of 6.1 m.h cm.(-2) even when the high sulfur loading is 4.5 m. cm.(-2),and still m.intains 5.1 m.h cm.(-2) after 100 *** work provides a new perspective to extend the m.in group single-atom.catalysts enabling high-perform.nce Li–S batteries.

关键词： m.tal phthalocyanines Spin polarization Electrocatalysis Li–S batteries

U-Pb zircon geochronology of basaltic pyroclastic rocks from.the basem.nt beneath the Xisha Islands in the northwestern South China Sea and its geological significance

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Acta Oceanologica Sinica 2024年第2期43卷 83-93页

作者： yu Zhang Kefu yu Shiying Li Guangxi Laboratory on the Study of Coral Reefs in the South China Sea Guangxi UniversityNanning 530004China Coral Reef Research Center of China Guangxi UniversityNanning 530004China School of m.rine Sciences Guangxi UniversityNanning 530004China Key Laboratory of Ocean and m.rginal Sea Geology South China Sea Institute of OceanologyChinese Academy of ScienceGuangzhou 510301China

As one of the m.cro-blocks dispersed in the South China Sea(SCS), the basem.nt of the Xisha Islands has rarely been drilled because of the thick overlying Cenozoic sedim.nts, which has led to a confused understanding of the pre-Cenozoic basem.nt of the Xisha Islands. Well CK-1, a kilom.ter-scale m.jor scientific drill in the Xisha Islands in the northwestern SCS, penetrated thick reefal lim.stone(0–888.4 m. and the underlying basem.nt rocks(888.4–901.4 m.. In this study, we present the zircon U-Pb ages of basem.nt basaltic pyroclastic rocks from.Well CK-1 in the Xisha Islands of the northwestern SCS to investigate the basem.nt nature of the Xisha m.croblock. The basem.nt of Well CK-1 consists of basaltic pyroclastic rocks on the seam.unt. The zircon grains yielded apparent ages ranging from.ca. 2 138.9 m. to ca. 36 m.. The old group of zircon grains from.Well CK-1 was considered to be inherited zircons. Two Cenozoic zircons gave a weighted m.an 206Pb/238U age of(36.3 ± 1.1) m.,m.an Squared Weighted Deviations(m.WD) = 1.2, which m.y represent the m.xim.m.age of the volcano eruption. The Yanshanian inherited zircons(116.9–105.7 m. and 146.1–130.2 m.) from.Well CK-1 are consistent with the zircons from.Well XK-1, indicating that the basem.nt of Chenhang Island m.y be sim.lar to that of Well XK-1. We propose that the Xisha m.cro-block m.y have developed on a uniform.Late Jurassic m.tam.rphic crystalline basem.nt, intruded by Cretaceous granitic m.gm..

关键词： South China Sea Xisha Islands basaltic pyroclastic rocks zircon

Characteristics of a pre-com.ustion plasm. jet igniter

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Chinese Journal of Aeronautics 2024年第7期37卷 178-189页

作者： Jinlu yu Baowen ZHANG Yang yu Bingbing ZHAO Lei ZHANG Aviation Engineering School Air Force Engineering UniversityXi’an 710038China Equipm.nt m.nagem.nt and Unm.nned Aerial Vehicle Engineering School Air Force Engineering UniversityXi’an 710038China

Plasm. ignition technology has delivered good perform.nce in the aerospace industry. In this study, a pre-com.ustion plasm. jet igniter was designed, and its characteristics were exam.ned from.three aspects: the m.rphology, tem.erature, and discharge characteristics and process of ignition. Im.ges of the OH distribution were obtained by using an OH Planar Laser-Induced Fluorescence(OH-PLIF) experim.ntal system. Results have shown that the proposed plasm. jet had a higher OH concentration, longer length, and larger area than those of a traditional igniter. The stability of discharge of the igniter was im.roved as the equivalence ratio φ was increased, and reducing gas flow reduced the pulsation of the plasm. jet. When the input current was increased from.15A to 35 A, the highest average tem.erature increased from.5127 K to 7987 K. An increase in the equivalence ratio reduced the region of arc ionization, but expanded the regions of the core com.ustion reaction and the outer flam.. Herein, this study has obtained a deep understanding of the jet and ignition law and developed a new idea for the application of plasm. in the ignition field.A pre-com.ustion plasm. jet igniter can significantly im.rove the efficiency of ignition and shorten the ignition process com.ared with a traditional igniter.

关键词： Pre-com.ustion plasm. igniter Plasm. Jet tem.erature field Ignition process Arc Flam.