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Association.of Polym.rphic Varian.s of <i>VEGF</i>an. <i>KDR</i>Gen.s with Developm.n. an. m.tastasin. of n.n.Sm.ll Cell Lun. Can.er

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Journ.l of Can.er Therapy 2018年第9期9卷 714-728页

作者： А. n. Shchayuk E. V. Krupn.va m. n. shapetska A. P. m.khalen.a n. V. Chebotareva A. V. Kilchevsky In.titute of Gen.tics an. Cytology National Academy of Sciences of Belarus Minsk Republic of Belarus Belarusian.State m.dical Un.versity Minsk Republic of Belarus

Vascular en.othelial growth factor (VEGF) is on. of the m.st im.ortan. an. specific factors affectin. an.iogen.sis in.tum.r developm.n.. VEGFR2 is a receptor en.oded by the KDR gen.. VEGF an. VEGFR2 tran.m.t a sign.l to in.racellular tyrosin. kin.se cascades. Polym.rphic varian.s of the VEGF an. KDR gen.s sign.fican.ly in.luen.e the expression.levels of the en.othelial growth factor an. its receptor, which leads to a chan.e in.the activation.of an.iogen.sis in.on.opathological processes. In.this study, the relation.hip between.the polym.rphic varian.s rs2010963, rs699947 an. rs3025039 of the VEGF gen. an. rs1870377 an. rs2071559 of the KDR gen. was an.lyzed with the developm.n. of a specific histological type of n.n.sm.ll cell lun. can.er an. its clin.cal an. m.rphological characteristics. It was established that the developm.n. of squam.us cell carcin.m. is associated with -634CC gen.type of the VEGF gen. an. the gen.types con.ain.n. -2578A allele of the VEGF gen. reduce the likelihood of this can.er type developm.n.. The developm.n. of aden.carcin.m. is associated with +936CC VEGF/1719TT KDR an. +936CT VEGF/1719TT KDR com.in.tion.. In.wom.n.with n.n.sm.ll cell lun. can.er, -634GC gen.type of the VEGF gen. is associated with a greater degree of the prim.ry lesion.spread. Gen.type -2578СС of the VEGF gen. is associated with a higher degree of the prim.ry tum.r spread in.the gen.ral group of patien.s an. with region.l m.tastases in.wom.n. Haplotypes -634G/-2578C/+936C are risky for the occurren.e of m.tastases in.region.l lym.h n.des in.wom.n.

关键词： n.n.Sm.ll Cell Lun. Can.er An.iogen.sis Vascular En.othelial Growth Factor VEGF Gen. Polym.rphism KDR Gen. Polym.rphism

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m.gn.tic,dielectric an. electrical m.dulus of Ce^(3+) doped cobalt-m.gn.sium.ferrite n.n.particles

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Journ.l of Rare Earths 2024年第2期42卷 373-382,I0005页

作者： n.m.Basfer Han.a Alm.gham.i Departm.n. of Physics Umm AL-Qura UniversityMakkahSaudi Arabia Physics Departm.n. College of Science and ArtKing Abdulaziz UniversityPOB344Rabigh291Saudi Arabi

In.this work,the m.gn.tic,dielectric properties an. electric m.dulus of Ce^(3+) substituted cobaltm.gn.sium.Co_(0.7)m._(0.3)Ce_(x)Fe_(2-x)O_4)(labeled as Cm.F) ferrite n.n.particles were in.estigated in.*** m.gn.tization.decreases from.50.05 to 34.87 em./g for further substitutin. Ce^(3+) ***,coercivity in.reases from.738.22 Gs for the Cm.FO sam.le to 912.10 Gs for the Cm.F2 sam.le,then.decreases m.n.ton.cally to 762.1 Gs for the Cm.F5 *** cerium.con.en. an. particle size play im.ortan. roles in.con.rollin. the m.gn.tization.an. coercivity of the Cm.F *** Cm.F n.n.ferrites are suitable for m.crowave application. sin.e their high-frequen.y respon.e ran.es from.7.72 to 11.07 *** Cm.F n.n.ferrites' dielectric param.ter dispersion.exhibits n.rm.l *** pristin. Co-m. n.n.ferrite on.y has ε' value of 28.25,but the n.n.ferrite m.m.2 has ε' value of365.03,with an.en.an.in. ratio of 1192%.The con.uction.m.chan.sm.of the m.m. n.n.ferrites was determ.n.d by fittin. the σ_(ac) results via the Jon.cher power *** 653 K,large polaron.tun.ellin. is thought to be respon.ible for this con.uction.process,which is followed by electron.barrier hoppin. at higher ***-Cole diagram. at differen. tem.eratures,assurin. the con.ribution. of the grain. an. their boun.aries at lower tem.eratures(653 K) an. on.y the grain. at higher *** on.our results,the Cm.F n.n.ferrites hold m.gn.tic an. sem.con.uctin. n.ture,which can.be used in.m.gn.tic devices an. dielectrics in.lower-frequen.ies or con.uctors in.higher-frequen.ies.

关键词： n.n.ferrites Rare earth ion. m.gn.tic properties Dielectric param.ters Im.edan.e spectroscopy

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First-prin.iples calculation. to in.estigate structural,electron.c,m.gn.tic,optical an. therm.dyn.m.c properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm.

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Journ.l of Rare Earths 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier R.m.srour m.Ham.doun.J.Kharbach A.Rezzouk A.Hourm.tallah n.Ben.akour K.Bouslykhan. Laboratory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In.this paper,we an.lyzed the physical characteristics of the tern.ry alloys RE_(2)Rh_(3)Ge(RE=Pr an. Sm.usin. the first prin.iples calculation.based on.fun.tion.l den.ity theory in.egrated in.the Wien.k *** calculated form.tion.en.rgies of Pr_(2)Rh_(3)Ge an. Sm.(2)Rh_(3)Ge are−5.3827 an.−5.2782 eV/atom.respectively,showin. that these alloys m.y exist *** results of the ban. structure an. den.ity of states in.icate that all of the com.oun.s tested are m.gn.tic m.tals,an. their m.gn.tism.is m.stly related to the con.ribution.of Pr an. Sm.*** total m.gn.tic m.m.n.s of Pr_(2)Rh_(3)Ge an. Sm.(2)Rh_(3)Ge are 4.07245 an. 11.16161μB/f.u,*** param.ters such as heat capacity at con.tan. pressure,en.ropy,Debye tem.erature,lattice volum.,com.ressibility coefficien.s,an. Grün.isen.param.ter alloys were calculated usin. the Gibbs algorithm.an. studied in.depth over a large tem.erature ran.e of 0-900 *** Debye tem.erature in.reases with in.reasin. pressure an. decreases with decreasin. ***,the Debye tem.eratures calculated at p=0 GPa an. T=300 K are equal to be 342 an. 322 K for Pr_(2)Rh_(3)Ge an. Sm.(2)Rh_(3)Ge,*** optical characteristics such as the real an. im.gin.ry portion. of the dielectric fun.tion.the absorption.coefficien.,the en.rgy-loss fun.tion.an. the refractive in.ex were in.estigated an. discussed in.m.re depth.

关键词： m.gn.tic m.tals Fun.tion.l den.ity theory Den.ity of states m.gn.tic m.m.n. Optical an. therm.dyn.m.c properties Rare earths

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Direct m.crowave leachin. con.ition. of rare earth elem.n.s in.fluorescen. wastes

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Journ.l of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.Bilen.B.Birol m.n.Saridede S.S.Kaplan.m.S.Son.0}z Departm.n. of m.tallurgical an. m.terials En.in.erin. Yildiz Technical UniversityIstanbulTurkey Departm.n. of Chem.cal En.in.erin. an. m.terials Scien.e Stevens Institute of TechnologyNew JereyUSA Departm.n. of m.tallurgical an. m.terials En.in.erin. Istanbul Technical UniversityIstanbulTurkey

The lum.n.scen. phosphor powder in.the fluorescen. lam. con.titutes 2%of the lam.’s *** can.be m.n.ion.d that fluorescen. wastes are a crucial raw m.terial to produce rare earth *** the presen. study,m.crowave leachin. process was con.ucted to dissolve rare earth elem.n.s yttrium.Y),europium.Eu),an. rem.in.n. rare earth elem.n.s(REEs)presen. in.the phosphor powder of the fluorescen. *** the yields were *** the m.crowave leachin. process,the effects of the tem.erature(80-160℃),acid type(hydrochloric acid(HCl),n.tric acid(Hn._(3)),sulphuric acid(H_(2)SO_(4))),acid con.en.ration.0.5-6 m.l/L),solid to liquid ratio(0.1:10-0.5:10)an. reaction.tim.(5-90 m.n.param.ters on.leachin. efficien.ies of varyin. rare earth elem.n.s an. calcium.were *** highest yield was obtain.d in.the direct m.crowave leachin. of fluorescen. waste with the experim.n.al con.ition. of 6 m.l/L HCl,160℃,0.1:10 solid-to-liquid ratio(S:L),an. 90 *** en.rgy calculation. were m.de,an. kin.tic m.dels of the reaction. were obtain.d,an. it is observed that Y an. Eu dissolution.is diffusion.con.rolled,on.the other han.,lan.han.m.La),cerium.Ce),an. terbium.Tb)were exam.n.d to be chem.cal reaction.***,calcium.Ca)an. gadolin.um.Gd)seem.coheren. with the m.xed ***,m.them.tical m.dels of all experim.n.al studies are created with the respon.e surface Box-Behn.en.m.thod an. the correlation.coefficien.s of all the m.dels are over 90%.

关键词： Rare earth elem.n.s(REEs) Direct m.crowave leachin. Fluorescen. waste Kin.tic m.dels Respon.e surface m.thod

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Laparoscopic plication.for diaphragm.tic even.ration.in.adults: Un.eilin. the m.stery of even.ration

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LAPAROSCOPIC En.OSCOPIC An. ROBOTIC SURGERY 2024年第2期7卷 92-96页

作者： m.hesan. Balika Reddy, Prasan.a Kum.r An.n., K. S. San.hosh Harsha, m. m.vva Sri Vijay, n. Srikan.h, Sudarsan Apollo Hosp Dept Minimal Access Surg Chennai India Apollo Hosp Dept Surg Gastroenterol Chennai India

Diaphragm.even.ration.is the perm.n.n. elevation.of a hem.diaphragm.an. can.be due to con.en.tal or acquired causes. It is a rather un.om.on.con.ition.in.adults an. causes a spectrum.of sym.tom., ran.in. from.asym.tom.tic in.iden.al fin.in.s on.im.gin. to life-threaten.n. respiratory distress. Asym.tom.tic patien.s do n.t require an. treatm.n., but plication.is the con.en.ion.l, well-kn.wn.m.thod for treatin. sym.tom.tic patien.s. m.n.gem.n. varies depen.in. on.the sym.tom.. In.this article, we discuss two rare cases of diaphragm.tic even.ration.that were treated with m.n.m.l access surgery. (c) 2024 Zhejian. Un.versity. Publishin. services by Elsevier B.V. on.behalf of KeAi Com.un.cation. Co. Ltd. This is an.open.access article un.er the CC BY-n.-n. licen.e (http://***/licen.es/ by-n.-n./4.0/).

关键词： Diaphragm.tic even.ration m.n.m.l access surgery Laparoscopy

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EDSUCh:A robust en.em.le data sum.arization.m.thod for effective m.dical diagn.sis

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Digital Com.un.cation. an. n.tworks 2024年第1期10卷 182-189页

作者： m.hiuddin.Ahm.d A.n.m.Bazlur Rashid School of Scien.e Edith Cowan UniversityPerthAustralia

Iden.ifyin. rare pattern. for m.dical diagn.sis is a challen.in. task due to heterogen.ity an. the volum. of *** sum.arization.can.create a con.ise version.of the origin.l data that can.be used for effective *** this paper,we propose an.en.em.le sum.arization.m.thod that com.in.s clusterin. an. sam.lin. to create a sum.ary of the origin.l data to en.ure the in.lusion.of rare *** the best of our kn.wledge,there has been.n. such techn.que available to augm.n. the perform.n.e of an.m.ly detection.techn.ques an. sim.ltan.ously in.rease the efficien.y of m.dical *** perform.n.e of popular an.m.ly detection.algorithm. in.reases sign.fican.ly in.term. of accuracy an. com.utation.l com.lexity when.the sum.aries are ***,the m.dical diagn.sis becom.s m.re effective,an. our experim.n.al results reflect that the com.in.tion.of the proposed sum.arization.schem. an. all un.erlyin. algorithm. used in.this paper outperform. the m.st popular an.m.ly detection.techn.ques.

关键词： Data sum.arization En.em.le m.dical diagn.sis Sam.lin.

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Effects of Supplem.n.al Glutam.n. an. Lysin. on.Growth Perform.n.e of Broiler Chicken.

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Open.Journ.l of An.m.l Scien.es 2024年第2期14卷 101-122页

作者： Ali F. Alsogair n.if m. Alhawiti Sam.el n. n.hashon n.tion.l Cen.er for Wildlife Riyadh KSA Californ.a An.m.l Health an. Food Safety Laboratory University of California Davis Davis USA Departm.n. of Agricultural an. En.iron.0}n.al Scien.es College of Agriculture Tennessee State University Nashville Tennessee USA

The optim.m.levels of Lysin. an. Glutam.n. n.eded for growth perform.n.e an. m.in.en.n.e of the chicken.broilers were evaluated in.a ran.om.zed 3 × 4 factorial arran.em.n. of dietary treatm.n.s. The battery cages m.asured 99 × 66 × 25 cm.that can.be sufficien. for 5 birds. Day old Chicken.broilers totalin. 180 were assign.d to dietary treatm.n.s com.risin. of 3 con.en.ration. of Lysin. (0.85, 1.14, an. 1.42) each in.com.in.tion.with 4 con.en.ration. of Glutam.n. (0, 1, 2, an. 3). Each dietary treatm.n. was replicated 3 tim.s an. each replication.had 5 birds. The birds were given.feed an. water ad libitum.with a 23-hour light regim.n.for a period of 4 weeks. Then. the experim.n.al birds were evaluated for body weight gain. feed con.um.tion. an. feed con.ersion.in.order to determ.n. their optim.m.requirem.n. for dietary Lysin. an. Glutam.n.. Based on.the fin.in.s of this study, the highest perform.n.e was observed in.birds fed the diet supplem.n.ed with 1.42 lysin. an. 1% glutam.n., but the highest im.rovem.n. in.feed con.ersion.was observed in.diet con.ain.1.14 an. 1.42 with 1% an. 3% glutam.n., respectively. Birds fed 1.42 lysin. an. 1% glutam.n. had the highest total body weight gain.an. feed con.um.tion. The lysin. requirem.n.s in.the diet for Chicken.are between.1.14 an. 1.42 with glutam.n. level of 1%.

关键词： Broiler Chicken. Lysin. Glutam.n. Am.n. Acid Dietary Protein Essen.ials AAs n.n.Essen.ial Am.n. Acids

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A FLEXIBLE OBJECTIVE-COn.TRAIn. APPROACH An. A n.W ALGORITHm.FOR COn.TRUCTIn. THE PARETO FROn. OF m.LTIOBJECTIVE OPTIm.ZATIOn.PROBLEm.

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Acta m.them.tica Scien.ia 2024年第2期44卷 702-720页

作者： n.HOSEIn.OOR m.GHAZn.VI Faculty of m.them.tical Scien.es Shahrood University of TechnologyShahroodIran

In.this article, a n.vel scalarization.techn.que, called the im.roved objective-con.train. approach, is in.roduced to fin. efficien. solution. of a given.m.ltiobjective program.in. problem. The presen.ed scalarized problem.exten.s the objective-con.train. problem. It is dem.n.trated that how addin. variables to the scalarized problem. can.lead to fin. con.ition. for (weakly, properly) Pareto optim.l solution.. Applyin. the obtain.d n.cessary an. sufficien. con.ition., two algorithm. for gen.ratin. the Pareto fron. approxim.tion.of bi-objective an. three-objective program.in. problem. are design.d. These algorithm. are easy to im.lem.n. an. can.achieve an.even.approxim.tion.of (weakly, properly) Pareto optim.l solution.. These algorithm. can.be gen.ralized for optim.zation.problem. with m.re than.three criterion.fun.tion., too. The effectiven.ss an. capability of the algorithm. are dem.n.trated in.test problem..

关键词： m.ltiobjective optim.zation Pareto fron. scalarization objective-con.train. approach proper efficien. solution

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Predictin. effects of tun.el throttlin. of an.ular freeway vehicular flow by a con.in.um.m.del

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Journ.l of Traffic an. Tran.portation.En.in.erin.(En.lish Edition. 2024年第4期11卷 733-746页

作者： Zhon.m.n.Huan. m.n.Sm.rn.va n.n.Sm.rn.v Zuojin.Zhu Faculty of En.in.erin. Scien.e University of Science and Technology of China In.titute of Plasm. Physics Hefei Institutes of Physical Science Chinese Academy of Sciences Faculty of m.chan.cs an. m.them.tics Lomonosov Moscow State University

Fluid flow throttlin. is com.on.in.in.ustrial an. buildin. services en.in.erin.. Sim.lar tun.el throttlin. of vehicular flow is caused by the abrupt n.m.er reduction.of roadway lan., as the tun.el has a lower lan. n.m.er than.in.the roadway n.rm.l segm.n.. To predict the effects of tun.el throttlin. of an.ular freeway vehicular flow, a three-lan. con.in.um.m.del is developed. Lan. Ⅲ of the tun.el is com.letely blocked due to the n.ed of tun.el rehabilitation. etc. There exists m.n.atory n.t lan.-chan.in. rate from.lan. Ⅲ to lan. Ⅱ just upstream.of the tun.el en.ran.e, which is described by a m.del of ran.om.n.m.er gen.rated through a golden.section.an.lysis. The n.t-chan.in. rate between.adjacen. lan.s is m.deled usin. a lan.-chan.in. tim. expressed explicitly in.algebraic form. This paper assum.s that the an.ular freeway has a total len.th of 100 km. a two-lan. tun.el of len.th 2 km.with a speed lim.t of 80 km.h. The free flow speeds on.lan.s Ⅰ, Ⅱ an. Ⅲ are assum.d to be 110, 100 an. 90 km.h respectively. Based on.the three-lan. con.in.um.m.del, n.m.rical sim.lation. of vehicular flows on.the an.ular freeway with such a tun.el are con.ucted with a reliable n.m.rical m.thod of 3rd-order accuracy. n.m.rical results reveal that the vehicular flow has a sm.ller threshold of traffic jam.form.tion.in.com.arison.with the case without tun.el throttlin.. Vehicle fuel con.um.tion.can.be estim.ted by in.erpolation.with tim. averaged grid traffic speed an. an.assum.d curve of vehicle perform.n.e. The vehicle fuel con.um.tion.is lan. n.m.er depen.en., distributes with in.tial den.ity con.avely, ran.in. from.5.56 to 8.00 L. Tun.el throttlin. leads to an.earlier traffic jam.form.tion.in.com.arison.with the case without tun.el throttlin..

关键词： Effects of tun.el throttlin. Vehicle fuel con.um.tion Travel tim. Threshold of traffic jam.form.tion Con.in.um.m.del

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Optim.zation.an. Characterization.of Cellulose Extraction.from.Grevillea robusta (Silky Oak) Leaves by Soda-An.hraquin.n. Pulpin. Usin. Respon.e Surface m.thodology

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Green.an. Sustain.ble Chem.stry 2024年第3期14卷 43-65页

作者： Catherin. n. m.ya John.m. On.ari Lydia W. n.en.a Joab O. On.an.o Wilson.m. Gitari Departm.n. of Chem.stry The University of Nairobi Nairobi Kenya School of Chem.cal an. m.terial Scien.e The Technical University of Kenya Nairobi Kenya

Respon.e surface m.thodology (RSm. usin. the cen.ral com.osite design.(CCD) was applied to exam.n. the im.act of soda-an.hraquin.n. pulpin. con.ition. on.Grevillea robusta fall leaves. The pulpin. factors studied were: n.OH charge 5% to 20% w/v, pulpin. tim. 30 to 180 m.n.tes, an. the an.hraquin.n. charge 0.1 to 0.5% w/w based on.the oven.dried leaves. The respon.es evaluated were the pulp yield, cellulose con.en., an. the degree of delign.fication. Various regression.m.dels were used to evaluate the effects of varyin. the pulpin. con.ition.. The optim.m.con.ition. attain.d were;n.OH charge of 14.63%, 0.1% an.hraquin.n., an. a pulpin. period of 154 m.n.tes, correspon.in. to 20.68% pulp yield, 80.56% cellulose con.en., an. 70.34% lign.n.rem.val. An.lysis of varian.e (An.VA), was used to determ.n. the m.st im.ortan. variables that im.rove the extraction.process of cellulose. The experim.n. outcom.s m.tched those predicted by the m.del (Predicted R2 = 0.9980, Adjusted R2 = 0.9994), dem.n.tratin. the adequacy of the m.del used. FTIR an.lysis con.irm.d the elim.n.tion.of the n.n.cellulosic fiber con.tituen.s. The lign.n.an. hem.cellulose-related ban.s (aroun. 1514 cm.1, 1604 cm.1, 1239 cm.1, an. 1734 cm.1) decreased with chem.cal treatm.n., in.icatin. effective cellulose extraction.by the soda-an.hraquin.n. m.thod. Sim.lar results were obtain.d by XRD, SEm.an. therm.gravim.tric an.lysis of the extracted cellulose. Therefore, Grevillea robusta fall leaves are suitable ren.wable, cost-effective, an. en.iron.0}n.ally frien.ly n.n.wood biom.ss for cellulose extraction.

关键词： Cellulose Extraction Respon.e Surface m.thodology Cen.ral Com.osite Design Delign.fication

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