检索结果-南通市图书馆

n.vel n.uroprotective an. hepatoprorective effects of citric acid in.acute m.lathion.in.oxication

在线全文

学校读者我要写书评

暂无评论

Asian.Pacific Journ.l of Tropical m.dicin. 2016年第12期9卷 1157-1169页

作者： Om.r m.E.Abdel-Salam.Em.n.R.Youn.ss n.dia A.m.ham.ed n.ha n.Yassen.Yasser A.Khadrawy Safin.z Ebrahim.El-Toukhy Am.n. A.Sleem Departm.n. of Toxicology an. n.rcotics National Research Centre m.dical Biochem.stry National Research Centre Pathology National Research Centre Physiology National Research Centre Pharm.cology National Research Centre

Objective: To study the effect of citric acid given.alon. or com.in.d with atropin. on.brain.oxidative stress, n.uron.l in.ury, liver dam.ge, an. Dn. dam.ge of peripheral blood lym.hocytes in.uced in.the rat by acute m.lathion.exposure. m.thods: Rats were received in.raperiton.al(i.p.) in.ection.of m.lathion.150 m./kg alon. with citric acid(200 or 400 m./kg, orally), atropin.(1 m./kg, i.p.) or citric acid 200 m./kg+atropin. 1 m./kg an. euthan.zed 4 h later. Results: m.lathion.resulted in.in.reased lipid peroxidation.m.lon.ialdehyde) an. n.tric oxide con.en.ration. accom.an.ed with a decrease in.brain.reduced glutathion., glutathion. peroxidase(GPx) activity, total an.ioxidan. capacity(TAC) an. glucose con.en.ration.. Paraoxon.se-1, acetylcholin.sterase(ach E) an. butyrylcholin.sterase activities decreased in.brain.as well. Liver aspartate am.n.tran.ferase an. alan.n. am.n.tran.ferase activities were raised. The Com.t assay showed in.reased Dn. dam.ge of peripheral blood lym.hocytes. Histological dam.ge an. in.reased expression.of in.ucible n.tric oxide syn.hase(i n.S) were observed in.brain.an. liver. Citric acid resulted in.decreased brain.lipid peroxidation.an. n.tric oxide. m.an.hile, glutathion., GPx activity, TAC capacity an. brain.glucose level in.reased. Brain.ach E in.reased but POn. an. butyrylcholin.sterase activities decreased by citric acid. Liver en.ym.s, the percen.age of dam.ged blood lym.hocytes, histopathological alteration. an. i n.S expression.in.brain.an. liver was decreased by citric acid. m.an.hile, rats treated with atropin. showed decreased brain.m.A, n.trite but in.reased GPx activity, TAC, ach E an. glucose. The drug also decreased Dn. dam.ge of peripheral blood lym.hocytes, histopathological alteration. an. i n.S expression.in.brain.an. liver. Con.lusion.: The study dem.n.trates a ben.ficial effect for citric acid upon.brain.oxidative stress, n.uron.l in.ury, liver an. Dn. dam.ge due to acute m.lathion.exposure.

关键词： Citric acid m.lathion Oxidative stress Paraoxon.se 1 Cholin.sterase Com.t assay

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

产前诊断为脐疝患儿的一次性外科手术治疗

世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 41-42页

作者： Rijhwan. A. Daven.ort m. Dawran. m. 宁亮 Departm.n. of Paediatric Surgery Kings College Hospital SE5 9RS London United Kingdom

Backgroun./Purpose: The m.n.gem.n. of exom.halos is con.roversial with m.n. cen.ers in.the Un.ted Kin.dom.an. elsewhere advocatin. a con.ervative n.n.urgical approach for the larger exam.les. n.vertheless, this approach is n.t without pr oblem. or com.lication. The aim.of the study was to ascertain.the outcom. of all in.an.s with an.an.en.tally diagn.sed exom.halos treated recen.ly at our in.tit ution.usin. a policy of aggressive abdom.n.l wall closure. m.thods: This is a re trospective review of all in.an.s with exom.halos treated from.Jan.ary 1995 to S eptem.er 2002. Results: There were 35 in.an.s, all of whom.un.erwen. surgery. Th ese were separated in.o 3 groups: group A (all exom.halos m.n.r) un.erwen. prim.ry closure (n.= 11), group B (exom.halos m.j or) un.erwen. prim.ry closure (n.= 13), an. group C (exom.halos m.jor)- un.erwe n. staged closure in.olvin. a silo (n.= 11). In.an.s in.group C had a lower birt h weight (P = .05) an. were less m.ture (P = .06). They required lon.er periods of ven.ilation.(Pn.er hospital stay (P =. 001), an. a lon.er period to achieve full en.eral feeds (P n.an.s. On. prem.ture in.an. who was born.with a ruptured exom.halos sac (birth weight, 862 g) died of n.n.urgical com.lication. (sepsis an. respiratory failur e) early after the creation.of a silo. Con.lusion.: An.aggressive surgical appro ach in.in.an.s with exom.halos is a safe option.resultin. in.effective abdom.n.l wall closure. This requires a skilled m.ltidisciplin.ry approach an. possibly g reater resources than.other option..

关键词：产前诊断外科手术外科并发症非手术方法闭合术保守性脓毒症肠内营养呼吸衰竭机械通气

Reduced peripheral vascular reactivity in.refractory an.in. pectoris:Effect of en.an.ed extern.l coun.erpulsation

在线全文

学校读者我要写书评

暂无评论

Journ.l of Geriatric Cardiology 2011年第4期8卷 215-223页

作者： Susan.e m.Bon.esson.m.rie-Louise Edvin.son.Thom.s Pettersson.Lars Edvin.son Departm.n. of m.dicin. Kristianstad HospitalSE-29185 KristianstadSweden Departm.n. of Health Scien.es Lun. Lund UniversitySE-22100 LundSweden Departm.n. of Em.rgen.y m.dicin. Lund University HospitalSE-22185 LundSweden

Objective To exam.n. if the skin.m.crovascular bed is altered an. can.be m.dified by en.an.ed extern.l coun.erpulsation.EECP)in.patien.s with chron.c refractory *** Twen.y patien.s diagn.sed with refractory an.in. were divided in.o EECP(n.10)or n. EECP(n.10)*** data were com.ared to m.tched healthy subjects(n.20).The cutan.ous forearm.m.crovascular blood flow was m.asured by Laser-Doppler *** vascular respon.iven.ss to ion.ophoretic adm.n.stration.of acetylcholin.(ach),sodium.n.troprusside(Sn.)an. local skin.warm.n. were *** of Can.dian.Cardiovascular Society(CCS)-class,blood pressure an. plasm. sam.les were *** EECP patien.s showed reduced CCS-class com.ared to n. EECP(Pn. n. EECP(Pm.ared to SBP at baselin.(Pn. differen.e in.restin. blood flow between.the two refractory groups at baselin. as well as after EECP an. seven.weeks of *** to heatin.,the respon.es to ach an. Sn. in.the cutan.ous m.crocirculation.were lower in.both groups of refractory an.in. patien.s as com.ared to healthy subjects(Pn.s correspon.ed positively to the treatm.n. shown.by reduced plasm. level of soluble in.erleukin.2 receptor an. *** Refractory an.in. patien.s have reduced respon.iven.ss in.their cutan.ous m.crocirculation.to ach,Sn. an. heat com.ared to healthy *** EECP reduced the CCS-class,this effect was n.t associated with im.rovem.n.s in.respon.iven.ss of the cutan.ous m.crocirculation.

关键词： refractory an.in. pectoris flowm.try m.crocirculation en.an.ed extern.l coun.erpulsation

评估OCT测量视网膜厚度确定老年性黄斑变性相关形态学变化的效果

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 36-37页

作者： m.n.e m.n. Feke G.T. 杜兆江 Schepen. Retin. Associates Foun.ation 1 Autumn Street Boston MA 02215 United StatesDr.

BACKGROUn. An. OBJECTIVE: Age-related m.cular degen.ration.(Am.) leads to m.r phological chan.es that can.in.erfere with optical coheren.e tom.graphy retin.l thickn.ss m.asurem.n.s. The effects of Am. on.two available retin.l thickn.ss sc an.m.des were tested. PATIEn.S An. m.THODS: n.n.ty four scan., equally divided i n.o Radial Lin. Scan. (RLS) an. Fast m.cula Scan. (Fm.), of 42 patien.s with Am. were reviewed. Patien.s were graded in.o 4 categories regardin. Am. severity. E ach scan.m.de was evaluated for each Am. category. RESULTS: In.dry m.derate Am., 2%of the RLS an. 5%of the Fm. thickn.ss m.asurem.n.s failed. In.dry progresse d Am., the RLS m.de perform.d better (26%failure rate) than.the Fm. m.de (42%f ailure rate). However, in.exudative Am. the Fm. m.de perform.d better (6%failur e rate) than.the RLS m.de (28%failure rate). The differen.e between.the RLS an. Fm. perform.n.e in.dry progressed Am. com.ared with exudative Am. was sign.fica n. (P n.LUSIOn. The optical coheren.e tom.graphy retin.l thickn.ss s can.m.des perform.differen.ly, depen.in. on.Am. severity. Retin.l thickn.ss algo rithm. with better perform.n.e are n.eded to facilitate m.asurem.n.s in.patien.s with Am..

关键词：老年性黄斑变性 OCT测量视网膜厚度扫描模式渗出性形态学改变干性斑点状线性扫描运算法则

Shapin. by m.tochon.ria of cytosolic Ca2+ tran.ien.s an. catecholam.n. release in.bovin. chrom.ffin.cells

在线全文

学校读者我要写书评

暂无评论

Shaping by mitochondria of cytosolic Ca2+ transients and cat...

Resveratrol Reverses the Im.aired Vasodilation.Observed in.2K-1C Hyperten.ion.through En.othelial Fun.tion.Im.rovem.n.

第十六届嗜铬细胞国际学术会议

作者： Afon.o Caricati-n.to Juan.Fern.n.o Padín.Edilson.Dan.as Silva-Jún.or An.on.o m.G de Diego Aron.Jurkiewicz An.on.o Garcia Garcia Departm.n. of Pharm.cology Federal Un.versity of Sao Paulo(Brazil) In.tituto Teofiló Hern.n.o(ITH) Un.versidad Autón.m. de m.drid(Spain.

Previous studies from.our laboratory have shown.that blockade by proton.phores of m.tochon.rial Ca uptake augm.n.s the release of chatecholam.n. from.bovin. chrom.ffin.cells(BCCs) triggered by acetylcholin.(ach),high ... 详细信息

关键词： catecholam.n. release chrom.ffin.cells cytosolic Ca2+ m.tochon.ria

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Open.Journ.l of m.dicin.l Chem.stry 2014年第2期4卷 61-69页

作者： B. F. m. Pereira A. C. Scalabrin. T. S. m.rin.o C. R. K. An.on.etto C. B. A. Restin. School of m.dicin. University of Ribeirao Preto (UNAERP) Sao Paulo Brazil

Backgroun.: The production.of en.othelial-derived factors in.uces either vasocon.triction.or vasodilation.n.tric oxide (n.) is the m.st distin.uished relaxin. factor. En.othelial dysfun.tion.is associated with hyperten.ion. The partial loss in.the n.-prom.ted vasodilation.is due to its decreased bioavailability an./or to an.activity reduction.of en.othelium.n. syn.hase (en.S). Reactive oxygen.species (ROS), presen. in.oxidative stress, seize n. an. dim.n.sh its bioavailability. Tran.resveratrol (RESV) has been.proved to in.rease n. an. en.S levels. Thus, RESV could be capable of im.rovin. n. depen.en. vascular relaxation.on.aortic rin.s isolated from.treated 2K-1C an.m.ls through ROS dam.ge reduction. Aim. Evaluate the effects of RESV treatm.n. on.the relaxation.of aortic rin.s isolated from.treated 2K-1C rats while focusin. on.the effects of the treatm.n. on.systolic blood pressure. m.thods: m.le Wistar rats (180 g) were grouped: two 2K-1C an. two Sham.groups, on. of each was treated with RESV (20 m./kg, gavage) dissolved in.Tween.80 an. on. of each was treated with water plus Tween.80 (con.rol) for six weeks. The rats had their systolic blood pressure (SBP) m.asured before an. after the treatm.n.s. Vascular reactivity studies were con.ucted in.order to observe an. com.are acetylcholin. (ach)-in.uced relaxation. in.the presen.e an. absen.e of the n.S in.ibitor L-n.m. (10-4 m.l/L). Results: SBP for 2K-1C was sign.fican.ly reduced in.the treated group (179.13 ± 4.90 m.Hg, n.= 23) when.com.ared to the un.reated group (196.66 ± 6.06 m.Hg, n.= 15, p m.xim.m.relaxation.of aortic rin.s isolated from.the 2K-1C treated group showed a higher efficacy (116.63% ± 1.72%, n.= 12) than.that from.the un.reated group (85.97% ± 0.69%, n.= 6, p n.m. exposure was respon.ible for a sign.fican. decrease in.each group’s m.xim.m.relaxation.efficacy. Con.lusion.: SBP reduction.observed after RESV treatm.n. in.rat ren.l hyperten.ion.could be due to the reestablishm.n

关键词： Resveratrol Ren.l Hyperten.ion n.tric Oxide (n.) Vasodilation Reactive Oxygen Species (ROS) En.othelium Vascular Sm.oth m.scle

An.In.en.ation.m.thod for n.n.precision.m.asurem.n. of Diam.n. Tool Edge Radius

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

厦门大学学报（自然科学版） 2002年第S1期41卷 98-99页

作者： X P Li m.Rahm.n.K Liu K S n.o C C Chan Departm.n. of m.chan.cal En.in.erin. National University of SingaporeDepartment of Mechanical Engineering National University of SingaporeDepartment of Mechanical Engineering National University of SingaporeDepartment of Mechanical Engineering National University of SingaporeDepartment of Mechanical Engineering National University of Singapore SingaporeSingaporeSingaporeProcess Technology Division Gintic Institute of Manufacturing Technology Si ngaporeSingaporeSingapore

In.ductile m.de cuttin. of brittle m.terials usin. di am.n. tools, such as ductile cuttin. of silicon.an. quartz for wafer fabrication., on. of the key con.ition. for achievin. ductile chip form.tion.is to get the r ight ratio of tool cuttin. edge radius to the un.eform.d chip thickn.ss. It has been.shown.that the un.eform.d chip thickn.ss has to be in.the order of n.n.m.te rs an. that the tool cuttin. edge radius has to be sm.ller than.the un.eform.d c hip thickn.ss. Therefore, n.n.precision.m.asurem.n. of diam.n. cuttin. tools has becom. a key issue for ductile m.de cuttin. of brittle m.terials. In.this paper , a n.n.destructive n.n.precision.m.asurem.n. m.thod for diam.n. tool cuttin. e dge radius is presen.ed. The basis of the m.thod is that the exact profile of th e tool cuttin. edge can.be perfectly copied by in.en.in. the tool cuttin. edge o n.the surface of a rigid-perfect plastic m.terial, an. that the copy of the pro file can.be m.asured at n.n.precision.level. Ideally, the first aspect of th e m.thod is to m.ke a perfect copy of the tool cuttin. edge profile by in.en.ati on.on.the surface of a rigid-perfect plastic m.terial which has n. elastic spri n. back, so that a true copy of the tool cuttin. edge is m.in.ain.d for subseque n. m.asurem.n.. Sin.e n. rigid-perfect plastic m.terial can.be foun. in.realit y, actual m.terials of rigid-elastic-plastic n.ture have to be used for the in.den.ation.in.the m.asurem.n. m.thod, an. the m.terial elastic error com.en.ation.coefficien.s have to be determ.n.d to can.el out the effect of elastic sprin. b ack. For the m.n.m.zation.of error com.en.ation. criteria for the selection.of t he optim.l m.terials for the in.en.ation.m.asurem.n. are foun. to be: 1) high ri gidity an. high den.ity, 2) large Youn.’s elastic m.dulus, an. 3) low yield stren.th. On. of such m.terials iden.ified is copper. The secon. aspect of the m.thod is to m.asure the radius of the in.en.ed profile on.the surface of the m. terial. This can.be ach

关键词： n.n.precision m.asurem.n. in.en.ation diam.n. tool cuttin. edge radius ductile m.de cuttin.

外科切除与莫氏显微外科手术治疗颌面部基底细胞癌的比较:随机对照研究

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 5-6页

作者： Sm.ets n.W.J. Krekels G.A.m. Ostertag J.U. 牛新武 Departm.n. of Derm.tology University Hospital MaastrichtMaastrichtNet herlandsDr.

Backgroun. Rates of recurren.e of facial basal-cell carcin.m. are c on.isten.tly lower after m.hs’m.crographic surgery (m.S) than.after other treatm.n.s, such as surgical excision.(SE). However, m.S is m.re tim.-con.um.n. an. theref ore m.re expen.ive than.SE. We in.estigated the types of facial basal-cell car cin.m.s in.which m.S was m.re effective than.SE. m.thods 408 prim.ry an. 204 rec urren. facial carcin.m.s (374 an. 191 patien.s, respectively) were an.lysed sepa rately in.this prospective ran.om.sed study. Patien.s were assign.d SE or m.S (e ach 204 prim.ry, 102 recurren.), an. received treatm.n. at two hospitals in.the n.therlan.s. The prim.ry outcom. was recurren.e of carcin.m.. An.lysis was by in.ten.ion.to treat. Fin.in.s Of the basal-cell carcin.m.s in.luded in.the trial, 397 prim.ry (198 m.S, 199 SE) an. 201 recurren. (99, 102) tum.urs were actually treated. Of patien.s with prim.ry carcin.m.s, 21 had both m.S an. SE on.differe n. tum.urs. n.n. with recurren. carcin.m.s had both treatm.n.s on.differen. skin.tum.urs. 66 prim.ry an. 13 recurren. carcin.m.s were lost to follow-up. Of th e prim.ry carcin.m.s, five (3% ) recurred after SE com.ared with three (2% ) a fter m.S durin. 30 m.n.hs of follow-up. Of the recurren. carcin.m.s, three (3 % ) recurred after SE an. n.n. after m.S durin. 18 m.n.hs of follow-up. Four recurren. carcin.m.s ran.om.y assign.d to the SE group were treated with m.S. Al though both differen.es favoured m.S, they were n.t sign.fican. (prim.ry, differ en.e 1% (95% CI- 2· 5% to 3· 7% ), P=0· 724; recurren., 3· 2% (- 2· 0% to 5· 0% ), P=0· 119). Total operative costs of m.S were higher than.those of SE (prim.ry e405· 79 vs e216· 86, recurren. e489· 06 vs e323· 49; both P n.erpretation.n. defin.tive con.lusion.on.recurren.e rates o f prim.ry or recurren. basal-cell carcin.m.s is yet possible. Although recurre n.e rates were lower after m.S than.after SE, the differen.es were n.t sign.fica n.. With com.rehen.ive an. reliable

关键词：基底细胞癌外科切除显微外科颌面部复发率随机研究其他治疗方法 Em.ASE 无显著性差异失访

CCh facilitates the LTP in.the den.ate gyrus in.the rat

在线全文

学校读者我要写书评

暂无评论

CCh facilitates the LTP in the dentate gyrus in the rat