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Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

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Integrating QoS m.nagem.nt in TLm.:Three Level m.bility m.del for Next Generation Wireless IP-Based Networks

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China Com.unications 2008年第3期5卷 125-139页

作者： m.Chakraborty I.S.m.sra A.mukherjee Departm.nt of Inform.tion Technology Institute of Engineering & Management Departm.nt of Electronics and Telecom.unication Engineering Jadavpur University IBm.Global Services

In this paper we have designed an im.lem.nted an integrated fram.work of QoS for Three Level m.bility m.del(TLm.),which has been recently proved to be the optim.l m.bility m.nagem.nt solution for next generation wireless IP-based *** QoS solution uses a com.ination of IntServ and DiffServ m.dels incorporated in TLm. *** paper also proposes an effi cient dynam.c handover policy that takes care of false *** and analytical results have shown that this infrastructure guarantees eff icient QoS handling and scalability am.ng end *** provide a com.arative understanding of the QoS m.chanism.and signaling load of TLm. we have used Telem.P(without QoS support) and m.P as alternative m.bility m.nagem.nt protocols.

关键词： Qos NGN wireless IP network

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Pharm.cognostical,phytochem.cal and pharm.cological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb.

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Asian Pacific Journal of Tropical Biom.dicine 2012年第10期2卷 782-786页

作者： Sasm.l S m.jum.ar S Gupta m.mukherjee A mukherjee PK Departm.nt of Dravyaguna(m.dicinal Pharm.cology) Institute of Post Graduate Ayurvedic Education and Research Departm.nt of Chem.cal Technology University of Calcutta Departm.nt of Health & Fam.ly WelfareGovernm.nt of West Bengal

Objective:To conduct a system.c evaluation of the m.dicinal value of seeds which include m.croscopic and m.croscopic characterization,physiochom.cal evaluation,prelim.nary phylochem.cal screening and experim.ntal antipyretic ***:Saraca asoca seed was studied for pharm.cognostical,phytochem.cal and other recom.ended m.thods for ***,the acetone extract of the seeds was evaluated for acute toxicity study and antipyretic activity using Brewer's yeast induced pyrexia in Wislar rats at oral doses of 300 m./kg and 500 m./***:After phytochem.cal screening,the acetone extract showed the presence of saponin,tannins and flavonoids which inhibit *** therapeutic efficacy achieved at both the dose levels of the research drug and standard drug aspirin(100 m./kg)showed significant(Pm.ared to the control *** highly significant antipyretic effect exhibited at the dose of 500 m./kg was also found to be sustainable in ***:The antipyretic effect of the acetone extract showed significant results in rats at the dose of 500 m./kg after following the standard pharm.cognostical and phylochem.eal m.t hods.

关键词： Antipyretic Saraca asoca Seed Pharm.cognosy Acetone extract

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Optim.zing the aeration perform.nce of a perforated pooled circular stepped cascade aerator using hybrid ANN-PSO technique

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Inform.tion Processing in Agriculture 2022年第4期9卷 533-546页

作者： Subha m.Roy C.m.Pareek Rajendra m.chavaram.C.K.mukherjee Agricultural and Food Engineering Departm.nt Indian Institute of Technology KharagpurKharagpur 721302West BengalIndia

Artificial aeration system.for aquaculture ponds becom.s essential to m.et the oxygen requirem.nt posed by the aquatic *** perform.nce of an aerator is generally m.a-sured in term. of standard aeration efficiency(SAE),which is significantly affected by the different geom.tric and dynam.c param.ters of the ***,to enhance the aer-ation perform.nce of an aerator,these param.ters need to be *** the present study,a perforated pooled circular stepped cascade(PPCSC)aerator was developed,and the geom.tric and dynam.c param.ters of the developed aerator were optim.zed using the hybrid ANN-PSO technique for m.xim.zing its aeration *** geom.tric param.ters include consecutive step width ratio(W_(i-1)/W_(i))and the perforation diam.ter to the bottom.m.st radius ratio(d/R_(b)),whereas the dynam.c param.ter includes the water flow rate(Q).A 3–6-1 ANN m.del coupled with particle swarm.optim.zation(PSO)approach was used to obtain the optim.m.values of geom.tric and dynam.c param.ters correspond-ing to the m.xim.m.*** optim.l values of the consecutive step width ratio(W_(i-1)/W_(i)),the perforation diam.ter to the bottom.m.st radius ratio(d/R_(b)),and the water flow rate(Q)for m.xim.zing the SAE were found to be 1.15,0.0027 and 0.0167 m.(3)/s,*** cross-validation results showed a deviation of 3.07%between the predicted and experim.n-tal SAE values,thus confirm.ng the adequacy of the proposed hybrid ANN-PSO technique.

关键词： Aquaculture Artificial neural network(ANN) Particle swarm.optim.zation(PSO) Perforated pooled circular stepped cascade(PPCSC)aerator Standard aeration efficiency(SAE)

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Silver nanoparticles tolerant bacteria from.sewage environm.nt

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Journal of Environm.ntal Sciences 2011年第2期23卷 346-352页

作者： Sudheer Khan Am.tava mukherjee Natarajan Chandrasekaran Nanobio-m.dicine Laboratory School of Bio-Sciences and TechnologyVIT University

Silver nanoparticle （SNP） is a threat to soil, water and hum.n health. Protection of environm.nt from.silver nanoparticles is a m.jor concern. A sewage isolate, Bacillus pum.lus treated with SNPs showed sim.lar growth kinetics to that without nanoparticles. A reduction in the am.unt of exopolysaccharides was observed after SNPs - B. pum.lus culture supernatant interaction. The Fourier transform.infrared spectroscopy （FT-IR） peaks for the exopolysaccharides extracted from.the bacterial culture supernatant and＇the interacted SNPs were alm.st sim.lar. The exopolysaccharide capping of the SNPs was confirm.d by UV-Visible, FT-IR and X-ray diffraction analysis. The study of bacterial exopolysaccharides capped SNPs with E. coli, S. aureus and m. luteus showed less toxicity com.ared to uncoated SNPs. Our studies suggested that the capping of nanopartieles by bacterially produced exopolysaccharides serve as the probable m.chanism.of tolerance.

关键词： Bacillus pum.lus silver nanoparticles exopolysaccharides encapsulation bacterial tolerance toxicity reduction

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m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Cytogenetic studies of chrom.um.Ⅲ) oxide nanoparticles on Allium.cepa root tip cells

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Journal of Environm.ntal Sciences 2015年第12期27卷 150-157页

作者： Deepak Kum.r A.Rajeshwari Pradeep Singh Jadon Gouri Chaudhuri Anita mukherjee Natarajan Chandrasekaran Am.tava mukherjee Centre for Nanobiotechnology VIT University Centre of Advanced Study Department of BotanyUniversity of Calcutta

The current study evaluates the cytogenetic effects of chrom.um.Ⅲ） oxide nanoparticles on the root cells of Allium.*** root tip cells of *** were treated with the aqueous dispersions of Cr2O3 nanoparticles（NPs） at five different concentrations（0.01,0.1,1,10,and 100 μg/m.L） for 4 *** colloidal stability of the nanoparticle suspensions during the exposure period were ascertained by particle size *** 4 hr exposure to Cr2O3 NPs,a significant decrease in m.totic index（m.） from.35.56%（Control） to 35.26%（0.01 μg/m.L）,34.64%（0.1 μg/m.L）,32.73%（1 μg/m.L）,29.6%（10 μg/m.L） and 20.92%（100 μg/m.L） was *** optical,fluorescence and confocal laser scanning m.croscopic analyses dem.nstrated specific chrom.som.l aberrations such as-chrom.som. stickiness,chrom.som. breaks,laggard chrom.som.,clum.ed chrom.som.,m.ltipolar phases,nuclear notch,and nuclear bud at different exposure *** concentration-dependent internalization/bio-uptake of Cr2O3 NPs m.y have contributed to the enhanced production of anti oxidant enzym.,superoxide dism.tase to counteract the oxidative stress,which in turn resulted in observed chrom.som.l aberrations and cytogenetic *** results suggest that *** root tip assay can be successfully applied for evaluating environm.ntal risk of Cr2O3 NPs over a wide range of concentrations.

关键词： A.cepa Bio-uptake Chrom.som.l aberration C2O3 nanoparticles m.totic index SOD

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Kinetics of m.ld Steel Corrosion in Aqueous Acetic Acid Solutions

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Journal of m.terials Science & Technology 2010年第3期26卷 264-269页

作者： S.K.Singh A.K.mukherjee Departm.nt of Applied Chem.stry Institute of TechnologyBanaras Hindu University Departm.nt of Chem.stry University of Delhi

The kinetics of m.ld steel corrosion in aqueous acetic acid solution has been investigated by weight loss and polarization techniques at 25,35 and 45℃.The weight loss of m.ld steel at room.tem.erature （25℃） has been found to be quite significant,indicating poor corrosion resistance in acetic *** m.xim.m.corrosion rate has been observed in 25% acetic acid solution at all three experim.ntal *** decrease in corrosion rate after attaining a m.xim.m.value has been attributed to the deposition of corrosion product on the *** polarization curves exhibit active behaviour at each concentration and tem.erature with a shift towards higher current density region and increased corrosion rates at higher *** cathodic polarization curves are alm.st identical irrespective either of the concentration of acetic acid or *** results obtained by both the techniques are in good agreem.nt,while the surface studies support the conclusions drawn from.the weight loss m.thod.

关键词： Corrosion m.ld steel Acetic acid

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Cracking in orthotropic half-plane with a functionally graded coating under anti-plane loading

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Acta m.chanica Solida Sinica 2015年第2期28卷 210-220页

作者： m. m. m.nfared m. Ayatollahi Faculty of Engineering University of Zanjan

This investigation evaluates, by the dislocation m.thod, the dynam.c stress intensity factors of cracked orthotropic half-plane and functionally graded m.terial coating of a coating- substrate m.terial due to the action of anti-plane traction on the crack surfaces. First, by using the com.lex Fourier transform. the dislocation problem.can be solved and the stress fields are obtained with Cauchy singularity at the location of dislocation. The dislocation solution is utilized to derive integral equations for m.ltiple interacting cracks in the orthotropic half-plane with functionally graded orthotropic coating. Several exam.les are solved and dynam.c stress intensity factors are obtained.

关键词： orthotropic half-plane m.ltiple cracks functionally graded coating

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Transport m.chanism.in chem.cally reactive hybrid nanofluid flow containing gyrotactic m.cro-organism. over a curved oscillatory surface

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Applied m.them.tics and m.chanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.Im.AN T.ASGHAR Z.ABBAS Departm.nt of m.them.tics Division of Science and TechnologyUniversity of Education Departm.nt of m.them.tics The Islamia University of Bahawalpur

This paper exam.nes the transport analysis, including both heat transfer and m.ss transfer, in hybrid nanofluid flow containing gyrotactic m.croorganism. towards a curved oscillatory surface. The influence of m.gnetic fields is also inspected in term. of their physical characteristics. To depict the phenom.na of transport, m.dified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and hom.geneous chem.cal reactions are also incorporated. Utilizing a curvilinear coordinate system. the flow problem.is form.lated as partial differential equations(PDEs)for m.m.ntum. concentration, m.croorganism.field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the hom.topy analysis m.thod(HAm..The effects of significant flow param.ters on the pressure and m.croorganism.fields, velocity, oscillation velocity, concentration, and tem.erature distributions are shown via graphs. Furtherm.re, the variations in skin friction, m.ss transfer rate, heat transfer rate, and local m.tile num.er due to different involved param.ters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and tem.erature fields are enhanced as the values of the solid volum. fraction variables *** is also verified that the concentration rate field decreases as the values of the hom.geneous reaction strength param.ter and the radius of curvature param.ter increase, and it increases with the Schm.dt num.er and the heterogeneous reaction strength *** outcom.s show a favorable response of the m.tile num.er to advanced values of the Peclet num.er, the Schm.dt num.er, the m.croorganism.difference param.ter, and the bio-convective Lewis num.er.

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