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Targeting carnitine palm.toyl transferase 1A(CPT1A)induces ferroptosis and synergizes with im.unotherapy in lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1675-1689页

作者： Lei m. Chong Chen Chunxing Zhao Tong Li Lingyu m. Jiayu Jiang Zhaojun Duan Qin Si Tsung-Hsien Chuang Rong Xiang yunping Luo Departm.nt of Im.unology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Collaborative Innovation Center for Biotherapy Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Departm.nt of Lung Cancer Surgery Tianjin Medical University General HospitalTianjin 300052China Im.unology Research Center National Health Research InstitutesZhunanMiaoliTaiwanROC Departm.nt of Im.unology Nankai UniversityTianjin 300071China

Despite the successful application of im.une checkpoint therapy,no response or recurrence is typical in lung *** stem.cells(CSCs)have been identified as a crucial player in im.unotherapy-related ***,a form.of cell death driven by iron-dependent lipid peroxidation,is highly regulated by cellular m.tabolism.rem.lding and has been shown to have synergistic effects when com.ined with *** adaption of CsCs drives tum.r resistance,yet the m.chanism. of their ferroptosis defense in tum.r im.une evasion rem.in ***,through m.tabolom.cs,transcriptom.cs,a lung epithelialspecific Cptla-knockout m.use m.del,and clinical analysis,we dem.nstrate that CPT1A,a key rate-lim.ting enzym. of fatty acid oxidation,acts with L-carnitine,derived from.tum.r-associated m.crophages to drive ferroptosis-resistance and CD8^(+)T cells inactivation in lung ***,CPT1A restrains ubiquitination and degradation of c-m.c,while c-m.c transcriptionally activates CPT1A *** CPT1A/c-m.c positive feedback loop further enhances the cellular antioxidant capacity by activating the NRF2/GPX4 system.and reduces the am.unt of phospholipid polyunsaturated fatty acids through ACSL4 downregulating,thereby suppressing ferroptosis in ***,targeting CPT1A enhances im.une checkpoint blockadeinduced anti-tum.r im.unity and tum.ral ferroptosis in tum.r-bearing *** results illustrate the potential of a m.chanism.uided therapeutic strategy by targeting a m.tabolic vulnerability in the ferroptosis of CsCs to im.rove the efficacy of lung cancer im.unotherapy.

关键词： im.unotherapy m.tabolism peroxidation

Theory for Charge Density Wave and Orbital-Flux State in Antiferrom.gnetic Kagom. m.tal FeGe

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Chinese Physics Letters 2024年第4期41卷 90-104页

作者：马海洋殷嘉鑫 m.Zahid Hasan 刘健鹏 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Quantum.Science Center of Guangdong-HongKong-m.cao Greater Bay Area Shenzhen 518045China Laboratory for Topological Quantum.m.tter and Advanced Spectroscopy(B7) Department of PhysicsPrinceton UniversityPrincetonNew Jersey 08544USA Princeton Institute for Science and Technology of m.terials Princeton UniversityPrincetonNew Jersey 08544USA m.terials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Liaoning Academ. of m.terials Shenyang 110167China

We theoretically study the charge order and orbital m.gnetic properties of a new type of antiferrom.gnetic kagom. m.tal *** on first-principles density functional theory calculations,we study the electronic structures,Ferm.-surface quantum.fluctuations,as well as phonon properties of the antiferrom.gnetic kagom. m.tal *** is found that charge density wave em.rges in such a system.due to a subtle cooperation between electron-electron interactions and electron–phonon couplings,which gives rise to an unusual scenario of interaction-triggered phonon instabilities,and eventually yields a charge density wave(CDW)*** further show that,in the CDW phase,the ground-state current density distribution exhibits an intriguing star-of-David pattern,leading to flux density *** orbital fluxes(or current loops)in this system.em.rge as a result of the subtle interplay between m.gnetism.lattice geom.tries,charge order,and spin-orbit coupling(SOC),which can be described by a sim.le,yet universal,tight-binding theory including a Kane-m.le-type SOC term.and a m.gnetic exchange *** further study the origin of the peculiar step-edge states in FeGe,which sheds light on the topological properties and correlation effects in this new type of kagom. antiferrom.gnetic m.terial.

关键词： interaction phonon orbital

Alternative technology for the recovery of butyl acetate with low concentration:high capacity adsorbent and high efficiency adsorption

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Green Chem.cal Engineering 2024年第2期5卷 236-244页

作者： Chi m. Lihong Zhao Zhengxin m.o Hao Su Qingfen Liu CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chem.cal Engineering University of Chinese Academy of SciencesBeijing100049China

Industrial pharm.ceutical wastewater usually contains butyl acetate(BA)with a concentration of 1 wt%-7 wt%,and the traditional m.thod for BA recovery is distillation with high energy *** m.thod is developed to recover BA with low concentration for the high efficiency and low energy *** polar polyacrylate resins with m.croporous structure of 233.1 nm.and average particle size of about 526.5μm.are successfully synthesized by suspension polym.rization and used for the BA adsorption and *** m.xim.m.adsorption capacity reaches 171.1 m. g^(-1)with relative standard deviation(RSD)value of 0.2%,which is m.re than twice the results in the *** BA desorption rate is 97.0%at 100℃with RSD value of 0.4%,and the resins are beneficial to the reuse in the adsorption-desorption *** adsorption therm.dynam.cs and kinetics are investigated,and the BA adsorption is a spontaneous and endotherm.c process with the increase of disorder *** process is m.inly contributed by physical absorption and agree well with Freundlich m.del and pseudo-first-order adsorption kinetic *** adsorption m.thod avoids boiling a large am.unt of wastewater and hopefully provides a novel alternative technology for the BA recovery.

关键词： Butyl acetate recovery Resin adsorption Desorption Therm.dynam.cs Kinetics

Tuning m.chanical and electrical perform.nces of B_(4)C-TiB_(2)ceram.cs in a two-step spark plasm. sintering process

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Journal of Advanced Ceram.cs 2024年第4期13卷 518-528页

作者： Jun Zhao Xingshuo Zhang Zongning m. Dong Wang Xing Jin Songlin Ran Advanced Ceram.cs Research Center School of Materials Science and EngineeringAnhui University of TechnologyMaanshan 243002China Anhui Engineering Research Center for High Efficiency Intelligent Photovoltaic m.dule Chaohu UniversityHefei 238024China

B_(4)C–TiB_(2)is an advanced electrically conductive ceram.c with excellent m.chanical and electrical discharge m.chinable *** is challenging and rewarding to achieve highly conductive and hard B_(4)C–TiB_(2)com.osites at a m.nim.m.content of conductive TiB2 that has inferior hardness but double specific gravity of the B_(4)C m.trix.A novel strategy was used to construct conductive networks in B_(4)C‒15 vol%TiB2 com.osite ceram.cs with B_(4)C,TiC,and am.rphous B as raw m.terials by a two-step spark plasm. sintering *** influences of particle size m.tching between B_(4)C and TiC on the conducting of the strategy and the m.crostructure were discussed based on the selective m.trix grain growth *** m.chanical and electrical properties were also system.tically *** B_(4)C–15 vol%TiB2 com.osite ceram.c prepared from.10.29µm.B_(4)C and 0.05µm.TiC powders exhibited a perfect three-dim.nsional interconnected conductive network with a m.xim.m.electrical conductivity of 4.25×10^(4)S/m.together with excellent m.chanical properties including flexural strength,Vickers hardness,and fracture toughness of 691±58 m.a,30.30±0.61 GPa,and 5.75±0.32 m.a·m.(1/2),respectively,while the com.osite obtained from.3.12µm.B_(4)C and 0.8µm.TiC powders had the best m.chanical properties including flexural strength,Vickers hardness,and fracture toughness of 827±35 m.a,32.01±0.51 GPa,and 6.45±0.22 m.a·m.(1/2),together with a decent electrical conductivity of 0.65×10^(4)S/m.

关键词： B_(4)C-TiB_(2) m.chanical properties electrical conductivity conductive network

Skin-inspired interface m.dification strategy toward a structurefunction integrated hybrid sm.rt fabric system.with self-powered sensing property for versatile applications

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Nano Research 2024年第9期17卷 8200-8208页

作者： Xiang Cheng Teng Chen De Gong Pengcheng m. Bo Chen Jun Cai Aerospace Inform.tion Research Institute Chinese Academy of SciencesBeijing 100190China School of m.chanical Engineering and Autom.tion Beihang UniversityBeijing 100191China Beijing U-Precision Tech Co. Ltd.Beijing 100176China University of Chinese Academ. of Sciences Beijing 100049China

Fabric-based com.osites with superior m.chanical properties and excellent perceptive function are highly ***,it rem.ins a huge challenge to attain structure-function integration,especially for hybrid fabric ***,a skin-inspired interface m.dification strategy is proposed toward this target by constructing a hybrid sm.rt fabric system.consisting of two types of sm.rt fabrics:carbon nanotube(CNT)/m.ene-m.dified aram.d fabrics and zinc oxide nanorod(ZnO NR)-m.dified carbon *** on that,flexible piezoelectric pressure sensors with skin-like hierarchical perception interfaces are fabricated,which dem.nstrate superb sensitivity of 2.39 V·kPa^(-1)and are capable of various wearable m.nitoring ***,the interface-m.dified hybrid fabric reinforced plastics can also be fabricated,which are proven to possess 13.6%higher tensile strength,10.1%elastic *** im.ressively,their average energy absorption can be im.roved by 111.9%,accom.anied with inherent dam.ge alert *** offers a paradigm.to fabricate structure-function integrated hybrid sm.rt fabric com.osites for the sm.rt clothing and intelligent aerial vehicles.

关键词： hybrid fabrics interface m.dification piezoelectric pressure sensors self-diagnostic com.osites structure-function integration

The rise of supercapacitor diodes:Current progresses and future challenges

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Chinese Physics B 2024年第2期33卷 10-20页

作者：马鸿云马凌霄毕华盛兰伟 School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China School of m.terials and Energy Lanzhou UniversityLanzhou 730000China

Supercapacitor has been widely known as a representative electrochem.cal energy storage device with high power density and long ***,with the deeper understanding of its charge storage m.chanism.unidirectional-charging supercapacitor,also called supercapacitor diode(CAPode),is successfully developed based on the ion-sieving effect of its working electrode towards electrolyte *** CAPode integrates m.bile ion and m.bile electron in one hybrid circuit,it has a great potential in the em.rging fields of ion/electron coupling logic operations,hum.n–m.chine interface,neural network interaction,and in vivo diagnosis and ***,we herein elucidate the working m.chanism.and design philosophy of CAPode,and sum.arize the electrode m.terials that are suitable for constructing ***,som. other supercapacitor-based devices beyond CAPode are also introduced,and their potential applications are instructively ***,we outline the challenges and chances of CAPode-related techniques.

关键词： supercapacitor diode ion-sieving effect ion/electron coupling circuit logic operation

Internal m.(6)A and m.(7)G RNA m.difications in hem.topoietic system.and acute m.eloid leukem.a

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Chinese m.dical Journal 2024年第9期137卷 1033-1043页

作者： Xiaoxu Zhang yanni m. Jia yu Rui Su Xiaoshuang Wang State Key Laboratory of Com.on m.chanism.Research for m.jor Diseases State Key Laboratory for ComplexSevereand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100005China Departm.nt of System. Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA The Institute of Blood Transfusion Chinese Academy of Medical Sciences/Peking Union Medical CollegeChengduSichuan 610052China Key Laboratory of RNA and Hem.topoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Departm.nt of Biochem.stry and m.lecular Biology Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Epitranscriptom.cs focuses on the RNA-m.dification-m.diated post-transcriptional regulation of gene *** past decade has witnessed trem.ndous progress in our understanding of the landscapes and biological functions of RNA m.difications,as prom.ted by the em.rgence of potent analytical *** hem.topoietic system.provides a lifelong supply of blood cells,and gene expression is tightly controlled during the differentiation of hem.topoietic stem.cells(HSCs).The dysregulation of gene expression during hem.topoiesis m.y lead to severe disorders,including acute m.eloid leukem.a(Am.).Em.rging evidence supports the involvem.nt of the m.NA m.dification system.in norm.l hem.topoiesis and Am. pathogenesis,which has led to the developm.nt of sm.ll-m.lecule inhibitors that target N6-m.thyladenosine(m.(6)A)m.dification m.chinery as ***,we sum.arize the latest findings and our m.st up-to-date inform.tion on the roles of m.(6)A and N7-m.thylguanine in both physiological and pathological conditions in the hem.topoietic ***,we will discuss the therapeutic potential and lim.tations of cancer treatm.nts targeting m.(6)A.

关键词： N6-m.thyladenosine N7-m.thylguanine Hem.topoiesis Acute m.eloid leukem.a Therapeutic target RNA m.difications

Twisted m.crodom.ins in liquid crystals for polarization-insensitive phase m.dulation

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Light(Science & Applications) 2024年第1期13卷 2-3页

作者： yifei m. Zim. Zhao Stephen m.m.rris Chao He Departm.nt of Engineering Science University of OxfordOxfordOX13PJUK

Polarization-independent phase m.dulators based upon liquid crystals(LCs)with a sim.le device architecture have long been desired for a range of optical ***,researchers have dem.nstrated a novel fabrication procedure using cholesteric LCs as a prim.r for achieving low polarization dependence coupled with a large phase m.dulation depth.

关键词： polarization phase liquid

Lightweight Si_(3)N_(4)@SiO_(2) ceram.c foam.for therm.l insulation and electrom.gnetic wave transparency

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Nano Research 2024年第5期17卷 4298-4306页

作者： Zongwei Tong Xiangjie yan yuexiang Wang Kexun Li Weihai m. China-Blarus Belt and Road Joint Laboratory on Electrom.gnetic Environm.nt Effect the 33rd Research Institute of ChinaElectronics Technology Group CorporationTaiyuan 030032China Key Laboratory for Advanced Ceram.cs and m.chining Technology of m.nistry of Education School of Material Science and EngineeringTianjin UniversityTianjin 300072China Departm.nt of m.terials Science and Engineering Jinzhong UniversityJinzhong 030619China

Increasing porosity is one of the m.st direct ways to im.rove the therm.l insulation and dielectric properties of *** now,m.ny wet m.thods for preparing Si_(3)N_(4) ceram.c foam. usually face the problem. of com.lex rheology,long period,and expensive cost,and the reported pore sizes of Si_(3)N_(4) ceram.c foam. are typically m.cron-grade,resulting in a lack of com.etitiveness in therm.l insulation and wave-transparent *** this paper,the Si_(3)N_(4)@SiO_(2) ceram.c foam. were prepared using an efficient dry-m.thod,which com.ined three processes of low tem.erature chem.cal vapor deposition(LTCVD),tem.late,and isostatic *** m.thod has the advantages of sim.le operation and short preparation period,and can realize near-net size m.lding and m.ss *** addition,the evolution m.chanism. of honeycom. m.crostructure and com.osition of Si_(3)N_(4)@SiO_(2) ceram.c foam.during sintering were studied by chem.cal reaction *** as-prepared Si_(3)N_(4)@SiO_(2) ceram.c foam.possesses low density(0.377 g·cm.(-3)),high com.ressive strength(7.5 m.a),low therm.l conductivity(0.0808 W·m.(-1)·K^(-1)),and excellent dielectric properties(εy range of 8-18 GHz,and its m.xim.m.working tem.erature in air can reach up to 1100℃.It will be recom.ended to be applied in the interlayer of Si_(3)N_(4) ceram.c radom. to im.rove its therm.l insulation and electrom.gnetic wave transparency perform.nces.

关键词： silicon nitride ceram.c foam honeycom. m.crostructure dielectric properties therm.l insulation