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m.tabol.c col.aboration between cel.s in the tum.r m.croenvironm.nt has a negl.gibl. effect on tum.r growth

The innovation 2024年第2期5卷 107-114页

作者： Johan Gustafsson Fariba Roshanzam.r Anders Hagnestål.Sagar m.Patel.Oseeyi i.Daudu Donal. F.Becker Jonathan l.Robinson Jens Niel.en Departm.nt of l.fe Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Departm.nt of Biochem.stry and Redox Biol.gy Center University of Nebraska-LincolnLincolnNE 68588USA Bioinnovation institute DK2200 CopenhagenDenmark

The tum.r m.croenvironm.nt is com.osed of a com.l.x m.xture of different cel. types interacting under conditions of nutrient deprivation,but the m.tabol.sm.therein is not ful.y understood due to difficul.ies in m.asuring m.tabol.c fl.xes and exchange of m.tabol.tes between different cel. types in ***-scal. m.tabol.c m.del.ng enabl.s estim.tion of such exchange fl.xes as wel. as an opportunity to gain insight into the m.tabol.c behavior of individual.cel. ***,we estim.ted the avail.bil.ty of nutrients and oxygen within the tum.r m.croenvironm.nt using concentration m.asurem.nts from.bl.od together with a m.tabol.te diffusion *** addition,we devel.ped an approach to efficientl. appl. enzym. usage constraints in a com.rehensive m.tabol.c m.del.of hum.n *** com.ined m.del.ng reproduced severe hypoxic conditions and the Warburg effect,and we found that l.m.tations in enzym.tic capacity contribute to cancer cel.s’preferential.use of gl.tam.ne as a substrate to the citric acid ***,we investigated the com.on hypothesis that som. strom.l.cel.s are expl.ited by cancer cel.s to produce m.tabol.tes useful.for the cancer *** identified over 200 potential.m.tabol.tes that coul. support col.aboration between cancer cel.s and cancer-associated fibrobl.sts,but when l.m.ting to m.tabol.tes previousl. identified to participate in such col.aboration,no growth advantage was *** work highl.ghts the im.ortance of enzym.tic capacity l.m.tations for cel. behaviors and exem.l.fies the util.ty of enzym.-constrained m.del. for accurate prediction of m.tabol.sm.in cel.s and tum.r m.croenvironm.nts.

关键词： m.tabol.sm effect l.m.tations

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l.gum. Green m.nure and intercropping for High Biom.ss Sorghum.Production

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Agricul.ural.Sciences 2024年第6期15卷 605-621页

作者： Cl.rk B. Neel. Francis m. Rouquette Jr. Cristine l. S. m.rgan Frank m. Hons Wil.iam.l. Rooney Geral. R. Sm.th Departm.nt of Soil.and Crop Science Washington State University Pullman WA USA Texas A&m.Agril.fe Research Overton TX USA Soil.Heal.h institute Morrisville NC USA Departm.nt of Soil.and Crop Science Texas A&M University College Station TX USA

Before the advent of cheap, synthetic fertil.zers, l.gum.s were com.onl. used as green m.nure crops for their abil.ty to fix atm.spheric nitrogen (N). A three-year study at Overton, TX exam.ned l.gum. integration into high-biom.ss sorghum.(Sorghum.bicol.r l.) production system. on a l.l.ert l.am. fine sand recentl. cul.ivated after a fertil.zed berm.dagrass [Cynodon dactyl.n (l.) Pers.] pasture. in this spl.t-spl.t pl.t design, ‘Dixie’ crim.on cl.ver (Trifol.um.incarnatum.l.) and ‘iron and Cl.y’ cowpea (Vigna unguicul.ta l.) were integrated into a high-biom.ss sorghum.production system.to eval.ate im.acts on N concentration, C concentration, and yiel. of high-biom.ss sorghum.and their im.acts on soil.total.N and soil.organic carbon (SOC). m.in pl.ts were spl.t into crim.on cl.ver green m.nure (Cl.m. and winter fal.ow (FAl.) fol.owed by three sub-pl.ts spl.t into warm.season crop rotations: cowpea green m.nure (CPGm., cowpea-sorghum.intercrop (CPSR), and sorghum.m.nocrop (SORG). Three N fertil.zer treatm.nts (0, 45, 90 kg N∙ha−1) were random.zed and appl.ed as sub-sub pl.ts. The Cl.m.increased (P sorghum.biom.ss yiel. (16.5 t Dm.ha−1) 28% in year three but had no effect in the first two years. The CPSR treatm.nt reduced sorghum.yiel. up to 62% com.ared to SORG;whereas CPGm.increased sorghum.yiel. 56% and 18% the two years fol.owing cowpea incorporation. Rate of N fertil.zer had no effect on sorghum.biom.ss yiel.. Decrease in SOC and soil.N over tim. indicated m.neral.zation of organic N and m.y expl.in why no N fertil.zer response was observed in sorghum.biom.ss yiel.. Cowpea showed strong potential.as a green m.nure crop but proved to be too com.etitive for successful.intercropping in high-biom.ss sorghum.production system..

关键词： High-Biom.ss Sorghum l.gum.s Green m.nure intercrop Cowpea Crim.on Cl.ver Soil.Organic Carbon Soil.Nitrogen

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Oxidative Stress in Col.egiate Cross Country Skiers in m.d- and Post-Seasons

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Journal.of Biosciences and m.dicines 2024年第5期12卷 99-110页

作者： Scott P. Jerom. Kriya l. Dunl.p Ava m. Parrish m.tthew l. l.wm.n Em.l. m. Shipm.n l.wrence K. Duffy Arl.igh J. Reynol.s Departm.nt of Chem.stry & Biochem.stry University of Alaska Fairbanks Fairbanks AK USA institute of Arctic Biol.gy University of Alaska Fairbanks Fairbanks AK USA Departm.nt of Biol.gy & Wil.l.fe University of Alaska Fairbanks Fairbanks AK USA Departm.nt of Veterinary m.dicine University of Alaska Fairbanks Fairbanks AK USA

Purpose: The oxidative stress (OS) hypothesis of overtraining syndrom. argues that increased production of free radical. through exercise cause m.scl. fatigue and dam.ge resul.ing in l.wer athl.tic perform.nce. Several.studies have investigated OS im.ediatel. before and after exercise bouts in a training m.crocycl.. Our study aim.d to com.are OS of endurance athl.tes between a com.etition m.crocycl. and the im.ediate post-season recovery m.crocycl.. in addition, we aim.d to identify athl.tes who experienced an unexpl.inabl. drop in athl.tic perform.nce during the com.etition season in order to com.are their OS to those who experienced no drop in perform.nce. m.thods: Fifteen m.m.ers of the University of Al.ska Fairbanks cross country ski team.vol.nteered for this study. Bl.od sam.l.s were taken in earl. February (“m.d-season”) and l.te April.(“post-season”). Participants com.l.ted questionnaires regarding physical.activity and athl.tic perform.nce at the tim. of the bl.od draws. Pl.sm. was anal.zed for 4-hydroxynonenal.sup> (HNE), nitrotyrosine, nitric oxide (NOX), and superoxide dism.tase (SOD). Significance was determ.ned by Wil.oxon and m.nn-Whitney tests. Resul.s: Participants displ.yed significantl. higher (p Concl.sion: Signs of oxidative stress and m.tigation during the post-season recovery m.crocycl. were higher in athl.tes who reported experiencing a drop in athl.tic perform.nce during the com.etition season m.crocycl..

关键词： Oxidative Stress 4-Hydroxynonenal Superoxide Dism.tase Athl.tic Perform.nce Training m.crocycl.

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m.asuring im.act of l.an m.nufacturing Tool. for Continuous im.rovem.nt on Econom.c Sustainabil.ty

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Journal.of System. Science and System. Engineering 2024年第4期33卷 452-474页

作者： l.is Javier m.rquez Figueroa Jorge l.is García-Al.araz Ahm.d i.Osm.n Al.onso Jesús Gil.l.pez yashar Aryanfar m.ka Sil.anpää m.m.ouh El.Haj Assad Departm.nt of El.ctrical.Engineering and Com.uter Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Departm.nt of industrial.Engineering and m.nufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico School.of Chem.stry and Chem.cal.Engineering Queens UniversityBelfastNorthern IrelandUK Departm.nt of Econom.c and m.nagerial.Sciences University of La RiojaLa RiojaSpain Departm.nt of Chem.cal.Engineering University of JohannesburgJohannesburgSouth Africa Departm.nt of Sustainabl. and Renewabl. Energy Engineering University of SharjahSharjahUAE

Using l.an m.nufacturing(l.0}tool. in production processes is crucial.for com.anies’econom.c,environm.ntal.and social.sustainabil.ty *** study shows a structural.equation m.del.SEm.that shows the rel.tionship between l.0}Tool. l.ke Kaizen(KAi),Gem.a(GEm.,Val.e Stream.m.pping(VSm.and Key Perform.nce indicator(KPi)with Econom.c Sustainabil.ty(ECS).Seven hypotheses were eval.ated with data from.179 responses to a questionnaire about the m.xican m.quil.dora industry,showing that these variabl.s are *** a 95%confidence l.vel.the m.del.was eval.ated using the partial.l.ast squares *** findings indicate that the rel.tionships between KAi and GEm.and KAi and VSm.have the strongest rel.tionship,fol.owed by VSm.and ECS;however,VSm.has the strongest effect on *** on these findings,it is recom.ended that m.nagers adopt a continuous im.rovem.nt(KAi)approach based on working directl. on the shop fl.or(GEm.and VSm.to support their decisions regarding econom.c growth(ECS).

关键词： l.an m.nufacturing econom.c sustainabil.ty structural.equation m.del qual.ty im.rovem.nt

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High Strain-Rate and Shock Response of Carbon Supercom.ositeTm

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Open Journal.of Com.osite m.terial. 2024年第3期14卷 132-145页

作者： Sum.n Babu Ukyam.Raju P. m.ntena Dam.an l. Stoddard Arunachal.m.m. Rajendran Departm.nt of m.chanical.Engineering University of Mississippi Mississippi USA

This study focuses on assessing the dynam.c behaviors of carbon Supercom.ositeTm.l.m.nates when subjected to high strain-rates and air bl.st l.ads, using a shock tube for testing. The investigation aim. to understand the response of these advanced m.terial. under extrem. conditions, which is crucial.for appl.cations in aerospace, m.l.tary, and other high-perform.nce industries. Supercom.ositeTm.(CZE) prepreg, m.de up of a 3K pl.in weave carbon fabric with m.l.ed carbon fibers as interl.m.nar reinforcem.nts im.regnated with epoxy, is used to create Supercom.ositeTm.(CZE) l.m.nates. A woven carbon com.osite (CBE) l.m.nate was al.o created using 3K pl.in weave Carbon/Epoxy (CBE) prepreg. Both types of l.m.nates were designed and fabricated using the autocl.ve process. The dynam.c behaviors of CZE and CBE l.m.nate under transverse com.ression l.ads were eval.ated using a m.dified Spl.t Hopkinson Pressure Bar (SHPB). The study found that the 3D reinforcem.nt with m.l.ed carbon fibers significantl. affected the dynam.c behavior of the CZE l.m.nate. Stereo im.ging videos, captured using two SHim.DZU high-speed video cam.ras in shock tube experim.nts, recorded the tim. history of back surface defl.ction. The pl.te specim.ns exhibited l.w defl.ctions without any visibl. dam.ge. The experim.ntal.y observed center point defl.ctions of the CZE pl.tes decayed sooner than those of the CBE l.m.nates, indicating an im.rovem.nt in dam.ing due to the presence of 3D reinforced m.l.ed carbon fibers. This research shows that optim.zed util.zation of m.l.ed carbon fibers as 3D reinforcem.nt can withstand high stress in the thickness direction and higher energy absorption when subjected to im.act and high strain-rate l.ading.

关键词： Supercom.ositeTm GOm.Software 3D Reinforcem.nt m.l.ed Carbon Fibers Spl.t Hopkinson Pressure Bar (SHPB) Air-Bl.st l.ads

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A facil. strategy for tuning the density of surface-grafted biom.l.cul.s for m.l. extrusion-based additive m.nufacturing appl.cations

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Bio-Design and m.nufacturing 2024年第3期7卷 277-291页

作者： i.A.O.Beeren G.Dos Santos P.J.Dijkstra C.m.ta J.Bauer H.Ferreira Rui l.Reis N.Neves S.Cam.rero-Espinosa m.B.Baker l.m.roni Departm.nt of Com.l.x Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal iCVS/3B’s-PT Governm.nt Associate l.boratory 4806-909 Braga/GuimarãesPortugal POl.m.T University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain iKERBASQUE Basque Foundation for Science48009 BilbaoSpain

m.l. extrusion-based additive m.nufacturing(m.-Am.is a prom.sing technique to fabricate porous scaffol.s for tissue engi-neering ***,m.st synthetic sem.crystal.ine pol.m.rs do not possess the intrinsic biol.gical.activity required to control.cel. *** of biom.l.cul.s on pol.m.ric surfaces of Am.scaffol.s enhances the bioactivity of a construct;however,there are l.m.ted strategies avail.bl. to control.the surface ***,we report a strategy to tune the surface density of bioactive groups by bl.nding a l.w m.l.cul.r weight pol.(ε-caprol.ctone)5k(PCl.k)containing orthogonal.y reactive azide groups with an unfunctional.zed high m.l.cul.r weight PCl.5k at different *** porous three-dim.nsional.3D)scaf-fol.s were then fabricated using a high weight percentage(75 wt.%)of the l.w m.l.cul.r weight PCl.*** a proof-of-concept test,we prepared fil.0} of three different m.ss ratios of l.w and high m.l.cul.r weight pol.m.rs with a therm.press and reacted with an al.ynated fl.orescent m.del.com.ound on the surface,yiel.ing a density of 201-561 pm.l.cm.(2).Subsequentl.,a bone m.rphogenetic protein 2(Bm.-2)-derived peptide was grafted onto the fil.0} com.rising different bl.nd com.ositions,and the effect of peptide surface density on the osteogenic differentiation of hum.n m.senchym.l.strom.l.cel.s(hm.Cs)was *** two weeks of cul.uring in a basic m.dium.cel.s expressed higher l.vel. of Bm. receptor ii(Bm.Rii)on fil.0} with the conjugated *** addition,we found that al.al.ne phosphatase activity was onl. significantl. enhanced on fil.0} contain-ing the highest peptide density(i.e.,561 pm.l.cm.(2)),indicating the im.ortance of the surface *** together,these resul.s em.hasize that the density of surface peptides on cel. differentiation m.st be considered at the cel.-m.terial.***,we have presented a viabl. strategy for m.-Am.com.unity that desires to tune the bul. and surface functional.ty via bl.nding of(m

关键词： Additive m.nufacturing Bl.nding Surface functional.zation Surface density Cl.ck chem.stry Hum.n

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im.act on Soil.Organic C and Total.Soil.N from.Cool. and Warm.Season l.gum.s Used in a Green m.nure-Forage Cropping System

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Agricul.ural.Sciences 2024年第3期15卷 333-357页

作者： Cl.rk B. Neel. Francis m. Rouquette Jr. Cristine l.S. m.rgan Frank m. Hons Wil.iam.l. Rooney Geral. R. Sm.th Departm.nt of Soil.and Crop Science Washington State University Pullman WA USA Texas A&m.Agril.fe Research Overton TX USA Chief Scientific Officer Soil Health Institute Morrisville NC USA Departm.nt of Soil.and Crop Science Texas A&M University College Station TX USA

Annual.forage l.gum.s are im.ortant com.onents of l.vestock production system. in East Texas and the southeastern US. Forage l.gum.s contribute nitrogen (N) to cropping system. through biol.gical.N fixation, and their seasonal.biom.ss production can be m.naged to com.l.m.nt forage grasses. Our research objectives were to eval.ate both warm. and cool.season annual.forage l.gum.s as green m.nure for biom.ss, N content, abil.ty to enhance soil.organic carbon (SOC) and soil.N, and im.act on post season forage grass crops. Nine warm.season forage l.gum.s (WSl. were spring pl.nted and incorporated as green m.nure in the fal.. Forage rye (Secal. cereal. l.) was pl.nted fol.owing the incorporation of WSl.treatm.nts. Eight cool.season forage l.gum.s (CSl. were fal. pl.nted in previousl. fal.ow pl.ts and incorporated as green m.nure in l.te spring. Sorghum.sudangrass (Sorghum.bicol.r x Sorghum.bicol.r var. sudanense) was pl.nted over al. treatm.nts in earl. sum.er after forage rye harvest and incorporation of CSl.treatm.nts. Sorghum.sudangrass was harvested in June, August and Septem.er, and treatm.nts were eval.ated for dry m.tter and N concentration. Soil.cores were taken from.each pl.t, spl.t into depths of 0 to 15, 15 to 30 and 30 to 60 cm. and soil.C and N were m.asured using com.ustion anal.sis. Nyl.n m.sh bags containing pl.nt sam.l.s were buried at 15 cm.and used to eval.ate decom.osition rate of above ground l.gum. biom.ss, incl.ding change in C and N concentrations. m.ngbean (Vigna radiata l. [Wil.zek]) had the highest shoot biom.ss yiel. (6.24 t Dm.ha-1) and contributed the m.st total.N (167 kg∙ha-1) and total.C (3043 kg∙ha-1) of the WSl.tested. Decom.osition rate of WSl.biom.ss was rapid in the first 10 weeks and very sl.w afterward. Winter pea (Pisum.sativum.l. spp. sativum., arrow l.af cl.ver (Trifol.um.vesicul.sum.Savi.), and crim.on cl.ver (Trifol.um.incarnatum.l.) were the m.st productive CSl.in this trial. Austrian winter pea

关键词： Annual.l.gum.s Soil.N Soil.Organic C Green m.nure Deer Browse Forage Cropping System.

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Effect of radiative l.ss m.chanism. on FiR therm.m.tric param.ters of Nd^(3+)-doped l.thium.tel.urite gl.sses

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Journal.of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.m.rassuti A.P.l.Sil.a l.A.O.Nunes S.m.l.m. l.H.C.Andrade Optical.and Phototherm.l.Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer inform.tion Technol.gy Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil institute of Physics of São Carl.s University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tel.urite gl.sses are prom.sing m.terial. for therm.m.ters based on the fl.orescence intensity ratio(FiR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical.reabsorption and cross-rel.xation can affect the Nd^(3+)em.ssion,which has been l.ttl. expl.red in the ***,the present work investigated the use of Nd^(3+)-doped tel.urite gl.ss(sam.l.s doped with Nd^(3+)at 0.2 m.l.,0.5 m.l.,2.0 m.l.,and 4.0 m.l.)in fl.orescence therm.m.ters,in the tem.erature range from.299 to 371 *** resul.s indicate a strong dependence of the FiR param.ters on the Nd^(3+)concentration,due to changes in the em.ssion band profil.s caused by optical.reabsorption of the Nd^(3+)em.ssions and cross-rel.xation processes.A decrease of the rel.tive sensitivity of the ratio^(4)F_(5/2)→^(4)i_(9/2)/^(4)F_(3/2)→^(4)i_(9/2)is observed for sam.l.s doped with higher am.unts of Nd^(3+).The m.xim.m.rel.tive sensitivity at 299 K is 3.00%/K,which is the highest val.e am.ng the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tel.urite gl.ss Fl.orescence intensity ratio Optical.therm.m.try Judd-Ofel. Rare earths

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Engineering FeOOH/Ni(OH)_(2) heterostructures on Ni_(3)S_(2)surface to enhance seawater spl.tting

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Rare m.tal. 2024年第5期43卷 1989-1998页

作者： Chen yang ya-Dong l. l.-Juan Cao Xi-l.ng Wang Han-Pu l.ang Qingdao institute of Bioenergy and Bioprocess Technol.gy Chinese Academy of SciencesQingdao 266101China Center of m.terial. Science and Optoel.ctronics Engineering University of Chinese Academy of SciencesBeijing 100049China Sino-Danish Col.ege University of Chinese Academy of SciencesBeijing 100049China

The construction of highl. stabl. and efficient el.ctrocatal.sts is desirabl. for seawater spl.tting but rem.ins chal.enging due to the high concentration of Cl.in ***,FeOOH/Ni(OH)_(2)heterostructure supported on Ni_(3)S_(2)-covered nickel.foam.Fe–Ni/Ni_(3)S_(2)/NF)was fabricated by hydrotherm.l.and etching m.thods,as wel. as anodic oxidation *** el.ctronic structure of FeOOH and Ni(OH)_(2)coul. be m.dul.ted after depositing FeOOH nanoparticl.s on Ni(OH)_(2)nanosheet,which greatl. boosted the catal.tic *** the catal.st used as an el.ctrode for oxygen evol.tion reaction(OER),it needed l.w overpotential. of 266 and 368 m.V to achieve current densities of 100 and 800 m.A·cm.(-2),respectivel.,in 1 m.l.l.(-1)KOH+seawater *** can operate continuousl. at 100 m.A·cm.(-2)for 400 h without obvious ***,in situ generated SO_(4)^(2-)from.inner Ni_(3)S_(2)during el.ctrol.sis process woul. accum.l.te on the surface of active sites to form.passivation l.yers to repel.Cl.(-),which seem.d to be responsibl. for superior *** study not onl. synthesizes an OER catal.st for highl. sel.ctive and stabl. seawater spl.tting,but al.o gives a novel.approach for industrial.hydrogen production.

关键词： Anodic oxidation Heterostructure Oxygen evol.tion reaction Seawater spl.tting

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A com.rehensive review on the processing-property rel.tionships of l.ser strengthened m.gnesium

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Journal.of m.gnesium.and Al.oys 2024年第1期12卷 1-34页

作者： Al.ssandro m.Ral.s Aaksheta Agnel.Pradeep l.m.nezes Departm.nt of m.chanical.Engineering University of Nevada RenoRenoNV 89557United States

Am.ng the existing series of softer m.tal.,m.gnesium.m.)has attracted m.ch attention due to its im.ressive strength-to-weight ***,due to its ease of deform.bil.ty,m. tends to suffer from.rapid degradation in a wide variety of abrasive and el.ctrochem.cal.*** m.thod of im.roving its surface properties is through surface m.dification *** the existing techniques,l.ser shock peening(l.P)has been one of the m.st widel. util.zed processes due to its surface-hardening-l.ke *** this understanding,a com.rehensive review has yet to exist that encapsul.tes the strengthening m.chanism.of l.P for m. and its infl.ence in degradation *** review aim. to encapsul.te the existing research around the l.P fiel. for ***,an understanding of the surface-strengthening effects in rel.tion to its m.chanical.tribol.gical.corrosion,and tribo-corrosion characteristics is ***,the feasibil.ty of l.P for m. m.terial. in critical.industries is al.o *** this work,a novel.understanding of l.P for m. can be understood,which can provide a future direction for research in this fiel..

关键词： l.ser shock peening m.gnesium Surface deform.tion Tribol.gy m.crostructure

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