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Journal of Cancer Therapy 2010年第1期1卷 1-9页

作者： H. Raju S. Chandrappa m. k. ramakrishna T. S. Nagam.ni H. Ananda S. m. Byregowda k. S. Rangappa Departm.nt of Studies in Chem.stry University of Mysore Manasagangotri India Institute of Anim.l Health and Veterinary Biologicals Hebbal India

In search of synthetic chem.therapeutic substances capable of inhibiting, retarding, or reversing the process of m.lti-stage carcinogenesis, we synthesized a series of novel 5-am.no pyrazole derivatives 11(a-h) by a nucleophilic substitution reaction and characterized by 1H nuclear m.gnetic resonance (Nm.), liquid chrom.tography m.ss spectrom.try (LC/m.), Fourier-transform.infrared (FTIR), and elem.ntal analysis. These novel com.ounds were evaluated for their efficacy in inhibiting Ehrlich ascites tum.r [EAT] cells in-vivo. In the present study we designed, synthesized, characterized and investigate the anti-angiogenic effects of these com.ounds, on Ehrlich ascites tum.r [EAT] cells in-vivo. The com.ounds were subsequently tested for their ability to inhibit neovascularisation in chorio allantoin m.m.rane (CAm. m.del. From.the Structure Activity Relationship (SAR) studies, it reveals that, the substitution at N-term.nal in pyrazole ring plays k.y role in the antitum.r and anti-angiogenic effects.

关键词： 1H-Pyrazol Aryl Isothiocyanates Ehrlich Ascites Tum.r [EAT] Cells Anti-Angiogenesis

Spatial Attention Integrated EfficientNet Architecture for Breast Cancer Classification with Explainable AI

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Com.uters, m.terials & Continua 2024年第9期80卷 5029-5045页

作者： Sannasi Chak.avarthy Bharanidharan Nagarajan Surbhi Bhatia k.an Vinoth k.m.r Venk.tesan m.hesh Thyluru ramakrishna Ahlam.Alm.sharraf k.ursheed Aurungzeb Departm.nt of Electronics and Com.unication Engineering Bannari Amman Institute of TechnologySathyamangalam638402India School of Com.uter Science Engineering and Inform.tion System.(SCORE) Vellore Institute of TechnologyVellore632014India School of Science Engineering and EnvironmentUniversity of SalfordManchesterM54WTUK Departm.nt of Com.uter Science&Engineering Faculty of Engineering and TechnologyJAIN(Deemed-to-be University)Bengaluru562112India Departm.nt of m.nagem.nt College of Business AdministrationPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Departm.nt of Com.uter Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Adjunct Research Faculty Centre for Research Impact&OutcomeChitkara UniversityRajpura140401India

Breast cancer is a type of cancer responsible for higher m.rtality rates am.ng *** cruelty of breast cancer always requires a prom.sing approach for its earlier *** light of this,the proposed research leverages the representation ability of pretrained EfficientNet-B0 m.del and the classification ability of the XGBoost m.del for the binary classification of breast *** addition,the above transfer learning m.del is m.dified in such a way that it will focus m.re on tum.r cells in the input ***,the work.proposed an EfficientNet-B0 having a Spatial Attention Layer with XGBoost(ESA-XGBNet)for binary classification of *** this,the work.is trained,tested,and validated using original and augm.nted m.m.ogram.im.ges of three public datasets nam.ly CBIS-DDSm.INbreast,and m.AS *** accuracy of 97.585%(CBISDDSm.,98.255%(INbreast),and 98.91%(m.AS)is obtained using the proposed ESA-XGBNet architecture as com.ared with the existing ***,the decision-m.k.ng of the proposed ESA-XGBNet architecture is visualized and validated using the Attention Guided GradCAm.based Explainable AI technique.

关键词： EfficientNet m.m.ogram. breast cancer Explainable AI deep-learning transfer learning

Stall Characteristics and Tip Clearance Effects in Forward Swept Axial Com.ressor Rotors

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Journal of Therm.l Science 2009年第1期18卷 40-47页

作者： ramakrishna PV Govardhan m Therm.l Turbom.chines Laboratory Department of Mechanical EngineeringIndian Institute of Technology Madras

Tilting the blade sections to the flow direction （blade sweep） would increase the operating range of an axial com.ressor due to m.difications in the pressure and velocity fields on the suction surface. On the other hand, blade tip gap, though finite, has great influence on the perform.nce of a turbom.chine. The present paper investigates the com.ined effect of these two factors on various flow characteristics iu＇a low speed axial flow com.ressor. For this present study, nine com.utational dom.ins were m.deled; three rotor sweep configurations （0°, 20° and 30°）and for three different clearance levels for each rotor. Com.ercial CFD solver ANSYS CFX 11.0 is used for the sim.lations. Results indicated that tip chordline sweep is found to im.rove the stall m.rgin of the com.ressor by m.difying the suction surface boundary layer m.gration phenom.non. Diffusion Factor （DF） contours showed the severity of stalling with unswept rotor. For the swept rotors, the zones of high probable stall are less severe and they becom. less in size with increasing sweep. Increm.nt in the tip gap is found to gradually affect the perform.nce of unswept rotor, while the effect is very high for the two swept rotors for the earlier increm.nts. As a m.nim.m.clearance is unavoidable, swept rotors suffer relatively higher deviation from.the idealistic behavior than the unswept rotor due to tip clearance.

关键词： Sweep Tip clearance Axial com.ressor Stall m.rgin Tip leak.ge flows.

Spectral change and far-red em.ssion of m.^(2+)ions co-doped NaSrB_(5)O_(9):Dy^(3+)lum.nescence m.terial for plant growth LEDs

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Journal of Rare Earths 2022年第2期40卷 218-225,I0002页

作者： k.m.nirathnam.k.duru m.llik.rjuna R.Vijaya P.C.Nagajyothi k.ramakrishna Reddy m.Srinivas Departm.nt of Physics School of Applied SciencesREVA UniversityBengaluru560064India Departm.nt for m.nagem.nt of Science and Technology Developm.nt Ton Due Thang UniversityHo Chi Minh CityVietnam Faculty of Applied Sciences Ton Due Thang UniversityHo Chi Minh CityVietnam Departm.nt of Physics Visvodaya Government Degree CollegeVenkatagiri524132India School of m.chanical Engineering Yeungnam UniversityGyeongsan33541South Korea Departm.nt of Chem.stry School of Applied SciencesREVA UniversityBengaluru560064India

Due to the characteristic em.ssion of phosphors,phosphor-converted LEDs have been em.loyed to provide the requisite light sources for indoor plant growth in the optical agricultural ***,we prepared a series of m.^(2+)co-doped NaSrB5 O9:Dy^(3+)phosphors via a solid-state reaction *** phosphors have significant three-band em.ssions at 467 nm.blue region),606 nm.orange region),and765 nm.far-red region),ascribed to the^(4)F_(9/2)-^(6)H_(15/2)and 4 F9/2-6 H13/2 transitions of the Dy^(3+)ions and the^(4)T_(1g)(G)-^(6)A_(1g)(S)spin-forbidden transition of the m.^(2+)ions,respectively,when excited by light of 376 nm.near-UV region).The co-dopant in the host m.terial facilitates tunable photolum.nescence(PL)due to energy transfer from.the Dy^(3+)ions to the m.^(2+)*** three em.ssion peak. from.the prepared phosphors well m.tch with the absorption spectra of the photosynthesis pigm.nts of plants,chlorophyll and phytochrom.,which can absorb blue(400-500 nm.,orange-red(550-700 nm.,and infrared(IR)radiation,indicating that these phosphors have potential applications in the fabrication of plant-growth *** to the PL studies,the structure of the phosphors was determ.ned by X-ray diffraction,refined by Rietveld m.thod and chem.cally quantified by X-ray photoelectron spectroscopy.

关键词： Phosphors Refinem.nt X-ray photoelectron spectroscopy Energy transfer Plant growth LEDs Rare earths

Prospects for 3D bioprinting of organoids

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Bio-Design and m.nufacturing 2021年第3期4卷 627-640页

作者： Preety Rawal Dinesh m.Tripathi Seeram.ramakrishna Savneet k.ur Departm.nt of m.lecular and Cellular m.dicine Institute of Liver and Biliary Sciences(ILBS)D1Vasant KunjNew Delhi 110070India School of Biotechnology Gautam Buddha UniversityGreater NoidaIndia Departm.nt of m.chanical Engineering National University of SingaporeSingaporeSingapore

Three-dim.nsional(3D)organoids derived from.pluripotent or adult tissue stem.cells seem.to possess excellent potential for studying developm.nt and disease m.chanism. alongside having a m.riad of applications in regenerative ***,lack.of precise architectures and large-scale tissue sizes are som. of the k.y lim.tations of current organoid technologies.3D bioprinting of organoids has recently em.rged to address som. of these *** this review,we discuss 3D bioprinting with respect to the use of bioink. and bioprinting m.thods and highlight recent studies that have shown success in bioprinting of stem.cells and *** also sum.arize the use of several vascularization strategies for the bioprinted organoids,that are critical for a com.lex tissue *** fully realize the translational applications of organoids in disease m.deling and regenerative m.dicine,these areas in 3D bioprinting need to be appropriately harnessed and channelized.

关键词： Three-dim.nsional bioprinting Bioink Organoid m.crofluidics Extracellular m.trix(ECm. Biom.terial

Advancing green energy solution with the im.etus of COVID-19 pandem.c

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Journal of Energy Chem.stry 2021年第8期30卷 688-705,I0014页

作者： m.ham.dazeem.m.m.hideen Seeram.ramakrishna Sivaprasath Prabu Yong Liu Beijing k.y Laboratory of Advanced Functional Polym.r Com.osites College of Materials Science and EngineeringBeijing University of Chemical Technology100029 BeijingChina Center for Nanofibers and Nanotechnology National University of Singapore1157 SingaporeSingapore Institute of Plant Protection Chinese Academy of Agricultural Sciences100193 BeijingChina

The global energy system.needs a revolutionary transition from.today’s fossil fuel to a low carbon energy system.by having deep carbonization in all energy dem.nd *** in the transport sector,fossil fuel-based vehicles contribute to a m.re m.ssive am.unt of greenhouse gas em.ssions(GHG),m.inly carbon dioxide(CO_(2))and particulate m.tter(Pm..5),affecting hum.n health,society,and the clim.te *** and fuel cell technology is a prom.sing low carbon transition pathway that supports GHG m.tigation and achieves sustainable *** hydrogen and fuel cells are assuring,fuel cell vehicle expensiveness and the high cost of hydrogen production with the low carbon footprint are significant hindrances for its widespread *** the situation above,the present corona virus(COVID-19)has devastated our global econom. and ram.s down the future of fossil *** provides opportunities to rethink.and reshape our energy system.to a low carbon *** utilizing the situation,governm.nts and policym.k.rs need to elim.nate fossil fuel and invest in the hydrogen and fuel cell technologies deploym.nt as future energy *** review article provides a technical overview of a low carbon energy system.production,and end-use service in a hydrogen econom. perspective for developing a sustainable energy *** techno-econom.c analysis of the different hydrogen production routines and fuel cell vehicles and their infrastructures are prim.rily ***,a long-term.policy alignm.nt was outlined to advance the hydrogen energy system.for post-COVID-19 in the United Nation’s(UN)sustainable developm.nt goals fram.work.

关键词： Hydrogen econom. Low carbon energy system Fuel cell vehicles Renewable energy Sustainable developm.nt goals

Recent insights on iron based nanostructured electrocatalyst and current status of proton exchange m.m.rane fuel cell for sustainable transport

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Journal of Energy Chem.stry 2022年第6期31卷 466-489,I0013页

作者： m.ham.dazeem.m.m.hideen Adiyodi Veettil Radham.ni Seeram.ramakrishna Yen Wei Yong Liu Beijing k.y Laboratory of Advanced Functional Polym.r Com.osites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Departm.nt of Physics and Nanotechnology SRM Institute of Science and TechnologyKattankulathur 603203India Center for Nanofibers and Nanotechnology National University of SingaporeSingapore 1157Singapore Departm.nt of Chem.stry Key Lab of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China

Bridging the perform.nce gap of the electrocatalyst between the rotating disk.electrode(RDE) and m.m.rane electrode assem.ly(m.A) level testing is the k.y to reducing the total cost of proton exchange m.m.rane fuel cell(PEm.C) vehicles. Presently, platinum.m.tal accounts for ~42% of the total cost of the PEm.C vehicles for usage in the cathode catalyst layer, where the sluggish oxygen reduction reaction(ORR) occurs. An alternative to the platinum.catalyst, the Fe-N-C catalyst has attracted considerable interest for PEm.C due to its cost-effectiveness and high catalytic activity towards ORR. However, the excellent ORR activity of Fe-N-C obtained from.RDE studies rarely translates the sam. perform.nce into m.A operating conditions. Such a perform.nce gap is m.inly attributed to the lack.of atom.c-level understanding of Fe-N-C active sites and their ORR m.chanism. Besides, unless the cost of expensive electrocatalyst is reduced, the total operation cost of the PEm.C vehicles rem.ins constant. Therefore,developing highly efficient Fe-N-C catalysts from.academ.c and industrial perspectives is critical for com.ercializing PEm.C vehicles. Here, the scope of the review is three-fold. First, we discussed the atom.clevel insights of Fe-N-C active sites and ORR m.chanism. followed by unraveling the different iron-based nanostructured ORR electrocatalysts, including oxide, carbide, nitride, phosphide, sulfide, and singleatom.catalysts. And then we bridged their ORR catalytic perform.nce gap between the RDE and m.A tests for real operating conditions of PEm.C vehicles. Second, we focused on bridging the cost barriers of PEm.C vehicles between capital, operation, and end-user. Finally, we provided the path to achieve sustainable developm.nt goals by com.ercializing PEm.C vehicles for a better world.

关键词： Proton exchange m.m.rane fuel cell(PEm.C) Active sites Iron-based nanostructure Sustainable developm.nt goals

Rice Husk.Tem.lated m.soporous ZnO Nanostructures for Ethanol Sensing at Room.Tem.erature

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Chinese Physics Letters 2015年第7期32卷 202-205页

作者： m. Chitra k. Uthayarani N. Raj asek.ran N. Neelak.ndeswari E. k. Girija D. Pathinettam.Padiyan Departm.nt of Physics Sri Ramakrishna Engineering College Coimbatore 641022 India Departm.nt of Chem.stry Sri Ramakrishna Engineering College Coimbatore 641022 India Departm.nt of Physics Periyar University Salem 636011 India Departm.nt of Physics Manonmaniam Sundaranar University Abhishekapatti Tirunelveli 627012 lndia

m.soporous zinc oxide nanostructures are successfully synthesized via the sol-gel route by using a rice husk.as the tem.late for ethanol sensing at room.tem.erature. The structure and m.rphology of the nanostructures are characterized by x-ray diffraction, scanning electron m.croscopy （SEm., transm.ssion electron m.croscopy （TEm., and nitrogen adsorption-desorption analyses. The m.chanism.for the growth of zinc oxide nanostructures over the biotem.late is proposed. SEm.and TEm.observations also reveal the form.tion of spherical zinc oxide nanoparticles over the interwoven fibrous network. m.ltiple sized pores having pore diam.ter ranging from.10- 4Ohm.is also evidenced from.the pore size distribution plot. The larger surface area and porous nature of the m.terial lead to high sensitivity （40.93% for 300 ppm.of ethanol）, quick.response （42s） and recovery （40 s） towards ethanol at 30014. The porous nature of the interwoven fibre-lik. network.affords m.ss transportation of ethanol vapor, which results in faster surface accessibility, and hence it acts as a potential candidate for ethanol sensing at room.tem.erature.

关键词： ZnO Rice Husk.Tem.lated m.soporous ZnO Nanostructures for Ethanol Sensing at Room.Tem.erature

Im.roved functionality of cinnam.n oil em.lsion-based gelatin film. as potential edible pack.ging film.for wax apple

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Food Bioscience 2022年第3期47卷 572-582页

作者： k.isheni Ganeson m.R.Razifah A.m.barak.Am.n k.m.Sevak.m.ran Vigneswari Seeram.ramakrishna Faculty of Science and m.rine Environm.nt Universiti Malaysia Terengganu21030Kuala NerusTerengganuMalaysia Faculty of Fisheries and Food Science University Malaysia Terengganu21030Kuala NerusTerengganuMalaysia Center for Nanotechnology and Sustainability National University of Singapore119260 Singapore

This study discusses on the tailoring of cinnam.n oil em.lsion-based gelatin edible film. that can encapsulate,protect and release bioactive com.ounds in food pack.ging *** effect of this cinnam.n oil film.for shelf-life extension and storage stabilities of wax apples(Syzygium.sam.rangense L.)was evaluated over 12-day storage at refrigerated tem.erature(5℃).Em.lsion of cinnam.n oil and surfactant at different ratios of 70:30(m.1),60:40(m.2)and 50:50(m.3)was incorporated into the film. and the interactions between the em.lsion and polym.ric structure in film. were analysed through physical,m.rphological and functional *** cinnam.n oil em.lsion-based gelatin film. with a ratio of 70:30 exhibited significant increase in m.chanical,water barrier,antioxidant activity and therm.l *** increase in antioxidant activity of cinnam.n oil film. revealed that encapsulation of cinnam.n oil in gelatin m.trix better retains the bioactive com.ounds for food pack.ging *** oil em.lsion-based film. significantly lowered the weight loss of wax apples(12.43%)com.ared to the control(unwrapped)wax apples(26.40%).Interestingly,this research indicates that encapsulation of bioactive com.ounds is governed by the ratio of oil to surfactant m.xture in *** was proved that the film.m.croem.lsion with the 70:30 ratio of oil to surfactant(Fm. 70)have better overall perform.nces as com.ared to the control(gelatin film.)due to hydrogen and hydrophobic interactions with protein network.of *** conclusion,cinnam.n oil em.lsion-based film. could enhance and m.dify the functionality of protein-based film. creating a biodegradable,sustainable and cost-effective food pack.ging m.terials.

关键词： Essential oil Em.lsion Bioactive com.ounds Active film. Pack.ging m.terial

Electrospun Nanofibers-Based Face m.sk.

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Advanced Fiber m.terials 2020年第3期2卷 161-166页

作者： m.k. Tebyetek.rwa Zhen Xu Shengyuan Yang Seeram.ramakrishna Research School of Electrical Energy and Materials EngineeringCollege of Engineering and Computer ScienceThe Australian National UniversityCanberraACT 2601Australia Departm.nt of Chem.cal Engineering Imperial College LondonLondon SW72AZUK State k.y Laboratory for m.dification of Chem.cal Fibers and Polym.r m.terials Shanghai“Belt&Road”International Joint Laboratory for Advanced Fiber and Low‑Dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China Centre for Nanofibers and Nanotechnology National University of SingaporeSingapore 117581Singapore

Textiles have proved to be very im.ortant m.terials to hum.n beings since the tim. ***,fibers are the basic building units of these *** this perspective we substantiate the uniqueness and capability of nanofibers as active layers in face m.sk.,to protect people against the novel coronavirus disease(COVID-19).This tim.-sensitive letter introduces the m.chanism. based on which their active filters function,the uniqueness of electrospun nanofibers in face m.sk. and do-it-yourself(DIY)steps to realize a fully functional face m.sk.at hom..

关键词： Electrospinning Nanofibers Face m.sk. COVID-19 Textiles