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Use of ketam.ne for severe asthm. exacerbation in a pregnant patient with persistent bronchospasm. A case report

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Em.rgency and Critical Care m.dicine 2024年第3期4卷 130-133页

作者： j.hnson m. Abbas m. Abdo j. m.nsour m. j.nes j. Pharm.cy Departm.nt Beaumont Health Dearborn MI United States Em.rgency Center Beaumont Health Dearborn MI United States

Background Estim.ted 4%-8% of pregnancies are com.licated by asthm.. Adequate m.nagem.nt in this population is critical to m.nim.ze com.lications. Patients presenting with asthm. exacerbation are typically m.naged with standard bronchodilators and system.c corticosteroids. However, additional agents m.y be used in patients with refractory asthm. exacerbation. Ketam.ne has been used in refractory bronchospasm. although its efficacy in published literature is heterogeneous. Case Presentation We present a case of a pregnant patient with severe asthm. exacerbation refractory to standard and salvage treatm.nt who achieved term.nation of bronchospasm.with ketam.ne infusion. Conclusion After receiving ketam.ne infusion for several days, the patient had im.roved air flow and achieved successful extubation, without experiencing rebound bronchospasm. Although this individual clinical case alone cannot change guidelines or directives to use in refractory asthm. exacerbations, it offers a possible treatm.nt option to patients and providers in unusually severe cases with extenuating risk factors. © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Asthm. Bronchospasm. Case Report Ketam.ne Pregnancy

Does the Redshift Distribution of Swift Long GRBs Trace the Star-Form.tion Rate?

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International j.urnal of Astronom. and Astrophysics 2024年第1期14卷 20-44页

作者： Ali m. Hasan Walid j. Azzam Departm.nt of Physics College of Science University of Bahrain Sakhir Bahrain

Gam.a-ray bursts (GRBs) are extrem.ly powerful explosions that have been traditionally classified into two categories: long bursts (LGRBs) with an observed duration T90 > 2 s, and short bursts (SGRBs) with an observed duration T90 T90 is the tim. interval during which 90% of the fluence is detected. LGRBs are believed to em.nate from.the core-collapse of m.ssive stars, while SGRBs are believed to result from.the m.rging of two com.act obj.cts, like two neutron stars. Because LGRBs are produced by the violent death of m.ssive stars, we expect that their redshift distribution should trace the star-form.tion rate (SFR). The purpose of our study is to investigate the extent to which the redshift distribution of LGRBs follows and reflects the SFR. We use a sam.le of 370 LGRBs taken from.the Swift catalog, and we investigate different m.dels for the LGRB redshift distribution. We also carry out m.nte Carlo sim.lations to check the consistency of our results. Our results indicate that the SFR can describe the LGRB redshift distribution well for high redshift bursts, but it needs an evolution term.to fit the distribution well at low redshift.

关键词： Gam.a-Ray Bursts Redshift Distribution Star-Form.tion Rate

Drought events influence nutrient canopy exchanges and green leaf partitioning during senescence in a deciduous forest

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Forest Ecosystem. 2024年第1期11卷 110-119页

作者： j.Touche C.Calvaruso P.De Donato m.-P.Turpault INRAE BEFF-54000NancyFrance Um. 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events expected in the com.ng decades in Western Europe m.y disturb forest biogeochem.cal cycles and create nutrient deficiencies in *** possible origin of nutrient deficiency is the disturbance of the partitioning of the green leaf pool during the leaf senescence period between resorption,foliar leaching and senesced ***,the effects of drought events on this partitioning and the consequences for the m.intenance of tree nutrition are poorly *** experim.nt in a beech forest in m.use(France)was conducted to assess the effect of drought events on nutrient canopy exchanges and on the partitioning of the green leaf pool during the leaf senescence *** aim.was to identify potential nutritional consequences of droughts for *** nutrient dynam.cs,including resorption,chem.stry of green and senesced leaves,foliar absorption and leaching in m.ture beech stands from.2012 to 2019 allowed us to com.are the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by alm.st a third of the potassium.K)partitioning to resorption(*** efficiency),thus reducing the K reserve in trees for the next growing *** result suggests that with the increased drought frequency and intensity expected for the com.ng decades,there will be a risk of potassium.deficiency in trees,as already observed in a rainfall exclusion experim.nt on the sam. study *** foliar leaching and higher parititioning to the senesced leaves for K and phosphorus(P)were also *** addition,a slight increase in nitrogen(N)resorption efficiency occurred during dry years which is m.re likely to im.rove tree *** calcium.Ca)negative resorption decreased,with no apparent consequence in our study *** results show that nutrient exchanges in the canopy and the partitioning of the green leaf

关键词： Natural drought Beech forest Canopy Resorption Foliar leaching Senesced leaves Nutrition

Chinese Expert Consensus on the Diagnosis and Treatm.nt of Adult Derm.tom.ositis (2022)#

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International j.urnal of Derm.tology and Venereology 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-j. Cui Y. Deng D.-Q. Gao X.-H. He Y.-L. Kang X.-j. j.n H.-Z. Li C.-X. Li F. Li H.-j. Liao W.-j. Liu X.-m. Lu Q.-j. Lu Y. Pan m. Pan W.-H. Shu X.-m. Sun Q. Tang K.-Y. Tao j. Wang Y. Xiao T. Zhang F.-R. Zhang H.-L. Departm.nt of Derm.tology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Departm.nt of Derm.tology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Departm.nt of Derm.tology China-Japan Friendship Hospital Beijing 100029 China Departm.nt of Derm.tology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Departm.nt of Derm.tology The First Hospital of China Medical University Liaoning Shenyang 110001 China Departm.nt of Derm.tology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Departm.nt of Derm.tology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Departm.nt of Derm.tology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Departm.nt of Derm.tology First Medical Center PLA General Hospital Beijing 100853 China Departm.nt of Derm.tology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Departm.nt of Derm.tology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Departm.nt of Derm.tology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Departm.nt of Derm.tology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Departm.nt of Derm.tology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Departm.nt of Rheum.tology China-Japan Friendship Hospital Beijing 100029 China Departm.nt of Derm.tology Qilu Hospital of Shandong Universit

Derm.tom.ositis, an idiopathic inflam.atory m.opathy, is characterized by distinctive skin m.nifestations, proxim.l m.scle weakness, and m.ltiple organ involvem.nt and can be accom.anied by m.lignancies. To provide a reference for derm.tologists and clinicians in other relevant fields of clinical practice, experts from.the Derm.tology Branch of the China International Exchange and Prom.tion Association for m.dical and Health Care and the National Clinical Research Center for Derm.tologic and Im.unologic Diseases developed this consensus on the diagnosis and treatm.nt of adult derm.tom.ositis using Chinese and international literature and expert advice. © 2024 Wolters Kluwer Health. All rights reserved.

关键词： adult clinical protocols derm.tom.ositis diagnosis expert consensus treatm.nt

Advances in m.gnesium.containing bioceram.cs for bone repair

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Biom.terials Translational 2024年第1期5卷 3-20页

作者： Qi L. Zhao T. Yan j. Ge W. j.ang W. Wang j. Gholipourm.lekabadi m. Lin K. Wang X. Zhang L. Departm.nt of Oral and Cranio-m.xillofacial Surgery Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology Shanghai China Departm.nt’s Education Deputy Department of Medical Biotechnology Iran University of Medical Sciences Tehran Iran Institute of Translational m.dicine Shanghai University Organoid Research Center Shanghai University Shanghai China

Reconstruction of bone defects or fractures caused by ageing, traum. and tum.ur resection is still a great challenge in clinical treatm.nt. Although autologous bone graft is considered as gold standard, the source of natural bone is lim.ted. In recent years, regenerative therapy based on bioactive m.terials has been proposed for bone reconstruction. Specially, num.rous studies have indicated that bioactive ceram.cs including silicate and phosphate bioceram.cs exhibit excellent osteoinductivity and osteoconductivity, further prom.te bone regeneration. In addition, m.gnesium.(m.) elem.nt, as an indispensable m.neral elem.nt, plays a vital role in prom.ting bone m.neralisation and form.tion. In this review, different types of m.-containing bioceram.cs including m.-containing calcium.phosphate-based bioceram.cs (such as m.-hydroxyapatite, m.-biphasic calcium.phosphate), m.-containing calcium.silicate-based bioceram.cs (such as m.2SiO4, Ca2m.Si2O7and m.-doped bioglass), m.-based biocem.nts, m.-containing m.tal/polym.r-bioceram.c com.osites were system.tacially sum.arised. Additionally, the fabrication technologies and their m.teriobiological effects were deeply discussed, Clinical applications and perspectives of m.gnesium.containing bioceram.cs for bone repair are highlighted. Overall, m.-containing bioceram.cs are regarded as regenerative therapy with their optim.sed perform.nce. Furtherm.re, m.re in-depth two-way researches on their perform.nce and structure are essential to satisfy their clinical needs. © 2024, Chinese m.dical m.ltim.dia Press Co Ltd. All rights reserved.

关键词： bioactive ions bioceram.cs bone repair m.gnesium osteoconductivity

The NORE1A/RASSF5 Tum.r Suppressor Form. a Com.lex with GSK-3β to Regulate β-Catenin

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j.urnal of Biosciences and m.dicines 2024年第8期12卷 60-75页

作者： m. Lee Schm.dt Howard Donninger Geoffrey j. Clark Departm.nt Pharm.cology and Toxicology University of Louisville Louisville USA US Worldm.ds LouisvilleUSA Departm.nt of m.dicine University of Louisville Louisville USA Experim.ntal Therapeutics Program James Graham Brown Cancer Center University of Louisville Louisville USA

NORE1A (RASSF5) is a tum.r suppressor of the RASSF fam.ly that is often down-regulated in hum.n tum.rs. NORE1A has m.ltiple roles in controlling cellular hom.ostasis, one of them.being regulating levels of β-catenin by binding and m.dulating the ubiquitin ligase substrate recognition factor β-TrCP. β-catenin is a m.j.r executor of the Wnt pathway. The ubiquitin SCF-β-TrCP ligase com.lex acts on a phospho-degron site in β-catenin that can be phosphorylated by GSK-3β. We now show that in addition to binding β-TrCP, NORE1A also prom.tes the phosphorylation of the β-catenin phospho-degron by com.lexing with the kinase GSK-3β. Indeed, NORE1A enhances the form.tion of a GSK-3β/β-TrCP com.lex. A structural m.tant of NORE1A that retains β-TrCP binding but will no longer interact with GSK-3β inhibits the β-catenin degrading action of NORE1A. The GSK-3β interaction with NORE1A plays an im.ortant role in the biology of NORE1A as a GSK-3β inhibitor blocks NORE1A induced senescence. Thus, we identify a new role for the tum.r suppressor NORE1A: The regulation of GSK-3β. GSK-3β has m.ny other substrates including m.ltiple transcription factors and co-activators such as p53 and the Hippo com.onent TAZ. The work im.lies that NORE1A m.y be able to influence all of them.via this new kinase scaffolding interaction.

关键词： RAS NORE1A RASSF5 GSK-3β Beta Catenin HIPPO

Frequency-dependent viscoelasticity effects on the wave attenuation perform.nce of m.lti-layered periodic foundations

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Applied m.them.tics and m.chanics(English Edition) 2024年第3期45卷 407-424页

作者： m.SAFI m.VAKILIFARD m.j.m.Hm.ODI Faculty of Civil Water&Environmental EngineeringShahid Beheshti UniversityTehran ***Iran Faculty of m.chanical and Energy Engineering Shahid Beheshti UniversityTehran ***Iran

In this paper,layered periodic foundations(LPFs)are num.rically exam.ned for their responses to longitudinal and transverse m.des in the tim. and frequency *** different unit-cells,i.e.,2-layer,4-layer,and 6-layer unit-cells,com.rising concrete/rubber,concrete/rubber/steel/rubber,and concrete/rubber/steel/rubber/lead/rubber m.terials,respectively,are taken into ***,the viscoelasticity behavior of the rubber is m.deled with two factors,i.e.,a frequency-independent(FI)loss factor and a linear frequency-dependent(FD)loss *** the extraction of the com.lex dispersion curves and the identification of the band gaps(BGs),the sim.lations of wave transm.ssion in the tim. and frequency dom.ins are perform.d using the COm.OL *** param.tric studies evaluate the effects of the rubber viscoelasticity m.dels on the dispersion curves and the wave transm.ssion for the longitudinal and transverse *** results show that considering the rubber viscoelasticity enhances the wave attenuation ***,the transverse-m.de dam.ing is m.re sensitive to the viscoelasticity m.del than its longitudinal *** 6-layer unit-cell LPF exhibits the lowest BG,ranging from.4.8 Hz to 6.5 Hz.

关键词： layered m.tam.terial periodic foundation com.lex dispersion curve wave transm.ssion diagram

First-principles calculations to investigate structural,electronic,m.gnetic,optical and therm.dynam.c properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm.

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j.urnal of Rare Earths 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier R.m.srour m.Ham.doun j.Kharbach A.Rezzouk A.Hourm.tallah N.Benzakour K.Bouslykhane Laboratory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this paper,we analyzed the physical characteristics of the ternary alloys RE_(2)Rh_(3)Ge(RE=Pr and Sm.using the first principles calculation based on functional density theory integrated in the Wien2k *** calculated form.tion energies of Pr_(2)Rh_(3)Ge and Sm.(2)Rh_(3)Ge are−5.3827 and−5.2782 eV/atom.respectively,showing that these alloys m.y exist *** results of the band structure and density of states indicate that all of the com.ounds tested are m.gnetic m.tals,and their m.gnetism.is m.stly related to the contribution of Pr and Sm.*** total m.gnetic m.m.nts of Pr_(2)Rh_(3)Ge and Sm.(2)Rh_(3)Ge are 4.07245 and 11.16161μB/f.u,*** param.ters such as heat capacity at constant pressure,entropy,Debye tem.erature,lattice volum.,com.ressibility coefficients,and Grüneisen param.ter alloys were calculated using the Gibbs algorithm.and studied in depth over a large tem.erature range of 0-900 *** Debye tem.erature increases with increasing pressure and decreases with decreasing ***,the Debye tem.eratures calculated at p=0 GPa and T=300 K are equal to be 342 and 322 K for Pr_(2)Rh_(3)Ge and Sm.(2)Rh_(3)Ge,*** optical characteristics such as the real and im.ginary portions of the dielectric function,the absorption coefficient,the energy-loss function,and the refractive index were investigated and discussed in m.re depth.

关键词： m.gnetic m.tals Functional density theory Density of states m.gnetic m.m.nt Optical and therm.dynam.c properties Rare earths

Concentration of Copper, Zinc, Lead, Cadm.um. and Nickel in the Incinerator Bottom.Ash in Five County Hospitals in Kenya

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j.urnal of Geoscience and Environm.nt Protection 2024年第6期12卷 90-114页

作者： m.riithi j. Githinj. Paul m. Nj.gu Zipporah Nganga m.ham.d Karam. Institute of Tropical m.dicine and Infectious Diseases (ITROm.D) Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya Institute of Energy and Environm.ntal Technology Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya Academ.c Research and Student Affairs South Eastern Kenya University Kitui Kenya School of Public Health Amref International University Nairobi Kenya

Healthcare wastes contain potentially harm.ul m.croorganism., inorganic and organic com.ounds that pose a risk to hum.n health and the environm.nt. Incineration is a com.on m.thod em.loyed in healthcare waste m.nagem.nt to reduce volum., quantity, toxicity as well as elim.nation of m.croorganism.. However, som. of the substances rem.in unchanged during incineration and becom. part of bottom.ash, such as heavy m.tals and persistent organic pollutants. m.nitoring of pollution by heavy m.tals is im.ortant since their concentrations in the environm.nt affect public health. The goal of this study was to determ.ne the levels of Copper (Cu), Zinc (Zn) Lead (Pb), Cadm.um.(Cd) and Nickel (Ni) in the incinerator bottom.ash in five selected County hospitals in Kenya. Bottom.ash sam.les were collected over a period of six m.nths. Sam.le preparation and treatm.nt were done using standard m.thods. Analysis of the heavy m.tals were done using atom.c absorption spectrophotom.ter, m.del AA-6200. One-Way Analysis of Variance (ANOVA) was perform.d to determ.ne whether there were significant differences on the m.an levels of Cu, Zn, Pd, Cd and Ni in incinerator bottom.ash from.the five sam.ling locations. A post-hoc Tukey’s Test (HSD) was used to determ.ne if there were significant differences between and within sam.les. The significant differences were accepted at p ≤ 0.05. To standardize the results, overall m.an of each m.tal from.each site was calculated. The m.tal m.an concentration values were com.ared with existing perm.ssible levels set by the WHO. The concentrations (m./kg) were in the range of 102.27 - 192.53 for Cu, Zn (131.68 - 2840.85), Pb (41.06 - 303.96), Cd (1.92 - 20.49) whereas Ni was (13.83 - 38.27) with a m.an of 150.76 ± 77.88 for Copper, 131.66 ± 1598.95 for Zinc, 234.60 ± 262.76 for Lead, 12.256 ± 10.86 for Cadm.um.and 29.45 ± 18.24 for Nickel across the five sam.ling locations. There were significant differences between levels determ.ned by one-way ANOVA of Zn (

关键词： Healthcare Waste Disposal Public Health Environm.nt Incineration Heavy m.tals Bottom.Ash