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Effects of supplem.ntation of green tea extract on the m.lk perform.nce of peripartal dairy cows and the expression of stress response genes in the liver

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Journal of Anim.l Science and Biotechnology 2020年第4期11卷 1163-1174页

作者： Denise K.Gessner Corinna Brock Lena m.hof Erika m.st Christian Koch Klaus Eder Institute of Anim.l Nutrition and Nutrition Physiology Justus-Liebig-University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany Educational and Research Centre for Anim.l Husbandry Hofgut Neumühle67728 Münchweiler an der AlsenzGermany.

Background: We hypothesised that supplem.ntation of green tea extract(GTE) in dairy cows during the transition period can attenuate proinflam.atory conditions and prevent endoplasm.c reticulum.ER) stress in the liver of these cows. Thirty Holstein cows with an average parity of 3.06(± 1.31, SD) were divided into a control group and a group that received a daily am.unt of 10 g of GTE from.d 7 before the calving day and a daily am.unt of 20 g of GTE from.the day of calving until d 7 of ***: Cows supplem.nted with GTE did not show differences in energy intake or m.lk yield in weeks 2–7 of lactation. However, these cows had a lower m.lk fat concentration and a lower energy corrected m.lk yield than the control cows and showed a trend of im.roved energy balance. The relative m.RNA concentrations of proinflam.atory genes, genes involved in the acute phase reaction and antioxidant genes in the liver in weeks 1, 4 and 7 of lactation were not different between the two groups of cows. The concentrations of α-tocopherol and the Trolox equivalent antioxidant capacity in plasm. were not different between the two groups. However, the group supplem.nted with GTE showed significant reductions of som. genes of the unfolded protein response(UPR) in week 1 and a trend of lower liver triacylglycerol(TAG) concentrations in the liver com.ared to the control ***: This study shows that supplem.ntation of GTE in dairy cows lowers the fat concentration in the m.lk but overall has no effect on the expression of inflam.atory genes and the antioxidative status in dairy cows during early lactation. The finding of reduced m.RNA levels of genes involved in the UPR at week 1, however, supports other results showing that supplem.ntation of polyphenols could prevent the developm.nt of ER stress in the liver of cows during early lactation. The finding of a tendency towards a reduced TAG concentration in the liver of cows supplem.nted with GTE m.ght be due to an im.roved ene

关键词： Anim.l nutrition Cow Green tea extract Liver m.tabolism m.lk perform.nce

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Interactions of prim.ry neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor m.intenance and differentiation by soluble factors and direct contact

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Cell Research 2007年第7期17卷 619-626页

作者： m.guel A Gam. Sosa Rita De Gasperi Anne B Rocher Gissel m.Perez Keila Sim.ns Daniel E Cruz Patrick R hof Gregory A Elder Departm.nts of Psychiatry Research and Developm.nt Service James J. Peters Department of Veterans Affairs Medical Center 130 West Kingsbridge Road Bronx New York 10468 USA Neuroscience Mount Sinai School of Medicine of New York University New York NY Departm.nt of Research and Developm.nt Service James J. Peters Department of Veterans Affairs Medical Center 130 West Kingsbridge Road Bronx New York 10468 USA

Neurovascular interactions are crucial for the norm.l developm.nt of the central nervous system. To study suchinteractions in prim.ry cultures, we developed a procedure to sim.ltaneously isolate neural progenitor and endothelialcell fractions from.em.ryonic m.use brains. Depending on the culture conditions endothelial cells were found to favorm.intenance of the neuroprogenitor phenotype through the production of soluble factors, or to prom.te neuronal differ-entiation of neural progenitors through direct contact. These apparently opposing effects could reflect differential cellularinteractions needed for the proper developm.nt of the brain.

关键词： differentiation culture endothelial cells neuroepithelial cells

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Alzheim.r’s Disease Aβ-Am.loid Plaque m.rphology Varies According to APOE Isotype

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World Journal of Neuroscience 2023年第3期13卷 118-133页

作者： Ina Caesar K. Peter R. Nilsson Per Ham.arström.m.kael Lindgren Stefan Prokop Jam.s Schm.idler Vahram.Haroutunian David m. Holtzm.n Patrick R. hof Sam.Gandy Departm.nt of Neurology Icahn School of Medicine at Mount Sinai New York NY USA Departm.nt of Physics Chemistry and Biology Link&#246ping University Link&#246ping Sweden Departm.nt of Physics Norwegian University of Science and Technology Trondheim Norway Departm.nt of Neuropathology Charité Universit&#228tsmedizin Berlin Berlin Germany Departm.nt of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Alzheim.r’s Disease Research Center Icahn School of Medicine at Mount Sinai New York NY USA Jam.s J. Peters VA m.dical Center Bronx NY USA Nash Fam.ly Departm.nt of Neuroscience and Friedm.n Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA Departm.nt of Neurology Hope Center for Neurological Disorders Knight Alzheimer’s Disease Research Center Washington University St. Louis MO USA Ronald m. Loeb Center for Alzheim.r’s Disease Icahn School of Medicine at Mount Sinai New York NY USA

Background: The apolipoprotein E (APOE, gene;apoE, protein) ε4 allele is the m.st com.only identified genetic risk factor for typical late-onset sporadic Alzheim.r’s disease (AD). Each APOE ε4 allele roughly triples the relative risk for AD com.ared to that of the reference allele, APOE ε3. m.thods: We have em.loyed hyperspectral fluorescence im.ging with an am.loid-specific, conform.tion-sensing probe, p-FTAA, to elucidate protein aggregate structure and m.rphology in fresh frozen prefrontal cortex sam.les from.hum.n postm.rtem.AD brain tissue sam.les from.patients hom.zygous for either APOE ε3 or APOE ε4. Results: As expected APOE ε4/ε4 tissues had a significantly larger load of CAA than APOE ε3/ε3. APOE isoform.dependent m.rphological differences in am.loid plaques were also observed. Am.loid plaques in APOE ε3/ε3 tissue had sm.ll spherical cores and large coronas while am.loid plaques in APOE ε4/ε4 tissues had large irregular and m.lti-lobulated plaques with relatively sm.ller coronas. Despite the different m.rphologies of their cores, the p-FTAA stained APOE ε3/ε3 am.loid plaque cores had spectral properties identical to those of APOE ε4/ε4 plaque cores. Conclusions: These data support the hypothesis that one m.chanism.by which the APOE ε4 allele affects AD is by m.dulating the m.crostructure of pathological protein deposits in the brain. APOE ε4 is associated with a higher density of am.loid plaques (as com.ared to APOE ε3). We speculate that m.ltilobulated APOE ε4-associated plaques arise from.m.ltiple initiation foci that coalesce as the plaques grow.

关键词： Alzheim.r’s Disease Am.loid Apolipoprotein Lum.nescent Conjugated Oligothiophenes Hyperspectral Separation

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m.del-Based Control and Optim.zation of Large Scale Physical System.-Challenges in Reservoir Engineering

Model-Based Control and Optimization of Large Scale Physical...

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2009中国控制与决策会议

作者： Paul m.J.Van den hof Jan-Dirk Jansen cijs van Essen Okko H.Bosgra Delft Center for System. and Control Delft University of TechnologyMekelweg 22628 CD DelftThe Netherlands Departm.nt of Geotechnology Delft University of TechnologyThe Netherlands Shell International Exploration and Production RijswijkThe Netherlands

＜正＞Due to urgent needs to increase efficiency in oil recovery from.subsurface reservoirs new technology is developed that allows m.re detailed sensing and actuation of m.ltiphase flow properties in oil *** of the exam.les is the controlled injection of water through injection wells with the purpose to displace the oil in an appropriate direction. This technology enables the application of m.del-based optim.zation and control techniques to optim.ze production over the entire production period of a reservoir,which can be around 25 *** scale reservoir flow m.dels are used for optim.zing production settings,but suffer from.high levels of uncertainty and lim.ted validation *** of the challenges is the developm.nt of reduced com.lexity m.dels that deliver accurate long-term.predictions,and at the sam. tim. are not m.re com.lex than can be warranted by the am.unt of data that is *** this paper an overview will be given of the problem. and opportunities for m.del-based control and optim.zation in this field aim.ng at the developm.nt of a closed-loop reservoir m.nagem.nt system.

关键词： Oil reservoir production optim.zation optim.l control param.ter estim.tion dynam.c optim.zation identifiability nonlinear observers

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接受直接冠状动脉介入治疗的急性心肌梗死患者中梗死区域对经酶学估测梗死面积校正后左室射血分数的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 17-18页

作者： Elsm.n P. van't hof A.W.J. de Boer m.-J. 罗亮 Departm.nt of Cardiology Isala Klinieken location Weezenlanden Zwolle Netherlands Dr.

Background: Left ventricular function and infarct size are strong predictors for prognosis after acute m.ocardial infarction(m.). Anterior m. is associated with greater reduction of left ventricular ejection fraction(LVEF) and worse prognosis. Our objective was to study whether the im.act of infarct size on global LVEF is dependent of infarct location. m.thods: We analyzed 888 patients treated with prim.ry percutaneous coronary intervention for acute m.. Enzym.tic infarct size and LVEF within 1 week were m.asured. In 490 patients(55%), LVEF was m.asured a second tim. at 6 m.nths. Results: Every 1000 U/L of cum.lative lactate dehydrogense release corresponded to a decrease of 4.7%(95%CI 4.1-5.3) in LVEF m.asured within 1 week post m. for left anterior descending coronary artery(LAD)related infarcts and to a decrease of 2.4%(95%CI 1.7-3.1) in LVEF m.asured within 1 week post m. for non-LAD-related infarcts(Pm.asured 6 m.nths post m. showed a decrease for every 1000 U/L cum.lative lactate dehydrogense release of 4.8%(95%CI 4.2-5.3) for LAD and 2.4%(95%CI 1.7-3.1) for non-LAD-related infarcts(Pm.ltivariate correction for relevant clinical and angiographic data did not change these results. Conclusion: In patients with a first acute m. treated with prim.ry percutaneous coronary intervention, LAD-related infarcts show for a sim.lar am.unt of m.ocardial necrosis as determ.ned by enzym.tic infarct size, a lower residual LVEF when com.ared with non-LAD-related infarcts.

关键词：后左室梗死面积梗死区域急性心肌梗死射血分数介入治疗左室功能酶学乳酸脱氢酶释放量

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旅行、资源和感受消费者剩余之间的理论关系

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中南林业调查规划 1987年第1期 55-56页

作者： DAVIDA.KING JOHNG.hof 章万富

如果把游览者看作既是从旅游资源和旅行投入中制造感受的生产者,并且也是那些感受的消费者,那未理论功效的合理模型就是求极小值: m.PT,PR）=PTT+PRR条件是:U（E）≥U° （2）和E=f（T,R）[和正文相同的方程（1）]式中:U——效用函数 ... 详细信息

如果把游览者看作既是从旅游资源和旅行投入中制造感受的生产者,并且也是那些感受的消费者,那未理论功效的合理模型就是求极小值: m.PT,PR）=PTT+PRR条件是:U（E）≥U° （2）和E=f（T,R）[和正文相同的方程（1）]式中:U——效用函数 U°——给定的效用水平 m.—感受费用 E——感受数量 PT——旅行价格（随旅行距离变化的各种费用） PR——旅游资源（旅游场所）价格

关键词：消费者资源补偿需求函数旅游场所

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早期多发性硬化质子密度及T1弛豫时间的改变及其变异是大脑皮质神经元损伤的m.I标志

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国际医学放射学杂志 2016年第5期 592-593页

作者： R.m.Gracien S.C.Reitz S.m.hof V.Fleischer H.Zim.ermann A.Droby 王慧燕 Departm.nt of Neurology University Hospital Goethe University

摘要目的质子密度（PD）和T1弛豫时间是多发性硬化（m.）病人神经元损伤具有前景的m.标志,然而在疾病早期阶段,尚不明确病人与健康人大脑皮质参数间是否存在差异。本研究假定上述参数有改变,且可出现高空间分布差异,

关键词：弛豫时间质子密度 T1 神经元损伤大脑皮质多发性硬化

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Veno occlusive disease: Update on clinical m.nagem.nt

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World Journal of Gastroenterology 2007年第29期13卷 3918-3924页

作者： m.Senzolo G Germ.ni E Cholongitas P Burra AK Burroughs Gastroenterology Department of Surgical and Gastroenterological Sciences University Hospital of Padua Padua Italy Liver Transplantation and Hepatobiliary Unit Royal Free Hospital London United Kingdom

Hepatic veno-occlusive disease is a clinical syndrom. characterized by hepatom.galy, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the m.st frequent cause is haem.topoietic stem.cell transplantation （STC） and is also seen after solid organ transplantation. The incidence of veno occlusive disease （VOD） after STC ranges from.0 to 70%, but is decreasing. Survival is good when VOD is a m.ld form. but when it is severe and associated with an increase of hepatic venous pressure gradient 〉 20 m.Hg, and m.rtality is about 90%. Prevention rem.ins the best therapeutic strategy, by using non-m.eloablative conditioning regim.ns before STC. Prophylactic adm.nistration of ursodeoxycholic add, being an antioxidant and antiapoptotic agent, can have som. benefit in reducing overall m.rtality. Defibrotide, which has pro-fibrinolytic and antithrom.otic properties, is the m.st effective therapy; decom.ression of the sinusoids by a b-ansjugular intrahepatic portosystem.c shunt （TIPS） can be tried, especially to treat VOD after liver transplantation and when m.ltiorgan failure （hof） is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concom.tant presence of m.ltiorgan failure contraindicates this procedure.

关键词： Veno occlusive disease Defibrotide Transjugular intrahepatic portosystem.c shunt Liver transplantation

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评价脑老化:超过7年的定量纵向m.I研究

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国际医学放射学杂志 2017年第3期 366-366页

作者： R.m.Gracien L.Nürnberger P.Hok S.m.hof S.C.Reitz U.Rüb 纪毅敏 Departm.nt of Neurology Goethe University

摘要目的 T1值是评估脑老化过程中的微观结构变化的有效工具。以前的横向研究表明人的一生中,脑白质中T1值逐渐升高,灰质中T1值逐渐减低。然而,这些研究结果尚未得到纵向研究基础上的证实。在这超过7年的纵向研究中,T1值被用来研究老年... 详细信息

摘要目的 T1值是评估脑老化过程中的微观结构变化的有效工具。以前的横向研究表明人的一生中,脑白质中T1值逐渐升高,灰质中T1值逐渐减低。然而,这些研究结果尚未得到纵向研究基础上的证实。在这超过7年的纵向研究中,T1值被用来研究老年健康学科中的与年龄相关微结构的动态变化。方法对17例健康受试者（年龄51～77岁）在基线和7年后进行T1m.pping。精确的皮质和白质分割被用来确定皮质和白质的平均T1值。结果分析显示,7年以后皮质平均T1值降低,受试者中年龄越大,T1值减少率越明显。T1减

关键词：脑老化 m.I 白质髓质

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高耐热蓝光阻隔剂应用于透明基材的耐候性探讨

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精细与专用化学品 2017年第4期25卷 5-7页

作者：洪诗雅谢杰修王敏莉简智娴胡明中宋宇书黄耀兴台湾永光化学工业(股)公司特用化学事业处台湾永光化学工业(股)公司管理技术组

为了满足日益提升的阻隔蓝光需求,本文以5%的热重损失温度为380℃的蓝光阻隔剂,添加于树脂中,射出透明基材,并进行紫外线加速老化试验,观察UV-vis图谱变化。结果显示PET受紫外线照射,造成严重劣化;添加蓝光阻隔剂Eversorb~ BL3的试片... 详细信息

为了满足日益提升的阻隔蓝光需求,本文以5%的热重损失温度为380℃的蓝光阻隔剂,添加于树脂中,射出透明基材,并进行紫外线加速老化试验,观察UV-vis图谱变化。结果显示PET受紫外线照射,造成严重劣化;添加蓝光阻隔剂Eversorb~ BL3的试片,经过1000h的紫外线加速老化试验,维持400nm.效阻隔的功效,且能保护树脂本身不受紫外线伤害。

关键词：蓝光热重损失紫外线加速老化试验

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