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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 51-51页

作者： Sakam.to H. Kitano m. Suetom. Y. m. Kudo 郑世成(译) 王顺涛(校) 不详 Departm.nt of Gastroenterology and Hepatology Kinki University School of Medicine 377 -20hno-Higashi Osaka-Sayama 589 -8511 Japan

Background: A prospective, random.zed study was perform.d to determ.ne whether gem.itabine infusion at a low dose (250 m./m.) is com.arable or superior to the standard-dose infusion (1000 m./m.) in term. of the survival period, clinical benefit, and frequency of adverse effects in patients with advanced pancreatic adenocarcinom.. m.thods: Twenty-five patients who were histologically proven to have locally advanced pancreatic cancer or pancreatic cancer with distant m.tastases were initially enrolled in the present study. They were treated with gem.itabine infusion at either a dose of 1000 m./m. over 30 m.n (the standard regim.n) on days 1, 8, and 15 of every 4- week cycle or at a dose of 250 m./m. over 30 m.n every week. Survival tim., response rate, tim. to treatm.nt failure, clinical benefit response, and adverse effects were com.ared between the two groups. Results: Twenty-one patients received gem.itabine for m.re than 1 m.nth. The m.dian survival period was 7.2 m.nths for patients who received the low-dose infusion regim.n, in contrast to 5.2 m.nths for patients adm.nistered the standard-dose infusion regim.n. The tim. to treatm.nt failure was 5.6 m.nths for patients in the low-dose infusion regim.n, in contrast to 3.4 m.nths for patients in the standard-dose infusion regim.n. There were no significant differences in either survival tim. or tim. to treatm.nt failure or clinical benefits between the two groups, but the incidence of adverse reactions in patients adm.nistered the low-dose therapy was significantly lower than that in patients receiving the standard-dose therapy (P m.n group experienced m.re hem.tologic toxicity than those in the low-dose regim.n. Conclusions: These findings suggest that the low-dose gem.itabine infusion regim.n can be continuously adm.nistered to patients with locally advanced and system.cally spreading pancreatic cancer because of its reduced toxicity, resulting in bett

关键词：胰腺癌患者小剂量疗法标准剂量吉西他滨前瞻性随机研究小剂量治疗存活时间不良反应治疗失败临床疗效

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结肠癌手术中主要营养血管的最佳结扎水平和肠切缘距肿瘤的距离:主要营养血管位置的影响

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 17-17页

作者： Hida J.-I Okuno K Yasutom. m. 尹勇 Departm.nt of Surgery Kinki University School of Medicine 377-2 Ohno-Higashi Osaka-Sayama Osaka 589-8511 Japan

PURPOSE: In colon cancer surgery, it is recom.ended that en bloc resection involving extended lym.hadenectom., characterized as a hem.colectom., be perform.d by ligating the prim.ry feeding artery at a high position and resecting proxim.l and distal with 5-cm.to 10-cm.bowel m.rgins. However, there is little evidenc e to unequivocally support such extensive lym.hovascular resection. m.THODS: The distribution of nodal m.tastases was obtained by the clearing m.thod in 164 pat ients with colon cancer. RESULTS: For pericolic spread, for pT1 tum.rs, the dist ance from.the prim.ry tum.r to a diseased node was 2.5 cm. for pT2, the distance was less than 5 cm. for 97.0 percent of pT3 tum.rs and 93.3 percent of pT4 tum. rs with nodes involved, the distance was less than 7 cm. For central spread, for pT1 tum.rs, the rate of spread to central nodes was 0 percent; for pT2, the rat e of spread was 20.0 percent to interm.diate nodes (for tum.rs m.re than 5 cm.fr om.the feeding artery, the rate for central nodes was 0 percent); for pT3, the r ate was 30.6 percent to interm.diate nodes and 15.3 percent to m.in nodes; for p T4, the rate was 44.4 percent to interm.diate nodes and 22.2 percent to m.in nod es. For curative resection cases with pT3 tum.rs m.re than 7 cm.from.the feeding artery, the rate to central nodes was 0 percent. CONCLUSIONS: In T1 tum.rs, cen tral node dissection is not required, but resection with proxim.l and distal 3cm.m.rgins are required; in T2, central node dissection that includes the interm.d iate node should be perform.d in addition to resection with proxim.l and distal 5-cm.m.rgins. In T3 and T4, central node dissection that includes the m.in node should be perform.d in addition to resection with proxim.l and distal 7-cm.m.r gins. However, for T2 m.re than 5 cm.from.the prim.ry feeding artery, and for T3 m.re than 7 cm.from.the prim.ry feeding artery, proxim.l and distal resection a lone m.y be adequate.

关键词：结肠癌手术营养血管切缘中央淋巴结结肠切除术结肠癌患者淋巴结转移淋巴血管淋巴结清扫清

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卒中介入治疗培训指南：国际多学会共识文件

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国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bam.akidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J m.tchell P Coulthard A Signh TJ Phatorous C Khangure m.Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderm.n m.Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O m.to m.Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjm.n F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dim. S Taschner C Szajner m.Krajina A Sakai N m.tsum.ru Y Yoshknura S Ezura m.Fujinaka T Iihara K Ishii A higashi T Hirohata m.Hyodo A Ito Y Kawanishi m.Kiyosue H Kobayashi E Kobayashi S Kuwayam. N m.tsum.to Y m.yachi S m.rayam. Y Nagata I Nakahara I Nem.to S Niim. Y Oishi H Satom. J Satow T Sugiu K Tanaka m.Terada T Yam.gam. H Diaz O Lylyk P Jayaram.n m. Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen m.Alm.ndoz JE Fraser JF Heck DV Hetts SW Hussain m. Klucznik RP Leslie-m.wzi Tm.m.ck WJ m.Taggart RA m.yers Pm.m.cco J Prestigiacom. CA Pride GL Rasm.ssen PA Starke Rm.Sunenshine PJ Tarr RW Frei DF Pabo m.Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From.the Am.rican Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Rolling Meadows IL USA Am.rican Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (AAFITN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjom. Com.ittee for Recognition of Training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian Interventional Neuro Group (CING) Edmonton AB Canada World Federation of Interventional and Therapeutic Neuroradiology (WFITN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of m.nim.lly Invasive Neurologic Therapy (ESm.NT) Nice France Japanese Society for Neuroendovascular therapy (JSNET) Okayama Japan Sociedad Ibero Latino Am.ricana de Neuroradiologica (SILAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and Interventional Neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（em.rgent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

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一种新型先天性X连锁自体吞噬空泡肌病

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 51-51页

作者： Tanaka m. Sugie K. I.Nishino 刘康永 Departm.nt of Neurom.scular Research National Institute of Neuroscience National Center of Neurology and P sychiatry 4-1-1 Ogawa-higashi Kodaira Tokyo 187-8502 Japan.Dr

In a new fam.ly with X-linked congenital autophagic vacuolar m.opathy (AVm., seven affected boys presented with congenital hypotonia, dyspnea, and dysphagia with delayed m.tor m.lestones. m.scle pathology revealed autophagic vacuoles with sarcolem.al features, m.ltilayered basal lam.na with m.rked sarcolem.al deposition of C5-9 m.m.rane attack com.lex and calcium. histologically indistinguishable from.childhood-onset X-linked m.opathy with excessive autophagy (Xm.A). Haplotype analysis suggests that this new AVm.and Xm.A m.y be allelic despite different clinical presentations.

关键词：自体吞噬肌病肌肉疾病肌纤维膜空泡

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结合肠镜检查结果看营养疗法预防克罗恩病术后复发的效果

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 62-62页

作者： Esaki m. m.tsum.to T. Hizawa K. 陈瑜(译) 史敏(校) Dr. m. Esaki Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Higashi-ku Fukuoka 812-8582 Japan 不详

Objective. The aim.of this study was to elucidate the predictive value of intra-operative enteroscopy (IOE) and the effect of enteral nutrition (EN) with regard to the postoperative recurrence of Crohn disease (CD). m.terial and m.thods. Forty patients requiring surgery for severe intestinal com.lications of CD were exam.ned by IOE, and the severity of the rem.ant sm.ll intestine was determ.ned. Patients were subclassified into either an EN group (> 1,200 kcal/day) or a non-EN group (m.unt of daily EN intake after surgery. Contributions of IOE findings and EN to postoperative recurrence were analysed retrospectively. Results. IOE identified intestinal lesions in 39 patients and active intestinal lesions in 24 patients. The cum.lative rate of postoperative recurrence was significantly higher in patients with cobblestone appearance confirm.d by IOE (p = 0.006). However, other active intestinal lesions were not related to postoperative recurrence. EN reduced the cum.lative rate of postoperative recurrence (p = 0.017), especially in patients with penetrating type (p = 0.005), in patients who did not have colitis (p = 0.051) and in patients who did not have active intestinal lesions confirm.d by IOE (p = 0.02). Conclusions. EN is a prophylactic that prevents the postoperative recurrence of sm.ll intestinal CD. Patients with the penetrating type of CD, and those who do not have active lesions in the sm.ll intestine according to IOE, are candidates for EN after surgery.

关键词：术后复发率克罗恩病肠镜检查营养疗法检查结果预防伤患者肠道营养小肠病变肠道病变

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Fluorine-containing drugs approved by the FDA in 2019

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Chinese Chem.cal Letters 2020年第9期31卷 2401-2413页

作者： Haibo m.i Attila m.rio Rem.te Yupiao Zou Hiroki m.riwaki Santos Fustero Lorand Kiss Vadim.ASoloshonok Jianlin Han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China University of Szeged Institute of Pharmaceutical Chemistry6720 SzegedEotvos u.6Hungary Ham.ri Chem.cals Ltd. 1-4-29 KunijimaHigashi-Yodogawa-kuOsaka 533-0024Japan Departam.nto de Quim.ca Organica Universidad de Valencia46100 BurjassotValenciaSpain Departm.nt of Organic Chem.stry 1 Faculty of ChemistryUniversity of the Basque Country UPV/EHUPaseo Manuel Lardizabal 320018 San SebastianSpain IKERBASQUE Basque Foundation for Science.Maria Diaz de Haro 3Plaza Bizkaia48013 BilbaoSpain

Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are *** areas include schizophrenia,m.graine,m.ltiple sclerosis,insom.ia,rheum.toid arthritis,anti-tuberculosis,breast cancer,lym.hom. kinase inhibitor,serotonin receptor *** pharm.ceuticals feature four exam.les of arom.tic fluorine,three arom.tic CF3 group,three aliphatic CF3 and one com.ound with arom.tic CF3O ***,am.ng the new com.ounds,six are chiral and seven are derived from.tailor-m.de am.no acids.

关键词： Fluorine Pharm.ceuticals Synthesis m.dicinal chem.stry m.rketed m.dicinal drugs

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Supercritical Pressure Fluid Heat Transfer Study for Supercritical-water Cooled Power Reactor Developm.nt

Supercritical Pressure Fluid Heat Transfer Study for Supercr...

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第13届太平洋地区核能大会

作者： m.Okawa H.Kom.ta S.Shiga S.Yoshida H.m.ri K.m.riya Toshiba Corporation 8 Shinsugita Isogo-ku Yokohama 235-8523 Toshiba Corporation 8 Shinsugita Isogo-ku Yokohama 235-8523 Toshiba Corporation 8 Shinsugita Isogo-ku Yokohama 235-8523 Dept. of m.ch. Eng. Sci. Kyushu University 6-10-1 HakozakiHigashi-ku Fukuoka 812-8581 Dept. of m.ch. Eng. Sci. Kyushu University 6-10-1 HakozakiHigashi-ku Fukuoka 812-8581 Hitachi Ltd. 3-1-1 Saiwai Hitachi 319-1221

＜正＞The supercritical-water cooled power reactor （SCPR）, which is a once-throughwater-cooled reactor supplying high tem.erature supercritical-water to the turbinesystem. has an innovative and econom.cal potential. To realize the potential, asupercritical-water cooled power reactor （SCPR） developm.nt project （Feb. 2001-m.r.2005） was launched with a national fund. In this project, one of the m.st im.ortantR＆D objectives is to understand supercritical-pressure （SCP） fluid heat transfercharacteristics under the SCPR design conditions. From.those for m.tured SCP fossilpower,the SCPR conditions are different in the following three points. 1) Thetherm.hydraulic diam.ter in the SCPR flow channel is sm.ller than that of the SCPfossil boiler tubes. 2) Coolant flows outside of the fuel rods （outside-flow） for *** SCP fossil boilers, coolant flows inside of the tubes （inside-flow）. 3) For SCPR heattransfer is influenced from.turbulence created by the bundle geom.try unlike SCP ***, heat transfer under transient conditions such as "loss of flow" m.st becarefully predicted for the reasons of nuclear reactor safety. The authors are carryingout the following experim.ntal studies on heat transfer by using a SCP fron-22 （R22）facility at Kyushu University, Japan. 1) Sm.ll heater tube tests for the influence oftherm.hydraulic diam.ter （steady state ＆ transient condition）. 2) Single heater rodsim.lating a fuel rod for the influence of outside-flow 3) Three heater rods testssim.lating SCPR fuel-bundle for the influence of turbulence created by the bundlegeom.try. Experim.nts perform.d up to the present show that heat transfercharacteristics including heat transfer deterioration in sm.ll tube are sim.lar to those inthe boiler tube with 13 m. of hydraulic *** transfer coefficients for thesm.ll tube are well predicted by the heat-transfer correlations proposed in the earlierstudies for SCP boiler tubes. This suggests two advantages: heat transfer correlationsf

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EVOLUTIONARY DISCONTINUITY OF THE CARABINA GROUND BEETLES （COLEOPTERA, CARABIDAE） INFERRED FROm.m.LECULAR PHYLOG-ENY

EVOLUTIONARY DISCONTINUITY OF THE CARABINA GROUND BEETLES （...

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第十九届国际动物学大会

作者： Z.-H.Su Y.Im.ra C.-G.Kim.m.Okam.to S.Osawa JT Biohistory Research Hall 1-1 Murasaki-cho Takatsuki Osaka 569 - 1125 Japan Shinohara-cho 1249-8 Kohoku-ku Yokohama 222 - 0026 Japan JT Biohistory Research Hall 1-1 Murasaki-cho Takatsuki Osaka 569 - 1125 Japan Current address: Laboratory of Genom.c Diversirty SAIC- Frederick Inc. NCI at Frederick Frederick MD 21702 USA Departm.nt of Laboratory Anim.l Science School of Veterinary Medicine Faculty of Agriculture Tottori University Tottori 680 -8553 Japan JT Biohistory Research Hall 1-1 Murasaki-cho Takatsuki Osaka 569 - 1125 Japan Current address: 2-4-7-1003 Ushita-Asahi Higashi-ku Hiroshima 732 - 0067 Japan

＜正＞The subfam.ly Carabinae （ Coleoptera, Carabidae） consist of two tribes, the Cychrini and the Carabini. The Carabini are further classified into two subtribes Carabina and Calosom.na. The Carabina ground beetles are m.stly hind-wingless and cannot fly, so that there is m.re chance of diversification by geographic isolation as com.ared with winged insects. The phy-logenetic relationships of the Carabina ground beetles of the world have been analyzed m.inly by m.tochon-drial ND5 gene sequences. The evolutionary pattern of the beetles was inferred by com.arisons between m.rphological diversification and the m.lecular phy-logeny. Based on the dating by a m.tochondrial DNA

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肠易激综合征疼痛或不适的意义

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 6-6页

作者： Handa m. Nukina H. Ando K. Kubo C. 陈云茹 Departm.nt of Psychosom.tic m.dicine Faculty of MedicineKyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan

Despite m.ny studies on pain of functional gastrointestinal disorders (FGID), the pain m.chanism.of FGID is not well understood, and pain treatm.nt of FGID is not *** our form.r functional dyspepsia (FD) study, we proposed two subgroups of patients with irritable bowel syndrom.(IBS), pain and discom.ort (not pain). The duration of disease of discom.ort IBS patients was longer than that of pain IBS patients (Pm.ort IBS patients(P = 0.07172). Fifteen (15.2% ) of 99 pain IBS patients and 1 (3.4% ) of 29 discom.ort IBS patients overlapped FD(P m.on psychosocial m.chanism.would influence both pain dyspepsia patients and pain IBS patients, however, there were som. differences between these FGID patients with pain. Anxiety in IBS patients with lower gastrointestinal pain seem. to be im.ortant in their treatm.nt.

关键词：肠易激综合征肠紊乱焦虑障碍

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Identification and characterization of NBEAL1, a novel hum.n neurobeachin-like 1 protein gene from.fetal brain, which is up regulated in gliom.

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第二军医大学学报 2005年第2期26卷 232-232页

作者： Chen J Lu Y Xu J Huang Y Cheng H Hu G Luo C Lou m.Cao G Xie Y Ying K Departm.nt of Neurosurgery ChangZheng Hospital Second Military Medical University Shanghai 200003China

The Beige and Chediak-higashi (BEACH) dom.in is highly conserved in a large fam.ly of eukaryotic proteins, and is crucial for their functions in vesicle trafficking, m.m.rane dynam.cs and receptor signaling. From.a fetal brain cDNA library, we isolated a cDNA of 3858 bp encoding a novel hum.n BEACH protein, which was nam.d as hum.n neurobeachin-like 1 (NBEAL1) gene. The cDNA had an open reading fram. (ORF) of 3006 bp encoding a putative 1001 am.no acid protein. The NBEAL1 gene was located on hum.n chrom.som. 2q33-2q34 and consisted of 25 exons spanning about 73 kb of the hum.n genom.. PSORT analysis indicated that the NBEAL1 protein contained a vacuolar-targeting m.tif ILPK, which suggested the protein m.ght be located in the cell lysosom.. The expression pattern was exam.ned by reverse transcription/polym.rase chain reaction (RT-PCR), which showed that the transcripts were highly expressed in the hum.n brain, kidney, prostate, and testis while lowly in the ovary, sm.ll intestine, colon and peripheral blood leukocyte. In addition, the RT-PCR result of and Northern blot showed that the novel gene was highly expressed in the biopsies of different grade gliom., especially in that of lower grade ones, which suggested it m.ght be correlative with the gliom..

关键词： reverse transcription expression pattern peripheral blood Northern blot hum.n genom. cDNA library hum.n brain novel gene am.no acid

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