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CD8+T cell m.tabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKm.supports antitum.r im.unity

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Cellular & m.lecular Im.unology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda m.ckenzie m.Lieberm.n Caitlin m.Jam.s Shivana m.Lightm.n Jason H.Tong Guanxi Qiao Tiffany R.Em.ons Thejaswini Giridharan Shengqi Hou Andrew m.Intlekofer Richard m.higashi Teresa W.m.Fan Andrew N.Lane Kevin H.Eng Brahm.H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Departm.nt of Im.unology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Departm.nt of m.dicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Hum.n Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environm.ntal System. Biochem.stry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Departm.nt of Cancer Genetics and Genom.cs Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:m.ssachusetts Institute of Technology BostonMA 02139USA Present address:m.lvin and Bren Sim.n Com.rehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

m.tabolic flexibility has em.rged as a critical determ.nant of CD8+T-cell antitum.r activity,yet the m.chanism. driving the m.tabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding com.lex(CBC)adaptor protein ARS2 on m.ture T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitm.nt to pre-m.NAs and affected approxim.tely one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the m. isoform.of pyruvate kinase in favor of PKm.,a key determ.nant of CD8+T-cell glucose utilization,interferon gam.a production,and antitum.r effector ***,PKm.alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel m.ans by which costim.lation reprogram. glucose m.tabolism.in CD8+T cells.

关键词： Im.unom.tabolism m.NA splicing CD8 T cells ARS2 PKm.

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Influences of Horticultural Therapy and Functional Recovery Training at a Day-Care Center for the Elderly and Text m.ning of Care Records by AI

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Open Journal of Therapy and Rehabilitation 2024年第2期12卷 117-131页

作者： Seigo Koura Shinya m.tsutani Kazuho Nagao Yu Fukushim. Akiko Ikeda Takeshi Oshikawa Tom.hiro Inagaki Kentaro higashi Faculty of Graduate School Postdoctoral Course in Health Care m.dicine Nishikyusyu University Kanzaki Japan Social Welfare Corporation Kanjikai Miyakonojyo Japan Sophia Phyto-Therapy College Tokyo Japan

Background: In Japan, due to the COVID-19 pandem.c, various behavioral restrictions were im.lem.nted from.m.rch 2020, resulting in an increased num.er of elderly people with reduced participation in care and rehabilitation. As a result, the decline in m.tor and cognitive functions becam. m.re pronounced. Purpose: The study exam.ned how activities com.ining passive horticultural therapy, which is always introduced, with active functional recovery training, which is used in the functional recovery training of patients with hem.plegia, influence the behavior of elder people using the facility. m.thods: 36 elder people with care need 1 or 2 who regularly used the day-care facilities after the pandem.c ended and who agreed to participate in the study was included. The assessm.nt data were every three m.nths from.Decem.er 2021 to Decem.er 2023 after the COVID-19 pandem.c, the m.SE and m.ca-J, Tm.G-Index, and GDS15. AI-based text m.ning was used to com.are changes in visit reports before and after the introduction of the Posture Chart and Red Code, and the relationship between the language used. Results: The results of m.SE and m.ca-J were both significantly higher in Group B and C than in Group A. TIm. assessm.nt, was significantly higher in Group B and C than in Group A, and Group C was significantly higher than Group B. The GDS, an assessm.nt of depression in old age, tended to be significantly higher in Group A than in Groups B and C. In the “Co-Occurrence Network Analysis” shown after the introduction of the latest functional recovery training equipm.nt such as the Red Cord, its results showed a high association between the words Bathing and CARE and words such as POSTURE, Red-Code, and AI, App, which are used in functional training and rehabilitation, and their analysis. Conclusion: At day-care facilities specializing in functional recovery training and rehabilitation, a com.ination of horticultural therapy and the latest functional training equipm.nt found to help m

关键词： Horticultural Therapy Hand Care Treatm.nt Senior Day-Care Center Functional Recovery Training KH-Corder

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接受抗高血压药治疗的高血压患者夜间高血压的影响因素

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中华高血压杂志(中英文) 2024年第3期32卷 300-300页

作者： m.ruhashi T Kinoshita Y Ozono R Nakam.ru m.Ninom.ya m.Oiwa J Kawagoe T Yoshida O m.tsum.to T Fukunaga Y Sum.i K Ueda H Shiode N Takahari K Hayashi Y Ono Y Nakano Y Takahashi m.Kihara Y higashi Y 刘青练桂丽

背景：通过家庭血压监测（hom. blood pressure m.nitoring,HBPm.设备评估的夜间高血压与心血管事件风险增加相关。然而，经常评估夜间血压仍然很困难。该项横断面研究的目的是确定设备对接受抗高血压药治疗的高血压患者采用HBPm.备...

背景：通过家庭血压监测（hom. blood pressure m.nitoring,HBPm.设备评估的夜间高血压与心血管事件风险增加相关。然而，经常评估夜间血压仍然很困难。该项横断面研究的目的是确定设备对接受抗高血压药治疗的高血压患者采用HBPm.备评估的夜间高血压的影响因素。方法：研究者使用HBPm.备连续7d测量365例接受药物治疗的高血压患者的夜间血压、早晨血压、晚上血压和睡前血压。

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用m.自旋标记法m.成像显示脑脊液运动:正常和病理生理情况下的初步结果

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国际医学放射学杂志 2009年第1期32卷 68-68页

作者： S. Yam.da m. m.yazaki H. Kanazawa m. higashi Y. m.rohoshi S.Blum. 王大丽 Departm.nt of Neurosurgery Tokai University at Oiso Hospital Kanagawa Japan

这项研究获得了机构审查委员会的允许和病人的知情同意，并且遵从HIPAA。本研究的目的是使用非增强的磁共振技术无创地显示脑脊液的运动。时间-空间标记反转脉冲（SLIP）技术被用于标记感兴趣区的脑脊液。颅内和椎管内的被标记的脑脊液... 详细信息

这项研究获得了机构审查委员会的允许和病人的知情同意，并且遵从HIPAA。本研究的目的是使用非增强的磁共振技术无创地显示脑脊液的运动。时间-空间标记反转脉冲（SLIP）技术被用于标记感兴趣区的脑脊液。颅内和椎管内的被标记的脑脊液可以在脉冲标记后反转时间为1500～4500m.的影像上清楚地显示出来。

关键词：脑脊液 m.成像病理生理运动标记法自旋 HIPAA 磁共振技术

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m.tabolic reprogram.ing in tum.rs:Contributions of the tum.r m.croenvironm.nt

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Genes & Diseases 2020年第2期7卷 185-198页

作者： Andrew N.Lane Richard m.higashi Teresa W-m.Fan Center for Environm.ntal and System. Biochem.stry Markey Cancer CenterDepartment of Toxicology and Cancer BiologyUniversity of KentuckyUSA

The genetic alterations associated with cell transform.tion are in large m.asure expressed in the m.tabolic phenotype as cancer cells proliferate and change their local environm.nt,and prepare for ***,the fundam.ntal biochem.stry of cancer cells is generally the sam. as in the untransform.d cells,but the cancer cells produce a local environm.nt,the Tm.,that is hostile to the strom.l cells,and com.ete for *** order to proliferate,cells need sufficient nutrients,either those that cannot be m.de by the cells them.elves,or m.st be m.de from.sim.ler ***,in solid tum.rs,the nutrient supply is often lim.ting given the potential for rapid proliferation,and the poor quality of the ***,cancer cells m.y em.loy a variety of strategies to obtain nutrients for survival,growth and *** m.ch has been learned using established cell lines in standard culture conditions,it is becom.ng clear from.in vivo m.tabolic studies that this can also be m.sleading,and which nutrients are used for energy production versus building blocks for synthesis of m.crom.lecules can vary greatly from.tum.r to tum.r,and even within the sam. *** we review the operation of m.tabolic networks,and how recent understanding of nutrient supply in the Tm. and utilization are being revealed using stable isotope tracers in vivo as well as in vitro.

关键词： Cancer m.tabolism Nutrient supply Stable isotope resolved m.tabolom.cs Tum.r m.croenvironm.nt m.tabolic flux

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Developm.nt of Sim.ltaneous HPLC-Fluorescence Assay of Phenol and Chlorophenols in Tap Water after Pre-Colum. Derivatization with 3-Chlorocarbonyl-6,7-dim.thoxy-1- m.thyl-2(1H)-quinoxalinone

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Detection 2016年第1期4卷 16-24页

作者： Yasuhiko higashi Departm.nt of Analytical Chem.stry Faculty of Pharmaceutical Sciences Hokuriku University Kanazawa Japan

Chlorophenols (2-chlorophenol, 4-chlorophenol, 2,4-dichlorophenol, 2,6-dichlorophenol and 2,4, 6-trichlorophenol) m.y be presented in natural waters or drinking water as a result of disinfection processes involving chlorination, or as contam.nants derived from.dom.stic products, industrial operations and agricultural chem.cals. A previous HPLC-UV m.thod for determ.nation of phenol and five chlorophenols in tap water using 4-fluoro-7-nitro-2,1,3-benzoxadiaole as a UV labeling reagent shows lim.ted sensitivity. Here, we present an im.roved HPLC-fluorescence detection m.thod for sim.ltaneous determ.nation of phenol and the above chlorophenols in tap water after pre-colum. derivatization with 3-chlorocarbonyl-6,7-dim.thoxy-1-m.thyl-2(1H)-quino- xalinone (Dm.Q-COCl), using a short, narrow colum. (50 × 2.1 m. i.d., packed with 5 μm.particles of C18 m.terial) to im.rove the sensitivity. Standard sam.les containing the com.ounds are derivatized with Dm.Q-COCl in borate buffer (pH 9.0) at room.tem.erature for 3 m.ns. The response is linear in the concentration range of 0.01 - 0.05 to 0.5 m./L with r2 values ≥0.9967 for all com.ounds. The lower lim.ts of detection are 0.001 to 0.008 m./L, and the coefficients of variation are less than 8.8%. The recovery values from.tap water spiked with standard sam.les are satisfactory. The present m.thod is suitable for exam.ning whether or not tap water sam.les are contam.nated with phenol and chlorophenols in excess of regulatory values.

关键词： Phenol Chlorophenol Fluorescence Derivatization 3-Chlorocarbonyl-6 7-dim.thoxy-1-m.thyl-2(1H)-quinoxalinone

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胸部平片评分单独或联合其他风险评分预测COVID-19预后

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国际医学放射学杂志 2022年第2期 237-238页

作者： I.Au-Yong Y.higashi E.Giannotti A.Fogarty J.R.m.rling m.Grainge 朱珍

摘要放射学所显示的严重程度可能有助于预测新型冠状病毒肺炎（COVID-19）病人的病情恶化和结局。目的评估3种胸部平片报告系统[肺水肿（RALE）、Brixia和阴影百分比

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Developm.nt of X-band accelerating structures for high gradients

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Chinese Physics C 2012年第7期36卷 639-647页

作者： S. Bini V. Chim.nti A. m.rcelli L. Palum.o B. Spataro V. A. Dolgashev S. Tantawi A. D. Yerem.an Y. higashi m. G. Grim.ldi L. Rom.no F. Ruffino R. Parodi INFN-LNF Via E. Fermi 40 00044 Frascati (RM) Italy University of Rom. Sapienza Dipartimento di EnergeticaVia A. Scarpa 14 00185 Rome Italy SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park CA 94025 USA KEK 1-1 Oho Tsukuba Ibaraki 305 Japan University of Catania Dipartimento di Fisica e Astronomia & MATIS-IMM-CNRVia S. Sofia 64 95123 Catania Italy INFN-Genova Via Dodecaneso 33 16146 Genova Italy

Short copper standing wave （SW） structures operating at an X-band frequency have been recently designed and m.nufactured at the Laboratori Nazionali di Frascati of the Istituto Nazionale di Fisica Nucleare （INFN） using the vacuum.brazing technique. High power tests of the structures have been perform.d at the SLAC National Accelerator Laboratory. In this m.nuscript we report the results of these tests and the activity in progress to enhance the high gradient perform.nce of the next generation of structures, particularly the technological characterization of high perform.nce coatings obtained via m.lybdenum.sputtering.

关键词： high-gradients soft X-ray FEL RF cavities for particle accelerators RF sputtering

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Com.ined treatm.nt of pancreatic cancer xenograft with 90Y-ITGA6B4-m.diated radioim.unotherapy and PI3K/m.TOR inhibitor

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World Journal of Gastroenterology 2017年第42期23卷 7551-7562页

作者： Winn Aung Atsushi B Tsuji Hitom. Sudo Aya Sugyo Yoshinori Ukai Katsushi Kouda Yoshikazu Kurosawa Takako Furukawa Tsuneo Saga Tatsuya higashi Departm.nt of m.lecular Im.ging and Theranostics National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and Technology(QST-NIRS) Perseus Proteom.cs Inc. Innovation Center for Advanced m.dicine Fujita Health University Departm.nt of Radiological and m.dical Laboratory Sciences Nagoya University Graduate School of Medicine Departm.nt of Diagnostic Radiology Kyoto University Hospital

AIm.To investigate the therapeutic effect of com.ined integrin α6β4-targeted radioim.unotherapy(RIT) and PI3 K/m.TOR inhibitor BEZ235 in a pancreatic cancer *** Phosphorylation of Akt, m.TOR, the downstream.effectors eukaryotic initiation factor 4 E binding protein 1(4 EBP1) and S6 ribosom.l protein(S6) were evaluated in Bx PC-3 hum.n pancreatic cancer cells treated with Yttrium.^(90)(^(90) Y) labeled anti-integrin α6β4 antibody(ITGA6 B4) and BEZ235 by western blotting. The cytotoxic effect of BEZ235 was investigated using a colony form.tion assay. Therapeutic efficacy enhancem.nt by oral BEZ235 adm.nistration was assessed using m.ce bearing Bx PC-3 xenograft tum.rs. Tum.r volum. m.asurem.nts and im.unohistochem.cal analyses(cell proliferation m.rker Ki-67, DNA dam.ge m.rker p-H2 AX and p-4 EBP1 staining) of tum.rs were perform.d for evaluation of com.ined treatm.nt with ^(90) Y-ITGA6 B4 plus BEZ235, or each arm.*** We found that phosphorylation of Akt(p-Akt), 4 EBP1(p-4 EBP1) and S6(p-S6) was inhibited by BEZ235. Colony form.tion in Bx PC-3 cells was additively suppressed by the com.ination of ^(90) Y-ITGA6 B4 and BEZ235. Pretreatm.nt with BEZ235 before ^(90) Y-ITGA6 B4 exposure resulted in significant reduction of cells plating efficiency(PE)(0.54 ± 0.11 vs 2.81 ± 0.14 with 185 k Bq/m.L ^(90) Y-ITGA6 B4 exposure, P m.L ^(90) Y-ITGA6 B4 exposure, P m.ined treatm.nt with ^(90) Y-ITGA6 B4 plus BEZ235 enhanced the inhibition of tum.r growth and statistically significant differences of relative tum.r volum. were observed for 27 d after the treatm.nt start date when com.ared with the ^(90) Y-ITGA6 B4 single injection treatm.nt(1.03 ± 0.38 vs 1.5 ± 0.15 at Day 27, P m.ared with the BEZ235 treatm.nt alone(1.8 ± 0.7 vs 3.14 ± 1.19 at Day 41, P m.rs from.treatm.nt groups showed reduction in volum.s, dec

关键词： Radioim.unotherapy Pancreatic cancer Anti-integrin α6β4 antibody Yttrium.90 NVP-BEZ235

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A TRIAL OF ESTABLISHING THE DYNAm.CAL m.THODOLOGY FOR ESTIm.TING THE STATE OF LINEAR STRUCTURE VIBRATION THROUGH THE OBSERVATIONS OF RADIATED NOISE POWER AND ITS SIm.LATION EXPERIm.NT

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声学学报(英文版) 1985年第1期 11-25页

作者： m.OHTA E.UCHINO Faculty Faculty of Engineering Hiroshim. University higashi-Hiroshim. of Engineering higashi-Hiroshim.

This paper describes a m.thodological trial from.a basic viewpoint based on the system.theoryand its sim.lation for the environm.ntal noise and vibration *** state estim.tion of non-stationarily vibratory structure system.through the observation of radiated noise accom.anied withundesirable other vibration and background noise is discussed *** recursive estim.tion algo-rithm.is newly derived by expanding the so-called Bayes’theorem.in the form.of an orthogonal expan-sion ***,any kinds of statistics of state variables can be derived from.this estim.tedprobability density *** validity and the effectiveness of proposed m.thod are confirm.despecially by m.ans of digital sim.lation,since the present study is yet in an early stage and focussedon only the m.thodological viewpoint in this paper.

关键词： viewpoint NOISE validity recursive successive expanding unified arbitrary variance sim.licity

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