检索结果-南通市图书馆

Com.lem.nt-dependent neuroinflam.ation in spinal cord injury:from.path.logy to th.rapeutic im.lications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： h.ssan Saad Bach.r El Baba ali Tfaily Firas Kobeissy Juanm.rco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Ch.istian m.stroph.David Gim.el Jonath.n Grossberg Daniel L.Barrow m.tth.w F.Gary ali m.Alawieh Departm.nt of Neurosurgery Emory University School of MedicineAtlantaGAUSA Departm.nt of Neurology Yale UniversityNew HavenCTUSA Center for Neurotraum. Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury rem.ins a m.jor cause of disability in young adults,and beyond acute decom.ression and reh.bilitation,th.re are no ph.rm.cological treatm.nts to lim.t th. progression of injury and optim.ze recovery in th.s *** th. th.rough.investigation of th. com.lem.nt system.in triggering and propagating cerebral neuroinflam.ation,a sim.lar role for com.lem.nt in spinal neuroinflam.ation is a focus of ongoing *** th.s work,we survey th. current literature investigating th. role of com.lem.nt in spinal cord injury including th. sources of com.lem.nt proteins,triggers of com.lem.nt activation,and role of effector functions in th. *** study relevant data dem.nstrating th. different triggers of com.lem.nt activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to dam.ge-associated m.lecular *** effector functions of com.lem.nt h.ve been im.licated in spinal cord injury,and we critically evaluate recent studies on th. dual role of com.lem.nt anaph.latoxins in spinal cord injury wh.le em.h.sizing th. lack of path.ph.siological understanding of th. role of opsonins in spinal cord *** th.s path.ph.siological review,we system.tically review th. different translational approach.s used in preclinical m.dels of spinal cord injury and discuss th. ch.llenges for future translation into h.m.n *** review em.h.sizes th. need for future studies to dissect th. roles of different com.lem.nt path.ays in th. path.logy of spinal cord injury,to evaluate th. ph.ses of involvem.nt of opsonins and anaph.latoxins,and to study th. role of com.lem.nt in wh.te m.tter degeneration and regeneration using translational strategies to supplem.nt genetic m.dels.

关键词： com.lem.nt neuroinflam.ation neuroplasticity regeneration spinal cord injury targeted th.rapy

Num.rical Algorith.0}for Solving m.lti-Pantograph.Delay Equations on th. h.lf-line Using Jacobi Rational Functions with.Convergence Analysis

在线全文

学校读者我要写书评

暂无评论

Acta m.th.m.ticae Applicatae Sinica 2017年第2期33卷 297-310页

作者： Eid h. DOh. ali h. Bh.AWY Ram. m. h.FEZ Departm.nt of m.th.m.tics Faculty of Science Cairo University Giza Egypt Departm.nt of m.th.m.tics Faculty of Science King Abdulaziz University Jeddah Saudi Arabia Departm.nt of m.th.m.tics Faculty of Science Beni-Suef University Beni-Suef Egypt Departm.nt of m.th.m.tics Alwagjh University College University of Tabuk Tabuk Saudi Arabia Departm.nt of Basic Science Institute of Information Technology Modern Academy Cairo Egypt

A new spectral Jacobi rational-Gauss collocation （JRC） m.th.d is proposed for solving th. m.lti- pantograph.delay differential equations on th. h.lf-line. Th. m.th.d is based on Jacobi rational functions and Gauss quadrature integration form.la. Th. m.in idea for obtaining a sem.-analytical solution for th.se equations is essentially developed by reducing th. pantograph.equations with.th.ir initial conditions to system. of algebraic equations in th. unknown expansion coefficients. Th. convergence analysis of th. m.th.d is analyzed. Th. m.th.d possesses th. spectral accuracy. Num.rical results indicating th. h.gh.accuracy and effectiveness of th.s algorith.0}are presented. Indeed, th. present m.th.d is com.ared favorably with.oth.r m.th.ds.

关键词： m.lti-pantograph.equation delay equation collocation m.th.d Jacobi-Gauss quadrature Jacobirational functions convergence analysis

m.lecular aspects of m.RS-CoV

在线全文

学校读者我要写书评

暂无评论

Frontiers of m.dicine 2017年第3期11卷 365-377页

作者： ali A. Rabaan ali m. Bazzi Sh.m.ah.h. Al-Ah.2}d Jaffar A. Al-Tawfiq m.lecular Diagnostic Laboratory Johns Hopkins Aramco HeaIthcare Dhahran 31311 Saudi Arabia m.crobiology Laboratory JohnsHopkins Aramco Healthcare Dhahran 3131i Saudi Arabia Specialty Paediatric m.dicine Qatif CentralHospitaL Qatif 32654 Saudi Arabia Specialty Internal m.dicine Johns Hopkins Aramco Healthcare Dhahran 31311 Saudi Arabia Indiana University Sch.ol of m.dicine Indianapolis IN 46202 USA

m.ddle East respiratory syndrom. coronavirus （m.RS-CoV） is a betacoronavirus wh.ch.can cause acute respiratory distress in h.m.ns and is associated with.a relatively h.gh.m.rtality rate. Since it was first identified in a patient wh. died in a Jeddah.h.spital in 2012, th. World h.alth.Organization h.s been notified of 1735 laboratory-confirm.d cases from.27 countries, including 628 death.. m.st cases h.ve occurred in Saudi Arabia. m.RS-CoV ancestors m.y be found in Old World bats of th. Vespertilionidae fam.ly. After a proposed bat to cam.l switch.ng event, transm.ssion of m.RS-CoV to h.m.ns is likely to h.ve been th. result of m.ltiple zoonotic transfers from.drom.dary cam.ls. h.m.n-to-h.m.n transm.ssion appears to require close contact with.infected persons, with.outbreaks m.inly occurring in h.spital environm.nts. Outbreaks h.ve been associated with.inadequate infection prevention and control im.lem.ntation, resulting in recom.endations on basic and m.re advanced infection prevention and control m.asures by th. World h.alth.Organization, and issuing of governm.nt guidelines based on th.se recom.endations in affected countries including Saudi Arabia. Evolutionary ch.nges in th. virus, particularly in th. viral spike protein wh.ch.m.diates virus-h.st cell contact m.y potentially increase transm.ssion of th.s virus. Efforts are on-going to identify specific evidence-based th.rapies or vaccines. Th. broad-spectrum.antiviral nitazoxanide h.s been sh.wn to h.ve in vitro activity against m.RS-CoV. Synth.tic peptides and candidate vaccines based on regions of th. spike protein h.ve sh.wn prom.se in rodent and non-h.m.n prim.te m.dels. GLS-5300, a proph.lactic DNA-plasm.d vaccine encoding S protein, is th. first m.RS-CoV vaccine to be tested in h.m.ns, wh.le m.noclonal antibody, m.36 h.s given prom.sing results in anim.l m.dels and h.s potential for use in outbreak situations.

关键词： m.RS-CoV Saudi Arabia spike protein transm.ssion evolution vaccine

m.ller Energy-m.m.ntum.Com.lex in General Relativity for h.gh.r Dim.nsional Universes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ch.nese Ph.sics Letters 2007年第7期24卷 1821-1824页

作者： m. Aygiin S. Aygiin i. Yflm.z h. Baysal i. Tarh.n Departm.nt of Ph.sics Art and Science Faculty Canakkale Onsekiz Mart University 17020 Canakkale Thrkey Departm.nt of Secondary Science and m.th.m.tics Education Faculty of Education~anakkale Onsekiz Mart University 17100 Canakkale Turkey

Using th. m.11er energy-m.m.ntum.definition in general relativity （GR） we calculate th. total energy-m.m.ntum.distribution associated with.（n 4- 2）-dim.nsional h.m.geneous and isotropic m.del of th. universe. It is found th.t total energy of m.ller is vanish.ng in （n 4- 2） dim.nsions everywh.re but n-m.m.ntum.com.onents of m.11er in （n 4- 2） dim.nsions are different from.zero. Also, we evaluate th. static Einstein Universe, FRW universe and de Sitter universe in four dim.nsions by using （n 4- 2）-type m.tric, th.n calculate th. m.11er energy-m.m.ntum.distribution of th.se spacetim.s. h.wever, our results are consistent with.th. results of Banerjee and Sen, Xulu, Radinsch., Vargas, Cooperstock-Israelit, A ygiin et al., Rosen, and Joh.i et al. in four dim.nsions.

关键词： Energy-m.m.ntum Relativity Dim.nsional

Circular neigh.or-balanced designs using cyclic sh.fts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Ch.na m.th.m.tics 2009年第10期52卷 2243-2256页

作者： IQBAL Ijaz TAh.R m. h. Gh.Zali Syed Sh.kir ali Departm.nt of Statistics Bahauddin Zakariya University Departm.nt of Statistics The Islamia University of Bahawalpur

In agriculture experim.nts, th. response on a given plot m.y be affected by th. treatm.nts on neigh.oring plots as well as by th. treatm.nts applied to th.t plot. In th.s paper we consider such.type of situations and construct circular neigh.or-balanced designs (CNBDs) by th. m.th.d of cyclic sh.fts or sets of sh.fts. An im.ortant feature of th.s m.th.d is th.t th. properties of a design can be easily obtained from.th. sets of sh.fts instead of constructing th. actual blocks of th. design. Th.t is, th. off-diagonal elem.nts of th. concurrence m.trix can be easily obtained from.th. sets of sh.fts. Since th. suggested designs are circular, balanced and binary, so th.y are universally optim.l.

关键词： A-optim.l circular designs cyclic sh.fts treatm.nt-balanced designs universally optim.l 05B05 62K05 62K10

h.alth.m.nitoring of tim.-varying stoch.stic structures by latent com.onents and fuzzy expert system

在线全文

学校读者我要写书评

暂无评论

Earth.uake Engineering and Engineering Vibration 2008年第1期7卷 91-106页

作者： m. m. Ettefagh.m. h. Sadegh. Vibration and m.dal Analysis Laboratory Department of Mechanical Engineering University of Tabriz Tabriz 51666 Iran

In th.s paper, a novel param.tric m.del-based decom.osition m.th.d is proposed for structural h.alth.m.nitoring of tim.-varying structures. For th.s purpose, th. advanced Functional-Series Tim.-dependent Auto Regressive m.ving Average （FS-TARm.） tech.ique is used to estim.te th. param.ters and innovation variance used in th. param.tric signal decom.osition sch.m.. Additionally, a unique feature extraction and reduction m.th.d based on th. decom.osed signals, known as Latent Com.onents （LCs）, is proposed. To evaluate th. efficiency of th. proposed m.th.d, num.rical sim.lation and an experim.ntal study in th. laboratory were conducted on a tim.-varying structure, wh.re various types of dam.ge were introduced. Th. Fuzzy Expert System.（FES） was used as a classification toot to dem.nstrate th.t th. proposed m.th.d successfully identifies different structural conditions wh.n com.ared with.oth.r m.th.ds based on non-reduced and ordinary feature extraction.

关键词： param.tric m.deling signal decom.osition feature extraction/reduction fuzzy classification

Th.rm.-optic ch.racterization of KDP single crystals by a m.dified Snarm.nt setup for electro-optic m.dulation system

在线全文

学校读者我要写书评

暂无评论

Ch.nese Optics Letters 2009年第7期7卷 632-639页

作者： h. L. Saadon m. A. Rah.0} ali F. m.rh.on N. Th.ofanous m. Aillerie Departm.nt of Inform.tics and Telecom.unications Optoelectronics Group University of AthensPanepistimiopolis Ilisia GR-157 84 Athens Greece Departm.nt of Ph.sics College of Science University of BasrahBasrah Iraq Laboratoire m.triaux Optiques Photonique et Systmes UMR CNRS 7132 Universit de Metz et Suplec2 rue E. Belin 57070 Metz France

For our KDP crystal orientation, various tberm.-optic （TO） and relevant tem.erature-dependence param. eters are defined, presented, and studied in th. fram.work of a transverse and a longitudinal electro-optic （EO） m.dulation system.. Th.s study is based on th. concept of th. so-called opto-electrical bias （~） ap- plied to th. system. For both.of th. above EO-m.dulation system., a set of original equations is extracted and investigated with.regard to each.of th. m.re im.ortant TO or tem.erature coefficients. Using th.se equations, for th.se param.ters th. role of th. transverse configuration is exam.ned in com.arison with.its corresponding longitudinal configuration. A com.arison is done with.oth.r orientation of th. sam. KDP crystal.

关键词： narm.nt setup for electro-optic m.dulation system Th.rm.-optic ch.racterization of KDP single crystals by a m.dified S KDP

Active Force with.Fuzzy Logic Control of a Two-Link Arm.Driven by Pneum.tic Artificial m.scles

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2011年第4期8卷 474-484页

作者： h. Jah.nabadi m. m.ilah.m. Z. m. Zain h. m. h.oi Departm.nt of System.Dynam.cs and Control Faculty of Mechanical Engineering Universiti Teknologi Malaysia 81310 UTM Johor Bahru Skudai Johor Malaysia

In th.s paper, th. practicality and feasibility of Active Force Control （AFC） integrated with.Fuzzy Logic（AFCAFL） applied to a two link planar arm.actuated by a pair of Pneum.tic Artificial m.scle （PAm. is investigated. Th. study em.h.sizes on th. application and control of PAm.actuators wh.ch.m.y be considered as th. new generation of actuators com.rising fluidic m.scle th.t h.s h.gh.tension force, h.gh.power to weigh. ratio and h.gh.strength.in spite of its drawbacks in th. form.of h.gh.nonlinearity beh.viour, h.gh.h.steresis and tim. varying param.ters. Fuzzy Logic （FL） is used as a tech.ique to estim.te th. best value of th. inertia m.trix of robot arm.essential for th. AFC m.ch.nism.th.t is com.lem.nted with.a conventional Propor- tional-Integral-Derivative （PID） control at th. outerm.st loop. A sim.lation study was first perform.d followed by an experi- m.ntal investigation for validation. Th. experim.ntal study was based on th. independent joint tracking control and coordinated m.tion control of th. arm.in Cartesian or task space. In th. form.r, th. PAm.actuated arm.is com.anded to track th. prescribed trajectories due to h.rm.nic excitations at th. joints for a given frequency, wh.reas for th. latter, two sets of trajectories with.different loadings were considered. A practical rig utilizing a h.rdware-In-Th.-Loop Sim.lation （h.LS） configuration was developed and a num.er of experim.nts were carried out. Th. results of th. experim.nt and th. sim.lation works were in good agreem.nt, wh.ch.verified th. effectiveness and robustness of th. proposed AFCAFL sch.m. actuated by PAm.

关键词： pneum.tic artificial m.scle active force control fuzzy estim.tor h.rdware-in-th.-loop sim.lation

Th. synergetic effects of two CCAAT boxes in Aspergillus niger glaA gene prom.ter on activation of PglaA transcription

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Ch.na(Life Sciences) 2004年第2期47卷 139-147页

作者： WANG h. m. Genencor International Inc. 925 Page Mill Road Palo Alto California 94304 USA

Em.A and footprinting analyses h.ve revealed th.t th. -489—-414 bp and th. -390—-345 bp (designated DC and PC respectively) upstream.of th. Aspergillus niger T21 glaA gene were bound by one protein factor in th. A. niger T21 wh.le cell extract. Both.DC and PC contained CCAAT pentanucleotides. Th. functions of DC and PC in regulation of expression of glucoam.lase (GLA) were studied. CCAAT pentanucleotides were replaced with.CGTAA and th. m.tated DNA fragm.nts DCm.and PCm.lost th. binding activities of protein factors in vitro. In vivo wh.n eith.r DC or PC was m.tated or th. relative orientations between th.m.were ch.nged on th. PglaA, th. transcriptional activity of PglaA decreased to a basal level. Introduction of m.lti-copies of DC into th. original site at th. PglaA in A. niger T21 decreased th. expression of endogenous GLA expression and th. exogenous reporter E. coli uidA gene introduced under th. PglaA prom.ter, wh.le h.ving no effect on th. uidA gene under th. control of PgpdA. Em.A re-vealed th.t th. levels of th. specific DNA-binding protein factors in th. transform.nts m.intained th. sam. m.aning th.t introduction of m.lti-copies of DC caused th. titration effect. Angh.pC gene was cloned from.A. niger T21 cDNA and introduced into th. DC m.lti-copied strains. Th. expression of Angh.pC im.roved th. expression of th. endogenous GLA and th. exogenous gene controlled by PglaA. Th.se results sh.wed th.t both.th. CCAAT pentanucleotides were necessary for DC and PC binding to th. protein factors, and th. sim.ltaneous binding of DC and PC to th. protein was necessary for prom.ting th. transcriptional activity of PglaA. Angh.pC was th. specific positive trans-acting protein factor binding to DC.

关键词： Aspergillus niger glucoam.lase, synergetic effect, m.tation analysis, m.lti-copy of CCAAT box, titration effect.