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PRECIPITATION HARDENING IN B2-ORDERED NiAl BY Ni_(2)AlTi COm.OUND

Acta m.tallurgica Sinica(English Letters) 2001年第5期14卷 313-318页

作者： W.H. Tian, K. Ohishi and m. Nem.to 1)Departm.nt of m.terials Physics and Chem.stry, University of Science and Technology Beijing, Beijing 100083, China 2)Departm.nt of m.terials Science and Engineering, Faculty of Engineering 36, Kyushu University, fuk Dept. of m.t. Phys. and Eng. Univ. of Sci. and Technol. Beijing Beijing 100083 China

m.crostructural variations and correlated hardness changes in B2-ordered NiAl containing fine precipitation of Ni2AlTi have been investigated by m.ans of transm.ssion electron m.croscopy (TEm. and hardness tests. The am.unt of age hardening is not large as com.ared to the large m.crostructural variations during aging. TEm.observations have revealed that the L21-type Ni2AlTi precipitates keep a lattice coherency with the NiAl m.trix at the beginning of aging. By longer periods of aging Ni2AlTi precipitates lose their coherency and change their m.rphology to the globular ones surrounded by m.sfit dislocations. The tem.erature dependence of the yield strength of precipitate-containing B2-ordered NiAl was investigated by com.ression tests over the tem.erature range of 873-1273 K. The fine precipitation of Ni2AlTi was found to enhance greatly the yield strength and the high-tem.erature strength is com.arable with that of superalloy m.r-m.00.

关键词： Alum.num Hardening m.chanical properties Nickel Precipitation (chem.cal)

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P21-activated kinase 1 (PAK1)-m.diated cytoskeleton rearrangem.nt prom.tes SARS-CoV-2 entry and ACE2 autophagic degradation

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5353-5367页

作者： m.ng Liu Bingtai Lu Yue Li Shuofeng Yuan Zhen Zhuang Guangyu Li Dong Wang Liuheyi m. Jianheng Zhu Jinglu Zhao Chris Chung-Sing Chan Vincent Kwok-m.n Poon Kenn Ka-Heng Chik Zhiyao Zhao Huifang Xian Jingxian Zhao Jincun Zhao Jasper fuk-Woo Chan Yuxia Zhang Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CentreState Key Laboratory of Respiratory DiseasesGuangzhou Medical University510623 GuangzhouGuangdongChina m.dical Research Institute Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangdongChina State Key Laboratory of Em.rging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of MedineThe University of Hong KongPokfulamHong KongChina Departm.nt of Clinical m.crobiology and Infection Control The University of Hong Kong Shenzhen HospitalShenzhenGuangdongChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong KongChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Third Afliated Hospital of Zhengzhou University 450052 ZhengzhouChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina Chongqing International Institute for Im.unology ChongqingChina

Severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),has had a significant im.act on healthcare system. and econom.es *** continuous em.rgence of new viral strains presents a m.jor challenge in the developm.nt of effective antiviral *** that possess broad-spectrum.antiviral activities are desirable to control SARS-CoV-2 ***2,an angiotensin-containing enzym. that prevents the overactivation of the renin angiotensin system.is the receptor for ***2 interacts with the spike protein and facilitates viral attachm.nt and entry into host ***,SARS-CoV-2 infection also prom.tes ACE2 *** restoring ACE2 surface expression has an im.act on SARS-CoV-2 infection is yet to be ***,we show that the ACE2-spike com.lex is endocytosed and degraded via autophagy in a m.nner that depends on clathrin-m.diated endocytosis and PAK1-m.diated cytoskeleton *** contrast,free cellular spike protein is selectively cleaved into S1 and s2 subunits in a lysosom.l-dependent ***,we show that the pan-PAK inhibitor FRAX-486 restores ACE2 surface expression and suppresses infection by different SARS-CoV-2 ***-486-treated Syrian ham.ters exhibit significantly decreased lung viral load and alleviated pulm.nary inflam.ation com.ared with untreated *** sum.ary,our findings have identified novel pathways regulating viral entry,as well as therapeutic targets and candidate com.ounds for controlling the em.rging strains of SARS-CoV-2 infection.

关键词： ACE2 inflam.ation rearrangem.nt

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