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m.lecular Analysis of Legum. Nodule Developm.nt and Autoregulation

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Journal of Integrative Plant Biology 2010年第1期52卷 61-76页

作者： Brett J. ferguson Arief Indrasum.nar Satom. Hayashi Yu-Hsiang Lin Dugald E. Reid Peter m. Gresshoff ARC Centre of Excellence for Integrative Legum. Research The University of Queensland

Legum.s are highly im.ortant food, feed and biofuel crops. With few exceptions, they can enter into an intricate sym.iotic relationship with specific soil bacteria called rhizobia. This interaction results in the form.tion of a new root organ called the nodule in which the rhizobia convert atm.spheric nitrogen gas into form. of nitrogen that are useable by the plant. The plant tightly controls the num.er of nodules it form., via a com.lex root-to-shoot-to-root signaling loop called autoregulation of nodulation （AON）. This regulatory process involves peptide horm.nes, receptor kinases and sm.ll m.tabolites. Using m.dern genetic and genom.c techniques, m.ny of the com.onents required for nodule form.tion and AON have now been isolated. This review addresses these recent findings, presents detailed m.dels of the nodulation and AON processes, and identifies gaps in our understanding of these process that have yet to be fully explained.

关键词： m.lecular Analysis of Legum. Nodule Developm.nt and Autoregulation

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A sim.lation-based evaluation of the absolute and com.arative approaches in a code com.liance process from.the energy use perspective: Cold-clim.te case study

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Building Sim.lation 2022年第8期15卷 1401-1418页

作者： Sara Gilani Alex ferguson m.li Stylianou Canm.tENERGY-Ottawa Natural Resources Canada1 Haanel DrOttawaON K1A 1M1Canada

Like m.ny countries,Canada's building code includes a perform.nce com.liance path that com.ares the energy use of a proposed design to that of a reference ***,provinces across Canada are contem.lating an alternative absolute energy use intensity ***,the effect of adopting the absolute approach on house design is not well *** study first developed a proof-of-concept m.thodology for a technical sim.lation-based com.arison of the two ***,it perform.d a com.arative analysis between the design outcom.s of the two approaches using the developed *** this end,statistically representative archetypes were configured to com.ly with the prescriptive requirem.nts of the building *** characteristics of each archetype were then varied through param.tric study,and the resulting energy perform.nce under the absolute and com.arative approaches were *** results of this study indicated that the two approaches had different effects on the design and energy use of houses in heating-dom.nated clim.te *** perform.ng better under the absolute approach consum.d less energy and exhibited m.re com.act architectural *** houses were also less sensitive to im.rovem.nts in airtightness and envelope than houses perform.ng better under the com.arative *** results suggest that adopting the absolute approach based on the energy use intensity m.tric in building codes would encourage design and construction of houses with higher energy efficiency.

关键词： perform.nce path energy efficiency absolute target percent better than code reference building archetype

双能量CT在离体颈动脉内膜切除术样本上测量动脉粥样硬化钙化斑块大小的变化:单能谱keV影像的重建效果

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国际医学放射学杂志 2013年第2期 195-195页

作者： L. m.nnelli L.m. m.tsum.ri m. ferguson D. Xu B. Chu K.R. Branch 孙珊珊 Departm.nt of Radiology University of Washington Medical Center University of Washington1959 NE Pacific Street Box 357115 SeattleWA 98195-7115 USA

目的此研究目的是在不同keV影像上按组织学标准对钙化大小测量的比较。方法对5个离体颈动脉内膜切除术(CEA)样本行双能量CT成像,在不同的单能谱下重建CT影像(40、60、77、80、120、140keV),测量每幅CT影像上有代表性的钙化斑块区。对每... 详细信息

目的此研究目的是在不同keV影像上按组织学标准对钙化大小测量的比较。方法对5个离体颈动脉内膜切除术(CEA)样本行双能量CT成像,在不同的单能谱下重建CT影像(40、60、77、80、120、140keV),测量每幅CT影像上有代表性的钙化斑块区。对每个相关CEA样本的组织学钙化区在甲苯胺蓝或碱性品红染色的塑胶切片数字化影像上手动追踪。将CT影像与相关组织学切片配对。对每个keV影像上CT衍生的钙化区域与组织学上测得的钙化区域进行比较。结果共107个组织学切片与相应的CT影像配对每个组织学切片的平均钙化区域为(7.6±7)m.2(范围026.4m.2)。组织学上测得的钙化面积与在77keV(P=0.08)80keV(P=0.20)和100keV(P=0.14)的CT虚拟单能谱成像(Vm.)的重建影像上测得的钙化面积没有显著差异。结论在80keV影像集上测得的钙化面积与组织学上测得的钙化总量最为接近。要点①双能量CT可重建虚拟的单能谱影像。②在不同的keV下重建虚拟的单能谱影像显示了不同的动脉粥样硬化钙化量。③虚拟的单能谱影像可对动脉粥样硬化的钙化斑块更好地进行评价。

关键词：双能量 CT 颈动脉钙化单能谱keV

Characterization of deep acceptor level in as-grown ZnO thin film.by m.lecular beam.epitaxy

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Chinese Physics B 2014年第9期23卷 364-368页

作者： m.Asghar K.m.hm.od m.A.Hasan I.T.ferguson R.Tsu m.Willander Departm.nt of Physics The Islamia University of Bahawalpur Departm.nt of Electrical and Com.uter Engineering University of North Carolina Charlotte Departm.nt of Science and Technology Linkping University Norrkping

We report deep level transient spectroscopy results from.ZnO layers grown on silicon by m.lecular beam.epitaxy （m.E）, The hot probe m.asurem.nts reveal m.xed conductivity in the as-grown ZnO layers, and the current-voltage （l-V） m.asurem.nts dem.nstrate a good quality p-type Schottky device. A new deep acceptor level is observed in the ZnO layer having activation energy of 0.49 ± 0.03 eV and capture cross-section of 8,57 ×10^-18 cm.2. Based on the results from.Ram.n spectroscopy, photolum.nescence, and secondary ion m.ss spectroscopy （SIm.） of the ZnO layer, the observed acceptor trap level is tentatively attributed to a nitrogen-zinc vacancy com.lex in ZnO,

关键词： ZnO secondary ion m.ss spectroscopy photolum.nescence Ram.n spectroscopy

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pHairyRed： A Novel Binary Vector Containing the DsRed2 Reporter Gene for Visual Selection of Transgenic Hairy Roots

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m.lecular Plant 2011年第3期4卷 537-545页

作者： m.ng-Han Lin Peter m. Gresshoff Arief Indrasum.nar Brett J. ferguson Australian Research Council Centre of Excellence for Integrative Legum. Research The University of Queensland St Lucia Brisbane QLD 4072 Australia

We developed a new plant transform.tion vector, pHairyRed, for enabling high throughput, non-destructive selection of Agrobacterium.rhizogenes-m.diated ＇hairy-root＇ transform.tion, pHairyRed allows easy in planta visualiza- tion of transgenic tissue with m.nim.l disturbance to the plant. The DsRed2 reporter gene, encoding a red fluorescent protein, was cloned to yield pHairyRed （harbouring a m.ltiple cloning site）, which was used with the highly efficient K599 A. rhizogenes strain to infect soybean （Glycine m.x L. m.rrill） plants. DsRed2 fluorescence was easily detected in planta for the duration of a 5-week study with negligible levels of background autofluorescence. This enabled visual selection of transform.d roots and subsequent excission of non-transform.d roots, pHairyRed-transform.d roots nodu- lated norm.lly when inoculated with Bradyrhizobium.aponicum. Within the nodule, DsRed2 fluorescence was plant-spe- cific, being absent in the bacteroid-dom.nated nodule infected zone. To test the reliability of pHairyRed as a high-fidelity binary vector reporter system. the gene encoding the soybean Nod factor receptor, Gm.FRloL, was cloned into the vector for use in a com.lem.ntation study with a non-nodulating nfrloL m.tant of soybean. Com.lem.ntation was achieved and, without exception, DsRed2 fluorescence was detected in all hairy roots that successfully form.d nodules （100%, n = 34）. We anticipate broad application of this reporter system.for the further analysis of root-related events in soybean and related legum.s.

关键词： Fluorescence im.ging genetics m.lecular biology plant-m.crobe interactions soybean plant transform.tion.

Portal hypertension in polycystic liver disease patients does not affect wait-list or im.ediate post-liver transplantation outcom.s

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World Journal of Gastroenterology 2016年第45期22卷 9966-9973页

作者： Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord Jam.s W ferguson Gideon m.Hirschfield Liver Unit Queen Elizabeth Hospital Centre for Liver Research NIHR Birmingham Liver Biomedical Research Unit University of Birmingham

AIm.To establish the im.act of portal hypertension(PH) on wait-list/post-transplant outcom.s in patients with polycystic liver disease(PCLD) listed for liver transplantation. m.THODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was perform.d from.our centre. PH in the PCLD cohort was defined by the one or m.re of following param.ters:(1) presence of radiological or endoscopic docum.nted varices from.our own centre or the referral centre;(2) splenom.galy(> 11 cm. on radiology inabsence of splenic cysts accounting for increased im.ging size;(3) throm.ocytopenia(platelets m.a single cyst. RESULTS Forty-seven PCLD patients(F: m.= 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; com.ined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When com.aring the PH group with non-PH group, the m.an listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), m.dian listing m.LD(PH group, 12; non-PH group, 11; P = 0.422) m.dian listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacem.nt therapy(P = 0.317) were sim.lar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacem.nt therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the im.ediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a m.jor im.act on wait-list or peri-transplant m.rbidity.

关键词： Polycystic liver disease Portal hypertension Liver transplantation

Augm.nted efficacy of exogenous extracellular vesicles targeted to injured kidneys

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Signal Transduction and Targeted Therapy 2020年第1期5卷 817-819页

作者： Xiao-Jun Chen Kai Jiang Christopher m.ferguson Hui Tang Xiangyang Zhu Am.r Lerm.n Lilach O.Lerm.n Division of Nephrology and Hypertension Mayo ClinicRochesterMNUSA Departm.nt of Nephrology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina Departm.nt of Cardiovascular Diseases Mayo ClinicRochesterMNUSA

Dear Editor,Extracellular vesicles(EVs)derived from.m.senchym.l stem.strom.l cells(m.Cs)contain genetic and protein m.terial that stim.late tissue repair and am.liorate injury in recipient *** of particulate m.C-EVs over m.Cs in treating kidney disease include better penetration of injured glom.rular filtration barrier to access podocytes or tubular ***,system.c EV delivery yields low kidney retention efficiency,lim.ting their regenerative benefits.1 Previously,we coated adipose tissue-derived(AD)-m.C with antibodies against kidney injury m.lecule(KIm.‐1(ab-KIm.),a protein upregulated in dam.ged kidneys.2 Conjugating ab-KIm. did not im.air m.C function but increased their retention and reparative potency in m.rine renal artery stenosis(RAS).2 We hypothesized that ab-KIm. conjugation would sim.larly enhance retention of exogenously delivered EVs in ischem.c kidneys and confer superior therapeutic benefits.

关键词： kidney retention sized

Three-dim.nsional m.pping and com.arative analysis of the distal hum.n corpus cavernosum.and the inflatable penile prosthesis

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Asian Journal of Andrology 2013年第4期15卷 567-570,I0012页

作者： Tariq S Hakky Daniel ferguson Philippe E Spiess Paul Bradley Tom.FLue Rafael E Carrion Departm.nt of Urology University of South Florida Tam.a General Circle Tampa FL 33602 USA 23D3Solutions Burnaby BCV5J 5M8 Canada and Departm.nt of Urology University of Southern California San Francisco 400 Parnassus Ave San Francisco CA 94143 USA

The intricate anatom. of the corpus cavernosum.in both the flaccid and tum.scent state has not been fully elucidated. We report our experience using a three-dim.nsional （3D） scanner to reconstruct cadaveric casts and com.are them.with 3D im.ges of two prototypes of penile prosthesis. Two different m.dels of the Titan Coloplast inflatable penile prosthesis were analyzed using a 3D scanner. The first was the standard m.del and the second was a newer m.del with a rounder silicone tip. Two cadaveric phalluses were harvested using Sm.oth-Cast 300Q polyurethane m.lding. The m.lds were excised and scanned along side the penile prosthesis. 3D scans were com.leted and analyzed using Leios m.sh software, and GOm.Inspect software. The 3D scans dem.nstrated the m.an hum.n corporal radii 2 m. from.the distal tip to be 36.51 m. （36.01-37.0 m.）, which is an obtuse angle. The standard Titan penile prosthesis spherical radius at the sam. level was 202.52 m., while the new silicone tip prosthesis had a radius of 139.33 m.. 3D m.pping further dem.nstrated the trajectory of the cavernosa appeared curvilinear and the distal ends appeared blunt. The use of cadaveric cavernosal m.lds in com.ination with the 3D scanner allowed us to accurately im.ge the corpus cavernosum.for the first tim.. Our findings suggest that anatom.cally accurate corporal tips appear to be relatively blunt and that the new Titan silicone tip penile prosthesis m.re closely resem.les the hum.n corporal tip.

关键词： corpus cavernosum penile prosthesis three-dim.nsional analysis

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Open Journal of Anesthesiology 2014年第4期4卷 88-98页

作者： Kris ferguson Jason Young Peter Panagopoulos Philip Khoury George m. m.Kelvey Sam.r F. Fuleihan Walid A. Osta Departm.nt of Anesthesiology Wayne State University/Detroit Medical Center Detroit USA

The analysis of closed claim. and litigations can provide an invaluable tool to im.rove patient safety by m.nim.zing adverse anesthesia-related outcom.s. Analysis of collective data describing such claim. is integral to develop new guidelines aim.d to reduce adverse anesthesia-related events. In this study, we give a descriptive analysis of anesthesia-related claim. at the Detroit m.dical Center, Detroit, m., USA. The study analyzed different com.onents in anesthesia-related closed claim. and litigations such as m.dical, dem.graphic and socio-econom.c factors. From.67,000 procedures in anesthesiology care provider, related cases claim. were m.de in 0.057% (38/67,000) of all cases. The m.jority of claim. involved procedures involving Caucasian fem.les aged 51-55 years. The highest risk periods involved early shift tim.s during m.nday and Tuesday, particularly of procedures perform.d during August. About 33% of all cases in which death occurred involved patients who received an Obstetrics/Gynecology or an Orthopedic procedure under general anesthesia. The m.jority of closed claim. and litigations cases were distributed between procedures treating nerves injuries and anoxic encephalopathy. The OR and PACU at urban hospitals had the highest claim.rates. m. anesthesiologists constituted the lowest proportion of all anesthesia providers involved in closed claim. incidents. The average com.ensation paid was predom.nately in the range of $200,000-$250,000. In addition to reporting anesthesia related factors involved in closed claim. and litigations this study also includes a series of recom.endations which m.y work as a fram.work for im.roving anesthesia practices.

关键词： Anesthesia Closed Claim. Com.lications Litigations m.lpractice Negligence