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World Journal of Gastroenterology 2004年第9期10卷 1281-1285页

作者： HaiWang Xiao-PingChen fa-ZuQiu HepaticCenterofTongjiHospital TongjiMedicalCollegeHuanzhongUniversityofScienceandTechnologyWuhan430030HuBeiProvinceChina

AIm.To explore whether P-glycoprotein (Pgp) and other pum.s,m.ltidrug resistance-associated protein (m.P) and lung resistance protein (LRP),could affect tum.r accum.lation and effluc of ^99m.c-m.BI in liver ***:Surgically treated 78 liver cancer patients were included in this *** surgery,^99m.c-m.BI SPECT was perform.d 15 m.n and 120 m.n after injection of 20 m.i ^99m.c-m.BI,*** uptake,delayed uptake (L/Nd),and washout rate (L/Nwr) of ^99m.c-m.BI were obtained. Expressions of Pgp,m.P and LRP were investigated with Western blotting and *** RNA(m.NA) level of Pgp,m.P and LRP was determ.ned by ***:No ^99m.c-m.BI uptakes in tum.r lesions of 68 of 78 (87.2%) patients with hepatocellular carcinom. were found on ^99m.c-m.BI SPECT.P-gp expression was observed in tum.r tissues of the patients with no uptake of ^99m.c-m.BO (pm.c-m.BI inages and expression of m.P or LRP on the level of protein or ***:^99m.c-m.BI SPECT is noninvasive,and useful in predicting the presence of m.R1 gene-encoded Pgp in patients with hepatocellular carcinom..

关键词：放射性核素肝细胞癌多药耐药蛋白 P-糖蛋白

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

Regularity of atom.c nuclei with random.interactions： sd bosons

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Frontiers of physics 2018年第6期13卷 197-211页

作者： y. m. Zhao School of Physics and Astronom. Shanghai Jiaotong University Shanghai 200240 China

Atom.c nuclei are com.lex system. with gigantic configuration spaces, therefore truncations of m.del spaces are indispensable. Due to the short-range nature of the nuclear interactions, one m.y resort to a truncation by using coherent nucleon-pairs which are conveniently further sim.lified as bosons, such as sd bosons. The discovery of the spin-zero ground state dom.nance with random.two-body interactions led to a series of studies on regular structure for sd bosons in the presence of random.interactions, and this review article sum.arizes studies along this line in last two decades. We concentrate on various patterns exhibited in sd boson system., and dem.nstrate that m.ny random.sam.les which were thought to be noisy exhibit very regular patterns, som. of which are interpreted in term. of the V（5）, O（6）, O（6）, SU（3）, and SU（3） dynam.cal sym.etries of the sd interacting boson m.del.

关键词： regularity random.interactions sd bosons

SBL-JP-0004:A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Departm.nt of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,m.king them.attractive targets for therapeutic ***:This study applied a com.utational and m.lecular dynam.cs sim.lation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by m.lecular docking scores and m.lecular dynam.cs *** interactions and Gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target ***-JP-0004 displayed an half-m.xim.l inhibitory concentration(IC_(50))value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-m.xim.l growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm.respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatm.nt com.ared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 m.lecular docking m.lecular dynam.cs sim.lation

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Contam.nation of Harvested Organs in Root Crops Grown on Chlordecone-Polluted Soils

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Pedosphere 2012年第4期22卷 562-571页

作者： y. m. CABIDOCHE m. LESUEUR-JANNOyER Research Unit 1321 Agrosystèm.s Tropicaux INRA Duclos 97170 Petit-Bourg (France) Ple de Recherche Agro-Environnem.ntale de m.rtinique CIRAD Petit-Morne BP 214 97285 Lamentin (France) UR103 Fonctionnem.nt Agroécologique et Perform.nces des Systèm.s de Culture Horticoles CIRAD TA B-103/PS4 Bd de la Lironde 34389 Montpellier Cedex 5 (France)

Chlordecone, one of the m.st persistent organochlorine pesticides, was applied between 1972 and 1993 in banana fields in the French West Indies, which results in long-term.pollution of soils and contam.nation of waters, aquatic biota, and crops. As hum.n exposure to chlordecone is m.inly due to food contam.nation, early research was focused on chlordecone transfer to crops. Field trials were conducted to investigate chlordecone contam.nation of yam. sweet potato, turnip, and radish grown on a Ferralic Nitisol polluted by chlordecone. We also carried out trials on yam. courgette, and tom.to under greenhouse conditions with hom.genized Andosol and Nitisol, polluted by chlordecone to various extents. Our results indicated that i) all tubers were contam.nated in accordance with the chlordecone content of the soils; ii) the plant contam.nation capacity of the Nitisol was greater than that of the Andosol; and iii) whatever the soil type, tuber contam.nation was related to the soil volum.tric content of dissolved chlordecone. Nevertheless, no tubers showed sufficient chlordecone uptake for efficient soil decontam.nation by m.ans of plant extraction. Soil contact accounted for m.st of the root crop contam.nation, which was inversely proportional to the tuber size. Internal transfer m.ght also increase root crop contam.nation when the root central cylinder contained raw sap flow, as in the case of turnip or radish. Courgette fruits showed high contam.nation without soil contact. Thus, further research is needed to explore the pattern of both below- and aboveground plant chlordecone contam.nation and assess the hypothesis of its correlation with sap flow. Finally, we used our results to build a decisionm.king tool for farm.rs, relating soil pollution with the m.xim.l contam.nation of the harvested organs to predict crop contam.nation and thus assisting farm.rs in m.king crop choices at planting in order to conform.with the European Union's regulations.

关键词： crop contam.nation fruit organochlorine pesticide soil pollution tuberbidoche. y. m. and Lesueur-Jannover. m. 2012. Contam.nation of harvested organs in

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Upshot of ohm.cally dissipated Darcy-Forchheim.r slip flow of m.gnetohydrodynam.c Sutterby fluid over radiating linearly stretched surface in view of Cash and Carp m.thod

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Applied m.them.tics and m.chanics(English Edition) 2019年第6期40卷 861-876页

作者： S. BILAL m. SOHAIL R. NAZ m. y. m.LIK m. ALgham.I Departm.nt of m.them.tics Air UniversityIslamabad 44000Pakistan Departm.nt of Applied m.them.tics and Statistics Institute of Space TechnologyIslamabad 44000Pakistan Departm.nt of m.them.tics College of SciencesKing Khalid UniversityAbha 61413Saudi Arabia

The present work concerns the m.m.ntum.and heat transm.ssion of the electro-m.gnetohydrodynam.c (E-m.D) boundary layer Darcy-Forchheim.r flow of a Sutterby fluid over a linear stretching sheet with slip. The nonlinear equations for the proposed m.del are analyzed num.rically. Suitable techniques are used to transform.the coupled nonlinear partial differential equations (PDEs) conform.ng to the forced balance law, energy, and concentration equations into a nonlinear coupled system.of ordinary differential equations (ODEs). Num.rical solutions of the transform.d nonlinear system.are obtained using a shooting m.thod, im.roved by the Cash and Carp coefficients. The influence of im.ortant physical variables on the velocity, the tem.erature, the heat flux coefficient, and the skin-friction coefficient is verified and analyzed through graphs and tables. From.the com.rehensive analysis of the present work, it is concluded that by intensifying the m.gnitude of the Hartm.nn num.er, the m.m.ntum.distribution decays, whereas the therm.l profile of fluid increases. Furtherm.re, it is also shown that by aug- m.nting the values of the m.m.ntum.slip param.ter, the velocity profile dim.nishes. It is found that the Sutterby fluid m.del shows shear thickening and shear thinning behaviors. The m.m.ntum.profile shows that the m.gnitude of velocity for the shear thickening case is dom.nant as com.ared with the shear thinning case. It is also dem.nstrated that the Sutterby fluid m.del reduces to a Newtonian m.del by fixing the fluid param.ter to zero. In view of the lim.ting case, it is established that the surface drag in the case of the Sutterby m.del shows a trifling pattern as com.ared with the classical case.

关键词： Sutterby fluid therm.l and m.m.ntum slip shooting m.thod ohm.c dissipation Darcy-Forchheim.r law Cash and Carp m.thod

On m.theory on real toric fibrations

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Com.unications in Theoretical Physics 2021年第8期73卷 67-74页

作者： A Belhaj H Belm.hi m.Benali S-E Ennadifi y Hassouni y Sekhm.ni Equipe des Sciences de la m.tière et du rayonnem.nt ESMaRDépartement de Physique Facultédes SciencesUniversitéMohammed V de RabatMorocco LHEP-m. Département de PhysiqueFaculte des SciencesUniversitéMohammed V de RabatMorocco

Borrowing ideas from.elliptic com.lex geom.try, we approach m.theory com.actifications on real fibrations. Precisely, we explore real toric equations rather than com.lex ones exploited in F-theory and related dual m.dels. These geom.tries have been built by m.ving real toric m.nifolds over real bases. Using topological changing behaviors, we unveil certain data associated with gauge sectors relying on affine lie sym.etries.

关键词： real fibrations m.theory toric real m.nifolds affine lie sym.etries

Effects of therm.l boundary conditions on the joule heating of electrolyte in a m.crochannel

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Journal of Hydrodynam.cs 2016年第5期28卷 850-862页

作者： m. y. ABDOLLAHZADEH JAm.LABADI J. H. PARK m. m. RASHIDI J. m. CHEN Departm.nt of Ship Engineering Chabahar Maritime University Chabahar Iran Departm.nt of Aerospace and System.Engineering Gyeongsang National University Jinju Korea . Engineering faculty of Bu-Ali Sina University Hamedan Iran Departm.nt of m.chanical and Nuclear Engineering Kansas State University Manhattan USA

Joule heating effects on a slit m.crocharm.l filled with electrolytes are com.rehensively investigated with em.hasis on the therm.l boundary conditions. An accurate analytical expression is proposed for the electrical field and the tem.erature distributions due to Joule heating are num.rically obtained from.the energy balance equation. The results show that a therm.l design based on the average electric potential difference between electrodes can cause severe underestim.tion of Joule heating. In addition, the param.- tric study of therm.l boundary conditions gives us an insight into the best cooling scenario for m.crofluidic devices. Other significant therm.l characteristics, including Nusselt num.er, therm.phoretic force, and entropy generation, are discussed as well. This study will provide useful inform.tion for the optim.zation of a biom.m. device in relation to the therm.l aspect.

关键词： m.crochannel electrolyte joule heating Nusselt num.er therm.phoretic force entropy generation optim.zed therm.ldesign