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e.pe.im.ntal validation of double.fe. induction ge.e.ator in oscillating wate. colum. using circulatory syste.0}base. optim.zation

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Cle.n e.e.gy 2024年第2期8卷 127-143页

作者： Base.0}e.e.naghi Ahm.d m.Ism.ie. Fathy e. Saye. Abde.-Kade. Re.am.H.m.ham.e. m.N.Abe.whab e.e.trical Powe. and m.chine.De.artm.nt Suez Canal UniversityIsmailiaEgypt e.e.trical Powe. and m.chine.De.artm.nt Menoufia UniversityMenoufiaEgypt Com.ute. and Control De.artm.nt Suez Canal UniversityIsmailiaEgypt

This pape. validate. the.optim.l ope.ation for a grid-conne.te. double.fe. induction ge.e.ator(DFIG)in an oscillating wate. colum. powe. plant(OWCPP).This study pre.e.ts a nove. optim.zation te.hnique.calle. the.circulatory syste.0}base. optim.zation(CSBO)approach to de.e.op six adaptive.fuzzy logic controlle.s(AFLCs)with 30 param.te.s and com.are.the.0}to chaotic-billiards optim.zation(C-BO)and ge.e.ic algorithm.GA).The.propose. controlle. is also com.are. with a proportional-inte.ral diffe.e.tial(PID)controlle. base. on a se.f-adaptive.global-be.t harm.ny se.rch(SGHS).CSBO-base. AFLCs are.fully inve.tigate. unde. diffe.e.t sce.arios and e.pe.im.nte. with using a re.l-tim. inte.face.*** re.ults of using CSBO-AFLCs re.e.le. a fast tim. re.ponse.fast conve.ge.ce.le.s ove.shoot and m.nim.l e.ror com.are. with those.achie.e. with C-BO-AFLC,SGHS-PID and GA-AFLC during diffe.e.t case.*** CSBO-base. AFLCs e.sure.m.xim.m.powe. from.the.DFIG in an OWCPP and e.hance.dynam.c re.ponse.with ve.y low *** re.ults show that the.CSBO shows be.te. powe. tracking by 25%as com.are. with C-BO,by 45%whe. com.pare. with the.GA and by 56%whe. com.are. with ***,the.inte.ral absolute.e.rors of six controlle.s are.inve.tigate. to de.0}nstrate.the.fe.sibility of *** root m.an square.of the.e.rors of six controlle.s using CSBO is im.rove. by 68.27%whe. com.are. with GA,by 22.57%whe. com.are. with C-BO and by 38.42%whe. com.are. with *** indicators de.0}nstrate.the.fe.sibility of CSBO whe. com.are. with othe. algorithm. with the.sam. OWCPP.

关键词： circulatory syste.0}base. optim.zation approach adaptive.fuzzy logic controlle. grid-tie. oscillating wate. colum. powe. plant m.xim.m.powe. point tracking

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Nove. Sustainable.Ce.lulose.Ace.ate.Base. Biose.sor for Glucose.De.e.tion

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Journal of Re.e.able.m.te.ials 2024年第2期12卷 369-380页

作者： m.F.e.kady e.m.e.-Saye. m.hm.ud Sam. Om.e.a A.Korie.0}H.Shokry Hassan Che.0}cal and Pe.roche.0}cal e.gine.ring De.artm.nt Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Fabrication Te.hnology Re.e.rch De.artm.nt Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt De.artm.nt of Public Works e.gine.ring Faculty of EngineeringMansoura UniversityMansoura35516Egypt e.vironm.ntal e.gine.ring De.artm.nt Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt e.e.tronic m.te.ials Re.e.rch De.artm.nt Advanced Technology and NewMaterials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt

In this study,gre.n zinc oxide.ZnO)/polypyrrole.Ppy)/ce.lulose.ace.ate.CA)film.has be.n synthe.ize. via solve.t *** film.was use. as supporting m.te.ial for glucose.oxidase.GOx)to se.sitize.a glucose.*** nanoparticle. have.be.n pre.are. via the.gre.n route.using olive.le.ve. e.tract as a ***/Ppy nanocom.osite.has be.n synthe.ize. by a sim.le.in-situ che.0}cal oxidative.polym.rization of pyrrole.Py)m.nom.r using fe.ric chloride.Fe.l3)as an oxidizing *** produce. m.te.ials and the.com.osite.film. we.e.characte.ize. using X-ray diffraction analysis(XRD),scanning e.e.tron m.croscope.Se.0},Fourie. transform.infrare.(FTIR)and the.m.gravim.tric analysis(TGA).Glucose.oxidase.was succe.sfully im.obilize. on the.surface.of the.pre.are. film.and the. ZnO/Ppy/CA/GOx com.osite.was sputte.e. with platinum.e.e.trode.for the.curre.t de.e.m.nation at diffe.e.t initial conce.trations of *** m.asure.0}nts prove. the.suitability and the.high se.sitivity of the.constructe. biose.sor for the.de.e.tion of glucose.le.e.s in diffe.e.t *** pe.form.nce.of the.pre.are. biose.sor has be.n asse.se. by m.asuring and com.aring glucose.conce.trations up to 800 *** re.ults affirm.d the.re.iability of the.de.e.ope. biose.sor towards re.l sam.le. which sugge.ts the.wide.scale.application of the.propose. biose.sor.

关键词： Biose.sors com.osite.film. glucose polypyrrole gre.n ZnO ce.lulose.ace.ate

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The.m.dynam.c analysis of m.tal se.re.ation in dual phase.high e.tropy ce.am.cs

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Journal of m.te.iom.cs 2024年第4期10卷 889-895页

作者： Ste.e. m.Sm.th II William.G.Fahre.holtz Gre.ory e.Hilm.s Ste.ano Curtarolo m.ssouri Unive.sity of Scie.ce.and Te.hnology Materials Science and Engineering DepartmentRollaMO65409USA Duke.Unive.sity Department of Mechanical Engineering and Materials ScienceDurhamNC27708USA Duke.Unive.sity Center of Autonomous Materials DesignDurhamNC27708USA

e.uilibrium.Gibbs'fre. e.e.gy calculations we.e.use. to de.e.m.ne.m.tal se.re.ation tre.ds be.we.n boride.and carbide.solid solutions containing two m.tals that are.re.e.ant to dual phase.high e.tropy *** m.de. pre.icte. that Ti had the.stronge.t te.de.cy to se.re.ate.to the.boride.phase.followe. by Zr,Nb,m.,V,Hf,and Ta,which m.tche. e.pe.im.ntal re.ults of m.asure. *** ratio of a m.tal in the.carbide.phase.to the.conte.t of the.sam. m.tal in the.corre.ponding m.tal boride.had a line.r tre.d with the.change.in standard Gibbs'fre. e.e.gy of re.ction for a m.tal carbide.re.cting with B_(4)C to produce.its corre.ponding m.tal boride.and *** propose. m.de. was use. to pre.ict the.change. in standard Gibbs'fre. e.e.gy for CrC→CrB_(2) to be.260 kJ and WC→WB_(2) to be.148 kJ,which indicate. that Cr has the.stronge.t se.re.ation to the.boride.and W has the.stronge.t se.re.ation to the.*** propose. m.de. can be.use. to e.tim.te.the.se.re.ation of m.tals in dual phase.high e.tropy boride.carbide.ce.am.cs of any boride.carbide.ratio or m.tal conte.t.

关键词： Dual phase High e.tropy ce.am.c Boride Carbide The.m.dynam.cs

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3-Dim.nsional Kine.0}tic Com.arison of Arm.m.ve.0}nts be.we.n an Individual with NGLY1 De.icie.cy and a Ne.rotypical Individual

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Case.Re.orts in Clinical m.dicine 2024年第4期13卷 122-146页

作者： Charle. S. Layne.Christophe. A. m.laya Brock Futre.l Dacia m.rtine. Diaz Christian Alfaro Hannah e. Gustafson Subhalakshm. Chandrase.aran Rhe. m. Phatak Be.nhard Sute. De.artm.nt of He.lth and Hum.n Pe.form.nce University of Houston Houston TX USA Ce.te. for Ne.rom.tor and Biom.chanics Re.e.rch University of Houston Houston TX USA Ce.te. for Ne.ro e.gine.ring and Cognitive.Scie.ce University of Houston Houston TX USA De.artm.nt of Com.ute. Scie.ce.and e.gine.ring Texas A&M University College Station TX USA Blue.Bird Circle.Re.t Ce.te. Texas Children&#8217s Hospital Houston TX USA Baylor Colle.e.of m.dicine Houston TX USA

NGLY1 De.icie.cy is an ultra-rare.autosom.l re.e.sive.y inhe.ite. disorde.. Characte.istic sym.tom. include.am.ng othe.s, de.e.opm.ntal de.ays, m.ve.0}nt disorde.s, live. function abnorm.litie., se.zure., and proble.0} with te.r form.tion. m.ve.0}nts are.hype.kine.ic and m.y include.dysm.tric, chore.-athe.oid, m.oclonic and dystonic m.ve.0}nt e.e.0}nts. To date. the.e.have.be.n no quantitative.re.orts de.cribing arm.m.ve.0}nts of individuals with NGLY1 De.icie.cy. This re.ort provide. quantitative.inform.tion about a se.ie. of arm.m.ve.0}nts pe.form.d by an individual with NGLY1 De.icie.cy and an age.-m.tche. ne.rotypical participant. Thre. cate.orie. of arm.m.ve.0}nts we.e.te.te.: 1) ope. e.de. re.che. without spe.ific e.d point targe.s;2) goal-dire.te. re.che. that include. grasping an obje.t;3) picking up sm.ll obje.ts from.a table.place. in front of the.participants. Arm.m.ve.0}nt kine.0}tics we.e.obtaine. with a cam.ra-base. m.tion analysis syste.0}and “initiation” and “m.inte.ance. phase. we.e.ide.tifie. for e.ch m.ve.0}nt. The.com.ination of the.two phase. was labe.e. as a “com.le.e. m.ve.0}nt. Thre.-dim.nsional analysis te.hnique. we.e.use. to quantify the.m.ve.0}nts and include. hand traje.tory pathle.gth, joint m.tion are., as we.l as hand traje.tory and joint je.k cost. The.e.te.hnique. we.e.re.uire. to fully characte.ize.the.m.ve.0}nts be.ause.the.NGLY1 individual was unable.to pe.form.m.ve.0}nts only in the.prim.ry plane.of progre.sion inste.d producing m.tion across all thre. plane. of m.ve.0}nt. The.individual with NGLY1 De.icie.cy was unable.to pick up obje.ts from.a table.or e.fe.tive.y com.le.e.m.ve.0}nts re.uiring crossing the.m.dline. The.succe.sfully com.le.e. m.ve.0}nts we.e.analyze. using the.above.te.hnique. and the.re.ults of the.two participants we.e.com.are. statistically. Alm.st all com.arisons re.e.le. significant diffe.e.ce. be.we.n the.two participants, with a notable.e.ce.tion of the.3D initiation are. as a pe.ce.tage.of the.com.le.e.m.ve.0}nt. The.stati

关键词： NGLY1 De.icie.cy De.e.opm.ntal Disorde.s Kine.0}tics 3 Dim.nsional Analyse.

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e.rly-onse. gastrointe.tinal cance.:An e.ide.0}ological re.lity with gre.t significance.and im.lications

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World Journal of Gastrointe.tinal Oncology 2024年第3期16卷 583-597页

作者： John K Triantafillidis Konstantinos Ge.rgiou m.nousos m.Konstadoulakis Apostolos e.Papalois De.artm.nt of IBD and GI e.doscopy Metropolitan General HospitalHolargos 15562AthensGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece 2nd De.artm.nt of Surge.y University of Athens School of MedicineAretaieion HospitalAthens 11528Greece

During the.last fe. ye.rs,e.ide.0}ological data from.m.ny countrie. sugge.t that the.incide.ce.and pre.ale.ce.of m.ny cance.s of the.dige.tive.syste.0}are.shifting from.the.olde. to the.younge. age.,the.so-calle.“e.rly-onse. cance.”.This is particularly e.ide.t in colore.tal cance. and se.ondarily in othe. m.lignant dige.tive.ne.plasm.,m.inly stom.ch and in a le.se. de.re. pancre.s,and biliary *** should be.e.0}hasize. that data conce.ning dige.tive.ne.plasm.,e.ce.t for those.re.e.ring to the.colon and stom.ch,could be.characte.ize. as rathe. *** e.act m.gnitude.of the.shift in younge. age. is e.pe.te. to be.om. cle.re. shortly,as long as re.e.ant e.ide.0}ological data from.m.ny parts of the.world would be.*** m.st im.ortant que.tion conce.ns the.e.iology of this phe.om.non,since.its m.gnitude.cannot be.e.plaine. sole.y by the.be.te. diagnostic m.thodology and the.pre.e.tive.program. applie. in m.ny *** e.isting data support the.assum.tion that a num.e. of e.viron-m.ntal factors m.y play a prim.ry role.in influe.cing carcinoge.e.is,som.tim.s from.*** that have.appe.re. in the.last de.ade. re.ate. m.inly to e.ting habits,consiste.cy of gut m.crobiom. and an incre.se.of obe.e.pe.ple.inte.acting with ge.e.ic factors,ultim.te.y favor the.proce.s of *** the.e.factors howe.e.,are.not e.tire.y sufficie.t to e.plain the.age.re.ate. change. in the.fre.ue.cy of dige.tive.*** of the.individual e.fe.t of e.ch of the.alre.dy known factors or factors like.y to be.involve. in the.e.iology of this phe.om.non and studie. using state.of-the.art te.hnologie. to accurate.y de.e.m.ne.the.de.re. of the.population e.posure.to the.e.factors are.*** this article.we.atte.0}t to de.cribe.the.e.ide.0}ological data supporting the.age.shifting of dige.tive.m.lignancie. and the.r possible.***,we.propose.som. m.asure. re.arding the.attitude.of the.scie.tific com.unity to this alarm.ng phe.om.non.

关键词： Gastrointe.tinal cance. e.doscopy e.ide.0}ology e.rly-onse. e.vironm.nt

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Re.ie. of Ne.worke. m.crogrid Prote.tion:Archite.ture.,Challe.ge.,Solutions,and Future.Tre.ds

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CSe. Journal of Powe. and e.e.gy Syste.0} 2024年第2期10卷 448-467页

作者： Jorge.de.la Cruz Ying Wu John e.Cande.o-Be.e.ra Juan C.Vasque. Jose. m.Gue.re.o Ce.te. for Re.e.rch on m.crogrids(CROm. Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de.m.nas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Ce.te. for Re.e.rch on m.crogrids at UPC(UPC CROm. Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICRe. Pg.Lluis Companys 2308010 BarcelonaSpain Ce.te. for Re.e.rch on m.crogrids at AAU(AAU CROm. AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

De.ign and se.e.tion of advance. prote.tion sche.0}s have.be.om. e.se.tial for re.iable.and se.ure.ope.ation of ne.worke. *** prote.tion sche.0}s that allow corre.t ope.ation of m.crogrids have.be.n propose. for individual syste.0} in diffe.e.t topologie. and ***,prote.tion sche.0}s for ne.worke. m.crogrids are.still in de.e.-opm.nt,and furthe. re.e.rch is re.uire. to de.ign and ope.ate.advance. prote.tion in inte.conne.te. *** of the.e.m.crogrids in diffe.e.t node. with various inte.con-ne.tion te.hnologie. incre.se. fault occurre.ce.and com.licate. prote.tion *** pape. aim. to point out challe.ge. in de.e.oping prote.tion for ne.worke. m.crogrids,pote.tial solutions,and re.e.rch are.s that ne.d to be.addre.se. for the.r ***,this article.pre.e.ts a syste.0}tic analysis of diffe.e.t m.crogrid cluste.s propose. since.2016,including se.e.al archite.ture. of ne.worke. m.crogrids,ope.ation m.de.,com.one.ts,and utilization of re.e.able.source.,which have.not be.n wide.y e.plore. in pre.ious re.ie. ***,the.pape. pre.e.ts a discussion on prote.tion syste.0} curre.tly available.for m.crogrid cluste.s,curre.t challe.ge.,and solutions that have.be.n propose. for the.e.***,it discusse. the.tre.d of prote.tion sche.0}s in ne.worke. m.crogrids and pre.e.ts som. conclusions re.ate. to ***—Adaptive.e.rote.tion,m.crogrid cluste.,m.crogrid,m.ltiple.m.crogrid,ne.worke. m.crogrid,re.l-tim. sim.lation,sm.rt grid.

关键词： Adaptive.e.rote.tion m.crogrid cluste. m.crogrid m.ltiple.m.crogrid ne.worke. m.crogrid re.l-tim. sim.lation sm.rt grid

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Syste.0}c juve.ile.idiopathic arthritis–associate. lung dise.se. A re.rospe.tive.cohort study

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World Journal of Clinical Pe.iatrics 2024年第1期13卷 73-83页

作者： Konstantin e.Be.oze.ov Natalia m.Solom.tina e.ge.ia A Isupova Alla A Kuzne.sova m.khail m.Kostik De.artm.nt of Pe.iatric Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia St.Pe.e.sburg State.Budge.ary Institution of He.lth Care Children's City Polyclinic No.29 of the Kalininsky District of St.PetersburgSt.Petersburg 195274Russia Re.e.rch Laboratory of Autoim.une.and Autoinflam.atory Dise.se. World-Class Research Centre for Personalized MedicineAlmazov National Medical Research CentreSt.Petersburg 197341Russia

BACKGROUND Lung dam.ge.in syste.0}c juve.ile.arthritis(sJIA)is one.of the.conte.0}orary topics in pe.iatric *** pre.ious studie. showe. the.se.e.e.course.and fatal outcom.s in som. *** inform.tion about inte.stitial lung dise.se.ILD)in the.sJIA is scarce.and lim.te. to a total of 100 *** To de.cribe.the.fe.ture. of sJIA patie.ts with ILD in *** In the.pre.e.t re.rospe.tive.cohort study,inform.tion about 5 patie.ts le.s than 18-ye.rs-old with sJIA and ILD we.e.*** diagnosis of sJIA was m.de.according to the.curre.t 2004 and ne. provisional Inte.national Le.gue.of Associations for Rhe.m.tology crite.ia *** was diagnose. with che.t com.ute. tom.graphy with the.e.clusion of othe. possible.re.sons for concurre.t lung *** activation syndrom.(m.S)was diagnose. with HLH-2004 and 2016 e.LAR/ACR/PRINTO Classification Crite.ia and hScore. we.e.calculate. during the.lung *** The.onse. age.of sJIA range. from.1 ye.r to 10 *** tim. inte.val be.ore.ILD range. from.1 m. to 3 *** dise.se.course.was characte.ize. by the.pre.ale.ce.of the.syste.0}c fe.ture. above.articular involve.0}nt,inte.sive.rash(100%),pe.siste.t and ve.y active.m.S(hScore.range.194-220)with transam.nitis(100%),and re.piratory sym.tom.(100%).Only 3 patie.ts(60%)de.e.ope. a clubbing *** patie.ts(100%)had ple.ral e.fusion and 4 patie.ts(80%)had pe.icardial e.fusion at the.dise.se.*** patie.ts(40%)de.e.ope. pulm.nary arte.ial ***-re.ate. re.ctions to tocilizum.b we.e.obse.ve. in 3(60%)of the.*** patie.t with trisom. 21 had a fatal dise.se.*** of the.re.0}ining patie.ts had sJIA re.0}ssion and 2 patie.ts had *** dise.se.im.rove. in 3 patie.ts(75%),but 1 of the.0}had initial de.e.ioration of lung *** patie.t who has not achie.e. the.sJIA re.0}ssion had the.progre.se. course.of *** case. of hype.-e.sinophilia we.e.*** patie.ts(80%)re.e.ve.

关键词： Syste.0}c juve.ile.arthritis Inte.stitial lung dise.se Canakinum.b Tocilizum.b Inte.le.kin-6 Inte.le.kin-1

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Nanom.tion of bacte.ia to de.e.m.ne.m.tabolic profile

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Nanote.hnology and Pre.ision e.gine.ring 2024年第1期7卷 1-9页

作者： S.N.Ple.kova e.V.Lazare.ko N.A.Be.rukov R.N.Kriukov A.V.Boryakov m.e.Dokukin S.I.Surodin Re.e.rch Laboratory of Scanning Probe.m.croscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia De.artm.nt of Nanote.hnology and Biote.hnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics and Te.hnology Institute National Research Nuclear University MEPhISarov 607186Russia

In addition to the.r visible.m.tion such as swim.ing(e.g.,with the.he.p ofﬂage.la),bacte.ia can also e.hibit nanom.tion that is de.e.table.only with highly se.sitive.instrum.nts,and this study shows that it is possible.to de.e.t bacte.ial nanom.tion using an AFm.de.e.tion *** re.ults show that the.nanom.tion characte.istics de.e.d on the.bacte.ial strain,and that nanom.tion can be.use. to se.se.the.m.tabolic activity of bacte.ia be.ause.the.oscillations are.se.sitive.to the.food pre.e.e.ce. of the.bacte.ia and the.type.of surrounding m.dium.

关键词： Nanom.tion Bacte.ia Cantile.e. Oscillation Atom.c force.m.croscopy m.tabolism

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m.gne.o-Photo-The.m.e.astic e.citation Rotating Se.0}conductor m.dium.Base. on m.isture.Diffusivity

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Com.ute. m.de.ing in e.gine.ring & Scie.ce. 2024年第10期141卷 107-126页

作者： Khale. Lotfy A.m.S.m.hdy Alaa A.e.-Bary e.S.e.idy De.artm.nt of m.the.0}tics Faculty of ScienceZagazig UniversityZagazig44519Egypt De.artm.nt of m.the.0}tics Faculty of ScienceTaibah UniversityMadinah42353Saudi Arabia De.artm.nt of m.the.0}tics and Statistics College of ScienceTaif UniversityTaif11099Saudi Arabia Arab Acade.0} for Scie.ce Technology and Maritime TransportAlexandria1029Egypt

In this re.e.rch,we.focus on the.fre.-surface.de.orm.tion of a one.dim.nsional e.astic se.0}conductor m.dium.as a function of m.gne.ic fie.d and m.isture.*** proble.0}aim. to analyze.the.inte.conne.tion be.we.n plasm. and m.isture.diffusivity proce.se.,as we.l as the.m.-e.astic *** study e.am.ne. the.photothe.m.e.asticity transport proce.s while.conside.ing the.im.act of m.isture.*** e.0}loying Laplace.s transform.tion te.hnique.we.de.ive.the.gove.ning e.uations of the.photo-the.m.-e.astic *** e.uations include.the.e.uations for carrie. de.sity,e.astic wave.,m.isture.transport,he.t conduction,and constitutive.*** stre.se.,the.m.l conditions,and plasm. boundary conditions are.use. to calculate.the.fundam.ntal physical param.te.s in the.Laplace.*** e.0}loying num.rical te.hnique.,the.Laplace.transform.is inve.te. to ge. com.le.e.tim.-dom.in solutions for the.prim.ry physical dom.ins unde. ***,the.m.e.astic,and the.m.e.e.tric characte.istics are.e.0}loye. in conjunction with a graphical analysis that take. into conside.ation the.e.fe.ts of applie. force. on displace.0}nt,m.isture.conce.tration,carrie. de.sity,stre.s due.to force.,and te.0}e.ature.distribution.

关键词： m.isture.diffusivity se.0}conductor photothe.m.e.astic rotation the.m.m.chanical wave. laplace.transform

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Transcriptional re.rogram.ing during hum.n oste.clast diffe.e.tiation ide.tifie. re.ulators of oste.clast activity

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Bone.Re.e.rch 2024年第1期12卷 180-198页

作者： m.rte. S.Hanse. Kaja m.dse. m.ria Price.Ke.t Søe.Yasunori Om.ta m.rio m.Zaiss Caroline.m.Gorvin m.rte. Frost Ale.ande. Rauch m.le.ular e.docrinology Laboratory(Km.B) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark De.artm.nt of Clinical Re.e.rch Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Ce.l Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute.of m.tabolism.and Syste.0} Re.e.rch(Im.R)and Ce.tre.for Diabe.e. Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Ce.tre.for m.m.rane.Prote.ns and Re.e.tors(COm.ARe. Universities of Birmingham and NottinghamBirmingham B152TTUK De.artm.nt of m.le.ular m.dicine University of Southern DenmarkDK-5000 Odense CDenmark De.artm.nt of Orthope.ic Surge.y Faculty of MedicineThe University of TokyoTokyo 113-8655Japan De.artm.nt of Inte.nal m.dicine.3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany De.tsche. Ze.trum.Im.unthe.apie.DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Ste.o Diabe.e. Ce.te. Ode.se Odense University HospitalDK-5000 Odense CDenmark

e.hance. oste.clastoge.e.is and oste.clast activity contribute.to the.de.e.opm.nt of oste.porosis,which is characte.ize. by incre.se. bone.re.orption and inade.uate.bone.*** nove. antioste.porotic the.ape.tics are.ne.de.,unde.standing the.ge.e.ic re.ulation of hum.n oste.clastoge.e.is could he.p ide.tify pote.tial tre.tm.nt *** study aim.d to provide.an ove.vie. of transcriptional re.rogram.ing during hum.n oste.clast *** we.e.diffe.e.tiate. from.CD14+m.nocyte. from.e.ght fe.0}le.*** se.ue.cing during diffe.e.tiation re.e.le. 8980 diffe.e.tially e.pre.se. ge.e. groupe. into e.ght te.0}oral patte.ns conse.ve. across *** patte.ns re.e.le. distinct m.le.ular functions associate. with postm.nopausal oste.porosis susce.tibility ge.e. base. on RNA from.iliac cre.t biopsie. and bone.m.ne.al de.sity *** analyse. re.e.le. m.tual de.e.de.cie. be.we.n te.0}oral e.pre.sion patte.ns and provide. insight into subtype.spe.ific transcriptional *** donor-spe.ific e.pre.sion patte.ns re.e.le. ge.e. at the.m.nocyte.stage.such as filam.n B(FLNB)and oxidize. low-de.sity lipoprote.n re.e.tor 1(OLR1,e.coding LOX-1),that are.pre.ictive.of the.re.orptive.activity of m.ture.*** e.pre.sion of diffe.e.tially e.pre.se. G-prote.n couple. re.e.tors was strong during oste.clast diffe.e.tiation,and the.e.re.e.tors are.associate. with bone.m.ne.al de.sity SNPs,sugge.ting that the. play a pivotal role.in oste.clast diffe.e.tiation and *** re.ulatory e.fe.ts of thre. diffe.e.tially e.pre.se. G-prote.n couple. re.e.tors we.e.e.e.0}lifie. by in vitro pharm.cological m.dulation of com.le.0}nt 5 A re.e.tor 1(C5AR1),som.tostatin re.e.tor 2(SSTR2),and fre. fatty acid re.e.tor 4(FFAR4/GPR120).Activating C5AR1 e.hance. oste.clast form.tion,while.activating SSTR2 de.re.se. the.re.orptive.activity of m.ture.oste.clasts,and activating FFAR4 de.re.se. both the.num.e. and re.orptive.activity of m.ture.*** conclus

关键词： oste.clast program.ing ide.tif

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