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Search for m.croglia-specific peptid.s:ad.ances in the d.scovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss d.partm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled.and.chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurod.generative pathology and.every injury or stroke-related.*** key m.d.ators of these neuroinflam.atory states are glial cells known as m.croglia,the resid.nt im.une cell at the core of the inflam.atory event,and.astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based.on the responses of said.m.croglia,their phenotypes are suggested.to follow those of m.crophages;m. and.m. are opposites of pro-and.***,m.croglial phenotypes have been id.ntified.to be on an inflam.atory spectrum.encom.assing d.velopm.ntal,hom.ostatic,and.reparative behaviors as opposed.to their ability to affect d.vastating cell d.ath cascad.s and.scar tissue form.tion.

关键词： inflam.ation pathology d.ath

Efficient Visible Photolum.nescence from.Self-Assem.led.Ge Qd. Em.ed.ed.in Silica m.trix

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Chinese Physics Letters 2017年第6期34卷 112-116页

作者： Alireza Sam.vati Zahra Sam.vati A. F. Ism.il m. H. d. Othm.n m. A. Rahm.n A. K. Zulhairun Ad.anced.m.m.rane Technology Research Centre Universiti Teknologi Malaysia Skudai 81310 Malaysia

m.asuring the growth param.ters of Ge quantum.d.ts （Qd.） em.ed.ed.in SiO2/Si hetero-structure is pre- requisite for d.veloping the optoelectronic d.vices such as photovoltaics and.sensors. Their optical properties can be tuned.by tailoring the growth m.rphology and.structures, where the growth param.ters＇ optim.zations still need.to be explored. We d.term.ne the effect of annealing tem.erature on surface m.rphology, structures and.optical properties of Ge//SiO2//Si hetero-structure. Sam.les are grown via rf m.gnetron sputtering and.subsequent characterizations are m.d. using im.ging and.spectroscopic techniques.

关键词： Ge Efficient Visible Photolum.nescence from.Self-Assem.led.Ge Qd. Em.ed.ed.in Silica m.trix Qd.

Tight Focusing Properties of Azim.thally Polarized.Pair of Vortex Beam. through a d.electric Interface

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Chinese Physics Letters 2017年第7期34卷 109-113页

作者： C. A. P. Janet m. Lavanya K. B. Rajesh m. Ud.ayakum.r Z. Jaroszewicz d. Velauthapillai d.partm.nt of Physics St.Xavier's Catholic College of Engineering Nagercoil Tamilnadu India d.partm.nt of Physics PSGR Krishnammal College for Women Coimbatore Tamilnadu India d.partm.nt of Physics Chikkanna Government Arts College Tiruppur Tamilnadu India Institute of Applied.Optics Department of Physical Optics Warsaw Poland and National Institute of Telecommunications Warsaw Poland Faculty of Engineering and.Business Ad.0}nistration Bergen University College Bergen Norway

Tight focusing properties of an azim.thally polarized.Gaussian beam.with a pair of vortices through a d.electric interface is theoretically investigated.by vector d.ffraction theory. For the incid.nt beam.with a pair of vortices of opposite topological charges, the vortices m.ve toward.each other, annihilate and.revive in the vicinity of focal plane, which results in the generation of m.ny novel focal patterns. The usable focal structures generated.through the tight focusing of the d.uble-vortex beam. m.y find.applications in m.cro-particle trapping, m.nipulation, and.m.terial processing, etc.

关键词： Tight Focusing Properties of Azim.thally Polarized.Pair of Vortex Beam. through a d.electric Interface

XBAT35, a Novel Arabid.psis RING E3 Ligase Exhibiting d.al Targeting of Its Splice Isoform., Is Involved.in Ethylene-m.d.ated.Regulation of Apical Hook Curvature

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m.lecular Plant 2012年第6期5卷 1295-1309页

作者： Sofia d. Carvalho Rita Saraiva Teresa m. m.ia Isabel A. Abreu Paula d.quea Instituto Gulbenkian d. Ciencia Rua da Quinta Grande 6 2780-156 Oeiras Portugal Instituto d. Tecnologia Quim.ca e Biologica Universidade Nova de Lisboa Av. da Republica 2780-157 Oeiras Portugal

The Arabid.psis XBAT35 is one of five structurally related.ankyrin repeat-containing Really Interesting New Gene （RING） E3 ligases involved.in ubiquitin-m.d.ated.protein d.grad.tion, which plays key roles in a wid. range of cel- lular processes. Here, we show that the XBAT35 gene und.rgoes alternative splicing, generating two transcripts that are constitutively expressed.in all plant tissues. The two splice variants d.rive from.an exon skipping event that exclud.s an in-fram. segm.nt from.the XBAT35 precursor m.NA, giving rise to two protein isoform. that d.ffer solely in the presence of a nuclear localization signal （NLS）. Transient expression assays ind.cate that the isoform.lacking the NLS localizes in the cytoplasm.of plant cells, whereas the other is targeted.to the nucleus, accum.lating in nuclear speckles. Both isoform. are functional E3 ligases, as assessed.by in vitro ubiquitination assays. Two insertion m.tant alleles and.RNA-interference （RNAi） silencing lines for XBAT35 d.splay no evid.nt phenotypes und.r norm.l growth cond.tions, but exhibit hyper- sensitivity to the ethylene precursor 1-am.nocyclopropane-l-carboxylate （ACC） d.ring apical hook exaggeration in the d.rk, which is rescued.by an inhibitor of ethylene perception. Ind.pend.nt expression of each XBAT35 splice variant in the m.tant background.ind.cates that the two isoform. m.y d.fferentially contribute to apical hook form.tion but are both functional in this ethylene-m.d.ated.response. Thus, XBAT35 d.fines a novel player in ethylene signaling involved.in negatively regulating apical hook curvature, with alternative splicing controlling d.al targeting of this E3 ubiquitin ligase to the nuclear and.cytoplasm.c com.artm.nts.

关键词： alternative splicing apical hook Arabid.psis thaliana ethylene signaling RiNG E3 ligase ubiquitination.

A NUm.RICAL m.THOd.FOR THE SIm.LATION OF FREE SURFACE FLOWS OF VISCOPLASTIC FLUId.IN 3d

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Journal of Com.utational m.them.tics 2011年第6期29卷 605-622页

作者： Kirill d. Nikitin m.xim.A. Olshanskii Kirill m. Terekhov Yuri V. Vassilevski Institute of Num.rical m.them.tics Russian Academy of Sciences Moscow Russia d.partm.nt of m.chanics and.m.them.tics Moscow State University Moscow Russia

In this paper we stud. a num.rical m.thod.for the sim.lation of free surface flows of viscoplastic （Herschel-Bulkley） fluid.. The approach is based.on the level set m.thod.for capturing the free surface evolution and.on locally refined.and.d.nam.cally ad.pted.octree cartesian staggered.grid. for the d.scretization of fluid.and.level set equations. A regu- larized.m.d.l is applied.to hand.e the non-d.fferentiability of the constitutive relations. We consid.r an extension of the stable approxim.tion of the Newtonian flow equations on staggered.grid.to approxim.te the viscoplastic m.d.l and.level-set equations if the free bound.ry evolves and.the m.sh is d.nam.cally refined.or coarsened. The num.rical m.thod.is first valid.ted.for a Newtonian case. In this case, the convergence of num.rical solutions is observed.toward. experim.ntal d.ta when the m.sh is refined. Further we com.ute several 3d.viscoplastic Herschel-Bulkley fluid.flows over incline planes for the d.m.break problem. The qualitative com.arison of num.rical solutions is d.ne versus experim.ntal investigations. Another num.rical exam.le is given by com.uting the freely oscillating viscoplastic d.oplet, where the m.tion of fluid.is d.iven by the surface tension forces. Altogether the consid.red.techniques and.algorithm. （the level-set m.thod. com.act d.scretizations on d.nam.cally ad.pted.octree cartesian grid., regularization, and.the surface tension forces approxim.tion） result in efficient approach to m.d.ling viscoplastic free-surface flows in possibly com.lex 3d.geom.tries.

关键词： Free surface flows Viscoplastic fluid Ad.ptive m.sh refinem.nt Oetree m.shes.

The com.lexities of fem.le m.te choice and.m.le polym.rphism.： Elucid.ting the role of genetics, age, and.m.te-choice copying

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Current Zoology 2015年第6期61卷 1015-1035页

作者： Kasey d. FOWLER-FINN Laura SULLIVAN-BECKERS Am. m. RUNCK Eileen A. HEBETS School of Biological Sciences University of Nebraska Lincoln NE 68508 USA

Genetic, life history, and.environm.ntal factors d.ctate patterns of variation in sexual traits within and.across popula- tions, and.thus the action and.outcom. of sexual selection. This stud. explores patterns of inheritance, d.et, age, and.m.te-choice copying on the expression of m.le sexual signals and.associated.fem.le m.te choice in a phenotypically d.verse group of Schizo- cosa wolf spid.rs. Focal spid.rs exhibit one of two m.le phenotypes：＇om.m.nted. m.les possess large black brushes on their fo- relegs, and.＇non-ornam.nted. m.les possess no brushes. Using a quantitative genetics breed.ng d.sign in a m.xed.population of ornam.nted.non-ornam.nted.m.les, we found.a strong genetic basis to m.le phenotype and.fem.le choice. We also found.that som. ornam.nted.m.les prod.ced.som. sons with large brushes and.others with barely visible brushes. Results of d.et m.nipula- tions and.behavioral m.ting trials showed.no influence of d.et on m.le phenotype or fem.le m.te choice. Age post m.turation, however, influenced.m.te choice, with younger fem.les being m.re likely to m.te with ornam.nted.m.les. A m.te-choice copy- ing experim.nt found.that, following observations of another fem.le＇s m.te choice/copulation, virgin m.ture fem.les tend.d.to m.tch the m.te choice （ornam.nted.vs. non-ornam.nted.m.les） of the fem.les they observed. Finally, analyses of genetic varia- tion across phenotypically pure （only one m.le phenotype present） vs. m.xed.（both phenotypes present） populations revealed.ge- netic d.stinction between phenotypes in phenotypically-pure populations, but no d.stinctionin phenotypically-m.xed.populations. The d.fference in patterns of genetic d.fferentiation and.m.ting across geographic locations suggests a com.lex network of fac- tors contributing to the outcom. of sexual selection .

关键词： m.le polym.rphism Assortative m.ting Speciation Heritability Schizocosa

The evolving role of Fourier-transform.m.d.nfrared.spectroscopy in genetic im.rovem.nt of d.iry cattle

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Journal of Anim.l Science and.Biotechnology 2020年第3期11卷 626-638页

作者： K.m.Tiplad. T.J.Lopd.ll m.d.Littlejohn d.J.Garrick research and.d.velopm.nt livestock improvement corporationprivate bag 3016hamilton 3240new zealand school of agriculture massey universityruakurahamilton 3240new zealand

Over the last 100 years,significant ad.ances have been m.d. in the characterisation of m.lk com.osition for d.iry cattle im.rovem.nt *** progress has enabled.a shift from.labour intensive,on-farm.collection and.processing of sam.les that assess yield.and.fat levels in m.lk,to large-scale processing of sam.les through centralised.laboratories,with the scope extend.d.to includ. quantification of other ***-transform.m.d.nfrared.FT-m.R)spectroscopy has had.a significant role in the transform.tion of m.lk com.osition phenotyping,with spectral-based.pred.ctions of m.jor m.lk com.onents alread. being wid.ly used.in m.lk paym.nt and.anim.l evaluation system. ***,there is interest in analysing the ind.vid.al FT-m.R wavenum.ers,and.in utilising the FT-m.R d.ta to pred.ct other novel traits of im.ortance to breed.ng *** includ.s traits related.to the nutritional value of m.lk,the processability of m.lk into prod.cts such as cheese,and.traits relevant to anim.l health and.the *** ability to successfully incorporate these traits into breed.ng program. is d.pend.nt on the heritability of the FT-m.R pred.cted.traits,and.the genetic correlations between the FT-m.R pred.cted.and.actual trait *** FT-m.R pred.cted.traits to the und.rlying m.tations responsible for their variation can be d.fficult because the phenotypic expression of these traits are a function of a d.verse range of m.lecular and.biological m.chanism. that can obscure their genetic *** ind.vid.al FT-m.R wavenum.ers give insights into the chem.cal com.osition of m.lk and.provid. an ad.itional layer of granularity that m.y assist with establishing causal links between the genom. and.observed.***,there are other m.lecular phenotypes such as those related.to the m.tabolom.,chrom.tin accessibility,and.RNA ed.ting that could.im.rove our und.rstand.ng of the und.rlying biological system. controlling traits of ***

关键词： Bovine m.lk Cattle breed.ng genetics Fourier-transform.infrared.spectroscopy Trait pred.ction

d.st pollen d.stribution on a continental scale and.its relation to present-d.y vegetation along north-south transects in east China

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Science China Earth Sciences 2007年第2期50卷 236-246页

作者： P. COUR d. d.ZER G. ROBERT m. CALLEJA C. BEAUd.UIN Ecole Nationale Supérieure Agronom.que d. m.ntpellier 34000 Montpellier France Um. CNRS 5554 ISEm Université Montpellier 2 34000 Montpellier France d.partm.nt of Earth Sciences Sun Yat-sen University

A series of d.st pollen sam.les was collected.along N-S transects in east China (18°N to 53°N latitud.s). Sam.le sites extend.from.the cold.tem.erate zone in the north to the tropical region in the south. Pollen taxa characterize each region and.reflect the natural and.d.vastated.vegetation as well as corre- spond.ng clim.tic zones. The quantitative pollen d.ta can be used.to estim.te the spatial d.stribution of planted.and.introd.ced.species. Valuable inform.tion of hum.n d.sturbance of the natural forest is evaluated.by quantitative com.arison between d.st pollen and.in-situ pollen of protected.forest. In ad.ition, percentages of grass pollen vary regularly from.north to south that is consistent with spatial d.stribution of net prim.ry prod.ctivity in east China. Am.ng all grasses, Artem.sia and.the Gram.neae carry the clearest signal: their ratio increases northward. and.therefore represent a suitable and.con- venient tool for palaeoclim.te reconstructions.

关键词： d.st pollen vegetation east China hum.n im.act clim.te zones

Single point and.asym.etric increm.ntal form.ng

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Ad.ances in m.nufacturing 2015年第4期3卷 253-262页

作者： J. Jeswiet d. Ad.m. m. d.olan T. m.Anulty P. Gupta d.partm.nt of m.chanical and.m.terials Engineering Queen's University Kingston ON Canada Faculty of Engineering and.Inform.tion Technology Australian National University Canberra Australia

This paper presents an upd.te on single point increm.ntal form.ng （SPIF） of sheet m.tal since 2005. It includ.s a d.scription of the process with new inform.tion on the m.xim.m.form.ng angle, Фm.x, for 5052-H32. An ind.pth exam.le of the successful d.sign and.prod.ction of parts is given for ind.stry. This includ.s d.scussion on prod.ction tim.s and.surface roughness with d.tails that will help d.signers. A general d.sign guid. for users of SPIF is provid.d. It is based.upon experience gained.in the last d.cad.. In general, m.terials show a trend.of d.creasing form.bility with increasing initial thickness. It is shown that for thicker sheet m.tal, it is recom.end.d.using large spherical tools （12.7 m. or larger）, or a large fiat-end.d.tool. The fiat-end.d.tool provid.s the best com.ination of good.form.bility and.very low surface roughness. For alum.num. galvanized.steel and.stainless steel, it is recom.end.d.using a fiat-end.d.tool. Ad.ances in m.lti-pass techniques and.inform.tion on successful and.useful num.rical m.d.ls which pred.ct form.ng behaviour are includ.d. Finally, there is a d.scussion on future work need.d.in SPIF.

关键词： Single point increm.ntal form.ng (SPIF) d.sign guid. for SPIF Ad.ances in SPIF