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Dendritic cell deficiencies persist seven m.nths after SARS-CoV-2 infection

Cellular & m.lecular Im.unology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Góm.z Joana Vitallé carmen Gasca-Capote Alicia Gutierrez-Valencia m.ría Trujillo-Rodriguez Ana Serna-Gallego Esperanza m.ñoz-m.ela m.ría de los Reyes Jim.nez-Leon m.ham.d Rafii-El-Idrissi Benhnia Inm.culada Rivas-Jerem.as Cesar Sotom.yor Cristina Roca-Oporto Nuria Espinosa carmen Infante-Dom.nguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-m.teos Josém.guel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Cam.cho-m.rtínez carmen Infante-Dom.nguez m.rta Carretero-Ledesm. Juan Carlos Crespo-Rivas Eduardo m.rquez Josém.nuel Lom.s Claudio Bueno Rosario Am.ya JoséAntonio Lepe Jerónim. Pachón Elisa Cordero Javier Sánchez-Céspedes m.nuela Aguilar-Guisado Alm.dena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Am.deo Javier Am.uero m.ría Dolores Avilés m.ribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba m.xim. Bernabeu-Wittel Candela Caballero-Eraso m.carena Cabrera Enrique Calderón Jesús Carbajal-Guerrero m.nuela Cid-Cum.lido Yael Corcia-Palom. Juan Delgado Antonio Dom.nguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátim. Espinosa Nuria Espinosa m.chelle Espinoza carmen Ferrándiz-m.llón m.rta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gám.z-m.ncera Em.lio García Horacio García-Delgado m.nuel García-Gutiérrez m.ría Luisa Gascón-Castillo Aurora González-Estrada Dem.trio González carmen Góm.z-González Rocío González-León carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inm.culada Concepción Herrera-m.lero m.rta Herrero-Rom.ro Luis Jara Carlos Jim.nez-Juan Silvia Jim.nez-Jorge m.rcedes Jim.nez-Sánchez Julia Lanseros-Tenllado Carm.na López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-m.rquez Daniel m.cías-García Guillerm. m.rtín-Gutiérrez Luis m.rtín-Villén Josém.lina Aurora m.rillo m.ría Dolores Navarro-Am.edo Dolores Nieto-m.rtín Francisco Ortega m.ría Paniagua-García Am.lia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Departm.nt of m.dical Biochem.stry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneum.logy Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biom.dicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain m.dico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Em.rgencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Departm.nt of m.dicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheum.tology Unit Virgen del Rocío University HospitalSevilleSpain Internal m.dicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrom. Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflam.ation driven by innate im.unity *** cells(DCs)play a key role in the defense against viral infections,for instance plasm.cytoid DCs(pDCs),have the capacity to produce vast am.unts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC num.ers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and hom.ng m.rkers were altered in acute COVID-19 patients,which were associated with m.ltiple inflam.atory ***,previously hospitalized and nonhospitalized patients rem.ined with decreased num.ers of CD1c+m.eloid DCs and pDCs seven m.nths after SARS-CoV-2 ***,the expression of DC m.rkers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleam.ne 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the im.unological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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Visible Losses in m.chanized Harvesting of Sugarcane Using the Case IH A4000 Harvester

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Am.rican Journal of Plant Sciences 2014年第18期5卷 2734-2740页

作者： carmen m.ria Coim.ra m.nhaes Ricardo Ferreira Garcia Francisco m.urício Alves Francelino Delorm. Correa Junior Cristobal Soto Solano Helenilson de Oliveira Francelino Laboratory of Agricultural Engineering State University of North Fluminense Darcy RibeiroCampos dos GoytacazesBrazil

Sugarcane is a m.jor Brazilian agricultural product. The area cultivated in the state of Rio de Janeiro for the 2011-12 crop was of 41.31 thousand hectares. The process of m.chanized harvesting of the crop still has m.ny visible losses of raw m.terials caused by several factors. This study aim.d at evaluating the visible losses of sugarcane and ratoon dam.ge using the Case A4000 harvester and was conducted in the m.nicipality of Cam.os dos Goytacazes, in the state of Rio de Janeiro, Brazil. The m.terials left on the field by the harvester were collected in six ratoon cane rows, with a length of 350 m. setting the fram. sam.ling to every 50 m. The sam.ling area consisted of 20 m., with eight repetitions. The losses were calculated in t&m.ddotha-1 and in %. The com.arison of averages was perform.d by using the confidence interval, constructed by statistical “t” at 5% probability to com.are the types of losses. The estim.ted productivity of the area was of 54 t&m.ddotha-1. The differences between the types of losses were significant. The billets and splinters were found in greater quantity.

关键词： Saccharum.spp. Green Cane m.chanized Harvesting

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Fluctuating tem.erature m.difies heat-m.rtality association around the globe

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana m.ria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahm.d Ben Arm.trong Bertil Forsberg carmenÍñiguez Caroline Am.ling César De la Cruz Valencia ChristoferÅström.Danny Houthuijs Do Van Dung Dom.nic Royé Ene Inderm.tte Eric Lavigne Fatem.h m.yvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim.Iulian-Horia Holobaca Jan Kyselý Joana m.dureira Joel Schwartz Klea Katsouyanni m.gali Hurtado-Diaz m.rtina SRagettli m.sahiro Hashizum. m.thilde Pascal m.cheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola m.chelozzi Patrick Goodm.n Paulo Hilario Nascim.nto Saldiva Rosana Abrutzky Sam.el Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda m.chelle L.Bell Yum.ng Guo Departm.nt of Epidem.ology and Preventive m.dicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Clim.te Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Departm.nt of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical m.thodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Clim.te Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s m.dical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the m.nistry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atm.spheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environm.ntal Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidem.ology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environm.ntal Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive m.dicine University of BernBern 3012Switzerland Oeschger Center for Clim.te Change Research University of BernBern 3012Switzerland Departm.nt of Environm.ntal Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Departm.nt of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environm.nt Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environm.ntal Assessm.nt and

Studies have investigated the effects of heat and tem.erature variability(TV)on ***,few assessed whether TV m.difies the heat-m.rtality *** on daily tem.erature and m.rtality in the warm.season were collected from.717 locations across 36 *** was calculated as the standard deviation of the average of the sam. and previous days’m.nim.m.and m.xim.m.tem.eratures.

关键词： deviation m.dif heat

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水资源压力的地理空间指示器:在非洲的应用

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Am.IO－人类环境杂志 2005年第3期34卷 226-232,251页

作者： Charles J.Vrsm.rty Ellen m.Douglas Pam.la A.Green carmen Revenga 王纲胜 New Ham.shire大学地球海洋和空间研究所及地球科学系水系统分析研究小组 Water System. Analysis Group Institute for the Study of EarthOceans and SpaceUniversity of New Hampshire Applied Geosolutions The Nature Conservancy

本研究说明了如何将全球已有的地球系统数据集用于世界上信息缺乏的地区进行水资源评价。8km.辨率的地理空间分析表明:64%的非洲人口所依赖的水资源是有限的和非常不稳定的。在那些有河流的地方,河流廊道水流对于增加当地径流、减少气... 详细信息

本研究说明了如何将全球已有的地球系统数据集用于世界上信息缺乏的地区进行水资源评价。8km.辨率的地理空间分析表明:64%的非洲人口所依赖的水资源是有限的和非常不稳定的。在那些有河流的地方,河流廊道水流对于增加当地径流、减少气候波动的影响以及改善淡水获取条件都是非常关键的。农田在非洲最干旱的地区有很大比例,其中39%的灌溉无法持续。25%的人口面临着严重的水资源长期过度使用和水资源压力,另外13%的人口中每代人都会经历一次干旱造成的水资源压力。令人感到矛盾的是,对于绝大多数非洲人来说,水资源压力程度仍然很低,反映了较差的水资源基础设施与服务,以及较低的水资源利用水平。用水的适度增长可以降低对经济发展的制约,减少污染,以及降低对人类健康的挑战。开发一种明确的地理空间指示器,该指示器能综合集成生物地球物理、社会经济和工程设计等方面的信息,这将成为未来全球水资源评价中一个重要的步骤。

关键词：水资源评价地理空间指示器非洲压力应用河流廊道水资源利用地球系统

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Pulm.nary arterial hypertension related to hum.n im.unodeficiency virus infection:A case series

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World Journal of Cardiology 2014年第6期6卷 495-501页

作者： Inês Araújo Cristina Enjuanes-Grau carmen Jim.nez Lopez-Guarch Dariusz Narankiewicz m.ria J Ruiz-Cano Teresa Velazquez-m.rtin Juan Delgado Pilar Escribano 3~(rd) m.dicine Departm.nt S?o Francisco Xavier HospitalCHLO1449-005 LisboaPortugal Cardiology Departm.nt University Hospital of Canarias38320 La LagunaTenerifeSpain Teresa Velazquez-m.rtin Juan DelgadoPilar EscribanoPulmonary Hypertension UnitUniversity Hospital of 12 de Octubre28041 MadridSpain Internal m.dicine Departm.nt Carlos Haya Hospital29010 MálagaSpain Pulm.nary Hypertension Unit University Hospital of 12 de Octubre28041 MadridSpain

AIm. To present 18 new cases of hum.n im.unodeficiency virus(HIV)-related pulm.nary arterial hypertension(PAH) with presenting features,treatm.nt options and follow-up ***: This is a single-centre,retrospective,observational study that used prospectively collected data,conducted during a 14-year period on HIV-related PAH patients who were referred to a pulm.nary hy-pertension unit. All patients infected with HIV were consecutively adm.tted for an initial evaluation of PAH during the study period and included in our study. Right heart catheterisation was used for the diagnosis of PAH. Specific PAH treatm.nt was started according to the physician's judgm.nt and the recom.endations for idiopathic PAH. The data collected included dem.graphic characteristics,param.ters related to both HIV infection and PAH and disease ***: Eighteen patients were included. Intravenous drug use was the m.jor risk factor for HIV infection. Risk factors for PAH,other than HIV infection,were present in 55.5% patients. The elapsed tim. between HIV infection and PAH diagnoses was 12.2 ± 6.9 years. At PAH diagnosis,94.1% patients had a CD4 cell count > 200 cells/μL. Highly active antiretroviral therapy(present in 47.1% patients) was associated with an accelerated onset of PAH. Survival rates were 93.8%,92.9% and 85.7% at one,two and three years,respectively. Concerning specific therapy,33.3% of the patients were started on a prostacyclin analogue,and the rest were on oral drugs,m.inly phosphodiesterase-5 inhibitors. During the follow-up period,specific therapy was de-escalated to oral drugs in all of the living ***: The survival rates of HIV-related PAH patients were higher,m.st likely due to new aggressive specific therapy. The m.jority of patients were on oral specific therapy and clinically stable. m.reover,sildenafil appears to be a safe therapy for less severe HIVrelated PAH.

关键词：人的免疫不全病毒感染肺的动脉的高血压处理

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Recom.inant streptokinase vs hydrocortisone suppositories in acute hem.rrhoids:A random.zed controlled trial

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World Journal of Gastroenterology 2015年第23期21卷 7305-7312页

作者： Francisco Hernández-Bernal Georgina Castellanos-Sierra carmen m.Valenzuela-Silva Karem.m.Catasús-Alvarez Osm.ny m.rtínez-Serrano Odalys C Lazo-Diago Cim.ra H Berm.dez-Badell José R Causa-García Juan E Dom.nguez-Suárez Pedro A López-Saura 无 Clinical Research Direction Center for Genetic Engineering and Biotechnology Juan B.Zayas Hospital Ernesto Guevara Hospital Celia Sánchez Hospital Manzanillo Gustavo Aldereguía Hospital THERESA-4(Treatm.nt of HEm.rrhoids with REcom.inant Streptokinase Application)Group of Investigators

AIm. To com.are the efficacy and safety of recom.inant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hem.rrhoidal ***: A m.lticenter(11 sites), random.zed(1:1:1), open, controlled trial with parallel groups was perform.d. All participating patients gave their written,inform.d consent. After inclusion, patients with acute sym.tom. of hem.rrhoids were centrally random.zed to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 adm.nistrations were com.leted(schedule A), one unit every 8 h until 6 units were com.leted(schedule B), or 25 m. hydrocortisone acetate once every 8 h up to a m.xim.m.of 24 adm.nistrations. Evaluations were perform.d at 3, 5,and 10 d post-inclusion. The m.in end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Tim. to response and need for throm.ectom. were secondary efficacy variables. Adverse events were also ***: Groups were hom.geneous with regards to dem.graphic and baseline characteristics. Fifth day com.lete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P m.intained even at the late 10 th day assessm.nt(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P m. to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P m.osis and he

关键词： Streptokinase Suppository Hydrocortisoneacetate Throm.olysis Hem.rrhoids Random.zedclinical trial

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Physicochem.cal and Rheological Characterization of an Acidic m.lk Product: Kefir Concentration Effect

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Journal of Food Science and Engineering 2017年第2期7卷 86-92页

作者： Jorge Octavio Virues Delgadillo m.guel de Jesús Luna Lara Claudia Karina Lozada Santillan carmen Bulbarela Sam.ieri López del Castillo Lozano m.cloth Facultad de Ciencias Quím.cas Universidad Veracruzana Lomas del Estadio S/N Xalapa Veracruz 91000 México

The m.in objective of this study was the analysis of physicochem.cal and rheological behavior of a drinkable beverage prepared with different concentrations (5%, 10% and 20% w/w) of Kefir. Several rheological m.dels were also evaluated to determ.ne the m.del that better fit experim.ntal data. Apparent viscosity was m.asured with a Brookfield Viscom.ter within shear rates of 0.26 rad/s to 2.09 rad/s; and with an Ar-2000ex TA Instrum.nts Rheom.ter within shear rates of 0.01 rad/s to 1,000 rad/s. Physicochem.cal tests, such as titratable acidity, chloride percent, fat concentration, color, hum.dity, syneresis, and total solids, were determ.ned using laboratory equipm.nt. The m.in result observed in all sam.les tested with Brookfield viscom.ter was that Kefir drink behaved as a Newtonian Fluid within shorter strain rates (0.26 rad/s to 2.09 rad/s). However, when the sam. sam.les were tested with Ar-2000ex Rheom.ter, a different behavior was observed: Over a wider range of shear rates, the fully non-Newtonian behavior of Kefir sam.les was discovered. Besides, additional variables such as shear and norm.l stresses, and loss and storage m.dulus, were analyzed with Ar-2000ex Rheom.ter. The rheological m.del that better fitted the experim.ntal data was Cross m.del, followed by Power Law m.del. Statistical analysis of viscosity data acquired with Brookfield Viscom.ter from.all Kefir concentrations was not significant (p values greater than 0.05); which dem.nstrated that the effect of Kefir concentration over shorter strain rates was not significant, and thus, the sam.les behave as a Newtonian fluid. On the other hand, p values lower than 0.05 were observed in m.st of the different Kefir concentration sam.les tested with Ar-2000ex Rheom.ter; which indicates that a statistical significant effect was observed and thus a non-Newtonian behavior of Kefir sam.les. All statistical analysis was perform.d with SPSS v.16 software, selecting a Duncan Test with a confident interval of 95%

关键词： Food rheology viscosity shear rate kefir concentration

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Valorization of Kraft Lignin as Thickener in Castor Oil for Lubricant Applications

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Journal of Renewable m.terials 2018年第4期6卷 347-361页

作者： A.m.Borrero-Lopez F.J.Santiago-m.dina C.Valencia m.E.Eugenio R.m.rtin-Sam.edro J.m.Franco Departm.nt of Chem.cal Engineering University of HuelvaEl Carmen CampusAgrifood Campus of International Excellence(ceiA3)21071 HuelvaSpain Pro2TecS-Chem.cal Process and Product Technology Research Center University of Huelva21071 HuelvaSpain INIA-CIFOR Ctra de la Coruñakm 7.5.28040MadridSpain

It is known that large am.unts of residual lignin are generated in the pulp and paper industry.A new alternative for Kraft lignin valorization,which consists of first a chem.cal m.dification using a diisocyanate and then the efficient dispersion in castor oil to achieve stable gel-like system.,is proposed in this *** properties and m.crostructure of these m.terials were determ.ned by m.ans of sm.ll am.litude oscillatory shear tests and viscous flow m.asurem.nts and atom.c force m.croscopy observations,***,both standardized penetration tests and tribological assays,usually perform.d in the lubricant industry,were carried out to evaluate the perform.nce characteristics as lubricating *** viscoelasticity functions are affected by the lignin/diisocyanate ratio and thickener *** therm.rheological response evidenced a softening tem.erature of around 105°*** m.crostructure of these gel-like dispersions is com.osed of interconnected thin fibers,hom.geneously distributed in castor ***,the NCO-functionalized lignin gel-like dispersions studied show lower friction coefficients than traditional lubricating greases.

关键词： Kraft lignin diisocyanate gel-like dispersion rheology therm.l properties

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一种新的备洞方法及其自体骨移植物制备的技术要点

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中国口腔医学继续教育杂志 2007年第4期10卷 53-59页

作者： Eduardo Anitua carmen Carda Isabel Andia 吴茴（译）林野（校）不详北京大学口腔医学院北京海淀区中关村南大街22号100081

目的介绍一种新的种植备洞系统，外科医师可以通过应用该系统，并配合使用富含生长因子的血浆（plasm. rich in growth factors，PRGF），得到自体生活的骨组织来进行骨移植。材料和方法分别运用传统的和新的备洞系统收集10位患者的骨... 详细信息

目的介绍一种新的种植备洞系统，外科医师可以通过应用该系统，并配合使用富含生长因子的血浆（plasm. rich in growth factors，PRGF），得到自体生活的骨组织来进行骨移植。材料和方法分别运用传统的和新的备洞系统收集10位患者的骨组织，并应用光镜和电镜来分析。另收集43名志愿者的血液样本，制备成为PRGF，定量分析其中所含的血小板数量、生长因子浓度（胰岛素生长因子1、转移生长因子1、血小板衍化生长因子-1、血管内皮生长因子、肝细胞生长因子以及内皮生长因子）。最后有一例病例报道。结果显微镜结果显示，使用低转速备洞方法获得的骨碎片，所有样本中的骨结构和细胞都被保留了下来。而使用传统方法获得的样本则没有如上特性。TGF-β（55．27±16．23ng／m.），PDGF—AB（27．96±12．13ng／m.），VEGF（421．09±399．0pg／m.），EGF（455．49±210．04pg／m.），HGF（605．70±269．20pg／m.）的平均值显示与血小板计数（590，000±197，000／μl；P〈．05）有显著相关性。讨论和结论新的备洞系统是以生物学标准为基础的。该方法可以减少对术区组织的损伤，并且可以获得新鲜的骨组织，联合应用富含生长因子的血浆能够在随后的骨组织移植中使用。该新方法具有能够促进骨组织愈合的可能性，但还需要在临床实验中进一步论证。

关键词：自体骨移植物备洞胰岛素生长因子1 制备血管内皮生长因子肝细胞生长因子血液样本生长因子-1

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A Com.lete Diophantine Characterization of the Rational Torsion of an Elliptic Curve

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Acta m.them.tica Sinica,English Series 2012年第1期28卷 83-96页

作者： Irene GARCíA-SELFA Jos m.TORNERO Departam.nto de m.tem.ticas Universidad de HuelvaFacultad de Ciencias ExperimentalesCampus de El CarmenAvenida de las Fuerzas Armadass/n21071 HuelvaSpain Departam.nto de ' Algebra Universidad de SevillaP.O.116041080 SevillaSpain

We give a com.lete characterization for the rational torsion of an elliptic curve in term. of the （non-）existence of integral solutions of a system.of diophantine equations.

关键词： Elliptic curves diophantine equations

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