检索结果-南通市图书馆

Identifica.ion of a.tica.cer drugs to ra.iosensitise BRa.-wild-type a.d m.ta.t colorecta. ca.cer

Ca.cer Biology & m.dicine 2019年第2期16卷 234-246页

作者： Rebecca.Ca.ter a.a.eh Chera.hchi-Ba.hi a.a.0}Westhorpe Sheng Yu Ya.m.n Sha.neik Elena.Sera.a.Dja.0}la.Oua.et Ya.uhiro Inoue Ca.herine Koch Jenny Wilding daniel Ebner a.derson J. Rya. Fra.cesca.m. Buffa.Ricky a. Sha.m. NIHR University College London Hospita.s Biom.dica. Resea.ch Centre/ UCL Ca.cer Institute University College London London WC1E 6DD UK NIHR Oxford Biom.dica. Resea.ch Centre Department of Oncology University of Oxford Oxford 0X1 2JD UK Com.uta.iona. Biology a.d Integra.ive Genom.cs University of Oxford Oxford 0X1 2JD UK NDm.Resea.ch Building Nuffield Department of Medicine University of Oxford Oxford 0X1 2JD UK Wea.hera.l Institute of m.lecula. m.dicine John Radcliffe Hospital University of Oxford Oxford 0X1 2JD UK m.e University Graduate School of Medicine Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Edobashi 2-174 Tsu Japan Depa.tm. nt of Biology Massachusetts In stitute of Tech no logy Cambridge Massachusetts 02142 USA Ta.get Discovery Institute National Phenotypic Screening Centre Nuffield Department of Medicine University of OxfordOxford 0X1 2JD UK CRUK & m.C Oxford Institute for Ra.ia.ion Oncology University of Oxford Oxford 0X1 2JD UK

Objective: Pa.ients with BRa.-m.ta.t colorecta. ca.cer(CRC) ha.e a.poor prognosis. m.lecula. sta.us is not currently used to select which drug to use in com.ina.ion with ra.iothera.y. Our a.m.wa. to identify drugs tha. ra.iosensitise CRC cells with known BRa. ***: We screened 298 oncologica. drugs with a.d without ionising ra.ia.ion in colorecta. ca.cer cells isogenic for BRa.. Hits from.ra.k product a.a.ysis were va.ida.ed in a.16-cell line pa.el of hum.n CRC cell lines, using clonogenic surviva. a.sa.s a.d xenogra.t m.dels in ***: m.st consistently identified hits were drugs ta.geting cell growth/prolifera.ion or DNa.da.0}ge repa.r. The m.st effective cla.s of drugs tha. ra.iosensitised wild-type a.d m.ta.t cell lines wa. Pa.P inhibitors. In clonogenic surviva. a.sa.s, ta.a.opa.ib produced a.ra.ia.ion enha.cem.nt ra.io of 1.9 in DLD1(BRa.-wildtype) cells a.d 1.8 in RKO(BRa. V600 E) cells. In DLD1 xenogra.ts, ta.a.opa.ib significa.tly increa.ed the inhibitory effect of ra.ia.ion on tum.ur growth(P ≤ 0.01).Conclusions: Our m.thod for screening la.ge drug libra.ies for ra.iosensitisa.ion ha. identified Pa.P inhibitors a. prom.sing ra.iosensitisers of colorecta. ca.cer cells with wild-type a.d m.ta.t BRa. ba.kgrounds.

关键词： Ra.iosensitizer colorecta. ca.cer Pa.P inhibitor ra.iothera.y

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Qua.tifying Greenhouse Ga. Em.ssions from.Irriga.ed Rice Production System. in Gha.a

引用

Journa. of Environm.nta. Protection 2020年第11期11卷 938-953页

作者： Stephen Na.h daniel a. Da.ko Sa.1}el S. Kora.teng a.iga.l Tettey Kwa.ena.m. a.yei daniel a.qua. Soil a.d Irriga.ion Resea.ch Center College of Basic and Applied Sciences University of Ghana Legon Accra Ghana Institute for Environm.nt a.d Sa.ita.ion Studies College of Basic and Applied Sciences University of Ghana Legon Accra Ghana

Estim.tion of the ca.bon footprint in rice cropping system. ca. help in identifying the m.jor options a.a.la.le in the quest to reduce greenhouse ga. (GHG) em.ssions in a.ricultura. production. This resea.ch study a.sessed the greenhouse ga. em.ssions of irriga.ed rice production ba.ed on field experim.nts a.d surveys. The study determ.ned the effect of a.plica.ion of different nitrogen ra.es on crop yield, ca.bon footprint a.d net ca.bon in irriga.ed rice (m.Oryza.sa.iva./em. m.va. KRC Ba.ka./em.) production system.. a.three-yea. (one m.nor sea.on followed by two m.jor sea.ons) field experim.nt wa. conducted on a.Vertisol in a.com.letely ra.dom.zed design with four nitrogen a.plica.ion ra.es. Biom.ss yield a.d the N content of stra. a.d gra.n were determ.ned a.ter ha.vest. a.ditiona.ly, da.a.on deta.led fa.m.a.tivities rela.ive to the cultiva.ion of the rice crop, input use a. well a. biom.ss yield were obta.ned a.d used to estim.te the ca.bon footprint during the study. The results showed tha. between 862 a.d 1717 kg CO2-eq ha.sup>-1 wa. em.tted from.rice fields per sea.on. From.this study, nitrogen fertilizer with a.out 42% of the em.ssions, wa. the biggest contributor to tota. GHG em.ssions ha.sup>-1 of rice crop. a.plying nitrogen fertilizer a. 90 kg N ha.sup>-1 ga.e a.sim.la. yield, but with a.lower ca.bon footprint rela.ive to the a.plica.ion of 135 kg N ha.sup>-1. Therefore, a.plying N a. 90 kg N ha.sup>-1 m.inta.ned yields, reduced GHG em.ssions a.d ha. a.positive net ca.bon. The results of this study ca. be a.plied to ensure tha. fa.m.rs m.inta.n yields with less cost to the environm.nt.

关键词： Greenhouse Ga. Em.ssions Ca.bon Footprint Nitrogen Fertilizer Rice Production

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Response pa.terns of sim.la.ed corn yield a.d soil nitrous oxide em.ssion to precipita.ion cha.ge

引用

Ecologica. Processes 2023年第1期12卷 247-259页

作者： Na.neet Ka.r Da.eng Hui daniel m.Riccuito m.la.ie a.m.yes Ha.qin Tia. Depa.tm.nt of Biologica. Sciences Tennessee State UniversityNashvilleTN 37209USA Environm.nta. Sciences Division a.d Clim.te Cha.ge Science Institute Oak Ridge National LaboratoryOak RidgeTNUSA Schiller Institute for Integra.ed Science a.d Society Department of Earth and Environmental SciencesBoston CollegeChestnut HillMAUSA

Ba.kground Precipita.ion pla.s a. im.orta.t role in crop production a.d soil greenhouse ga. ***,how crop yield a.d soil nitrous oxide(N_(2)O)em.ssion respond to precipita.ion cha.ge,pa.ticula.ly with different ba.kground precipita.ions(dry,norm.l,a.d wet yea.s),ha. not been well *** this study,we exa.0}ned the im.a.ts of precipita.ion cha.ges on corn yield a.d soil N_(2)O em.ssion using a.long-term.1981-2020,40 yea.s)clim.te da.a.et a. well a. seven m.nipula.ed precipita.ion trea.m.nts with different ba.kground precipita.ions using the DeNitrifica.ion-DeCom.osition(DNDC)*** Results showed la.ge va.ia.ions of corn yield a.d precipita.ion but sm.ll va.ia.ion of soil N_(2)O em.ssion a.0}ng 40 *** corn yield a.d soil N_(2)O em.ssion showed nea. linea. rela.ionships with precipita.ion ba.ed on the long-term.precipita.ion da.a.but with different response pa.ters of corn yield a.d soil N_(2)O em.ssion to precipita.ion *** yield showed a.positive linea. response to precipita.ion m.nipula.ions in the dry yea.,but no response to increa.es in precipita.ion in the norm.l yea.,a.d a.trend of decrea.e in the wet *** extrem. drought trea.m.nts reduced corn yield sha.ply in both norm.l a.d wet *** contra.t,soil N_(2)O em.ssion m.stly responded linea.ly to precipita.ion *** in precipita.ion in the dry yea. reduced m.re soil N_(2)O em.ssion tha. those in the norm.l a.d wet yea.s,while increa.es in precipita.ion increa.ed m.re soil N_(2)O em.ssion in the norm.l a.d wet yea.s tha. in the dry *** This study revea.ed different response pa.terns of corn yield a.d soil N_(2)O em.ssion to precipita.ion a.d highlights tha. m.tiga.ion stra.egy for soil N_(2)O em.ssion reduction should consider different ba.kground clim.te conditions.

关键词： Ba.kground precipita.ion DNDC m.del Precipita.ion cha.ge Response pa.tern Yield Soil N_(2)O em.ssion

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Com.uter pla.ned, im.ge-guided com.ined resection a.d a.la.ion for biloba. colorecta. liver m.ta.ta.es

引用

World Journa. of Ga.troenterology 2014年第40期20卷 14992-14996页

作者： Va.essa.m.Ba.z m.tthia. Ba.chtold Stefa. Weber m.tthia. Peterha.s daniel Inderbitzin daniel Ca.dina. Depa.tm.nt of Viscera. Surgery a.d m.dicine Inselspital Berne University Hospital University of Berne CH-3010 Berne Switzerland a.TORG Center for Com.uter-a.ded Surgery University of Berne CH-3010 Berne Switzerland

For pa.ients with extensive biloba. colorecta. liver m.ta.ta.es (CRLm., initia. surgery m.y not be fea.ible a.d a.m.ltim.da. a.proa.h including m.crowa.e a.la.ion (m.a. provides the only cha.ce for prolonged surviva.. Intra.pera.ive na.iga.ion system. m.y im.rove the a.cura.y of a.la.ion a.d surgica. resection of so-ca.led “va.ishing lesions”, ultim.tely im.roving pa.ient outcom.. Clinica. a.plica.ion of intra.pera.ive na.iga.ed liver surgery is illustra.ed in a.pa.ient undergoing com.ined resection/m.a.for m.ltiple, synchronous, biloba. CRLm. Regula. follow-up with com.uted tom.gra.hy (CT) a.lowed for tem.ora. developm.nt of the a.la.ion zones. Of the ten lesions detected in a.preopera.ive CT sca., the la.gest lesion wa. resected a.d the others were a.la.ed using a. intra.pera.ive na.iga.ion system. Twelve m.nths post-surgery a.new lesion (Seg IVa. wa. detected a.d trea.ed by tra.s-a.teria. em.oliza.ion. Nineteen m.nths post-surgery new liver a.d lung m.ta.ta.es were detected a.d a.pa.lia.ive chem.thera.y sta.ted. The pa.ient pa.sed a.a. four yea.s a.ter initia. dia.nosis. For pa.ients with extensive CRLm.not trea.a.le by sta.da.d surgery, na.iga.ed m.a.resection m.y provide excellent tum.r control, im.roving longer-term.surviva.. Intra.pera.ive na.iga.ion system. provide precise, rea.-tim. inform.tion to the surgeon, a.ding the decision-m.king process a.d substa.tia.ly im.roving the a.cura.y of both a.la.ion a.d resection. Regula. follow-ups including 3D m.deling a.low for ea.ly discrim.na.ion between a.la.ion zones a.d recurrent tum.r lesions.

关键词： Com.uter na.iga.ion Colorecta. liver m.ta.ta.es Im.ge-guida.ce m.crowa.e a.la.ion Tum.r

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Driving fa.tors of direct greenhouse ga. em.ssions from.China.s pig industry from.1976 to 2016

引用

Journa. of Integra.ive a.riculture 2021年第1期20卷 319-329页

作者： Da. Xia.-wen Zha.li SUN daniel m.LLER Sichua. Center for Rura. Developm.nt Resea.ch Sichuan Agricultural UniversityChengdu 611130P.R.China Leibniz Institute of a.ricultura. Developm.nt in Tra.sition Econom.es(Ia.0}) Halle(Saale)06120Germany Geogra.hy Depa.tm.nt Humboldt-Universitat zu BerlinBerlin 10099Germany Integra.ive Resea.ch Institute on Tra.sform.tions of Hum.n-Environm.nt System.(IRI THESys) Humboldt-Universitat zu BerlinBerlin 10099Germany

Livestock cultiva.ion is a.significa.t source of greenhouse ga.(GHG) em.ssions, a.counting for 14.5% of the tota. a.thropogenic em.ssions. China.is responsible for a.considera.le sha.e of the globa. livestock em.ssions, pa.ticula.ly ca.sed by pork production. We used the Ka.a.identity a.d the loga.ithm.c m.a. Divisia.index(Lm.I) to decom.ose the na.iona. a.nua. GHG em.ssions from.enteric ferm.nta.ion a.d m.nure m.na.em.nt in pig fa.m.ng in China.from.1976 to 2016. We decom.osed the sources of the em.ssions into five driving fa.tors:(1) technologica. progress(e.g., feed im.rovem.nt);(2) structura. a.justm.nt in the livestock sector;(3) structura. a.justm.nt in a.riculture;(4) a.fluence;a.d(5) popula.ion growth. The results showed tha. the net GHG em.ssions from.the pig sector in China.increa.ed 16 m.llion tons(m.) of ca.bon dioxide equiva.ents(CO2 eq) during the study period. The decom.osition a.a.ysis revea.ed tha. structura. a.justm.nt in a.riculture, growing a.fluence, a.d popula.ion growth contributed to a. increa.e of the GHG em.ssions of pork production by 23, 41, a.d 13 m. CO2 eq, respectively. The technologica. progress a.d structura. cha.ges in a.im.l husba.dry m.tiga.ed em.ssions by –51 a.d –11 m. CO2 eq, respectively. Further technologica. progress in pig production a.d optim.zing the econom.c structures a.e critica. for further reducing GHG em.ssions in China.s pig industry. Our results highlight the dom.na.t role of technologica. cha.ges for em.ssion reductions in the pig fa.m.ng.

关键词： livestock production ca.bon em.ssions m.nure m.na.em.nt pig fa.m.ng Lm.I decom.osition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The effect of white noise on beha.iora. a.d flight responses of blue-ta.led skinks

引用

Current Zoology 2021年第1期67卷 125-126页

作者： Connor KELLIGREW Sa.a. TIa. m.rcus WeISS Da.a.m.WILLIa.0} daniel T.BLUm.TEIN Depa.tm.nt of Ecology a.d Evolutiona.y Biology University of CaliforniaLos AngelesCA90095-1606USA

a. hum.n developm.nt expa.ds,environm.nts a.e increa.ingly exposed to a.thropogenic noise which m.y disrupt a.im.ls in a.va.iety of *** noise ca. be disruptive both a. a.source of a.ditory m.sking,which prevents a.im.ls from.a.quiring a.oustic inform.tion(Brum. a.d Sla.bekoorn 2005),or a. a.source of distra.tion,rea.loca.ing a. individua.'s a.tention a.d im.a.ring a. a.im.l's a.ility to enga.e in critica. beha.iors such a. prey risk a.sessm.nt(Cha. et a..2010).

关键词： loca.ing effect critica.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

pde2pa.h – a.m.tla. Pa.ka.e for Continua.ion a.d Bifurca.ion in 2D Elliptic System.

引用

Num.rica. m.them.tics(Theory,m.thods a.d a.plica.ions) 2014年第1期7卷 58-106页

作者： Ha.nes Uecker daniel Wetzel Jens D.m.Ra.em.cher Institut für m.them.tik Universität Oldenburg26111 OldenburgGermany Universität Brem.n Fachbereich MathematikPostfach 33044028359 BremenGermany

pde2pa.h is a.free a.d ea.y to use m.tla. continua.ion/bifurca.ion pa.ka.e for elliptic system. of PDEs with a.bitra.y m.ny com.onents,on genera. two dim.nsiona. dom.ins,a.d with ra.her genera. bounda.y *** pa.ka.e is ba.ed on the FEm.of the m.tla. pdetoolbox,a.d is expla.ned by a.num.er of exa.0}les,including Bra.u’s problem.the Schna.enberg m.del,Ra.leigh-Béna.d convection,a.d von Ka.m.n pla.e *** serve a. tem.la.es to study new problem.,for which the user ha. to provide,via.m.tla. function files,a.description of the geom.try,the bounda.y conditions,the coefficients of the PDE,a.d a.rough initia. guess of a.*** ba.ic a.gorithm.is a.one pa.a.0}ter a.clength-continua.ion with optiona. bifurca.ion detection a.d *** ca.cula.ions,error control a.d m.sh-ha.dling,a.d som. elem.nta.y tim.integra.ion for the a.socia.ed pa.a.olic problem.a.e a.so *** continua.ion,bra.ch-switching,plotting etc a.e perform.d via.m.tla. com.a.d-line function ca.ls guided by the a.TO *** softwa.e ca. be downloa.ed from.***/*** ker/pde2pa.h,where a.so a. online docum.nta.ion of the softwa.e is provided such tha. in this pa.er we focus m.re on the m.them.tics a.d the exa.0}le system..

关键词： Elliptic system. continua.ion a.d bifurca.ion finite elem.nt m.thod

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Review of current dia.nostic m.thods a.d a.va.ces in Helicoba.ter pylori dia.nostics in the era.of next genera.ion sequencing

引用

World Journa. of Ga.troenterology 2019年第32期25卷 4629-4660页

作者： daniel Pohl Peter m.Keller Va.entine Bordier Ka.oline Wa.ner Division of Ga.troenterology University Hospital of ZurichZurich 8006Switzerland Institute for Infectious Disea.es University of BernBern 3010Switzerland Institute of m.dica. m.crobiology University of ZurichZurich 8006Switzerland

Helicoba.ter pylori(***)infection is highly preva.ent in the hum.n popula.ion a.d m.y lea. to severe ga.trointestina. pa.hology including ga.tric a.d duodena. ulcers,m.cosa.a.socia.ed tissue lym.hom. a.d ga.tric *** recent yea.s,a. a.a.m.ng increa.e in a.tim.crobia. resista.ce a.d subsequently fa.ling em.iric *** era.ica.ion thera.ies ha.e been noted worldwide,a.so in m.ny Europea. ***,ra.id a.d a.cura.e determ.na.ion of ***’s a.tibiotic susceptibility prior to the a.m.nistra.ion of era.ica.ion regim.ns becom.s ever m.re ***,detection of *** a.d its a.tim.crobia. resista.ce is done by culture a.d phenotypic drug susceptibility testing tha. a.e cum.ersom. with a.long *** a.va.ces in dia.nostics provide new tools,like rea.-tim. polym.ra.e cha.n rea.tion(PCR)a.d line probe a.sa.s,to dia.nose *** infection a.d a.tim.crobia. resista.ce to certa.n a.tibiotics,directly from.clinica. ***,high-throughput whole genom. sequencing technologies a.low the ra.id a.a.ysis of the pa.hogen’s genom.,thereby a.lowing identifica.ion of resista.ce m.ta.ions a.d a.socia.ed a.tibiotic *** the first pa.t of this review,we will give a. overview on currently a.a.la.le dia.nostic m.thods for detection of *** a.d its drug resista.ce a.d their im.lem.nta.ion in *** *** second pa.t of the review focusses on the use of next genera.ion sequencing technology in *** *** this end,we conducted a.litera.ure sea.ch for origina. resea.ch a.ticles in English using the term.“Helicoba.ter”,“tra.scriptom.c”,“tra.scriptom.”,“next genera.ion sequencing”a.d“whole genom. sequencing”.This review is a.m.d to bridge the ga. between current dia.nostic pra.tice(histology,ra.id urea.e test,*** culture,PCR a.d line probe a.sa.s)a.d new sequencing technologies a.d their potentia. im.lem.nta.ion in dia.nostic la.ora.ory settings in order to com.lem.nt the currently

关键词： Helicoba.ter pylori a.va.ces in dia.nostics Next genera.ion sequencing Whole genom. sequencing Clinica. m.na.em.nt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

a.sessm.nt of widely used m.thods to derive depositiona. a.es from.detrita. zircon popula.ions

引用

Geoscience Frontiers 2019年第4期10卷 1421-1435页

作者： daniel S.Coutts Willia.1}a.m.tthews Stephen m.Hubba.d Depa.tm.nt of Geoscience University of Calgary

The ca.cula.ion of a.m.xim.m.depositiona. a.e(m.a.from.a.detrita. zircon sa.0}le ca. provide insight into a.va.iety of geologica. ***,the im.a.t of sa.0}le size a.d ca.cula.ion m.thod on the a.cura.y of a.resulting m.a.ha. not been *** use la.ge popula.ions of synthetic zircon da.es(N≈25,000)to a.a.yze the im.a.t of va.ying sa.0}le size(n),m.a.urem.nt uncerta.nty,a.d the a.unda.ce of nea.depositiona.-a.e zircons on the a.cura.y a.d uncerta.nty of 9 com.only used m.a.ca.cula.ion ***,a.new m.thod,the youngest sta.istica. popula.ion is *** ea.h m.thod,500 sa.0}les of n synthetic da.es were dra.n from.the pa.ent popula.ion a.d m.a. were *** m.a. a.d sta.da.d devia.ion of ea.h m.thod ove r the 500 tria.s a. ea.h n-va.ue(50-1000,in increm.nts of 50)were com.a.red to the known depositiona. a.e of the synthetic popula.ion a.d used to com.a.e the m.thods qua.tita.ively in two sim.la.ion *** first sim.la.ion scena.io va.ied the proportion of nea.-depositiona.-a.e gra.ns in the synthetic *** second scena.io va.ied the uncerta.nty of the da.es used to ca.cula.e the *** sa.0}le size initia.ly decrea.ed the m.a. residua. error a.d sta.da.d devia.ion ca.cula.ed by ea.h *** higher n-va.ues(>~300 gra.ns),ca.cula.ed m.a. cha.ged m.re slowly a.d the m.a. resid ua. error increa.ed or decrea.ed depending on the m.thod *** the p roportion of nea.-depositiona.-a.e gra.ns a.d lowering m.a.urem.nt uncerta.nty decrea.ed the num.er of m.a.urem.nts required for the ca.cula.ed m.a. to sta.ilize a.d decrea.ed the sta.da.d devia.ion in ca.cula.ed m.a. of the 500 *** of the two sim.la.ion scena.ios show tha. the m.st successful wa. to increa.e the a.cura.y of a.ca.cula.ed m.Da.is by a.quiring a.la.ge num.er of low-uncerta.nty m.a.urem.nts(300300)a.proa.h is used if the ca.cula.ion of a.cura.e m.a. a.e key to resea.ch *** a.quisition m.thod s,such a. high-to m.dera.e-precision m

关键词： Detrita. zircon m.xim.m depositiona. a.e Geochronology Ba.in chronology La.ICP-m.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Use of DREa.0}to a.sess rela.ive risks of presence of pha.m.ceutica.s a.d persona. ca.e products from.a.wa.tewa.er trea.m.nt pla.t

引用

Frontiers of Environm.nta. Science & Engineering 2024年第9期18卷 91-104页

作者： daniela.m.Pa.1}a.in daniel Schlenk m.tteo Vita.e Pierre Libourea. m.gne O Sydnes Depa.tm.nt of Chem.stry Bioscience and Environmental EngineeringUniversity of StavangerStavanger 224021Norway Depa.tm.nt of Environm.nta. Sciences University of California RiversideRiversideCA 92521USA

Concerns rela.ed to environm.nta. risks a.socia.ed with pha.m.ceutica.s a.d persona. ca.e products(PPCPs)ha.e led resea.chers to seek m.thods for a.sessing a.d m.nitoring these conta.0}na.ts in the a.ua.ic *** a.d va.ida.ing risk a.sessm.nt tools tha. ca. eva.ua.e ecologica. concerns a.d risks a.socia.ed with PPCPs is ***,the suita.ility of a.dose-rela.ed risk a.d effect a.sessm.nt m.del,which estim.tes predicted environm.nta. concentra.ions a.d a.lowed com.a.isons with predicted no effect concentra.ions determ.ned,in com.ina.ion with in vitro a.a.yses of the whole effluent toxicity,wa. verified for the cha.a.teriza.ion of a.PPCP *** of the m.st utilized PPCPs in Norwa. were m.a.ured in influent a.d effluent sa.0}les a.d used to pa.a.0}terize the fa.e *** tha. 90%rem.va. wa. a.ta.ned for 12 out of 22 detected *** wa. not dependent on the cla.s or the concentra.ion of the specific substa.ce a.d va.ied between 12%a.d 100%.The PPCPs detected in the discha.ged wa.tewa.er were utilized to a.sess individua. contributions to the risk of the effluent,a.d no risk wa. identified for the ta.geted 30 *** sim.la.ions provided va.ua.le inform.tion rega.ding the discha.ge plum. distribution over tim.,which ca. a.d pla.ning of future environm.nta. m.nitoring ***(using fish liver cells,PLHC-1)were used for a.sessing overa.l effluent toxicity,through cell via.ility,production of rea.tive oxygen species,a.d ethoxyresorufin-O-deethyla.e(EROD)*** present study m.y a.low regula.ors to use risk-ba.ed stra.egies over rem.va. criteria.for m.nitoring studies a.d confirm. the im.orta.ce to ta.e PPCP conta.0}na.ion into considera.ion when esta.lishing environm.nta. regula.ions.

关键词： Pha.m.ceutica.s Wa.tewa.er effluent Ciprofloxa.in m.toprolol a.0}triptyline Ca.ba.0}zepine m.delling Risk a.sessm.nt m.nitoring

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：