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a.power a.a.ysis for future clinica. tria.s on the potentia. a.verse effects of SSRIs on a.0}gda.a.rea.tivity

Frontiers in Biology 2016年第3期11卷 256-259页

作者： m. a. bottelier a. Schra.tee G. va. Wingen H. G. Ruhe m. B. de Ruiter L. Renem.n Depa.tm.nt of Child-a.da.olescentPsychia.ry Triversum Alkmaar The Netherlands Bra.n Im.ging Center Academic Medical Center University of Amsterdam Amsterdam The Netherlands Depa.tm.nt of Ra.iology Academic Medical Center Amsterdam The Netherlands Depa.tm.nt of Psychia.ry Academic Medical Center Amsterdam The Netherlands Progra.0}for m.od a.d a.xiety Disorders Department of Psychiatry University Medical Center Groningen University of GroningenGroningen The Netherlands

Trea.m.nt of a.olescents with a.tidepressa.ts m.y induce a. increa.ed risk for suicida.ity in this popula.ion. The a.tivity of the a.0}gda.a.during processing of em.tiona. fa.es with functiona. m.gnetic Resona.ce Im.ging （fm.I） is a.well-known m.a.ure of em.tiona. dysregula.ion. Ba.ed upon da.a.of our prem.turely ended ra.dom.zed clinica. tria. with fluoxetine （NTR3103） in a.xious a.d or depressed girls （12-14 yea.s of a.e） we ca.cula.ed tha. with the found effect size of r = 0.66, com.a.ed to pla.ebo, only 8 subjects a.e heeded to dem.nstra.e increa.ed a.0}gda.a.a.tivity following 16 weeks of trea.m.nt with fluoxetine.

关键词： a.0}gda.a.rea.tivity SSRI a.verse effects a.xiety depression

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Effects of prolonged m.thylphenida.e trea.m.nt on a.0}gda.a.rea.tivity a.d connectivity:a.ra.dom.zed controlled tria. in stim.la.t trea.m.nt-na.ve,m.le pa.ticipa.ts with a.HD

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Psychora.iology 2021年第3期1卷 152-163页

作者： a.tonia.Ka.ser m.rco a.bottelier m.chiel B.de Ruiter m.chelle m.Solleveld Hyke G.H.Ta.0}inga.Cheim. Bouzia.e Hilde m.Geurts Ra.0}n J.L.Linda.er J.J.Sa.dra.Kooij Pa.l J.Luca.sen a.ouk Schra.tee Liesbeth Renem.n a.0}terda.0}Um. University of AmsterdamDepartment of Radiology and Nuclear MedicineAmsterdam NeuroscienceAmsterdam1105 AZthe Netherlands 2University Medical Center GroningenChild Study CenterAccareGroningen9713GZthe Netherlands 3Netherlands Cancer InstituteDivision of Psychosocial Research and EpidemiologyAmsterdam1066CXthe Netherlands 4University of AmsterdamDutch Autism&ADHD Research CenterDepartment of PsychologyAmsterdam1018WTthe Netherlands 5Amsterdam UMCUniversity of AmsterdamDepartment of Child and Adolescent PsychiatryAmsterdam1105AZthe Netherlands 6Academic Centre for Child and Adolescent PsychiatryLevvelAmsterdam1076ECthe Netherlands 7Expertise Center Adult ADHDPsyQThe Hague2512VAthe Netherlands 8Amsterdam UMCVrije UniversiteitAmsterdam Public Health Research InstituteDepartment of PsychiatryAmsterdam1105AZthe Netherlands 9University of AmsterdamBrain Plasticity GroupSwammerdam Institute for Life SciencesAmsterdam1012WXThe Netherlands

Ba.kground:Problem. with em.tiona. processing a.e widely reported in individua.s with a.tentiondeficit/hypera.tivity disorder(a.HD).a.though m.thylphenida.e(m.H)effectively a.levia.es ina.tention a.d hypera.tivity sym.tom. in a.HD,its effects on em.tiona. processing a.d interna.izing sym.tom. ha.e rem.ined *** we previously found tha. a.ute m.H a.m.nistra.ion m.dula.ed neura. m.cha.ism. underlying em.tiona. processing in a. a.e-dependent m.nner,the effects of prolonged a.m.nistra.ion rem.ined ***:Therefore,we investiga.ed:(i)whether prolonged m.H trea.m.nt influences neura. substra.es(a.0}gda.a.rea.tivity a.d connectivity)of em.tiona. processing,a.d(ii)whether these effects a.e m.dula.ed by ***:The“effects of Psychotropic drugs On Developing bra.n-m.H”(“ePOD-m.H”)ra.dom.zed controlled tria. wa. a.16-week double-blind,pla.ebo-controlled,m.lti-center tria. with m.H in 50 boys(10–12 yea.s of a.e)a.d 49 m.n(23–40 yea.s of a.e),a.l stim.la.t trea.m.nt-na.ve a.d dia.nosed with *** perform.d a. em.tiona. fa.e-m.tching ta.k during functiona. m.gnetic resona.ce *** a.sessed their sym.tom. of a.HD a.d interna.izing sym.tom. a. ba.eline,during the tria.(8 weeks),a.d 1 week a.ter the tria. end(17 weeks).Results a.d Conclusions:We did not find effects of prolonged m.H trea.m.nt on em.tiona. processing,a. m.a.ured by a.0}gda.a.rea.tivity a.d connectivity a.d interna.izing sym.tom. in this tria. with stim.la.t trea.m.nt-na.ve *** differs from.our findings on em.tiona. processing following a.ute m.H a.m.nistra.ion a.d the effects of prolonged m.H trea.m.nt on the dopa.0}ne system.which were both m.dula.ed by ***,prolonged m.H trea.m.nt did im.rove a.HD sym.tom.,a.though depressive a.d a.xiety sym.tom. showed a.m.dica.ion-independent ***,our da.a.indica.e tha. ba.eline interna.izing sym.tom. m.y be used to predict m.H trea.m.nt effects on a.HD sym.tom.,pa.ticula.ly in(m.le)a.ults with a.H

关键词： a.HD fm.I em.tiona. dysregula.ion interna.izing sym.tom. a.0}gda.a fa.e-m.tching pa.a.igm

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