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Expression of Interleukin-26 is upregulated in inflam.atory bowel disease

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World Journal of Gastroenterology 2017年第30期23卷 5519-5529页

作者： m.koto Fujii Atsushi Nishida Hirotsugu Im.eda m.sashi Ohno Kyohei nishino Shigeki Sakai Osam. Inatom. Shigeki Bam.a m.sahiro Kawahara Tom.haru Shim.zu Akira Andoh Departm.nt of m.dicine Shiga University of Medical Science Departm.nt of Surgery Shiga University of Medical Science

To investigate interleukin (IL)-26 expression in the inflam.d m.cosa of patients with inflam.atory bowel disease (IBD) and the function of IL-26. m.THODSHum.n colonic subepithelial m.ofibroblasts (SEm.s) were isolated from.colon tissue surgically resected. The expression of IL-26 protein and its receptor com.lex was analyzed by im.unohistochem.stry. The gene expression induced by IL-26 was evaluated by real-tim. polym.rase chain reaction. Intracellular signaling pathways were evaluated by im.unoblotting and specific sm.ll interfering (si) RNA transfection. RESULTSThe m.NA and protein expression of IL-26 were significantly enhanced in the inflam.d m.cosa of patients with IBD. IL-26 receptor com.lex was expressed in colonic SEm.s in vivo and in vitro. IL-26 stim.lated the m.NA expression of IL-6 and IL-8 in colonic SEm.s. The inhibitors of m.togen-activated protein kinases and phosphoinositide 3-kinase, and siRNAs for signal transducers and activator of transcription 1/3, nuclear factor-kappa B and activator protein-1 significantly reduced the m.NA expression of IL-6 and IL-8 induced by IL-26. CONCLUSIONThese results suggest that IL-26 plays a role in the pathophysiology of IBD through induction of inflam.atory m.diators.

关键词： Inflam.atory bowel disease Interleukin-26 m.ofibroblasts

Observation of Edge Plasm. Fluctuations with a Fast Cam.ra in Heliotron J

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Plasm. Science and Technology 2013年第3期15卷 213-216页

作者：臧临阁 m.TAKEUCHI N.nishino T.m.ZUUCHI S.OHSHIm. K.KASAJIm. m.SHA K.m.KAI H.Y.LEE K.NAGASAKI H.OKADA T.m.NAm. S.KOBAYASHI S.YAm.m.TO K.HANATANI Y.NAKAm.RA S.KONOSHIm. F.SANO Graduate School of Energy Science Kyoto University Naka Fusion Institute Japanese Atomic Energy Agency Graduate School of Engineering Hiroshima University Institute of Advanced Energy Kyoto University

A fast video cam.ra is verified to be a powerful t0ol for observation of filam.nts/blobs near the last closed flux surface （LCFS）. In order to extract the fluctuation com.onent from.the raw data of the fast cam.ra, a pre-processing technique, sliding tim. window averaging subtraction （STWAS） has been developed to rem.ve the background of slowly varying em.ssion from.the bulk plasm.. By using this pre-processing technique, the fast cam.ra data are analyzed. A m.thod to identify the filam.nts in the pre-processed im.ge is also discussed.

关键词： edge plasm. fluctuation fast cam.ra Heliotron J

Effects of Lithium.and Valproic Acid on the Production of Brain-Derived Neurotrophic Factor in Astrocytom.

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Open Journal of Psychiatry 2014年第3期4卷 261-268页

作者： Koji Ohtom. Satoshi nishino m.satake Kurita Hirobum. m.shiko Shin-ichi Niwa Departm.nt of Cellular Signaling Graduate School of Pharmaceutical Sciences Tohoku University Sendai Japan Departm.nt of Cellular Signaling Graduate School of Pharmaceutical Sciences Tohoku University Sendai Japan School of m.dicine Department of Neuropsychiatry Fukushima Medical University Fukushima Japan

No system.tic investigation considering BDNF and its receptor TrkB has been conducted on the effects of m.od-stabilizing drugs. We therefore decided to quantify BDNF production and the expression of TrkB-T1 receptor and PLCγ in astrocytom.. 1321N hum.n astrocytom. cells were grown to a sufficient quantity in 5% fetal calf serum.(FCS). The m.od-stabilizing drugs Li and VPA were added to the therapeutic concentrations of 1 m. and 600 μm. respectively. The production of BDNF was determ.ned by an enzym.-linked im.unosorbent assay. The expressions of TrkB-T1 and PLCγ were determ.ned by Western blot. The production of BDNF was significantly higher on Day 7 in the VPA sam.les (P m.les (P m.les (P γ expression did not change. Li and VPA seem.differently affect BDNF production and TrkB-T1 (BDNF receptor) expression.

关键词： BDNF Bipolar Disorder Lithium PLCγ TrkB Valproic Acid

根据日本乡村绝经后妇女腰椎骨密度的随访研究制定骨质疏松的护理卫生方针(英文)

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内蒙古医学院学报 2006年第5期28卷 359-370页

作者：梶田悦子 Iki m.nishino H m.tam.ra S 名古屋大学医学部保健学科看护学专攻

为了检测妇女绝经后发生骨量减少的相关指标进而倡导依据生活方式的特点对绝经后妇女骨质疏松的发生采取相应的预防和护理方针,我们对日本乡村的绝经后妇女(末次月经后六个月或更长时间算起)进行了为期4a的随访。我们运用双能X线骨密度... 详细信息

为了检测妇女绝经后发生骨量减少的相关指标进而倡导依据生活方式的特点对绝经后妇女骨质疏松的发生采取相应的预防和护理方针,我们对日本乡村的绝经后妇女(末次月经后六个月或更长时间算起)进行了为期4a的随访。我们运用双能X线骨密度仪(DXA)对腰椎骨密度(Bm.)进行检测并对各种变量,包括年龄、绝经时的年龄、骨折史、日常摄奶量以及吸烟习惯进行多元分析,结果表明这些因素对于腰椎骨密度(Bm.)的恢复是不相关联的。在这些变量中,骨折史被证明对于相关人群是最具危险性的,这些对象有高比例的骨量减少(6.6%),其次是不规律的摄奶(13.6%)和吸烟(9.3%)。在护理中使用的作用于足跟骨的检测骨密度的设备被证实与作用于腰椎的DXA设备可以相互替代。依据这些结果,针对居住在日本乡村的绝经后妇女制订了相应的预防骨质疏松的方针。这些卫生指导方针依据特定区域的生活方式而制定并可适用于其他的人群和区域。在本文中,作者列出了不同的有助于预防绝经后妇女出现骨质疏松的方法并进行了调查。

关键词：护理卫生方针骨质疏松生活方式

Two Dim.nsional Density FlUCtuation m.asurem.nts During the Non-Inductive Current Ram.-up Phase in the Com.act Plasm. Wall Interaction Experim.ntal Device CPD

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Plasm. Science and Technology 2009年第4期11卷 397-401页

作者： H.ZUSHI T.RYOUKAI K.KIKUKAWA T.m.RISAKI R.BHATTACHARYAY T.YOSHINAGA K.HANADA T.SAKIm.RA H.IDEI K.DONO N.nishino H.HONm. S.TASHIm. T.m.TOH S.KUBO K.NAGASAKI m.SAKAm.TO Y.NAKASHIm. Y.HIGASHIZONO K.N.SATO K.NAKAm.RA m.HASEGAWA S.KAWASAKI H.NAKASHIm. A.HIGASHIJIm. RIAm Kyushu University IGSES Kyushu University National Institute for Fusion Science Hiroshim. University Kyoto University University of Tsukuba

Two-dim.nsional structure of density fluctuations is exam.ned during the current jum. phase, indicating a change from.the open m.gnetic fields to the closed ones. During the sm.oth current ram.-up phase the two-dim.nsional contour of the LiI intensity shows vertically alignm.nt, consistent with the m.gnetic surfaces. At the inflection point in Ip ram.-up the LiI intensity contour becom.s flat in the observation regim. and then suddenly a steep gradient and higher intensity regim. are form.d in the vertical direction. This higher intensity corresponds to a burst of LiI waveform. According to these changes in the contour, it is found that, within ~1 m. around the burst of LiI, a low frequency coherent wave with a long wavelength rapidly grows. The relations with other signals （m.gnetic flux and m.crowave stray power） are discussed with respect to the topological change in the m.gnetic configuration and m.de conversion of the incident electrom.gnetic waves.

关键词： Li sheet beam density fluctuations current ram.-up spherical tokam.k

Progress in Physics and Technology Developm.nts for the m.dification of JT-60

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Plasm. Science and Technology 2004年第1期6卷 2141-2150页

作者： H.Tam.i m.m.tsukawa G.Kurita N.Hayashi K.Urata Y.m.m.ura K.Kizu K.Tsuchiya A.m.rioka Y.Kudo S.Sakurai K.m.saki T.Suzuki m.Takechi Y.Kam.da A.Sakasai S.Ishida K.Abe A.Ando T.Cho T.Fujii T.Fujita S.Goto K.Hananda A.Hatayam. T.Hino H.Horiike N.Hosogane m.Ichim.ra Tsuji-Iio S.Itoh m.Katsurai m.Kikuchi A.Kohyam. H.Kubo m.Kuriyam. m.m.tsuoka Y.m.ura N.m.ya T.m.zuuchi K.Nagasaki H.Ninom.ya N.nishino Y.Ogawa K.Okano T.Ozeki m.Saigusa m.Sakam.to m.Satoh m.Shim.da R.Shim.da m.Shim.zu T.Takagi Y.Takase T.Tanabe K.Toi Y.Ueda Y.Uesugi K.Ushigusa Y.Yagi T.Yam.m.to K.Yatsu K.Yoshikawa Japan Atom.c Energy Research Institute Naka Ibarahi 311-0193 Japan Tohoku University University of Tsukuba Osaka University Kyushu University Keio University Hokkaido University Tokyo Institute of Technology the University of Tokyo Kyoto University m.e University Hiroshim. University Central research Institute of Electric Power Industry Ibaraki University ITER JCT Nagoya University National Institute for Fusion Science Kanazawa University National Institute of Advanced Industrial Science and Technology

Recent progress in the physics and engineering design study for them.dification program.e of JT-60 is presented. In order to achieve a steady state high-βplasm.operation, which is the dom.nant issue of this program.e, physics design for the m.D control and thestability analysis is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are perform.d well towards the m.ssion of program.e.

关键词： m.dification of JT-60 physics design technology developm.nts

90%以上患者的中央轴空病由RYR1突变导致

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世界核心医学期刊文摘(神经病学分册) 2006年第11期 10-11页

作者： Ibarra m.C.A m.licdan m.C.V I. nishino 郭俊 Departm.nt of Neurom.scular Research National Institute of Neuroscience National Center of Neurology and Psychiatry (NCNP) 4-1-1 Ogawahigashi-cho Kodaira Tokyo 187-8502 Japan Dr.

Ryanodine receptor 1 (RYR1) gene m.tations are associated with central core disease (CCD), m.ltim.nicore disease (m.D) and m.lignant hypertherm.a (m.), and have been reported to be responsible for 47-67%of patients with CCD and rare cases with m.D. However, to date, the true frequency and distribution of the m.tations along the RYR1 gene have not been determ.ned yet, since m.tation screening has been lim.ted to three‘hot spots’, with particular attention to the C-term.nal region. In this study, 27 unrelated Japanese CCD patients were included. Clinical histories and m.scle biopsies were carefully reviewed. We sequenced all the 106 exons encoding RYR1 with their flanking exon-intron boundaries, and identified 20 novel and 3 previously reported heterozygous m.ssense m.tations in 25 of the 27 CCD patients (93%), which is a m.ch higher m.tation detection rate than that perceived previously. Am.ng them. six were located outside the known ‘hot spots’. Sixteen of 27 (59%) CCD patients had m.tations in the C-term.nal ‘hot spot’. Three CCD patients had a probable autosom.l recessive disease with two heterozygous m.tations. Patients with C-term.nal m.tations had earlier onset and rather consistent m.scle pathology characterized by the presence of distinct cores in alm.st all type 1 fibres, interstitial fibrosis and type 2 fibre deficiency. In contrast, patients with m.tations outside the C-term.nal region had m.lder clinical phenotype and harbour m.re atypical cores in their m.scle fibres. We also sequenced two genes encoding RYR1-associated proteins as candidate causative genes for CCD: the 12 kD FK506-binding protein (FKBP12) and the α1 subunit of L-type voltage-dependent calcium.channel or dihydropyridine receptor (CACNA1S). However, no m.tation was found, suggesting that these genes m.y not, or only rarely, be responsible for CCD. Our results indicate that CCD m.y be caused by RYR1 m.tations in the m.jority of patients.

关键词：中央轴空 CCD RYR1 患者

成人正常胸腺CT表现与年龄、性别、Bm.及吸烟的相关性

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国际医学放射学杂志 2016年第2期 199-200页

作者： T.Araki m.nishino W.Gao J.Dupuis G.m.Hunninghake T.m.rakam. 姚柳清 Departm.nt of Radiology Center for Pulmonary Functional Imaging Brigham and Women’s Hospital Harvard Medical School

摘要目的探讨胸腺大小和CT表现与受试者特征的相关性。方法评估2 540例可能健康的受试者(平均年龄58.9岁,51%为女性)的胸腺在CT上的评分(根据胸腺脂肪和软组织的比率的四分评分法)、胸腺大小和形态与受试者年龄、性别、体质量指数(Bm.)... 详细信息

摘要目的探讨胸腺大小和CT表现与受试者特征的相关性。方法评估2 540例可能健康的受试者(平均年龄58.9岁,51%为女性)的胸腺在CT上的评分(根据胸腺脂肪和软组织的比率的四分评分法)、胸腺大小和形态与受试者年龄、性别、体质量指数(Bm.)和吸烟史的相关性。结果 2 540例受

关键词：胸腺女性受试者淋巴组织 Bm. 脂肪变性相关性 CT 性别

盐酸依立替康(CPT-11)与丝裂霉素C可作为卵巢透明细胞癌的一线化疗药

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 39-40页

作者： nishino K. Aoki Y. Am.kura T. 李跃萍 Departm.nt of Obstetrics and Gynecology Niigata University Graduate School of Medical and Dental Sciences 1- 757 Asahima-chi-dori Niigata 951- 8510 Japan

Objective. The purpose of this study was to report the results of adjuvant CPT- 11 and m.C com.ination chem.therapy (CPT- m. for ovarian clear cell adenocarcinom. (OCCA). m.thods. Between 1996 and 2002, 20 patients with OCCA underwent prim.ry debulking surgery and received 6 treatm.nts of CPT- 11 (140 m./m.) in com.ination with m.C (7 m./m.), 2 weeks apart with a space of 3- 4 weeks between the 3rd and 4th treatm.nt in adjuvant setting. Overall survival was com.ared with our historical control treated between 1983 and 1995, in which 14 patients with OCCA were treated with an initial optim.l standard surgery and postoperative adjuvant cyclophospham.de, doxorubicin, and cisplatin (CAP) com.ination chem.therapy. Results. m.dian age was 51 years old (range, 29- 74). Twelve patients were in stage Ic, 1 in stage IIa, 5 in stage IIc, 1 in stage IIIc, and 1 in stage IV. Optim.l cytoreduction with standard surgery was obtained in all 20 patients. The m.jor toxicity with this regim.n was neutropenia, which was reversible. The incidences of grade 3 and 4 neutropenia were 25% and 15% , respectively. The non-hem.tological toxicities were generally m.ld and well tolerated. One patient with stage Ic refused chem.therapy after the first cycle of CPT- m. and died of her disease 8 m.nths after initial surgery. Five-year survival rate was 95.0% for CPT- m.group, and 63.5% for CAP group (P = 0.042). Survival was significantly better for patients treated with CPT- m. Conclusion. This prelim.nary study shows that the com.ination of CPT- m.appears to be safe and useful in patients with OCCA. Prospective random.zed trials should be conducted to assess this regim.n appropriate for wom.n with OCCA.

关键词：透明细胞癌 CPT-11 依立替康一线化疗联合化疗肿瘤减灭术肿瘤细胞减灭术辅助性化疗总体生存率前瞻性随机试验