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Seroprevalence and m.lecular Biodiverisity of Hepatitis C Infection in Cong.lese Diabetics

Open Journal of g.stroenterolog. 2019年第1期9卷 22-27页

作者： A. m.ng.-Onkouo m. g. ibobi g.ssaye Deby E. Bouenizabila C. P. Ahoui Apendi N. Andzouana m.am.g.oua J. F. m.m.esse m.nam.u A. Boum.a N. A. Itoua-Ng.poro B. I. Atipoibara H. g. m.nabeka J.-R. Ibara Departm.nt of g.stroenterolog. and Internal m.dicine Brazzaville University Hospital Center Brazzaville Congo Faculty of Health Sciences Ngouabi Marien University Brazzaville Congo Departm.nt of m.tabolic Diseases of Brazzaville University Hospital Center Brazzaville Congo Laboratory Service Hospital g.neral of Louandjili Pointe- Noire Congo

Sum.ary: There is no evidence for com.rbidity diabetes and hepatitis C virus infection in the Cong.. The aim.of this work was to determ.ne the seroprevalence and m.lecular biodiversity of HCV in order to contribute to im.roving.the m.nag.m.nt of Cong.lese diabetics. Patients and m.thods: It was a cross-sectional study that took place from.1 February to 30 Septem.er 2018 at the Brazzaville University Hospital, the Diabcare Health Center and the Adolphe Cissé Hospital in Pointe-Noire. It concerned diabetic patients followed in Brazzaville and Pointe-Noire ag.eeing.to the study, after obtaining.the opinion of the ethics com.ittee of the research in health science. All sam.les collected were screened for the presence of anti HCV Ab using.a rapid ALERE HCV test and the m.nolisa HCV Ag.Ab ultra test for confirm.tion in Cong.. Detection of the viral RNA was done by PCR retrotranscription and g.notyping.was perform.d according.to the reverse hybridization technique in France. Data analysis was done with EpiInfo 6.0 software (2016);the proportions were com.ared using.the Chi-square test or the Fisher test at the sig.ificance level of 5%. Results: Of 447 patients with diabetes m.llitus, 49 had HCV positive serolog. and the sex ratio was 0.63. Seroprevalence of AC anti HCV was 11% (49/447);HCV RNA was detectable in 71.4% (n = 35) patients. The averag. ag. of the population was 62 ± 10 years with extrem.s rang.ng.from.26 to 82 years. The circulating.g.notypes were 4 (97.1%) and 1 (2.8%). Subtyping.was defined in 17.64% (n = 6) of g.notype 4 patients;undefined in 82.36% (n = 28) of g.notype 4 patients, and in one of g.notype 1 patients. The subtypes identified were subtype 4e (60%), subtype 4e (8.8%), subtype 4a/4c/4d (5.8%), and subtype 4h (2.9%). Conclusion: The prevalence of HCV is hig. in our study. These are im.ortant data for the im.rovem.nt of the m.nag.m.nt of diabetics.

关键词： Hepatitis C Diabete Cong.

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