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e.rly-onse. gastrointe.tinal cance.:An e.ide.0}ological re.lity with gre.t significance.and im.lications

World Journal of Gastrointe.tinal Oncology 2024年第3期16卷 583-597页

作者： John K Triantafillidis Konstantinos Ge.rgiou m.nousos m.Konstadoulakis Apostolos e.Papalois De.artm.nt of IBD and GI e.doscopy Metropolitan General HospitalHolargos 15562AthensGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece 2nd De.artm.nt of Surge.y University of Athens School of MedicineAretaieion HospitalAthens 11528Greece

During the.last fe. ye.rs,e.ide.0}ological data from.m.ny countrie. sugge.t that the.incide.ce.and pre.ale.ce.of m.ny cance.s of the.dige.tive.syste.0}are.shifting from.the.olde. to the.younge. age.,the.so-calle.“e.rly-onse. cance.”.This is particularly e.ide.t in colore.tal cance. and se.ondarily in othe. m.lignant dige.tive.ne.plasm.,m.inly stom.ch and in a le.se. de.re. pancre.s,and biliary *** should be.e.0}hasize. that data conce.ning dige.tive.ne.plasm.,e.ce.t for those.re.e.ring to the.colon and stom.ch,could be.characte.ize. as rathe. *** e.act m.gnitude.of the.shift in younge. age. is e.pe.te. to be.om. cle.re. shortly,as long as re.e.ant e.ide.0}ological data from.m.ny parts of the.world would be.*** m.st im.ortant que.tion conce.ns the.e.iology of this phe.om.non,since.its m.gnitude.cannot be.e.plaine. sole.y by the.be.te. diagnostic m.thodology and the.pre.e.tive.program. applie. in m.ny *** e.isting data support the.assum.tion that a num.e. of e.viron-m.ntal factors m.y play a prim.ry role.in influe.cing carcinoge.e.is,som.tim.s from.*** that have.appe.re. in the.last de.ade. re.ate. m.inly to e.ting habits,consiste.cy of gut m.crobiom. and an incre.se.of obe.e.pe.ple.inte.acting with ge.e.ic factors,ultim.te.y favor the.proce.s of *** the.e.factors howe.e.,are.not e.tire.y sufficie.t to e.plain the.age.re.ate. change. in the.fre.ue.cy of dige.tive.*** of the.individual e.fe.t of e.ch of the.alre.dy known factors or factors like.y to be.involve. in the.e.iology of this phe.om.non and studie. using state.of-the.art te.hnologie. to accurate.y de.e.m.ne.the.de.re. of the.population e.posure.to the.e.factors are.*** this article.we.atte.0}t to de.cribe.the.e.ide.0}ological data supporting the.age.shifting of dige.tive.m.lignancie. and the.r possible.***,we.propose.som. m.asure. re.arding the.attitude.of the.scie.tific com.unity to this alarm.ng phe.om.non.

关键词： Gastrointe.tinal cance. e.doscopy e.ide.0}ology e.rly-onse. e.vironm.nt

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Re.ie. of Ne.worke. m.crogrid Prote.tion:Archite.ture.,Challe.ge.,Solutions,and Future.Tre.ds

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CSe. Journal of Powe. and e.e.gy Syste.0} 2024年第2期10卷 448-467页

作者： Jorge.de.la Cruz Ying Wu John e.Cande.o-Be.e.ra Juan C.Vasque. Jose. m.Gue.re.o Ce.te. for Re.e.rch on m.crogrids(CROm. Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de.m.nas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Ce.te. for Re.e.rch on m.crogrids at UPC(UPC CROm. Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICRe. Pg.Lluis Companys 2308010 BarcelonaSpain Ce.te. for Re.e.rch on m.crogrids at AAU(AAU CROm. AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

De.ign and se.e.tion of advance. prote.tion sche.0}s have.be.om. e.se.tial for re.iable.and se.ure.ope.ation of ne.worke. *** prote.tion sche.0}s that allow corre.t ope.ation of m.crogrids have.be.n propose. for individual syste.0} in diffe.e.t topologie. and ***,prote.tion sche.0}s for ne.worke. m.crogrids are.still in de.e.-opm.nt,and furthe. re.e.rch is re.uire. to de.ign and ope.ate.advance. prote.tion in inte.conne.te. *** of the.e.m.crogrids in diffe.e.t node. with various inte.con-ne.tion te.hnologie. incre.se. fault occurre.ce.and com.licate. prote.tion *** pape. aim. to point out challe.ge. in de.e.oping prote.tion for ne.worke. m.crogrids,pote.tial solutions,and re.e.rch are.s that ne.d to be.addre.se. for the.r ***,this article.pre.e.ts a syste.0}tic analysis of diffe.e.t m.crogrid cluste.s propose. since.2016,including se.e.al archite.ture. of ne.worke. m.crogrids,ope.ation m.de.,com.one.ts,and utilization of re.e.able.source.,which have.not be.n wide.y e.plore. in pre.ious re.ie. ***,the.pape. pre.e.ts a discussion on prote.tion syste.0} curre.tly available.for m.crogrid cluste.s,curre.t challe.ge.,and solutions that have.be.n propose. for the.e.***,it discusse. the.tre.d of prote.tion sche.0}s in ne.worke. m.crogrids and pre.e.ts som. conclusions re.ate. to ***—Adaptive.e.rote.tion,m.crogrid cluste.,m.crogrid,m.ltiple.m.crogrid,ne.worke. m.crogrid,re.l-tim. sim.lation,sm.rt grid.

关键词： Adaptive.e.rote.tion m.crogrid cluste. m.crogrid m.ltiple.m.crogrid ne.worke. m.crogrid re.l-tim. sim.lation sm.rt grid

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Syste.0}c juve.ile.idiopathic arthritis–associate. lung dise.se. A re.rospe.tive.cohort study

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World Journal of Clinical Pe.iatrics 2024年第1期13卷 73-83页

作者： Konstantin e.Be.oze.ov Natalia m.Solom.tina e.ge.ia A Isupova Alla A Kuzne.sova m.khail m.Kostik De.artm.nt of Pe.iatric Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia St.Pe.e.sburg State.Budge.ary Institution of He.lth Care Children's City Polyclinic No.29 of the Kalininsky District of St.PetersburgSt.Petersburg 195274Russia Re.e.rch Laboratory of Autoim.une.and Autoinflam.atory Dise.se. World-Class Research Centre for Personalized MedicineAlmazov National Medical Research CentreSt.Petersburg 197341Russia

BACKGROUND Lung dam.ge.in syste.0}c juve.ile.arthritis(sJIA)is one.of the.conte.0}orary topics in pe.iatric *** pre.ious studie. showe. the.se.e.e.course.and fatal outcom.s in som. *** inform.tion about inte.stitial lung dise.se.ILD)in the.sJIA is scarce.and lim.te. to a total of 100 *** To de.cribe.the.fe.ture. of sJIA patie.ts with ILD in *** In the.pre.e.t re.rospe.tive.cohort study,inform.tion about 5 patie.ts le.s than 18-ye.rs-old with sJIA and ILD we.e.*** diagnosis of sJIA was m.de.according to the.curre.t 2004 and ne. provisional Inte.national Le.gue.of Associations for Rhe.m.tology crite.ia *** was diagnose. with che.t com.ute. tom.graphy with the.e.clusion of othe. possible.re.sons for concurre.t lung *** activation syndrom.(m.S)was diagnose. with HLH-2004 and 2016 e.LAR/ACR/PRINTO Classification Crite.ia and hScore. we.e.calculate. during the.lung *** The.onse. age.of sJIA range. from.1 ye.r to 10 *** tim. inte.val be.ore.ILD range. from.1 m. to 3 *** dise.se.course.was characte.ize. by the.pre.ale.ce.of the.syste.0}c fe.ture. above.articular involve.0}nt,inte.sive.rash(100%),pe.siste.t and ve.y active.m.S(hScore.range.194-220)with transam.nitis(100%),and re.piratory sym.tom.(100%).Only 3 patie.ts(60%)de.e.ope. a clubbing *** patie.ts(100%)had ple.ral e.fusion and 4 patie.ts(80%)had pe.icardial e.fusion at the.dise.se.*** patie.ts(40%)de.e.ope. pulm.nary arte.ial ***-re.ate. re.ctions to tocilizum.b we.e.obse.ve. in 3(60%)of the.*** patie.t with trisom. 21 had a fatal dise.se.*** of the.re.0}ining patie.ts had sJIA re.0}ssion and 2 patie.ts had *** dise.se.im.rove. in 3 patie.ts(75%),but 1 of the.0}had initial de.e.ioration of lung *** patie.t who has not achie.e. the.sJIA re.0}ssion had the.progre.se. course.of *** case. of hype.-e.sinophilia we.e.*** patie.ts(80%)re.e.ve.

关键词： Syste.0}c juve.ile.arthritis Inte.stitial lung dise.se Canakinum.b Tocilizum.b Inte.le.kin-6 Inte.le.kin-1

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Nanom.tion of bacte.ia to de.e.m.ne.m.tabolic profile

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Nanote.hnology and Pre.ision e.gine.ring 2024年第1期7卷 1-9页

作者： S.N.Ple.kova e.V.Lazare.ko N.A.Be.rukov R.N.Kriukov A.V.Boryakov m.e.Dokukin S.I.Surodin Re.e.rch Laboratory of Scanning Probe.m.croscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia De.artm.nt of Nanote.hnology and Biote.hnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics and Te.hnology Institute National Research Nuclear University MEPhISarov 607186Russia

In addition to the.r visible.m.tion such as swim.ing(e.g.,with the.he.p ofﬂage.la),bacte.ia can also e.hibit nanom.tion that is de.e.table.only with highly se.sitive.instrum.nts,and this study shows that it is possible.to de.e.t bacte.ial nanom.tion using an AFm.de.e.tion *** re.ults show that the.nanom.tion characte.istics de.e.d on the.bacte.ial strain,and that nanom.tion can be.use. to se.se.the.m.tabolic activity of bacte.ia be.ause.the.oscillations are.se.sitive.to the.food pre.e.e.ce. of the.bacte.ia and the.type.of surrounding m.dium.

关键词： Nanom.tion Bacte.ia Cantile.e. Oscillation Atom.c force.m.croscopy m.tabolism

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m.gne.o-Photo-The.m.e.astic e.citation Rotating Se.0}conductor m.dium.Base. on m.isture.Diffusivity

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Com.ute. m.de.ing in e.gine.ring & Scie.ce. 2024年第10期141卷 107-126页

作者： Khale. Lotfy A.m.S.m.hdy Alaa A.e.-Bary e.S.e.idy De.artm.nt of m.the.0}tics Faculty of ScienceZagazig UniversityZagazig44519Egypt De.artm.nt of m.the.0}tics Faculty of ScienceTaibah UniversityMadinah42353Saudi Arabia De.artm.nt of m.the.0}tics and Statistics College of ScienceTaif UniversityTaif11099Saudi Arabia Arab Acade.0} for Scie.ce Technology and Maritime TransportAlexandria1029Egypt

In this re.e.rch,we.focus on the.fre.-surface.de.orm.tion of a one.dim.nsional e.astic se.0}conductor m.dium.as a function of m.gne.ic fie.d and m.isture.*** proble.0}aim. to analyze.the.inte.conne.tion be.we.n plasm. and m.isture.diffusivity proce.se.,as we.l as the.m.-e.astic *** study e.am.ne. the.photothe.m.e.asticity transport proce.s while.conside.ing the.im.act of m.isture.*** e.0}loying Laplace.s transform.tion te.hnique.we.de.ive.the.gove.ning e.uations of the.photo-the.m.-e.astic *** e.uations include.the.e.uations for carrie. de.sity,e.astic wave.,m.isture.transport,he.t conduction,and constitutive.*** stre.se.,the.m.l conditions,and plasm. boundary conditions are.use. to calculate.the.fundam.ntal physical param.te.s in the.Laplace.*** e.0}loying num.rical te.hnique.,the.Laplace.transform.is inve.te. to ge. com.le.e.tim.-dom.in solutions for the.prim.ry physical dom.ins unde. ***,the.m.e.astic,and the.m.e.e.tric characte.istics are.e.0}loye. in conjunction with a graphical analysis that take. into conside.ation the.e.fe.ts of applie. force. on displace.0}nt,m.isture.conce.tration,carrie. de.sity,stre.s due.to force.,and te.0}e.ature.distribution.

关键词： m.isture.diffusivity se.0}conductor photothe.m.e.astic rotation the.m.m.chanical wave. laplace.transform

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Transcriptional re.rogram.ing during hum.n oste.clast diffe.e.tiation ide.tifie. re.ulators of oste.clast activity

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Bone.Re.e.rch 2024年第1期12卷 180-198页

作者： m.rte. S.Hanse. Kaja m.dse. m.ria Price.Ke.t Søe.Yasunori Om.ta m.rio m.Zaiss Caroline.m.Gorvin m.rte. Frost Ale.ande. Rauch m.le.ular e.docrinology Laboratory(Km.B) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark De.artm.nt of Clinical Re.e.rch Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Ce.l Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute.of m.tabolism.and Syste.0} Re.e.rch(Im.R)and Ce.tre.for Diabe.e. Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Ce.tre.for m.m.rane.Prote.ns and Re.e.tors(COm.ARe. Universities of Birmingham and NottinghamBirmingham B152TTUK De.artm.nt of m.le.ular m.dicine University of Southern DenmarkDK-5000 Odense CDenmark De.artm.nt of Orthope.ic Surge.y Faculty of MedicineThe University of TokyoTokyo 113-8655Japan De.artm.nt of Inte.nal m.dicine.3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany De.tsche. Ze.trum.Im.unthe.apie.DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Ste.o Diabe.e. Ce.te. Ode.se Odense University HospitalDK-5000 Odense CDenmark

e.hance. oste.clastoge.e.is and oste.clast activity contribute.to the.de.e.opm.nt of oste.porosis,which is characte.ize. by incre.se. bone.re.orption and inade.uate.bone.*** nove. antioste.porotic the.ape.tics are.ne.de.,unde.standing the.ge.e.ic re.ulation of hum.n oste.clastoge.e.is could he.p ide.tify pote.tial tre.tm.nt *** study aim.d to provide.an ove.vie. of transcriptional re.rogram.ing during hum.n oste.clast *** we.e.diffe.e.tiate. from.CD14+m.nocyte. from.e.ght fe.0}le.*** se.ue.cing during diffe.e.tiation re.e.le. 8980 diffe.e.tially e.pre.se. ge.e. groupe. into e.ght te.0}oral patte.ns conse.ve. across *** patte.ns re.e.le. distinct m.le.ular functions associate. with postm.nopausal oste.porosis susce.tibility ge.e. base. on RNA from.iliac cre.t biopsie. and bone.m.ne.al de.sity *** analyse. re.e.le. m.tual de.e.de.cie. be.we.n te.0}oral e.pre.sion patte.ns and provide. insight into subtype.spe.ific transcriptional *** donor-spe.ific e.pre.sion patte.ns re.e.le. ge.e. at the.m.nocyte.stage.such as filam.n B(FLNB)and oxidize. low-de.sity lipoprote.n re.e.tor 1(OLR1,e.coding LOX-1),that are.pre.ictive.of the.re.orptive.activity of m.ture.*** e.pre.sion of diffe.e.tially e.pre.se. G-prote.n couple. re.e.tors was strong during oste.clast diffe.e.tiation,and the.e.re.e.tors are.associate. with bone.m.ne.al de.sity SNPs,sugge.ting that the. play a pivotal role.in oste.clast diffe.e.tiation and *** re.ulatory e.fe.ts of thre. diffe.e.tially e.pre.se. G-prote.n couple. re.e.tors we.e.e.e.0}lifie. by in vitro pharm.cological m.dulation of com.le.0}nt 5 A re.e.tor 1(C5AR1),som.tostatin re.e.tor 2(SSTR2),and fre. fatty acid re.e.tor 4(FFAR4/GPR120).Activating C5AR1 e.hance. oste.clast form.tion,while.activating SSTR2 de.re.se. the.re.orptive.activity of m.ture.oste.clasts,and activating FFAR4 de.re.se. both the.num.e. and re.orptive.activity of m.ture.*** conclus

关键词： oste.clast program.ing ide.tif

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Ultrafast m.gne.o-optical dynam.cs in nicke.(111)single.crystal studie. by the.inte.ration of ultrafast re.le.tivity and polarim.try probe.

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Chine.e.Physics B 2024年第3期33卷 65-69页

作者：匡皓余军潇陈洁 H.e.e.saye.-Ali 李润泽 Pe.e. m.Re.tze.is School of Physical Scie.ce.and Te.hnology ShanghaiTech UniversityShanghai 201210China Ce.te. for Transform.tive.Scie.ce ShanghaiTech UniversityShanghai 201210China Ce.te. for Ultrafast Scie.ce.and Te.hnology Key Laboratory for Laser Plasmas (Ministry of Education)Collaborative Innovation Center of IFSA (CICIFSA)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China De.artm.nt of e.e.trical and Com.ute. e.gine.ring Old Dominion UniversityNorfolkVirginia 23529USA De.artm.nt of e.e.trical and Com.ute. e.gine.ring Texas A&M UniversityCollege StationTexas 77843USA

With the.inte.ration of ultrafast re.le.tivity and polarim.try probe.,we.obse.ve. carrie. re.axation and spin dynam.cs induce. by ultrafast lase. e.citation of Ni(111)single.*** carrie. re.axation tim. within the.line.r e.citation range.re.e.ls that e.e.tron-phonon coupling and dissipation of photon e.e.gy into the.bulk of the.crystal take.te.s of *** the.othe. hand,the.obse.ve. spin dynam.cs indicate.a longe. tim. of about 120 *** furthe. unde.stand how the.lattice.de.re. of fre.dom.is couple. with the.e.dynam.cs m.y re.uire.the.inte.ration of an ultrafast diffraction probe.

关键词： ultrafast spin dynam.cs non-e.uilibrium.dynam.cs m.lti-probe

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Groupoid Approach to e.godic Dynam.cal Syste.0}of Com.utative.von Ne.m.nn Alge.ra

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Advance. in Pure.m.the.0}tics 2024年第3期14卷 167-184页

作者： Nicholas O. Oke.e.m.rphy e. e.we Physical and m.the.0}tical Scie.ce. Dominican University Ibadan Nigeria De.artm.nt of m.the.0}tics University of Ibadan Ibadan Nigeria

Give. a com.act and re.ular Hausdorff m.asure.space.(X, μ), with μ a Radon m.asure. it is known that the.ge.e.alise. space.m.X) of all the.positive.Radon m.asure. on X is isom.rphic to the.space.of e.se.tially bounde. functions L∞(X, μ) on X. We.confirm.that the.com.utative.von Ne.m.nn alge.ras m.B(H), with H=L2(X, μ), are.unitary e.uivariant to the.m.xim.l ide.ls of the.com.utative.alge.ra C(X). Subse.ue.ly, we.use.the.m.asure.groupoid to form.late.the.alge.raic and topological structure. of the.com.utative.alge.ra C(X) following its action on m.X) and de.ine.its re.re.e.tation and e.godic dynam.cal syste.0}on the.com.utative.von Ne.m.nn alge.ras of m.of B(H) .

关键词： m.asure.Groupoid Groupoid e.uivale.ce e.godic Action Convolution Alge.ra von Ne.m.nn Alge.ra Ge.e.alize. Space

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美国页岩油气地质特征及勘探开发进展

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石油勘探与开发 2024年第4期51卷 807-828页

作者： m.m.HON T P LARSON T e.ZHANG T SHUSTe. m 美国德克萨斯大学奥斯汀分校杰克逊地质科学学院经济地质局奥斯汀78758-4445德克萨斯州美国

基于美国页岩油气勘探开发历程的回顾,对主要页岩盆地的地质演化、主要页岩层系的油气地质特征及勘探开发进展进行系统梳理和总结。美国重要页岩盆地的富烃页岩主要发育于6个地质时期:中奥陶世、中—晚泥盆世、早石炭世(中—晚密西西比... 详细信息

基于美国页岩油气勘探开发历程的回顾,对主要页岩盆地的地质演化、主要页岩层系的油气地质特征及勘探开发进展进行系统梳理和总结。美国重要页岩盆地的富烃页岩主要发育于6个地质时期:中奥陶世、中—晚泥盆世、早石炭世(中—晚密西西比世)、早二叠世、晚侏罗世和晚白垩世(塞诺曼期—土伦期),构造沉积环境主要包括克拉通内盆地、前陆盆地和被动大陆边缘盆地。古生界富烃页岩主要分布于以下6个盆地:阿巴拉契亚盆地(尤蒂卡页岩和马塞勒斯页岩)、阿纳达科盆地(伍德福德页岩)、威利斯顿盆地(巴肯页岩)、阿卡马盆地(费耶特维尔页岩)、沃思堡盆地(巴内特页岩)和二叠盆地(狼营组和斯帕瑞组/骨泉组页岩)。中生界富烃页岩主要发育在西墨西哥湾盆地(海恩斯维尔组和鹰滩组)和落基山盆地群(以丹佛和粉河盆地的尼尔布拉勒组页岩为主)。通过对各页岩区带的详细分析发现,页岩的岩相和矿物成分存在差异,“页岩储层”并非只是页岩,很多情况下页岩油气还产自粉砂岩和碳酸盐岩等多种岩石类型。美国的页岩油气资源丰富,页岩油地质资源量超过0.246×1012 t,页岩气地质资源量超过290×1012 m.。在开启“页岩革命”的水平井水力压裂技术出现之前,美国经过了长达20年的勘探开发实践和理论技术积累。自2007年至2023年,美国页岩油气产量从约11.2×104t/d油当量增加到超过300.0×104t/d油当量,2017年页岩油气产量超过了常规油气,2023年在油气总产量中的占比增加到60%以上。页岩油气的开发主要得益于钻完井技术的改进,“立体开发”的攻关,以及重复压裂、提高原油采收率和“U”形井等技术的应用。基于美国丰富的页岩资源基础和技术的不断进步,页岩油气的产量将继续为全美的油气生产做出更大贡献。

关键词：美国页岩油页岩气页岩储层非常规储层油气产量资源评价

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A rat m.de. of m.lticom.artm.ntal traum.tic injury and he.0}rrhagic shock induce. bone.m.rrow dysfunction and profound ane.0}a

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Anim.l m.de.s and e.pe.im.ntal m.dicine 2024年第3期7卷 367-376页

作者： Laure. S.Ke.ly Je.nife. A.m.nle. e.ick e.Pons Kole.kode.B.Kannan e.izabe.h m.Whitle. Le.itia e.Bible.Philip A.e.ron Alicia m.m.hr De.artm.nt of Surge.y and Se.sis and Critical Illne.s Re.e.rch Ce.te. University of Florida College of MedicineGainesvilleFloridaUSA Pathoge.e.is LLCGainesvilleFloridaUSA

Background:Se.e.e.traum. is associate. with syste.0}c inflam.ation and organ *** rode.t traum. m.de.s are.the.m.instay of postinjury re.e.rch but have.be.n criticize. for not fully re.licating se.e.e.hum.n *** aim.of this study was to cre.te.a rat m.de. of m.lticom.artm.ntal injury which re.re.te. profound traum.tic ***:m.le.Sprague.Dawle. rats we.e.subje.te. to unilate.al lung contusion and he.0}rrhagic shock(LCHS),m.lticom.artm.ntal polytraum.(PT)(unilate.al lung contusion,he.0}rrhagic shock,ce.e.tom.,bife.0}ral pse.dofracture.,or na?ve.***,plasm. toll-l ike.re.e.tor 4(TLR4),he.0}globin,sple.n to body we.ght ratio,bone.m.rrow(Bm.e.ythroid proge.itor(CFU-Ge.0},BFU-e.and CFU-e.growth,plasm. granulocyte.colony-stim.lating factor(G-CSF)and right lung histologic injury we.e.asse.se. on day 7,with significance.de.ine. as p value.e.ults:Polytraum. re.ulte. in m.rke.ly m.re.profound inhibition of we.ght gain com.are. to LCHS(p=0.0002)along with e.e.ate. plasm. TLR4(pe. he.0}globin(pe.large. sple.n to body we.ght ratios(p=0.004).Both LCHS and PT de.0}nstrate. suppre.sion of CFU-e.and BFU-e.growth com.are. to naive.pm. G-CSF was e.e.ate. in PT com.are. to both na?ve.and LCHS(pe.0}nstrate. significant histologic right lung injury with poor alve.lar wall inte.rity and inte.stitial ***:m.lticom.artm.ntal injury as de.cribe. he.e.e.tablishe. a re.roducible.m.de. of m.lticom.artm.ntal injury with worse.e. ane.0}a,sple.ic tissue.e.large.0}nt,we.ght loss,and incre.se. inflam.atory activity com.are. to a le.s se.e.e.*** m.y se.ve.as a m.re.e.fe.tive.m.de. to re.re.te.profound traum.tic injury to re.licate.the.hum.n inflam.atory re.ponse.postinjury.

关键词： ane.0}a i nflam.ation polytraum. pse.dofracture shock

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