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中华医学杂志(英文版) 1989年第9期102卷 708-708页

作者： h m zheng G Z Zhou S J Ding Department of Neurology First Affiliated Hospital Second Military Medical College Shanghai

Four cases of rigid rigid spine syndrome are reported for the first time in China. They are 2 males and 2 females. One girl has a positive family history. Limitation of flexion of the cervical and dorsolumbar spine, contractures of joints, especially the elbow joints, extreme flattening of the chest and scoliosis are the prominent symptoms of this syndrome. The clinical criteria for this rigid spine syndrome tally with those described by Dubowitz (1965). Symptomatology, diagnosis, differential diagnosis and genetics are discussed. however, the question whether rigid spine syndrome is a single, well defined disease entity remains to be explored.

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B-implantation and Annealing for SiGe Epilayers

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Semiconductor Photonics and Technology 1997年第4期3卷 286-289页

作者： JIANG R L,LIU W P,JIANG N, ZhU S m,hU L h,zheng Y D (Dept.of Physics,Nanjing University,Nanjing 210093,ChN)

Si 0.8 Ge 0.2 strained epilayer were grown on Si substrates by rapid thermal process/very low pressure-chemical vapor deposition (RTP/VLP-CVD) and implanted with boron at 40 keV,a dosage of 2.5×10 14 cm -2 .Rapid thermal annealing (RTA) and steady-state furnace annealing with different temperature and time period were performed for *** indicate that RTA is better than furnace *** RTA at 750 ℃～850 ℃ for 10 s or at 700 ℃ for 40 s,the implantation induced damage can be removed,the carrier mobility was about 300 cm 2/V·s and the activity was nearly 100%.

关键词： Activity Annealing B-implantation Doping Technique SiGe/Si heterostructures

EFFECT OF COmPREhENSIVE mANAGEmENT ON STROKE PREVENTION

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中华医学杂志(英文版) 1988年第5期101卷 364-364页

作者： Y m Shi G Q Wang h m zheng L Z Niu D R Chen G B Xue Department of Neurology Changhai Hospital the Second Military Medical College Shanghai Department of Epidemiology the Second Military Medical College

This article reports the effect of comprehensive management on the prevention of stroke observed during 1981 to 1984 in Guangzhong neighborhood, hongkou District, Shanghai, which was chosen randomly as a prevention group. About 50 000 people were included. A non-prevention group including about 70 000 people was selected randomly from other 12 neighborhoods of the same district. The results of the study show that the effect of comprehensive management on stroke prevention in the community is remarkable, especially in cutting stroke incidence. For example, the mean stroke incidence was 34.56/100 000/year in the prevention group whereas it was 103.23/100 000/year in the non-prevention group during 1981 to 1984. Comparison of the two groups showed u=9.66, the difference being extremely significant (phat stroke mortafity in the prevention group was much lower than that of the non-prevention group, except in 1981. The difference in stroke mortality between the two groups was very significant (phe protection rate for stroke using comprehensive measurement was up to 66.52% and the average effective index was 2.99.

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Defect Engineering with Rational Dopants modulation for high-Temperature Energy harvesting in Lead-Free Piezoceramics

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NANO-mICRO LETTERS 2025年第1期17卷 1-15页

作者： Xi, Kaibiao Guo, Jianzhe zheng, mupeng Zhu, mankang hou, Yudong Beijing Univ Technol Coll Mat Sci & Engn Key Lab Adv Funct Mat Minist Educ Beijing 100124 Peoples R China

high temperature piezoelectric energy harvester (hT-PEh) is an important solution to replace chemical battery to achieve independent power supply of hT wireless sensors. however, simultaneously excellent performances, including high figure of merit (FOm), insulation resistivity (rho) and depolarization temperature (T-d) are indispensable but hard to achieve in lead-free piezoceramics, especially operating at 250 degrees C has not been reported before. herein, well-balanced performances are achieved in BiFeO3-BaTiO3 ceramics via innovative defect engineering with respect to delicate manganese doping. Due to the synergistic effect of enhancing electrostrictive coefficient by polarization configuration optimization, regulating iron ion oxidation state by high valence manganese ion and stabilizing domain orientation by defect dipole, comprehensive excellent electrical performances (T-d = 340 degrees C, rho(250) (degrees C) > 10(7) Omega cm and FOm2(50 degrees C) = 4905 x 10(-15 )m(2) N-1) are realized at the solid solubility limit of manganese ions. The hT-PEhs assembled using the rationally designed piezoceramic can allow for fast charging of commercial electrolytic capacitor at 250 degrees C with high energy conversion efficiency (eta = 11.43%). These characteristics demonstrate that defect engineering tailored BF-BT can satisfy high-end hT-PEhs requirements, paving a new way in developing self-powered wireless sensors working in hT environments.

关键词： Lead-free piezoceramic Defect engineering Dopants modulation high-temperature Piezoelectric energy harvester

microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli zheng Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation m1/m2 activation macrophages microglia neuroinflammation spinal cord injury therapy

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia ma Ke Ye Xue Zhao Fangliang Ge Feifei zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of heilongjiang Province for Genetically modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui he Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and m1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and m2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4h-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan huijuan zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4h-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Observability Analysis of Integrated Electricity and heating Systems with Thermal Quasi-dynamics in Pipelines

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1145-1158页

作者： Zhigang Li Wenjian zheng Junbo Zhao J.h.zheng Q.h.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China Fuzhou Changle District Power Supply Company of State Grid Fujian Electric Power Co. Ltd.Fuzhou 350000China Department of Electrical and Computer Engineering University of ConnecticutStorrsCT 06269USA CSEE IEEE

Observability analysis(OA)is vital to obtaining the available input measurements of state estimation(SE)in an integrated electricity and heating system(IEhS).Considering the thermal quasi-dynamics in pipelines,the measurement equations in heating systems are dependent on the estimated results,leading to an interdependency between OA and *** OA methods require measurement equations be known exactly before SE is performed,and they are not applicable to *** bridge this gap,a scenario-based OA scheme for IEhSs is devised that yields reliable analysis results for a predefined set of time-delay scenarios to cope with this *** its core procedure,the observable state identification and observability restoration are formulated in terms of integer linear *** tests are conducted to demonstrate the validity and superiority of the proposed formulation.

关键词： Integrated electricity and heating system measurement observability analysis state estimation thermal quasi-dynamics