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Abnormal liver enzymes: A review for clinicians

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World Journal of Hepatology 2021年第11期13卷 1688-1698页

作者： m ammar kalas Luis Chavez monica Leon Pahnwat Tonya Taweesedt Salim Surani Department of Internal medicine Texas Tech University Health Science CenterEl PasoTX 79905United States Department of General Surgery University of MexicoCiudad de Mexico 01120Mexico Department of medicine Corpus Christi Medical CenterCorpus ChristiTX 78412United States Department of medicine Texas A&M UniversityCollege StationTX 77843United States Department of Anesthesiology Mayo ClinicRochesterMN 55905United States

Liver biochemical tests are some of the most commonly ordered routine tests in the inpatient and outpatient setting,especially with the automatization of testing in this technological *** tests include aminotransferases,alkaline phosphatase,gamma-glutamyl transferase,bilirubin,albumin,prothrombin time and international normalized ratio(INR).Abnormal liver biochemical tests can be categorized based on the pattern and the magnitude of aminotransferases ***,abnormalities in aminotransferases can be classified into a hepatocellular pattern or cholestatic pattern and can be further sub-classified based on the magnitude of aminotransferase elevation to mild[mit of normal(ULN)],moderate(>5-15×ULN).Hepatocellular pattern causes include but are not limited to;non-alcoholic fatty liver disease/non-alcoholic steatohepatitis,alcohol use,chronic viral hepatitis,liver cirrhosis(variable),autoimmune hepatitis,hemochromatosis,Wilson’s disease,alpha-1 antitrypsin deficiency,celiac disease,medication-induced and ischemic *** pattern causes include but is not limited to;biliary pathology(obstruction,autoimmune),other conditions with hyperbilirubinemia(conjugated and unconjugated).It is crucial to interpret these commonly ordered tests accurately as appropriate further workup,treatment and referral can greatly benefit the patient due to prompt treatment which can improve the natural history of several of the diseases mentioned and possibly reduce the risk of progression to the liver cirrhosis.

关键词： Liver function test Liver enzymes Hepatitis Liver biochemical studies Nonalcoholic steatohepatitis Hyperbilirubenemia

Prevalence and associated factors of clubfoot in the eastern province of Saudi Arabia: A hospital-based study

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World Journal of Orthopedics 2024年第7期15卷 635-641页

作者： ammar K Alomran Bandar A Alzahrani Bader S Alanazi mohammed A Alharbi Loay m Bojubara Eman m Alyaseen Department of Orthopedic College of MedicineImam Abdulrahman bin Faisal UniversityDammam 34212Saudi Arabia College of medicine Imam Abdulrahman bin Faisal UniversityDammam 34212Saudi Arabia College of medicine Arabian Gulf UniversityManama 329Bahrain

BACKGROUND Clubfoot,or congenital talipes equinovarus,is a widely recognized cause of disability and congenital deformity worldwide,which significantly impacts the quality of *** management of clubfoot requires long-term,multidiscip-linary *** is important to understand how common this condition is in order to assess its impact on the ***,few studies have investigated the prevalence of clubfoot in Saudi *** To determine the prevalence of clubfoot in Saudi Arabia via the patient population at King Fahad University Hospital(KFUH).mETHODS This was a retrospective study conducted at one of the largest hospitals in the country and located in one of the most densely populated of the administrative *** Of the 7792 births between 2015 to 2023 that were included in the analysis,42 patients were diagnosed with clubfoot,resulting in a prevalence of 5.3 per 1000 live births at *** The observed prevalence of clubfoot was significantly higher than both global and local estimates,indicating a substantial burden in the study population.

关键词： Clubfoot Talipes equinovarus Congenital talipes equinovarus Prevalence Saudi Arabia

Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer

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Friction 2024年第3期12卷 539-553页

作者： Agnese FRAGASSI Antonietta GRECO martina DI FRANCESCO Luca CESERACCIU Aiman ABU ammar Israel DVIR Thomas Lee mOORE Haytam KASEm Paolo DECUZZI Laboratory of Nanotechnology for Precision medicine Fondazione Istituto Italiano di TecnologiaGenova 16163Italy Department of Chemistry and Industrial Chemistry University of GenovaGenoa 16146Italy materials Characterization Facility Istituto Italiano di TecnologiaGenova 16163Italy Department of Pharmaceutical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel Department of mechanical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel

Nano-and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications,from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic ***,we assessed the tribological properties of a simulated synovial fluid enriched with non-spherical,poly lactic-co-glycolic acid(PLGA)microparticles(μPL)that have been previously demonstrated for the pharmacological management of osteoarthritis(OA).Three different μPL configurations were fabricated presenting a 20μm×20μm square base and a thickness of 5μm(thin,5H μPL),10μm(10H μPL),and 20μm(cubical,20H μPL).After extensive morphological and physicochemical characterizations,the apparent Young’s modulus of the μPL was quantified under compressive loading returning an average value of~6 kPa,independently of the particle ***,using a linear two-axis tribometer,the static(μ_(s))and dynamic(μ_(d))friction coefficients of the μPL-enriched simulated synovial fluid were determined in terms of particle configuration and concentration,varying from 0(fluid only)to 6×10^(5) μPL/*** particle morphology had a modest influence on friction,possibly because the μPL were fully squeezed between two mating surfaces by a 5.8 N normal load realizing boundary-like lubrication ***,friction was observed to depend on the dimensionless parameterW,defined as the ratio between the total volume of the μPL enriching the simulated synovial fluid and the volume of the fluid *** coefficients of friction were documented to grow withWreaching a plateau of μ_(s)~0.4 and μ_(d)~0.15,already at Ω~2×10^(-3).Future investigations will have to systematically analyze the effect of sliding velocity,normal load,and rigidity of the mating surfaces to elucidate in full the tribological behavior of μPL in the context of osteoarthritis.

关键词： osteoarthritis microparticles tribology synovial fluid pin on plate

Burden of routine orthopedic implant removal a single center retrospective study

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World Journal of Orthopedics 2024年第2期15卷 139-146页

作者： ammar K AlOmran Nader Alosaimi Ahmed A Alshaikhi Omar m Bakhurji Khalid J Alzahrani Basil Ziyad Salloot Tamim Omar Alabduladhem Ahmed I Almulhim Arwa Alumran Department of Orthopedic College of MedicineImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Health Information management and Technology Department Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

BACKGROUND Open reduction and internal fixation represent prevalent orthopedic procedures,sparking ongoing discourse over whether to retain or remove asymptomatic *** consensus on this matter is paramount for orthopedic *** study aims to quantify the impact of routine implant removal on patients and healthcare facilities.A retrospective analysis of implant removal cases from 2016 to 2022 at King Fahad Hospital of the University(KFHU)was conducted and subjected to statistical *** these cases,44%necessitated hospitalization exceeding one day,while 56%required only a single *** exhibited a 55%need for extended hospital stays,contrasting with 22.8%among the pediatric *** complication rate was 6%,with all patients experiencing at least one ***,34.1%required sick leave and 4.8%exceeded 14 *** anesthesia was predominant(88%).Routine implant removal introduces unwarranted complications,particularly in adults,potentially prolonging *** procedure strains hospital resources,tying up the operating room that could otherwise accommodate critical *** defined institutional guidelines are imperative to regulate this *** To measure the burden of routine implant removal on the patients and *** This is a retrospective analysis study of 167 routine implant removal cases treated at KFHU,a tertiary hospital in Saudi *** were collected in the orthopedic department at KFHU from February 2016 to August 2022,which includes routine asymptomatic implant removal cases across all age *** indications such as infection,pain,implant failure,malunion,nonunion,restricted range of motion,and prominent hardware were *** who had external fixators removed or joints replaced were also *** Between February 2016 and August 2022,360 implants were retrieved;however,only 167 of those who met the inclusion criteria were included in this

关键词： Implant removal Healed fracture Orthopedic implant Complications Healthcare system

New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADmET Properties

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International Journal of Organic Chemistry 2024年第3期14卷 107-122页

作者： marwa Dhiabi Sirine Karoui mehdi Fakhfakh Souhir Abid Emmanuelle Limanton Rémy Le Guével Thierry Charlier Ludovic Paquin Jean-Pierre Bazureau Houcine ammar Laboratoire de Chimie Applique: Htrocycles Corps et Polymres Facult des Sciences de Sfax Universit de Sfax Sfax Tunisie Institut des Sciences Chimiques de Rennes Universit de Rennes Campus de Beaulieu Rennes Cedex France Department of Chemistry (Science and Arts): Al Qurayat Al-Jouf University Al Jawf Saudi Arabia S2Wave Platform ScanMAT UAR CNRS Universit de Rennes Campus de Beaulieu Rennes Cedex France ImPACcell Platform Biosit SFR UMS CNRS Inserm Campus de Villejean Rennes France Institut de Recherche en Sant Environnement et Travail IRSET Inserm UMR_S Rennes France

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NmR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, mDA-mB231, mDA-mB468, HCT116, PC3 and mCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μm). Finally, in silico ADmET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

关键词： 2-Amino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-Amine microwave Irradiation Tumoral Cell Line in Silico ADmET

Cyberbullying Detection and Recognition with Type Determination Based on machine Learning

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Computers, materials & Continua 2023年第6期75卷 5307-5319页

作者： Khalid m.O.Nahar mohammad Alauthman Saud Yonbawi ammar Almomani Computer Science Department Yarmouk UniversityIrbidJordan Department of Information Security Faculty of Information TechnologyUniversity of PetraAmmanJordan Software Engineering Department University of JeddahJeddahKSA Research and Innovation Department Skyline University CollegeP.O.Box 1797SharjahUAE IT Department-Al-Huson University College Al-Balqa Applied UniversityP.O.Box 50IrbidJordan

Social media networks are becoming essential to our daily activities,and many issues are due to this great involvement in our *** is a social media network issue,a global crisis affecting the victims and society as a *** results from a misunderstanding regarding freedom of *** this work,we proposed a methodology for detecting such behaviors(bullying,harassment,and hate-related texts)using supervised machine learning algo-rithms(SVm,Naïve Bayes,Logistic regression,and random forest)and for predicting a topic associated with these text data using unsupervised natural language processing,such as latent Dirichlet *** addition,we used accuracy,precision,recall,and F1 score to assess prior *** show that the use of logistic regression,support vector machine,random forest model,and Naïve Bayes has 95%,94.97%,94.66%,and 93.1%accuracy,respectively.

关键词： Cyberbullying social media naïve bayes support vector machine natural language processing LDA

Interactive effects of deficit irrigation and vermicompost on yield,quality,and irrigation water use efficiency of greenhouse cucumber

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Journal of Arid Land 2022年第11期14卷 1274-1292页

作者： Halimeh PIRI Amir NASERIN ammar A ALBALASmEH Department of Water Engineering Faculty of College of Water and SoilUniversity of ZabolZabol ***Iran Department of Water Engineering Agricultural Sciences and Natural Resources University of KhuzestanMollasani ***Iran Department of Natural Resources and the Environment Faculty of AgricultureJordan University of Science and TechnologyIrbid 22110Jordan

Water scarcity is the most significant barrier to agricultural development in arid and semi-arid *** irrigation is an effective solution for managing agricultural water in these *** use of additives such as vermicompost(VC)to improve soil characteristics and increase yield is a popular *** this,there is still a lack of understanding of the interaction between irrigation water and VC on various *** study aimed to investigate the interaction effect of irrigation water and VC on greenhouse cucumber yield,yield components,quality,and irrigation water use efficiency(IWUE).The trials were done in a split-plot design in three replicates in a semi-arid region of southeastern Iran in 2018 and *** levels of VC in the experiments,i.e.,10(V_(1)),15(V_(2)),and 20 t/hm^(2)(V_(3)),and three levels of irrigation water,i.e.,50%(I_(1)),75%(I_(2)),and 100%(I_(3))of crop water requirement were *** results showed that the amount of irrigation water,VC,and their interaction significantly affected cucumber yield,yield components,quality,and IWUE in both *** the amount of irrigation water and VC application rates reduced the weight,diameter,length,and cucumber *** maximum yield(175 t/hm^(2))was recorded in full irrigation using 20 t/hm^(2)of VC,while the minimum yield(98 t/hm^(2))was found in I_(1)V_(1)*** maximum and minimum values of IWUE were recorded for I_(1)V_(3)and I_(3)V_(1)treatments as 36.07 and 19.93 kg/(m^(3)•hm^(2)),***,reducing irrigation amount decreased chlorophyll a and b,but increased vitamin ***,the maximum carbohydrate and protein contents were obtained in mild water-stressed conditions(I_(2)).Although adding VC positively influenced the value of quality traits,no significant difference was observed between V_(2)and V_(3)*** on the results,adding VC under full irrigation conditions leads to enhanced yield and ***,in the case of applying deficit ir

关键词： irrigation water use efficiency greenhouse size and weight of fruit soil amendment semi-arid region

A Robust model for Translating Arabic Sign Language into Spoken Arabic Using Deep Learning

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Intelligent Automation & Soft Computing 2023年第8期37卷 2037-2057页

作者： Khalid m.O.Nahar ammar Almomani Nahlah Shatnawi mohammad Alauthman Department of Computer Sciences Faculty of Information Technology and Computer SciencesYarmouk University-Irbid21163Jordan School of Computing Skyline University CollegeSharjahP.O.Box 1797United Arab Emirates IT-Department-Al-Huson University College Al-Balqa Applied UniversityP.O.Box 50IrbidJordan Department of Information Security Faculty of Information TechnologyUniversity of PetraAmmanJordan

This study presents a novel and innovative approach to auto-matically translating Arabic Sign Language(ATSL)into spoken *** proposed solution utilizes a deep learning-based classification approach and the transfer learning technique to retrain 12 image recognition *** image-based translation method maps sign language gestures to corre-sponding letters or words using distance measures and classification as a machine learning *** results show that the proposed model is more accurate and faster than traditional image-based models in classifying Arabic-language signs,with a translation accuracy of 93.7%.This research makes a significant contribution to the field of *** offers a practical solution for improving communication for individuals with special needs,such as the deaf and mute *** work demonstrates the potential of deep learning techniques in translating sign language into natural language and highlights the importance of ATSL in facilitating communication for individuals with disabilities.

关键词： Sign language deep learning transfer learning machine learning automatic translation of sign language natural language processing Arabic sign language

Entropy generation of mHD natural convection heat transfer in a heated incinerator using hybrid-nanoliquid

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Propulsion and Power Research 2021年第2期10卷 143-154页

作者： Bouchmel mliki mohamed ammar Abbassi materials Energy and Renewable EnergiesFaculty of Sciences of GafsaB.P.19ZarrougGafsa2112Tunisia

The present study explores magnetic hybrid-nanoliquid(Al_(2)O_(3)-Cu/H_(2)O)natural convection in a heated incinerator shaped cavity by using the lattice Boltzmann method(LBm).Numerical results are presented in the form temperature contours,stream function and local entropy *** interaction between various physical phenomena characterizing this problem including the natural convection and the magnetic field has been *** of Rayleigh number(Ra=10^(3)-10^(6)),volumetric fraction of nanoparticles(ϕ=0-0.04),and Hartmann number(Ha=0-90)are clarified in details through graphical *** depict that the average Nusselt number(Nu_(m))and average entropy generation(S_(gen,A))increases with an increase of the Rayleigh number while are decreased by applying a magnetic *** addition,it is found that the average Nusselt number(Nu_(m))increases with the rise of volumetric fraction of nanoparticles for all Rayleigh and Hartmann ***,an opposite effect is obtained by an increase in volumetric fraction of nanoparticles on the average entropy generation(S_(gen,A)).Finally,the numerical results demonstrate that the effect of Lorentz force is reduced when the heat transfer regime conduction is considered.

关键词： Incinerator Entropy generation Natural convection Hybrid-nanoliquid magnetohydrodynamic(mHD)