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SImAp500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Nekisa Zakeri Konstantinos Koilias rosemary E Faulkes rachel Brown Owen Cain m thamara p r perera Keith J roberts rebeca Sanabria-mateos David C Bartlett Yuk Ting ma Shivan Sivakumar Shishir Shetty Tahir Shah Bobby V m Dasari Department of HBp and Liver Transplantation Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver research Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Department of Hepatology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Department of pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGrOUND recurrence of hepatocellular carcinoma(HCC)following liver transplantation(LT)has a devastating influence on recipients’survival;however,the risk of recur-rence is not routinely *** stratification is vital with a long LT waiting time,as that could influence the recurrence despite strict listing *** This study aims to identify predictors of recurrence and develop a novel risk pre-diction score to forecast HCC recurrence following *** A retrospective review of LT for HCC recipients at University Hospitals Bir-mingham between July 2011 and February *** and multivariate analyses were performed to identify recurrence predictors,based on which the novel SImAp500(satellite nodules,increase in size,microvascular invasion,AFp>500,poor differentiation)risk score was *** 234 LTs for HCC were performed with a median follow-up of 5.3 *** developed in 25 patients(10.7%).On univariate analyses,rETrEAT score>3,α-fetoprotein(AFp)at listing 100-500 and>500,bridging,increased tumour size between imaging at the listing time and explant histology,increase in the size of viable tumour between listing and explant,presence of satellite nodules,micro-and macrovascular invasion on explant and poor differentiation of tumours were significantly associated with recurrence,based on which,the SImAp500 risk score is *** SImAp500 demonstrated an excellent predictive ability(c-index=0.803)and outper-formed the rETrEAT score(c-index=0.73).SImAp500 is indicative of the time to disease *** SImAp500 risk score identifies the LT recipients at risk of HCC *** stratification allows patient-centric post-transplant surveillance *** validation of the score is recommended.

关键词： Liver transplantation Hepatocellular carcinoma recurrence Survival

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machine perfusion and the prevention of ischemic type biliary lesions following liver transplant:What is the evidence?

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World Journal of Gastroenterology 2023年第20期29卷 3066-3083页

作者： manuel Durán rafael Calleja Angus Hann George Clarke ruben Ciria Anisa Nutu rebeca Sanabria-mateos maría Dolores Ayllón pedro López-Cillero Hynek mergental Javier Briceño m thamara p r perera Department of Liver Transplantation Reina Sofía University HospitalCórdoba 14004Spain The Liver Unit Queen Elizabeth Hospital BirminghamBirmingham B152THUnited Kingdom Centre for Liver and Gastrointestinal research Institute of Immunology and ImmunotherapyUniversity of BirminghamBirmingham B152THUnited Kingdom

The widespread uptake of different machine perfusion(mp)strategies for liver transplant has been driven by an effort to minimize graft *** to the cholangiocytes during the liver donation,preservation,or early posttransplant period may result in stricturing of the biliary tree and inadequate biliary *** problem continues to trouble clinicians,and may have catastrophic consequences for the graft and *** injury,as a result of compromised hepatic artery flow,is a well-known cause of biliary strictures,sepsis,and graft ***,very similar lesions can appear with a patent hepatic artery and these are known as ischemic type biliary lesions(ITBL)that are attributed to microcirculatory dysfunction rather than main hepatic arterial *** the warm and cold ischemic period duration appear to influence the onset of *** of the commonly used mp techniques deliver oxygen to the graft cells,and therefore may minimize the cholangiocyte injury and subsequently reduce the incidence of *** clinical experience and published evidence grows for these modalities,the impact they have on ITBL rates is important to *** this review,the evidence for the three commonly used mp strategies(abdominal normothermic regional perfusion[A-Nrp],hypothermic oxygenated perfusion[HOpE],and normothermic machine perfusion[Nmp])for ITBL prevention has been critically *** with ITBL definitions used in trials,coupled with variations in techniques of mp,make interpretation ***,the evidence suggests that both HOpE and A-Nrp prevent ITBL in donated after circulatory death grafts compared to cold *** evidence for ITBL prevention in donor after brain death grafts with any mp technique is weak.

关键词： Liver transplant Ischemic type biliary lesions Hypothermic oxygenated machine perfusion Normothermic machine perfusion Abdominal normothermic regional perfusion Donation after circulatory death

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Assessing the biennial conference on science and technology(BICOST IX)2023 technical output on renewable energy,energy storage,and green hydrogen in line with UN SDG commitments

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Clean Energy 2024年第2期8卷 85-88页

作者： S.K.B.D.Silva K.G.D.piyumali rasitha Thilini Suranjana perera K.D.K.G.Kaluarachchi Thilini munagamage r.m.r.Ahammed C.S.p.piyankarage Seyed Shahmy Veranja Karunaratne National Science and Technology Commission of Sri Lanka ColomboSri Lanka Sri Lanka Technological Campus(SLTC) PadukkaSri Lanka University of peradeniya PeradeniyaSri Lanka

The development,production and utilization of renewable energy,energy storage and green hydrogen and the associated technologies in Sri Lanka have great potential to contribute to the United Nations’Sustainable Development Goals(SDGs).The island aims to achieve 70%electricity generation from renewable energy sources by 2030(within the target of 40%utilization of renewable energy sources for the entire energy generation of the country by 2030).The power sector has to invest US$11 billion from 2023 to 2030 to contribute to reaching this *** commentary aims to provide a critical perspective on the recommendations of the report from the National Science and Technology Commission’s 9th biennial conference in 2023 on science and technology,the sub-thematic technical report on clean energy,energy storage and green hydrogen in line with the SDGs in the Sri Lankan *** technical report provides insightful recommendations for Sri Lanka’s energy sector under three main sections:renewable energy,energy storage and green ***,it explores the potential of various renewable energy sources,energy storage systems and green hydrogen as sustainable solutions to address the country’s energy challenges while emphasizing the spillover effects of them,which could contribute to the enterprise’s job creation and uplift the economy.

关键词： renewable energy energy storage green hydrogen sustainable development goals Sri Lanka social economic environmental sustainable affordable

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Struvite recovery from Swine Waste Biogas Digester Effluent through a Stainless Steel Device under Constant pH Conditions

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Biomedical and Environmental Sciences 2009年第3期22卷 201-209页

作者： p.W.ANTON perera College of Environmental and resource Sciences Zhejiang University

Objective To investigate the struvite precipitation under constant and non-constant pH conditions and to test a stainless steel device under different operating regimes to maximize the recovery of struvite. methods The molar ratio of NH4^＋： mg^2＋ pO43 was adjusted to 1： 1.2：1.2 and pH was elevated to 9.0. The absorbance measurement was used to trace the process of struvite crystallization. Wastewater and precipitate analysis was done by standard analytical methods. results The pH constant experiment reported a significantly higher struvite precipitation （24.6±0.86 g） than the non-constant pH experiment （19.8±1.86 g）. The SAr ranged from 5.6 to 8.2 g m^-2h^-1 to 3.6-4.8 g m^-2h^-1 in pH constant and non-constant experiments, respectively. The highest struvite deposit on the device was found in regime 3 followed by in regimes 2 and 4. The highest pO4^3- （97.2%） and NH4^＋（71%） removal was reported in the r1 regime. None of the influent Cu^2＋ or Zn^2＋ was precipitated on the device. Conclusion A higher struvite yield is evident in pH constant experiments. moreover, the stainless steel device facilitates the isolation of heavy metal free pure （around 96%） struvite from swine waste biogas digester effluent contaminated with Cu^2＋ and Zn^2＋ and the highest yield is attainable with the device operating at 50 rpm with agitation by a magnetic stirrer.

关键词： Struvite recovery Accumulation device Swine waste Constant pH Struvite precipitation

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Influence of barley inclusion method and protease supplementation on growth performance,nutrient utilisation,and gastrointestinal tract development in broiler starters

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Animal Nutrition 2022年第1期8卷 61-70页

作者： L.m.Tari W.N.U.perera F.Zaefarian m.r.Abdollahi A.J.Cowieson V.ravindran monogastric research Centre School of Agriculture and EnvironmentMassey UniversityPrivate Bag 11222Palmerston North4442New Zealand Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya20400Sri Lanka DSm Nutritional products Wurmisweg 576KaiseraugstSwitzerland

The influence of the method of barley inclusion(fine,coarse and whole barley)in a wheat-based diet and protease supplementation(0 and 0.20 g/kg)on growth performance,nutrient utilisation and gastrointestinal tract development of broilers(d 1 to 21)was evaluated in a 32 factorial *** barley(WB)grains were ground in a hammer mill to pass through the screen sizes of 2.5 and 8.0 mm to achieve fine(FB)and coarse(CB)barley particle sizes,respectively.A total of 288,one-day-old male broilers were allotted to 36 cages(6 cages/treatment;8 birds/cage).There was no significant(p>0.05)interaction between barley inclusion method and protease for any growth performance or nutrient utilisation *** fed diets containing CB and WB showed higher(pry matter,nitrogen,calcium,gross energy,and ileal digestible energy compared to those fed FB *** to the birds fed FB diets,feed per gain was lower(prds fed diets made of *** digestibility of the birds fed CB was higher(presulted in heavier(prds but reduced(prd *** protease,however,had no effects(p>0.05)on growth performance and nutrient utilisation,most likely due to the well balanced digestible amino acids and high inherent digestibility of protein in the basal diet,and/or the presence of exogenous carbohydrase and *** conclusion,the present results showed that the inclusion of coarsely ground and whole barley in a wheat-based diet can enhance nutrient and energy utilisation and is beneficial to the growth performance of young broilers.

关键词： Barley Broiler particle size protease Whole grain

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Current status and recent advances of liver transplantation from donation after cardiac death

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World Journal of Gastrointestinal Surgery 2011年第11期3卷 167-176页

作者： m thamara pr perera Simon r Bramhall The Liver Unit Queen Elizabeth HospitalEdgbaston Birmingham B15 2TH United Kingdom

The last decade saw increased organ donation activity from donors after cardiac death (DCD). This contributed to a signif icant proportion of transplant activity. Despite certain drawbacks, liver transplantation from DCD donors continues to supplement the donor pool on the backdrop of a severe organ shortage. Understanding the pathophysiology has provided the basis for modulation of DCD organs that has been proven to be effective outside liver transplantation but remains experimental in liver transplantation models. research continues on how best to further increase the utility of DCD grafts. most of the work has been carried out exploring the use of organ preservation using machine assisted perfusion. Both ex-situ and in-situ organ perfusion systems are tested in the liver transplantation setting with promising results. Additional techniques involved pharmacological manipulation of the donor, graft and the recipient. Ethical barriers and end-of-life care pathways are obstacles to widespread clinical application of some of the recent advances to practice. It is likely that some of the DCD offers are in fact probably "prematurely" of-fered without ideal donor management or even prior to brain death being established. The absolute benef its of DCD exist only if this form of donation supplements the existing deceased donor pool; hence, it is worthwhile revisiting organ donation process enabling us to identify counter remedial measures.

关键词： Non-heart beating donor Liver graft pri- mary non-function reperfusion injury modulation

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Apolipoprotein B Is a Good Tool for Screening Dyslipidaemia in Apparently Healthy population

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Journal of Biosciences and medicines 2016年第5期4卷 58-64页

作者： L. V. Athiththan m. F. F. Nusha U. p. K. Hettiaratchi p. p. r. perera Department of Biochemistry University of Sri Jayewardenepura Nugegoda Sri Lanka

Dyslipidaemia is the major risk factor for cardiovascular disease (CVD) which is the leading cause of death in the world. Even though several lipid parameters are used, currently apolipoprotein B (apoB) is considered as the best predictor of CVD. Thus this study was carried out to find out the association between conventional lipid parameters and apoB in apparently healthy subjects. A descriptive cross-sectional study was carried out in 170 apparently healthy volunteers who were not diagnosed with dyslipidaemia. After 12 hours overnight fast venous blood was obtained and Total cholesterol (TC), Triglyceride (TG), High density lipoprotein cholesterol (HDL-C) were measured by enzymatic kit method. Low density lipoprotein cholesterol (LDL-C) was calculated by Friedewald formula and apoB was analyzed by immune turbid metry using a Konelabp>®p> auto analyzer. Among the participants, majority (63.5%) were females. The mean value of apoB concentration of the population was 103 ± 42 mg/dL which was similar and not significantly different between the genders (males, 102 ± 37 mg/dL and Females, 104 ± 45 mg/dL). All lipid parameters showed a positive correlation with apoB concentration whereas HDL-C had a negative correlation (r = -0.165). HDL-C significantly (p reased with increase in apoB concentration while LDL-C, TC/HDL-C and non-HDL-C significantly (p reased with an increase in apoB concentration. present study suggests that serum apoB has better correlations and associations with the parameters that are used in conventional lipid profile and with markers recommended for diagnosing dyslipidaemia. Hence apoB could be used as a single marker for screening dyslipidaemia in apparently healthy people.

关键词： Apolipoprotein B Dyslipidaemia High Density Lipoprotein Low Density Lipoprotein

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Facial Index Based 2D Facial Composite process for Forensic Investigation in Sri Lanka

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Forensic medicine and Anatomy research 2016年第1期4卷 7-16页

作者： p. B. Jayasekara L. Sivaneasharajah m. A. S. perera J. perera D. D. Karunaratne K. D. Sandaruwan r. N. rajapakse University of Colombo School of Computing Colombo Sri Lanka Department of Forensic medicine and Toxicology Faculty of Medicine University of Colombo Colombo Sri Lanka

The “facial composite” is one of the major fields in the forensic science that helps the criminal investigators to carry out their investigation process. The survey conducted by United States Law Enforcement Agencies confirms that 80% of the law enforcement agencies use computer automated composite systems whereas Sri Lanka is still far behind in the process of facial composite with lot of inefficiencies in the current manual process. Hence this research introduces a novel approach for the manual facial composite process, while eliminating the inefficiencies of the manual procedure in Sri Lanka. In order to overcome this situation, this study introduces an automated image processing based software solution with 2D facial feature templates targeting the Sri Lankan population. Thus, this was the first ever approach that creates the 2D facial feature templates by incorporating both medically defined indexes and relevant aesthetic aspects. Hence, this research study is comprised of two separate analyses on anthropometric indices and facial feature shapes which were carried out targeting the local population. Subsequently, several evaluation techniques were utilized to evaluate this methodology where we obtained an overall success rate as 70.19%. The ultimate goal of this research study is to provide a system to the law enforcement agencies in order to carry out an efficient and effective facial composite process which can lead to increase the success rate of suspect identification.

关键词： Facial Composite Facial Index Facial Feature Templates Sri Lanka

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profile of Bionectriaceae,Calcarisporiaceae,Hypocreaceae,Nectriaceae,Tilachlidiaceae,Ijuhyaceae ***.,Stromatonectriaceae *** Xanthonectriaceae ***

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Fungal Diversity 2023年第1期118卷 95-271页

作者： r.H.perera K.D.Hyde E.B.G.Jones S.S.N.maharachchikumbura D.Bundhun E.Camporesi A.Akulov J.K.Liu Z.Y.Liu Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China Center of Excellence in Fungal research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand mushroom research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Key Laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Innovative Institute of plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Department of Entomology and plant pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Botany and microbiology College of ScienceKingdom of Saudi ArabiaKing Saud UniversityP.O Box 2455Riyadh 11451Saudi Arabia A.m.B Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly A.m.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18ForliItaly Societaper Gli Studi Naturalistici Della romagna C.P.143BagnacavalloRAItaly Department of mycology and plant resistance V.N.Karazin Kharkiv National UniversityMaidan Svobody 4Kharkiv 61022Ukraine

This paper provides outlines for Bionectriaceae,Calcarisporiaceae,Hypocreaceae,Nectriaceae,Tilachlidiaceae,Ijuhy-aceae,Stromatonectriaceae and Xanthonectriaceae with taxonomic *** provide up-to-date DNA sequence-based phylogenies including combined gene analysis of ITS,LSU,rpb2,tef1 and tub2 for Hypocreales and accept 17 *** new families and 12 new species are introduced with descriptions and illustrations,while 13 new records and one new species combination are *** we mainly detail the taxonomy of Bionectriaceae,Hypocreaceae,Nectriaceae and Tilachlidiaceae,Ijuhyaceae ***.,Stromatonectriaceae *** Xanthonectriaceae *** introduced in this study based on phenotypic and molecular *** each family we provide a list of accepted genera,the taxo-nomic history,morphological descriptions,taxonomic placement based on DNA sequence data and illustrate the type *** of each family are illustrated based on the type herbarium material or fresh specimens where available,or provide relevant *** on ecological and economic importance of the families are also given.

关键词： 15 New taxa Genera incertae sedis Hypocreales New records Outline phylogeny Sordariomycetes Taxonomy

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Fungal diversity notes 709–839: taxonomic and phylogenetic contributions to fungal taxa with an emphasis on fungi on rosaceae

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Fungal Diversity 2018年第2期89卷 1-236页

作者： Dhanushka N.Wanasinghe Chayanard phukhamsakda Kevin D.Hyde rajesh Jeewon Hyang Burm Lee E.B.Gareth Jones Saowaluck Tibpromma Danushka S.Tennakoon Asha J.Dissanayake Subashini C.Jayasiri Yusufjon Gafforov Erio Camporesi Timur SBulgakov Anusha HEkanayake rekhani Hansika perera milan CSamarakoon Ishani DGoonasekara Ausana mapook Wen-Jing Li Indunil CSenanayake Junfu Li Chada Norphanphoun mingkwan Doilom Ali H Bahkali Jianchu Xu peter Emortimer Leif Tibell Sanja Tibell Samantha C.Karunarathna Key Laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China mushroom research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Environmental microbiology Lab Division of Food TechnologyBiotechnology&AgrochemistryCollege of Agriculture and Life SciencesChonnam National UniversityYongbong-Dong 300Buk-GuGwangju 61186Korea Nantgaredig 33 B St.Edwards Road Southsea HantsHampshire PO53DHUK Institute of plant and Environment protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Laboratory of mycology Institute of BotanyAcademy of Sciences of the Republic of Uzbekistan32 Durmon Yuli StreetTashkentUzbekistan 100125 A.m.B.Gruppo Micologico Forlivese"Antonio Cicognani"Via Roma 18Forlı`Italy A.m.B Circolo Micologico"Giovanni Carini"C.P.314 BresciaItaly Societa`per gli Studi Naturalistici della romagna C.P.144 BagnacavalloRAItaly russian research Institute of Floriculture and Subtropical Crops 2/28 Yana Fabritsiusa StreetSochiKrasnodar RegionRussia 354002 Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Engineering research Center of Southwest Biopharmaceutical resources Ministry of EducationGuizhou UniversityGuiyang 550025GuizhouPeople’s Republic of China Department of Botany and microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of plant medicine National Chiayi University300 Syuefu RoadChiayi City 60004Taiwan Department of Ecology University of KasselHeinrich-PlettStrasse4034132 KasselGermany Department of Organismal Biology Uppsala Univer

This paper is the seventh in the Fungal Diversity Notes series,where 131 taxa accommodated in 28 families are mainly described from rosa(rosaceae)and a few other *** fungal taxa are described in the present study,including 17 new genera,93 new species,four combinations,a sexual record for a species and new host records for 16 ***,Cycasicola,Dactylidina,Embarria,Hawksworthiana,Italica,melanocucurbitaria,melanodiplodia,monoseptella,Uzbekistanica,Neoconiothyrium,Neopaucispora,pararoussoella,paraxylaria,marjia,Sporormurispora and Xenomassariosphaeria are introduced as new ascomycete *** also introduce the new species Absidia jindoensis,Alternaria doliconidium,***,Angustimassarina rosarum,Astragalicola vasilyevae,Backusella locustae,Bartalinia rosicola,Bhatiellae rosae,Broomella rosae,Castanediella camelliae,Coelodictyosporium rosarum,Comoclathris rosae,***,Comoclathris rosigena,Coniochaeta baysunika,***,Cycasicola goaensis,Dactylidina shoemakeri,Dematiopleospora donetzica,***,***,Diaporthe rosae,***,Endoconidioma rosaehissaricae,Epicoccum rosae,Hawksworthiana clematidicola,***,Italica achilleae,Keissleriella phragmiticola,***,***,***,Lophiostoma rosae,marjia tianschanica,***,melanocucurbitaria uzbekistanica,melanodiplodia tianschanica,monoseptella rosae,mucor fluvius,muriformistrickeria rosae,murilentithecium rosae,Neoascochyta rosicola,Neoconiothyrium rosae,Neopaucispora rosaecae,Neosetophoma rosarum,***,***,Neostagonospora artemisiae,Ophiobolus artemisiicola,paraconiothyrium rosae,paraphaeosphaeria rosae,***,pararoussoella rosarum,parathyridaria rosae,paraxylaria rosacearum,penicillium acidum,***,phragmocamarosporium rosae,pleospora rosae,***-caninae,poaceicola agrostina,***,***,populocrescentia ammophilae,***,pseudocamarosporium pteleae,***-minoris,pseudocercospora rosae,pseudopithomyces rosae,pseudost

关键词： Ascomycota Dothideomycetes Eurotiomycetes Italy Lecanoromycetes mucoromycetes phylogeny rosa rosaceae russia Sordariomycetes Taxonomy UK Uzbekistan

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