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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Assessing the reproductive health of men with occupational exposures

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Asian Journal of Andrology 2014年第1期16卷 23-30页

作者： Steven m Schrader katherine L marlow Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Division of Applied Research and Technology Cincinnati OH USA.

The earliest report linking environmental （occupational） exposure to adverse human male reproductive effects dates back to1775 when an English physician, Percival Pott, reported a high incidence of scrotal cancer in chimney sweeps. This observation led to safety regulations in the form of bathing requirements for these workers. The fact that male-mediated reproductive harm in humans may be a result of toxicant exposures did not become firmly established until relatively recently, when Lancranjan studied lead-exposed workers in Romania in 1975, and later in 1977, when Whorton examined the effects of dibromochloropropane （DBCP） on male workers in California. Since these discoveries, several additional human reproductive toxicants have been identified through the convergence of laboratory and observational findings. many research gaps remain, as the pool of potential human exposures with undetermined effects on male reproduction is vast. This review provides an overview of methods used to study the effects of exposures on male reproduction and their reproductive health, with a primary emphasis on the implementation and interpretation of human studies. Emphasis will be on occupational exposures, although much of the information is also useful in assessing environmental studies, occupational exposures are usually much higher and better defined.

关键词： accessory glands endocrine epidemiology semen sexual function sperm testis toxicology

Wild bee distribution near forested landscapes is dependent on successional state

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Forest Ecosystems 2020年第2期7卷 159-171页

作者： katherine A.Odanaka Sandra m.Rehan Department of Biological Sciences University of New HampshireDurhamNHUSA Department of Biology York UniversityTorontoONCanada

Background:Forested landscapes are valuable sources of ecosystem services especially in areas dedicated to intense agricultural *** from forest margin is known to influence the wild bee community in the landscape surrounding forested *** little is known regarding how bee communities distribute themselves in landscapes that exhibit different forest successional ***:We examined how land use type and distance from the forest edge affect the abundance and richness of the wild bee community across four forest successional *** were collected in sites representing four stages of forest succession and analyzed using generalized linear mixed models with negative binomial ***:Wild bee diversity is reduced in forested environments that maintain dense stands of trees and high canopy ***,distance from the forest edge was an important factor determining wild bee distribution in successional stages adjacent to forest ***,we found that bees maintain high specificity for distinct successional states and ***:Our results demonstrate how different successional stages can harbor different bee species and highlight the ability of microhabitats to act as reservoirs of bee diversity in and around forest ***,we found that maximizing successional patchiness across forested landscapes increases the amount of available habitat that can support a diverse suite of bees with different nesting biologies and behaviors.

关键词： Pollinator Forest margin Bee habitat Nesting biology Wild bees

Two-dimensional d-πconjugated metal-organic framework based on hexahydroxytrinaphthylene

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Nano Research 2021年第2期14卷 369-375页

作者： Zheng meng katherine A.mirica Department of Chemistry Burke Laboratory41 College Streety Dartmouth CollegeHanoverNH 03755USA

The development of new two-dimensional(2D)d-πconjugated metal-organic frameworks(mOFs)holds great promise for the construction of a new generation of porous and semiconductive *** paper describes the synthesis,structural characterization,and electronic properties of a new d-πconjugated 2D mOF based on the use of a new ligand 2,3,8,9,14,*** reticular self-assembly of this largeπ-conjugated organic building block with Cu(II)ions in a mixed solvent system of 1,3-dimethyl-2-imidazolidinone(DmI)and H2 O with the addition of ammonia water or ethylenediamine leads to a highly crystalline mOF Cu3(HHTN)2,which possesses pore aperture of 2.5 ***3(HHTN)2 mOF shows moderate electrical conductivity of 9.01×10^(-8)S·cm^(-1)at 385 K and temperature-dependent band gap ranging from 0.75 to 1.65 *** chemical oxidation by l2,the conductivity of Cu3(HHTN)2 can be increased by 360 *** access to HHTN based mOF adds an important member to previously reported mOF systems with hexagonal lattice,paving the way towards systematic studies of structure-property relationships of semiconductive mOFs.

关键词： two-dimensional metal-organic framework(mOF) trinaphthylene conductive mOF

Applications of carbon nanomaterials in perovskite solar cells for solar energy conversion

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Nano materials Science 2021年第3期3卷 276-290页

作者： katherine moore Wei Wei Department of mechanical Engineering Wichita State University1845 Fairmount StWichitaKS67260USA

The energy issues and environmental concern have led to intense research activities in renewable energy conversion,such as photovoltaic(PV)to convert solar energy into *** solar cells(PSCs)based on metal halides are rapidly emerging as the most promising and competing PV technology due to its high record power conversion efficiencies and potentially low production *** carbon materials,which are abundantly available and low-cost,are introduced into the *** article provides a mini review of applications of carbon materials for perovskite solar ***,a brief introduction of the development of perovskite solar cell is ***,applications of carbon nanomaterials in perovskite solar cells are presented and ***,an outlook and perspective on the future research directions of carbon nanomaterial for perovskite solar cells is provided.

关键词： Carbon nanomaterials Perovskite solar cells Solar energy

Alcohol associated liver disease and bariatric surgery:Current perspectives and future directions

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 650-657页

作者： katherine m Cooper Alessandro Colletta Nicholas Hebda Deepika Devuni Department of medicine UMass Chan Medical SchoolWorcesterMA 01655United States Division of Gastroenterology UMass Chan Medical SchoolWorcesterMA 01655United States

Bariatric surgery is a routinely performed procedure and is associated with a reduction in all-cause mortality in patients with ***,bariatric sur-gery has also been linked to increased alcohol use with up to 30%of these patients developing alcohol use disorder(AUD).The mechanism of AUD after bariatric surgery is multifactorial and includes anatomic,metabolic,and neurohumoral changes associated with post-surgical *** patients are at increased risk of alcohol associated liver disease and,in some cases,require liver *** this article,we provide a scoping review of epidemiology,patho-physiology,and clinical outcomes of alcohol-related health conditions after bariatric surgery.

关键词： Obesity medicine Alcohol use disorder Roux-en-Y gastric bypass Vertical sleeve gastrectomy Liver transplant Simultaneous liver transplant and bariatric surgery

Effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine: An in silico pharmacological model

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Asian Pacific Journal of Tropical medicine 2020年第8期13卷 366-374页

作者： mila Nu Nu Htay Ian m Hastings Eva maria Hodel katherine Kay Liverpool School of Tropical medicine Liverpool L35QAUnited Kingdom Department of Community medicine Melaka-Manipal Medical CollegeManipal Academy of Higher Education(MAHE)MelakaMalaysia malawi-Liverpool-Wellcome Trust Clinical Research Programme BlantyreMalawi University of Liverpool Liverpool L693GFUnited Kingdom metrum Research Group TariffvilleConnecticut06081United States of America

Objective:To explore the efficacy of intermittent preventive treatment in pregnancy(IPTp)with sulfadoxine and pyrimethamine(SP)against sensitive ***:A pharmacological model was used to investigate the effectiveness of the previous recommended at least two-dose regimen,currently recommended three-dose regimen and 4,6,8-weekly regimens with specific focus on the impact of various nonadherence patterns in multiple transmission ***:The effectiveness of the recommended three-dose regimen is high in all the transmission intensities,i.e.>99%,98%and 92%in low,moderate and high transmission intensities *** simulated 4 and 6 weekly IPTp-SP regimens were able to prevent new infections with sensitive parasites in almost all women(>99%)regardless of transmission ***,8 weekly interval dose schedules were found to have 71%and 86%protective efficacies in high and moderate transmission areas,*** highlights that patients are particularly vulnerable to acquiring new infections if IPTp-SP doses are ***:The pharmacological model predicts that full adherence to the currently recommended three-dose regimen should provide almost complete protection from malaria infection in moderate and high transmission ***,it also highlights that patients are particularly vulnerable to acquiring new infections if IPTp doses are spaced too widely or if doses are *** to the recommended IPTp-SP schedules is recommended.

关键词： Intermittent preventive treatment in pregnancy Sulfadoxine-pyrimethamine malaria infection in pregnancy Three-dose regimen In silico pharmacological model

Kidney disease in patients with chronic liver disease:Does sex matter?

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World Journal of Clinical Cases 2023年第17期11卷 3980-3992页

作者： katherine m Cooper Alessandro Colletta Kristen moulton Kenneth m Ralto Deepika Devuni Department of medicine UMass Chan Medical SchoolWorcesterMA 01665United States Department of medicine Division of GastroenterologyUMass Chan Medical SchoolWorcesterMA 01665United States Department of medicine Division of Renal MedicineUMass Chan Medical SchoolWorcesterMA 01665United States

Kidney disease in patients with liver disease is serious and increases *** to 50%of patients hospitalized experience an episode of acute kidney *** general,men with liver disease are thought to be at increased risk of kidney ***,this association should be considered with caution because most studies use creatinine-based inclusion criteria,which is negatively biased against *** this review,we synthesize data on sex differences in kidney disease in patients with chronic liver disease in the clinical setting and discuss potential physiologic underpinnings.

关键词： Sex differences Renal disease Gender disparity Hepatorenal syndrome Renal replacement therapy

The effect of the CHAmP intervention on fundamental motor skills and outdoor physical activity in preschoolers

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Journal of Sport and Health Science 2019年第2期8卷 98-105页

作者： Kara K.Palmer katherine m.Chinn Leah E.Robinson Child movement Activity and Developmental Heanlth Laboratory University of Michigan Center for Human Growth and Development University of Michigan

Purpose: Physical activity(PA) and fundamental motor skills are important components of current and future trajectories of health in young children. This study examined the effects of a 5-week motor skill intervention on preschoolers' motor skill competence and their PA behaviors while participating in the motor skill intervention or outdoor free play(recess).methods: A total of 102 preschoolers served as participants and were part of a motor skill intervention group(n = 64) or a control/outdoor free play group(n = 38). Children's motor skills were assessed before and after the intervention using the Test of Gross motor Development-3 rd edition. PA during the motor skill intervention and outdoor free play was assessed using accelerometers both immediately before the start(baseline, Week 0 or Week 1) and end(late, Week 5 or Week 6) of the ***: All children significantly improved their motor skills from baseline to late assessment(p motor skill intervention demonstrated greater rates of change(p motor skills at the late assessment compared with the control group(p milarly, there was no effect of group on PA during days with the movement program(intervention vs. outdoor free play) at either time point, but boys were more active than girls at the late assessment(p more PA while participating in the intervention toward the end of the intervention than at the ***: The 5-week motor skill intervention was effective at improving preschoolers' motor skills and rates of change in motor skills were higher for children who completed the intervention compared with children in the control group. Preschoolers in the intervention did demonstrate PA changes while par

关键词： Gross motor skills Intervention motor development: Pediatrics Physical activity