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Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity

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World Journal of Gastroenterology 2007年第9期13卷 1378-1383页

作者： Leo K Cheng Rie Komuro Travis m austin martin L Buist Andrew J Pullan Bioengineering Institute The University of Auckland Private Bag 92019 Auckland 1142 New Zealand Division of Bioengineering National University of SingaporeSingapore Bioengineering Institute The University of Auckland Private Bag 92019 Auckland 1142 New ZealandDepartment of Engineering Science The University of Auckland

One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.

关键词： model Bidomain Simulation Interstitial cells of Cajal Physiome GIOIE

lrys:De Novo Assembly and Structural Variation Detection in Complex Genomes Using Extremely Long Single-molecule Imaging

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lrys:De Novo Assembly and Structural Variation Detection in ...

Irys:de novo assembly and structural variation detection in complex genomes using extremely long single-molecule imaging

中国遗传学会第九次全国会员代表大会暨学术研讨会

作者： H VanSteenhouse A Hastie m Requa m austin F Trintchouk m Saghbini X Yang H Cao BioNano Genomics Inc.

De novo genome assemblies using only short read data are generally incomplete and highly fragmented due to the intractable complexity found in most *** complexity, consisting mainly of large duplications and repetitive regions,hinders sequence assembly and subsequent comparative analyses. The lrys platform from BioNano Genomics overcomes the limitations of short fragment technologies to provide unprecedented insights into whole-genome biology,lrys is a single-molecule genome analysis system based on NanoChannel Array technology that linearizes extremely long DNA molecules for *** high-throughput platform automates massively parallel imaging of individual molecules of genomic DNA hundreds of kilobases in size to measure sufficient sequence uniqueness and long-range contiguity critical for unambiguous de novo assembly of complex ***-resolution genome maps assembled de novo retain the original context and architecture of the genome,making them extremely useful for sequence assembly scaffolding and structural variation detection applications. Specifically,these genome maps provide dense genome-wide anchor points for ordering and orienting sequencing contigs or scaffolds to greatly increase completion and accuracy of de novo *** variants and repeats are measured directly within long "reads" for comprehensive analysis of what has been dubbed "the inaccessible genome".Following an introduction to the platform and underlying single-molecule technology,several examples of real-world application will demonstrate its use in large complex genomes.

关键词： Irys de novo assemblies structural variants

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Irys:De Novo Assembly and Structural Variation Detection in Complex Genomes Using Extremely Long Single-molecule Imaging

第十四届全国植物基因组学大会

作者： H VanSteenhouse A Hastie m Requa m austin F Trintchouk m Saghbini X Yang H Cao BioNano Genomics Inc.

关键词： irys de novo assemblies structural variants

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Irys:De Novo Assembly and Structural Variation Detection in ...

中国遗传学会第九次全国会员代表大会暨学术研讨会

作者： H VanSteenhouse A Hastie m Requa m austin F Trintchouk m Saghbini X Yang H Cao BioNano Genomics Inc.

De novo genome assemblies using only short read data are generally incomplete and highly fragmented due to the intractable complexity found in most *** complexity, consisting mainly of large duplications and repetitive regions,hinders sequence assembly and subsequent comparative analyses. The lrys platform from BioNano Genomics overcomes the limitations of short fragment technologies to provide unprecedented insights into whole-genome *** is a single-molecule genome analysis system based on NanoChannel Array technology that linearizes extremely long DNA molecules for *** high-throughput platform automates massively parallel imaging of individual molecules of genomic DNA hundreds of kiiobases in size to measure sufficient sequence uniqueness and long-range contiguity critical for unambiguous de novo assembly of complex ***-resolution genome maps assembled de novo retain the original context and architecture of the genome,making them extremely useful for sequence assembly scaffolding and structural variation detection applications. Specifically,these genome maps provide dense genome-wide anchor points for ordering and orienting sequencing contigs or scaffolds to greatly increase completion and accuracy of de novo *** variants and repeats are measured directly within long "reads" for comprehensive analysis of what has been dubbed "the inaccessible genome".Following an introduction to the platform and underlying single-molecule technology,several examples of real-world application will demonstrate its use in large complex genomes.

关键词： Irys de novo assemblies structural variants

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照像显影剂的纸层析法

感光材料 1986年第4期 27-29页

作者： m.austin 宋华烈

本文介绍了十四种显影剂在两种溶剂体系中的层析数据,在紫外线照射下对色层谱的检查和使用专门的喷淋试剂,可以清楚地鉴射出每种显影剂.以常用的柯达D76显影液的分析为例,说明了色层分析中制做样品的重要性.

关键词：米吐尔层析柯达色层色层分析 1,4-二羟基苯苯酚对苯二酚显影液中灰显影剂摩尔浓度克分子浓度

Investigation of effect of near-fault motions on substandard bridge structures

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Earthquake Engineering and Engineering Vibration 2011年第1期10卷 1-11页

作者： austin Brown m. Saiid Saiidi Dynamic Certification Laboratories Department of Civil & Environmental Engineering

The objective of this study was to investigate the effects of near-fault ground motions on substandard bridge columns and piers. To accomplish these goals, several large scale reinforced concrete models were constructed and tested on a shake table using near- and far-field ground motion records. Because the input earthquakes for the test models had different characteristics, three different measures were used to evaluate the effect of the input earthquake. These measures are peak shake table acceleration, spectral acceleration at the fundamental period of the test specimens, and the specimen drift ratios. For each measure, force-displacement relationships, strains, curvatures, drift ratios, and visual damage were evaluated. Results showed that regardless of the measure of input or response, the near-fault record generally led to larger strains, curvatures, and drift ratios. Furthermore, residual displacements were small compared to those for columns meeting current seismic code requirements.

关键词： near-fault reinforced concrete bridge columns dynamic response

Compositional Effect of ZrO_2 Nanofillers on a PVDF-co-HFP Based Polymer Electrolyte System for Solid State Zinc Batteries

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Chinese Journal of Polymer Science 2016年第3期34卷 332-343页

作者： m.Johnsi S.austin Suthanthiraraj Department of Energy University of MadrasGuindy Campus

Composite polymer electrolytes（CPEs） comprising poly（vinilydene fluoride-hexafluoro propylene）, PVDF-coHFP and zinc triflate, Zn（CF3SO3）2 with varying concentrations of ZrO_2 nanofillers were prepared by solution casting technique with N,N-dimethyl formamide（DmF） as the common solvent. The polymer electrolyte specimen with the particular composition 75 wt% PVDF-co-HFP： 25 wt% Zn Tf ＋ 7 wt% Zr O2 showed the highest conductivity of 4.6 × 10-4 S/cm at 298 K as confirmed from impedance measurements and favored by the rich amorphous phase of the CPE revealed from room temperature X-ray diffraction analysis（XRD）. The electrical conductivity relaxation time and its distribution within the materials have been evaluated from the electric modulus m 2 and impedance Z＂ data which showed the occurrence of non-Debye type of relaxation phenomenon. The changes in the surface morphology of the CPEs were examined using scanning electron microscopy（SEm）. The electrochemical stability window of CPE is found to be 2.6 V with a thermal stability up to 300 °C. An electrochemical cell has been fabricated based on Zn/mnO_2 electrode couple under a constant load of 1 mΩ and its discharge characteristics have been evaluated.

关键词： Nanocomposites Dielectric properties Thermal stability Electrochemical stability Batteries

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全髋关节置换术后是否需要常规物理治疗

临床骨科杂志 2017年第3期20卷 347-347页

作者： austin m Urbani B Fleischman A 李军荆珏华

全髋关节置换术后物理治疗的价值尚不明确.作者对120例行初次单侧全髋关节置换术的患者进行了随机对照研究,最终108例患者完成随访.其中,

关键词：全髋关节置换术后物理治疗随机对照研究患者

Is the propensity to emit alarm calls associated with health status?

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Current Zoology 2020年第6期66卷 607-614页

作者： austin L.Nash Alexandra H.m.Jebb Daniel T.BLUmSTEIN Department of Ecology and Evolutionary Biology University of Colorado265 UCBBoulderCO 80309USA School of Biological Sciences University of AberdeenZoology BuildingTillydrone AvenueAberdeenAB242TZUK The Rocky mountain Biological Laboratory Box 519 Crested ButteCO 81224USA Department of Ecology and Evolutionary Biology University of California621 Young Drive SouthLos AngelesCA 90095-1606USA

The production and structure of animal signals may depend on an individual's health status and may provide more than one type of information to *** alarm calls are not typically viewed as health condition dependent,recent studies have suggested that their structure,and possibly their propensity to be emitted,depends on an individual,s health condition and *** asked whether the propensity of yellow-bellied marmots(marmota flaviventer)to emit calls is influen ced by their immuno logical or parasite status,by quantifying both trap-elicited and n atural calling rates as a function of their neutrophil-to-lymphocyte(NL)ratio,the presence of a blood borne trypanosome,and the presenee of several intestinal parasites(Eimeria sp.,Entamoeba sp.,and Ascaris sp.).We fitted mixed effects models to determine if the health measures we collected were associated with the probability of calling in a trap and with annual rates of natural alarm *** infected with a blood-borne trypanosome were marginally more likely to call naturally and when trapped,while those infected with the intestinal parasite Ascaris were less likely to call when *** ratio was not directly associated with in-trap calling probability,but males were more likely to call when they had higher NL ***,health conditions,such as parasite infection and immune system activation,can modulate the production of alarm signals and potentially provide in formation to both predators and prey about the caller's *** experiments are required to confirm if receivers use such information.

关键词： alarm calling animal communication antipredator behavior condition dependenee immune function parasites