检索结果-南通市图书馆

World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos m Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive over.iew of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip microorganism identification Diagnostics Point-ofcare testing Biosensors

Advanced Functional Electromagnetic Shielding materials:A review Based on micro‑Nano Structure Interface Control of Biomass Cell Walls

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed m.Asiri runzhou Huang Hua Hou Zeinhom m.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

research efforts on electromagnetic interference(EmI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EmI shielding *** concerted efforts on the EmI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EmI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EmI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EmI shielding field are critically discussed in this paper,and similar biomass EmI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EmI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding micro-nano structure interface control Conductivity

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

在线全文

学校读者我要写书评

暂无评论

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU W.m.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

关键词： three-dimensional (3D) braided composite braiding direction composite thin plate large overall motion dynamic model O313.7

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain ramón y Cajal Institute for Health research(IrYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Coarse to Fine: The role of Severe Plastic Deformation in Advancing Titanium-Based medical Implants - A Comprehensive review

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(materials Science) 2025年第1期40卷 295-306页

作者： Dragana r mihajlović Bojan I međo Ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an over.iew of the proper.ies of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile proper.ies),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical proper.ies without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical proper.ies mechanical proper.ies

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EmBL Partnership for molecular medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison N.DeVore marisol Lauffer Nilufer S.Atasoy Deniz Atasoy rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(rGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel rGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of rGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by rGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by rGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these rGS6-expressing ***,rGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying rGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(rGS6)

Security Strategy of Digital medical Contents Based on Blockchain in Generative AI model

在线全文

学校读者我要写书评

暂无评论

Computers, materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko marek r.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition

The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology research 2025年第1期33卷 149-160页

作者： Nasser mulla Yousef Katib Asim m Almughamsi Duaa S Alkhayat mohamed mosaad Samir T Alfotih rawan Alaofi Department of Internal medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King Salman bin Abdulaziz medical City Madinah 42311 Saudi Arabia. Prince mohammed Bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNm staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients' overall survival (OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HBV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in OS (-value = 0.027). AFP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the OS in terms of AFP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and OS (-value = 0.02). CTP class B had the longest survival. BSC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in OS among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC, AFP, and tumor size. Being having non-viral etiology, a tumor size >5 cm, an AFP > 400 ng/mL, and a CTP score class C were all negatively associated with OS.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival