检索结果-南通市图书馆

Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection

引用

World Journal of Gastroenterology 2013年第48期19卷 9377-9382页

作者： mustafa Kemal Celen Duygu mert müzeyyen ay Tuba Dal Safak Kaya Necmettin Yildirim Serda Gulsun Tunga Barcin Sevgi Kalkanli mehmet Sinan Dal Celal ayaz Department of Infectious Diseases Faculty of Medicine Dicle University 21280 YenisehirDiyarbakir Turkey State Hospital 72000 Merkez Batman Turkey State Hospital Kiziltepe 47500 Mardin Turkey Department of medical microbiology Faculty of Medicine Dicle University 21280 Yenisehir Diyarbakir Turkey Department of Infectious Disease Teaching and Research Hospital 21100 Diyarbakir Turkey Department of Infectious Diseases State Hospital 47000 Mardin Turkey Department of Infectious Diseases State Hospital 21100 Diyarbakir Turkey Department of Infectious Diseases Mardin Park Hospital 47000 Mardin Turkey Department of Immunology Faculty of Medicine Dicle University 21280 Yeni?ehir Diyarbakir Turkey Department of Internal medicine Faculty of Medicine Dicle University 21280 Yenisehir Diyarbakir Turkey

AIm:To evaluate the effects of tenofovir disoproxil fumarate(TDF)use during late pregnancy to reduce hepatitis B virus(HBV)transmission in highly viremic ***:This retrospective study included 45 pregnant patients with hepatitis B e antigen(+)chronic hepatitis B and HBV DNA levels>107copies/mL who received TDF 300 mg/d from week 18 to 27 of gestation(n=21).Untreated pregnant patients served as controls(n =24).All infants received 200 IU of hepatitis B immune globulin(HBIG)within 24 h postpartum and 20μg of recombinant HBV vaccine at 4,8,and 24 *** transmission rate was determined by hepatitis B surface antigen and HBV DNA results in infants at week ***:At week 28,none of the infants of TDFtreated mothers had immunoprophylaxis failure,whereas2(8.3%)of the infants of control mothers had immunoprophylaxis failure(P=0.022).There were no differences between the groups in terms of adverse events in mothers or congenital deformities,gestational age,height,or weight in *** postpartum week 28,significantly more TDF-treated mothers had levels of HBV DNAmL and normalized alanine aminotransferase compared with controls(62%vs none,Pmester reduced perinatal transmission rates of HBV and no adverse events were observed in mothers or infants.

关键词： Hepatitis B Tenofovir Reverse transcriptase inhibitors Vertical transmission Chronic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes

引用

World Journal of Diabetes 2025年第1期16卷 74-90页

作者： ayşe N Erbakan müzeyyen Arslan Bahadır FatoşN Kaya Büşra Güleç miraçVural Keskinler Ümmügülsüm AktemurÇelik Özge Faydalıel Banu mesçi aytekin Oğuz Department of Internal medicine Prof Dr Suleyman Yalcin City HospitalIstanbul Medeniyet UniversityIstanbul 34722Türkiye Department of Family medicine Istanbul Medeniyet UniversityIstanbul 34722Türkiye

BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2Dm)is a major public health problem and a significant risk factor for the progression of diabetic *** To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2Dm with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic *** This prospective observational study investigated glycemic control in patients with poorly controlled T2Dm over 12 *** were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as *** analysis focused on the success rates of good glycemic control and the associated factors within each *** The study showed significant improvements in HbA1c levels in all *** most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,*** one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and *** In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored ***

关键词： Type 2 diabetes mellitus Glycated hemoglobin Glycemic control Patient-centered care Diabetes management glycemic background

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of age on long term survival following transcatheter aortic valve implantation

引用

Journal of Geriatric Cardiology 2019年第3期16卷 265-271页

作者： Nuray Kahraman ay Department of Cardiology Bezmialem Vakif University

Objective To compare the long-term survival following transcatheter aortic valve implantation (TAVI) in an octogenarian population with that in a younger *** This retrospective study included 274 patients that underwent TAVI for severe symptomatic aortic *** study group was divided into two age groups,as those with an age ≥ 80 years (octogenarians,n = 132),and age mpared in terms of clinical outcomes and *** addition,significant predictors of survival were *** Non-cardiac mortality (during follow-up)(21.9% vs.10.5%,P = 0.01) and in-hospital stroke (8.3% vs.2.8%,P = 0.01) were more common among *** two groups did not differ in terms of mean survival (41.0 ± 2.1 vs.38.2 ± 2.2 months,respectively,P =0.18).multivariate analysis identified left ventricular ejection fraction moderate to severe mitral insufficiency (OR: 1.88,95% CI: 1.15–3.06;P = 0.01),postoperative major and life-threating bleeding (OR: 2.49,95% CI: 1.05–5.89;P =0.03),and in-hospital stroke (OR: 2.29,95% CI: 1.04–5.04;P = 0.03) as potential predictors of poor *** In this study,similarly favorable survival outcomes were achieved in the elderly population as in younger patients,despite the presence of comorbid conditions.A consideration should be given to non-surgical management of severe aortic stenosis with the TAVI procedure in elderly patients,in the absence of co-existent conditions associated with shortened life expectancy.

关键词： Aortic stenosis Clinical outcome Non-surgical management Octogenarian The elderly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Use of petrological and organic geochemical data in determining hydrocarbon generation potential of coals:miocene coals of malatya Basin(Eastern Anatolia-Turkey)

引用

International Journal of Coal Science & Technology 2021年第4期8卷 510-533页

作者： Nazan Yalcin Erik Faruk ay Department of Geological Engineering Cumhuriyet University58140 SivasTurkey Department of Anthropology Cumhuriyet University58140 SivasTurkey

With this study,the hydrocarbon generation potential of miocene aged coals around Arguvan-Parçikan in the northern district of malatya province was evaluated with the aid of petrological and organic geochemical *** to organic petrography,coal quality data,and low thermal maturity,the Arguvan-Parçikan coals are of high-ash,high-sulfur subbituminous B/C *** organic fraction of the coals is mostly comprised of humic group macerals,with small percentages derived from the inertinite and liptinite *** mineral matter of the coals is comprised mainly of calcite and clay *** total organic carbon(TOC,wt%)values of the shale and coal samples are between 2.61 wt%and 43.02 wt%,and the hydrogen index values are between 73 and 229 mg HC/g ***(T_(max),PI),huminite/vitrinite reflectance(R_(o),%),and biomarker ratios CPI,Pr/Ph ratio,Ts/(Ts+Tm)ratio,C_(32) homohopane ratio(22S/22S+22R)and C_(29)ββ/(ββ+ααsterane ratio)indicate that the organic matter of the studied coals is thermally *** all these data are taken together,miocene aged coals around Arguvan are suitable for hydrocarbon generation,especially gas,in terms of organic matter type(Type III and Type II/III mixed),organic matter amount(>10 wt%TOC),however,low liptinitic macerals(mg HC/g TOC)and low thermal maturity values inhibit the hyrocarbon generation.

关键词： Arguvan malatya basin Eastern Anatolia Organic geochemistry Organic petrography miocene coal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantification of the impact of TOF and PSF on PET images using the noise-matching concept: clinical and phantom study

引用

Nuclear Science and Techniques 2017年第11期28卷 258-265页

作者： m. Shekari P. Ghafarian S. Ahangari m. R. ay Department of medical Physics and Biomedical Engineering Tehran University of Medical Sciences Tehran Iran Research Center for molecular and Cellular Imaging Tehran University of Medical Sciences Tehran Iran Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases(NRITLD) Shahid Beheshti University of Medical SciencesTehran Iran PET/CT and Cyclotron Center Masih Daneshvari HospitalShahid Beheshti University of Medical Sciences Tehran Iran

This study was to assess quantitatively the accuracy of ^(18)F-FDG PET/CT images reconstructed by TOF+PSF and TOF only, considering the noise-matching concept to minimize probable bias in evaluating algorithm performance caused by noise. PET images of similar noise level were considered. measurements were made on an inhouse phantom with hot inserts of Φ10–37 mm, and oncological images of 14 patients were analyzed. The PET images were reconstructed using the OSEm, OSEm+TOF and OSEm+TOF+PSF algorithms. Optimal reconstruction parameters including iteration, subset, and FWHm of post-smoothing filter were chosen for both the phantom and patient data. In terms of quantitative accuracy, the recovery coefficient(RC) was calculated for the phantom PET images. The signal-to-noise ratio(SNR),lesion-to-background ratio(LBR), and SUV_(max)were evaluated from the phantom and clinical data. The smallest hot insert(Ф10 mm) with 2:1 activity concentration ratio could be detected in the PET image reconstructed using the TOF and TOF+PSF algorithms, but not the OSEm algorithm. The relative difference for SNR between the TOF+PSF and OSEm showed significantly higher values for smaller sizes, while SNR change was smaller for Ф22–37 mm inserts both 2:1 and 4:1 activity concentration ratio. In the clinical study, SNR gains were 1.6 ± 0.53 and 2.7 ± 0.74 for the TOF and TOF+PSF, while the relative difference of contrast was 17 ± 1.05 and 41.5 ± 1.85% for the TOF only and TOF+PSF, respectively. The impact of TOF+PSF is more significant than that of TOF reconstruction, in smaller inserts with low activity concentration ratio. In the clinical PET/CT images, the use of the TOF+PSF algorithm resulted in better SNR and contrast for lesions, and the highest SUV_(max)was also seen for images reconstructed with the TOF+PSF algorithm.

关键词： Time of flight (TOF) Point spread function(PSF) Lesion detectability PET Quantification Image reconstruction SUV

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Toxicity, inheritance and biochemistry of clofentezine resistance in Tetranychus urticae

引用

Insect Science 2011年第5期18卷 503-511页

作者： Recep ay Fatma Ebru Kara Suleyman Demirel University Faculty of Agriculture Department of Plant Protection Cunur Isparta Turkey

This study evaluates the toxicological and biochemical response of two-spotted spider mites to clofentezine selection pressure. The mortality rate of Tetranychus urticae in adult females depends on increased clofentezine concentration and clofentezine was found to be effective against females. The resistance rate of the CUm strain selected 12 times once per generation with clofentezine was increased from 1.28- to 105.27-fold. The interaction of some synergists with clofentezine was analyzed in the clofentezine-resistant CLOF 12 strain. Synergists had no effect on clofentezine toxicity. The clofentezine-resistant CLOF 12 strain showed resistance against chlorpyrifos, abamectin, propargite, fenpyroximate and amitraz. The modes of inheritance of resistance to clofentezine were found to be incompletely dominant and not sex-linked. Esterase enzyme activity was detected both by gel electrophoresis and microplate reader methods, while glutathione S-transferase （GST） and monooxygenase （P450） activity were detected only by the microplate reader method. During the selection period the esterase, the GST and the P450 enzymes activities were raised from 7.69, 7.09 and 0.003 3 to 18.40, 13.11 and 0.003 7 milli-optical density/rain/rag proteins, respectively. An increase was observed in the band intensity of esterases and esterase enzymes may play a role in clofentezine resistance in T. urticae.

关键词： acaricide resistance clofentezine esterase glutathione S-transferase monooxygenase Tetranychus urticae

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein adsorption, cell viability and corrosion properties of Ti6Al4V alloy treated by plasma oxidation and anodic oxidation

引用

International Journal of minerals,metallurgy and materials 2020年第9期27卷 1269-1280页

作者： ÖzgüBayrak Hojjat Ghahramanzadeh Asl ayşe Ak Department of mechanical Engineering Erzincan Binali Yıldırım UniversityErzincan 24100Turkey Department of mechanical Engineering Karadeniz Technical UniversityTrabzon 61080Turkey Vocational School of Health Services Medical Imaging Techniques ProgrammeKocaeli UniversityKocaeli 41001Turkey

The hardness,wettability,and electrochemical properties of Ti6Al4V alloy surfaces treated with anodic oxidation and plasma oxidation as well as the viabilities of the different cell lines on the obtained surfaces were *** anodic oxidation was performed for 10 min under 100 V potential,and it resulted in a 0.95μm thick nanoporous anatase-TiO2 *** the other hand,plasma oxidation was carried out at 650℃ for 1 h and resulted in a dense rutile-TiO2 structure with a thickness of 1.2μ*** a hardness of HV0.025823 and roughness of^220 nm were obtained by plasma oxidation,those obtained by anodic oxidation were HV0.025512 and^130 nm,*** anodic oxidation process created a more hydrophilic surface with a contact angle of 87.2°.Both oxidation processes produced similar properties in terms of corrosion behavior and showed better resistance than the as-received state in a certain range of ***,the surface treatments led to no significant change in the protein adsorption levels,which indicates that the difference in viability between the osteoblast and fibroblast cells was not due to the difference in surface protein *** all the factors,the surfaces obtained by anodic oxidation treatment revealed higher cell viability than those obtained by plasma oxidation(p=0.05).

关键词： Ti6Al4V oxidation corrosion cell viability protein adsorption

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

引用

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

引用

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The residual symmetry,Bäcklund transformations,CRE integrability and interaction solutions:(2+1)-dimensional Chaffee–Infante equation

引用

Communications in Theoretical Physics 2023年第11期75卷 30-37页

作者： Nursena Günhan ay Emrullah Yaşar Department of mathematics Faculty of Engineering and Natural Sciencesİstanbul Medeniyet University34700ÜsküdarIstanbulTurkey Department of mathematics Faculty of Arts and SciencesUludag University16059 BursaTurkey

In this paper,we consider the(2+1)-dimensional Chaffee-Infante equation,which occurs in the fields of fluid dynamics,high-energy physics,electronic science *** build Bäcklund transformations and residual symmetries in nonlocal structure using the Painlevétruncated expansion *** use a prolonged system to localize these symmetries and establish the associated one-parameter Lie transformation *** this transformation group,we deliver new exact solution profiles via the combination of various simple(seed and tangent hyperbolic form)exact solution *** this manner,we acquire an infinite amount of exact solution forms ***,we demonstrate that the model may be integrated in terms of consistent Riccati *** the maple symbolic program,we derive the exact solution forms of solitary-wave and soliton-cnoidal *** 3D and 2D illustrations,we observe the dynamic analysis of the acquired solution forms.

关键词： (2+1)-dimensional Chaffee-Infante equation Painlevétruncated exapansion approach dynamic analysis Bäcklund transformations residual symmetries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：