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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 39-40页

作者： müller-ehmsen j. Scheid C. Grundmann F. 孙凯 Laboratory of muscle Research and molecular Cardiology Department of Internal Medicine III University of Cologne Joseph-Stelzmann-Str. 24 50924 Kln Germany

Background: The mobilization of hematopoietic progenitor cells from bone marrow has been proposed to play a role in cardiac regeneration after myocardial infarction(mI). Accordingly, an increase in CD34 positive cells(CD34+) has been observed in the peripheral blood of patients after acute myocardial infarction. Here, we evaluated the influence of an acute percutaneous coronary intervention(PCI) of the occluded artery on the mobilization of CD34+in acute mI. methods: CD34 positive cells were quantified by flow cytometry(FACS analysis) and expressed as number per million white blood cells. Peripheral blood was obtained and analyzed at day 5 after the onset of symptoms from patients with acute mI without early PCI(n=11, age 63±5 years), acute mI with rapid PCI(n=7, age 63±3), patients with pneumonia(n=5, age 51±6), patients without angiographical signs of coronary artery disease(control, n=5, age 66±8) and young healthy volunteers(n=11, age 28±1). Results: Patients with mI but without PCI had a higher CD34+count at day 5(312±48 per 106 leukocytes) than control(156±40, P=0.03) and mI with PCI(173±31, P=0.03). No increase in CD34+was observed in patients who underwent PCI vs. control. Patients with pneumonia had higher CD34+(350±44) than patients with mI with PCI(P=0.01) and control(P=0.01). Healthy individuals who were much younger than all other groups(28±1 years, PmI without PCI, P=0.00003 vs. mI with PCI, P=0.02 vs. pneumonia, P=0.00006 vs. control). Conclusions: Shorter time of ischemia and reduced cell death may be the reasons for reduced CD34+cell count after acute mI with early percutaneous intervention vs. acute mI without intervention. Besides ischemia, also inflammation as present in pneumonia may cause a mobilization of CD34+cells. Age may be a maj.r factor that influences the mobilization of CD34+cells and the regenerative capacity of the heart.

关键词：血管再通心肌再生细胞计数合并肺炎流式细胞计量术肺炎患者缺血时间造血干细胞血管造影活性细胞

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Triple combination targeting PI3K,ER,and CDK4/6 inhibits growth of ER-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor

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Cancer Communications 2023年第6期43卷 720-725页

作者： mikkel G.Terp martina Tuttolomondo Neil Portman Sidse ehmsen Lene E.j.hansen martin Bak Elgene Lim Henrik j.Ditzel Department of Cancer and Inflammation Research Institute of Molecular MedicineUniversity of Southern DenmarkOdenseDenmark Garvan Institute of medical Research DarlinghurstSydneyNew SouthWalesAustralia St.Vincent’s Clinical School Faculty of MedicineUniversity of New SouthWales SydneySydneyNew South WalesAustralia Department of Oncology Institute of Clinical ResearchOdense University HospitalOdenseDenmark Department of Pathology Sydvestjysk SygehusEsbjergDenmark Academy of Geriatric Cancer Research(AgeCare) Odense University HospitalOdenseDenmark

Dear Editor,Despite the improved outcome of advanced estrogen receptor-positive(ER+)breast cancer patients treated with endocrine therapy in combination with either a cyclindependent kinase 4/6 inhibitor(CDK4/6i)or a phosphoinositide 3-kinase inhibitor(PI3Ki),the disease will eventually progress,and the optimal treatment strategy upon progression remains undefined[1-4].To address this,we developed mCF-7-and T47D-derived PIK3CAmutated breast cancer cell lines[5]resistant to combined CDK4/6i palbociclib and fulvestrant(mPF-R and TPFR)or combined PI3Ki alpelisib and fulvestrant(mAF-R and TAF-R),respectively(Supplementary materials and methods).Drug-sensitive isogenic cells(m-S and T-S)grown in parallel with mPF-R and TPF-R cells and the original mCF-7/S0.5 and T47D cells were analyzed for comparison.

关键词： PIK3CA breast cancer

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冠状动脉旁路移植病人单核骨髓细胞移植后经SPECT和18F-PET检查心肌无恢复迹象

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心血管病学进展 2006年第5期27卷 679-679页

作者： Tossios P maller-ehmsen j.程希富（摘译）马康华（校）不详重庆医科大学附属第一医院

现在有推测认为心肌内注射单核骨髓细胞联合冠状动脉旁路移植(CABG)术可提高心肌梗死区组织的存活力或功能,德国学者通过实验测试了该假说。[第一段]

关键词：冠状动脉旁路移植心肌内注射骨髓细胞 PET检查 SPECT 移植病人单核移植后

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