检索结果-南通市图书馆

5-Fluorouracil loaded guar gum microspheres for colon delivery： preparation, characterization and in vitro release

在线全文

学校读者我要写书评

暂无评论

药学学报 2009年第11期44卷 1278-1284页

作者： KAUSHIK Dinesh SARDANA Satish mISHRA dn Department of Pharmaceutics Hindu College of Pharmacy Sonepat-131001 India Department of Pharmaceutical Sciences Guru Jambheswar University of Science and Technology Hisar (Haryana) India

The present investigation is aimed to develop a new formulation containing chemically crosslinked guar gum microspheres loaded with 5-fluorouracil for targeting colorectal cancer. The emulsification polymerization method involving the dispersion of aqueous phase of guar gum in castor oil was used to prepare spherical microspheres. Various processing parameters were studied in order to optimize the formulation. Particle size and surface morphology of the microspheres were determined using optical microscopy and scanning electron microscopy. The in vitro drug release studies performed in simulated gastric fluid (SGF) for 2 h followed by intestinal fluid for 3 h, revealed the retention of the drug inside the microspheres from which only (15.27 ± 0.56) % of the drug was released in 5 h. In vitro release rate studies were also carried out in simulated colonic fluid (SCF) in the presence of rat caecal contents, which showed improved drug release. The drug release from the formulation was found to be (41.6 ± 3.5) % with 2% (w/v) caecal matter in 24 h as compared to control study where (25.2 ± 3.5) % of drug was released. The drug release from the formulation with 2% and 4% rat caecal contents medium after 2 days of enzyme induction was found to be (56.3 ± 4.1) % and (78.9 ± 2.8) % in 24 h respectively. Similarly, (61.3 ± 5.4) % and (90.2 ± 2.9) % drug was released respectively with 2% and 4% rat caecal matter after 4 days of enzyme induction and (72.1 ± 2.9) % and (90.2 ± 3.2) % after 6 days of enzyme induction. In this way, 5-fluorouracil loaded guar gum microspheres have shown promising results in the management of colorectal cancer, warranting thorough in vivo study for scale up technology.

关键词：制剂学药学氟尿嘧啶临床

Effect of ciprofloxacin and chloramphenicol on humoral immune response elicited by bovine albumin encapsulated in niosomes

在线全文

学校读者我要写书评

暂无评论

药学学报 2007年第8期42卷 905-909,910页

作者： mADAN Jitender KAUSHIK Dinesh SARDANA Satish mISHRA dn Department of Pharmaceutics Hindu College of Pharmacy Faculty of Pharmacy Guru Jambheshwar University of Science and Technology

The aim is to evaluate the effect of ciprofloxacin and chloramphenicol on anti-BSA antibody production triggered by bovine albumin encapsulated in non-ionic surfactant vesicle,*** phase evaporation method was adopted to entrap the antigen in colloidal carrier composed of Span 80 and Span 85 followed by simultaneous characterization for particle size,entrapment efficiency and in vitro *** protein content was determined by Bradford method using UV Visible Spectrophotometer at 595 *** immune response was measured in terms of systemic IgG antibody titre by ELISA *** data indicated that 7∶3 molar ratio of Span 80 and cholesterol based niosomal formulation possessed maximum(39.8±2.9)% of soluble *** markedly(Pmphenicol did not reduce the antibody titre significantly in comparison to control group(P>0.05).It is necessary to explore the effect of a vaccine antigen when a candidate is medicated with a therapeutic agent,which might help in programming a new drug management and vaccination programme.

关键词：环丙沙星氯霉素体液免疫 IgG抗体牛蛋白胶囊免疫应答泡囊

Lingual hematoma causing upper airway obstruction:an unusual manifestation of dengue fever

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical medicine 2011年第5期4卷 412-413页

作者： Jaydeep Sarkar Charu mohan dn misra Atul Goel Department of Internal medicine Lady Hardinge Medical CollegePGIMERDrRML Hospital

The spectrum of dengue infection varies from dengue fever to more severe forms such as dengue hemorrhagic fever(DHF) and dengue shock syndrome(DSS).In DHF bleeding may be overt (external) or *** time bleeding can occur at unusual *** report one such case of DHF in which bleeding occurred within the tongue manifesting as an intra-lingual hematoma, causing significant upper airway obstruction.

关键词： Hematoma Tongue Dengue Platelet

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

挤奶机检测专家系统

农业工程学报 1994年第A9期10卷 27-33页

作者：安居白 Kerr,dn

成套挤奶设备的检测是设备检测人员的日常工作，内容包括设备故障的检测，这些故障经常导致乳头杯离开乳牛的乳头，乳头的损坏，乳房炎发病率的增加等，在研制过程中采用了逐步提练技术来获取专家知识；系统中主要使用演绎推理技术，个... 详细信息

成套挤奶设备的检测是设备检测人员的日常工作，内容包括设备故障的检测，这些故障经常导致乳头杯离开乳牛的乳头，乳头的损坏，乳房炎发病率的增加等，在研制过程中采用了逐步提练技术来获取专家知识；系统中主要使用演绎推理技术，个别问题用模糊推理技术处理，该系统能使没有经验的设备检测人员的不咨询专家的情况下完成检测的各项内容，从而减少了专家进行重复性咨询的时间，并能更那地，有效地消除事故隐患，提高设备效率。

关键词：挤奶机检测专家系统

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

皮肤淋巴细胞增生性疾病的进展

国外医学（皮肤性病学分册） 1989年第1期15卷 25-30页

作者： Slater dn 谭仲楷

本综述重点介绍有关皮肤淋巴细胞增生性疾病的诊断、病因和发病机理方面的主要进展。蕈样肉芽肿和 Sézary 综合征现已明确,大多数蕈样肉芽胖(mF)

关键词：皮肤淋巴细胞 mF 蕈样肉芽肿

在线全文

学校读者我要写书评

暂无评论

城市化的动态：替代假设的实证

经济译文 1990年第5期 41-44页

作者：饶,dn 费洪平

Saprobic Dothideomycetes in Thailand: Vaginatispora appendiculata sp. nov. (Lophiostomataceae) introduced based on morphological and molecular data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Studies in Fungi 2016年第1期1卷 56-68页

作者： Wanasinghe dn Jones EBG Dissanayake AJ Hyde KD Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai57100Thailand School of Science Mae Fah Luang UniversityChiang Rai57100Thailand Department of Botany and microbiology King Saudi UniversityRiyadhSaudi Arabia Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 100097P.R.China

In order to establish the evolutionary relationships and resolve the polyphyletic nature of Dothideomycetes,we are studying their natural classification based on both morphology and multigene *** this paper we introduce Vaginatispora appendiculata,a novel species on dead twigs from southern *** character differences and analyses of combined LSU,TEF,SSU and ITS sequence datasets support the validity of the new species and its placement in Vaginatispora(Lophiostomataceae).

关键词： Appendages massarina Phylogeny

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

小儿烧伤治疗

国外医学（创伤与外科基本问题分册） 1993年第4期14卷 212-214页

作者： Dobke mK Herndon dn 葛绳德

小儿烧伤占烧伤总数的30％～40％,平均年龄2岁8个月。男孩占67％。烧伤原因:火焰占13％,热水或液85％,电和化学2％。致伤情况:16％不属意外,其中一半属虐待所致。早期复苏补液婴儿烧伤面积≥10％,儿童≥15％,就应给予补液。按450ml/m^2... 详细信息

小儿烧伤占烧伤总数的30％～40％,平均年龄2岁8个月。男孩占67％。烧伤原因:火焰占13％,热水或液85％,电和化学2％。致伤情况:16％不属意外,其中一半属虐待所致。早期复苏补液婴儿烧伤面积≥10％,儿童≥15％,就应给予补液。按450ml/m^2体表面积掌握,维持尿量在1ml/kg/h。故需按标准图中小儿体表比例来估计烧伤面积。补液公式要求5000ml/m^2烧伤面积,维持量200ml/m^2。第一个8小时给半量,用等渗电解质溶液乳酸林格液。

关键词：烧伤儿童

在线全文

学校读者我要写书评

暂无评论

皮肤淋巴增生性疾病:目前研究技术的评价

国外医学（皮肤性病学分册） 1992年第5期18卷 287-290页

作者： Slater dn 孙建方

本文就皮肤淋巴增生性疾病的免疫组化表型、抗原受体基因重组以及分子遗传学方面的改变进行了详细的综述,并讨论了这些变化对于皮肤淋巴增生性疾病的细胞起源、诊断、鉴别诊断以及预后判断方面的意义。同时对某些皮肤淋巴增生性疾病的... 详细信息

本文就皮肤淋巴增生性疾病的免疫组化表型、抗原受体基因重组以及分子遗传学方面的改变进行了详细的综述,并讨论了这些变化对于皮肤淋巴增生性疾病的细胞起源、诊断、鉴别诊断以及预后判断方面的意义。同时对某些皮肤淋巴增生性疾病的病毒病因学进行了探讨,指出人类T细胞淋巴瘤病毒、单纯疱疹病毒及EB病毒可能与蕈样肉芽肿或Sézary综合征的发病有关。最后,作者认为聚合酶链式反应将会对皮肤病理学的前景产生重大影响。

关键词：皮肤淋巴增生性病免疫组化 CLPD