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Rare metals 2006年第z1期25卷 195-200页

作者： GROmBALL F müller j Department of mikrosystemtechnik Technische Universitt Hamburg-Harburg Hamburg 21073 Germany

A line shaped electron beam recrystallised polycrystalline silicon film on the low cost substrate was investigated for the use of the solar cell absorber. The applied EB energy density strongly influences the surface morphology of the film system. Lower EB energy density results in droplet morphology and the rougher SiO2 capping layer due to the low fluidity. With the energy increasing, the capping layer becomes smooth and continuous and less and small pinholes form in the silicon film. Tungstendisilicide (WSi2) is formed at the interface tungsten/silicon but also at the grain boundaries of the silicon. Because of the fast melting and cooling of the silicon film, the eutectic of silicon and tungstendisilicide mainly forms at the grain boundary of the primary silicon dendrites. The SEm-EDX analysis shows that there are no chlorine and hydrogen in the area surrounding a pinhole after recrystallization because of outgassing during the solidification.

关键词： polycrystalline silicon film solar cell recrystallization energy surface morphology outgassing

Fabry病患者白质病变严重程度与性别的关系

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世界核心医学期刊文摘(神经病学分册) 2006年第1期 33-34页

作者： Fellgiebel A. müller m.j. mazanek m. 谢琰臣 Department of Psychiatry University Hospital of Mainz Untere Zahlbacher Str. 8 55131 MainzGerma-ny Dr.

In male patients with Fabry disease (FD), significant agerelated cerebral white matter lesions (WmLs) can be found. Although characteristic symptoms including cerebrovascular events are highly prevalent also in females with FD, cerebral structural changes have not been investigated in female FD patients yet. The authors quantified the WmL load of 13 male and 14 age-matched female patients with FD and could demonstrate a comparably high frequency and severity of WmLs in both groups.

关键词：严重程度患者 Fabry

心肌梗死患者其“罪犯”血管再通后CD34^+单核细胞的动员终止

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 39-40页

作者： müller-Ehmsen j. Scheid C. Grundmann F. 孙凯 Laboratory of muscle Research and molecular Cardiology Department of Internal Medicine III University of Cologne Joseph-Stelzmann-Str. 24 50924 Kln Germany

Background: The mobilization of hematopoietic progenitor cells from bone marrow has been proposed to play a role in cardiac regeneration after myocardial infarction(mI). Accordingly, an increase in CD34 positive cells(CD34+) has been observed in the peripheral blood of patients after acute myocardial infarction. Here, we evaluated the influence of an acute percutaneous coronary intervention(PCI) of the occluded artery on the mobilization of CD34+in acute mI. methods: CD34 positive cells were quantified by flow cytometry(FACS analysis) and expressed as number per million white blood cells. Peripheral blood was obtained and analyzed at day 5 after the onset of symptoms from patients with acute mI without early PCI(n=11, age 63±5 years), acute mI with rapid PCI(n=7, age 63±3), patients with pneumonia(n=5, age 51±6), patients without angiographical signs of coronary artery disease(control, n=5, age 66±8) and young healthy volunteers(n=11, age 28±1). Results: Patients with mI but without PCI had a higher CD34+count at day 5(312±48 per 106 leukocytes) than control(156±40, P=0.03) and mI with PCI(173±31, P=0.03). No increase in CD34+was observed in patients who underwent PCI vs. control. Patients with pneumonia had higher CD34+(350±44) than patients with mI with PCI(P=0.01) and control(P=0.01). Healthy individuals who were much younger than all other groups(28±1 years, PmI without PCI, P=0.00003 vs. mI with PCI, P=0.02 vs. pneumonia, P=0.00006 vs. control). Conclusions: Shorter time of ischemia and reduced cell death may be the reasons for reduced CD34+cell count after acute mI with early percutaneous intervention vs. acute mI without intervention. Besides ischemia, also inflammation as present in pneumonia may cause a mobilization of CD34+cells. Age may be a major factor that influences the mobilization of CD34+cells and the regenerative capacity of the heart.

关键词：血管再通心肌再生细胞计数合并肺炎流式细胞计量术肺炎患者缺血时间造血干细胞血管造影活性细胞

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

高危早产孕妇妊娠中期早期的血清松弛素、可溶型CD163及宫颈长度

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世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 3-4页

作者： Vogel I. Goepfert A.R. mФller H.j. 朱国栋 NANEA Department of Epidemiology Institute for Public Health Dr.

Objective: The purpose of this study was to evaluate the relationship between serum concentrations of relaxin and soluble CD163 with cervical length and preterm delivery in women with previous spontaneous preterm delivery. Study design: Sixty-one of 69 pregnant women with a previous spontaneous preterm had serum relaxin and soluble CD163 measured at week 16(range, 12-25 weeks). End points were cervical length and gestational age at delivery. Results: Of the 61 women, 26%had > 1 previous spontaneous preterm delivery; 84%were black; 87%were unmarried; 13%were smokers, and 39%were delivered before 37 weeks of gestation. Neither relaxin(median, 368 ng/L; range, 83-1493 ng/L) nor soluble CD163(2.4 mg/L; range, 0.86-6.85 mg/L) correlated with cervical length or gestational age at delivery. Black women had higher relaxin levels(436 vs 205 ng/L; P=.002), but soluble CD163 levels were similar among racial groups. Conclusion: Relaxin and soluble CD163 measured at 16 weeks of gestation are not clinically useful predictors of short cervical length or preterm delivery in women with a previous spontaneous preterm delivery.

关键词：宫颈长度早产孕妇 CD163 妊娠中期可溶型松弛素早产史分娩孕周研究设计种组

室壁运动评分指数和射血分数在急性心肌梗死后风险分层中的作用

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 17-18页

作者： mφller j.E. Hillis G.S. Oh j.K. P.A. Pellikka 宁宁 mayo Clinic 200 First Street SW Rochester MN 55905 United States Dr.

Background: The prognostic importance of regional systolic function, as assessed by wall motion score index(WmSI), compared with global function, as assessed by left ventricular ejection fraction(LVEF), has not been assessed in large populations after acute myocardial infarction. methods: Echocardiograms, including the assessment of WmSI and LVEF, were performed in 767 patients with acute myocardial infarction at a median of 1 day(25th and 75th percentiles 0- 2 days) after admission. Patients were followed for a median of 19 months(range 12- 28 months). Cox proportional hazards models were constructed for the primary study end point(all- cause mortality) and for a secondary end point(hospitalization for congestive heart failure). Results: During follow- up(median 40 months; range 32- 50 months), 216 patients died and 54 patients were hospitalized for congestive heart failure. By univariate analysis, both LVEF(PmSI(Pmortality. By a forward conditional Cox model, WmSI proved to be an independent predictor of death(hazard ratio 1.15 per 0.2- unit increase, 95% CI 1.10- 1.21, PmSI was included in the model, LVEF did not provide additional prognostic information(P=.77). Wall motion score index also proved to be an independent predictor of hospitalization for congestive heart failure(hazard ratio 1.21 per 0.2- unit increase, 95% CI 1.07- 1.37, P=.002), whereas LVEF did not(P=.56). Conclusion: Both LVEF and WmSI provide powerful prognostic information after acute myocardial infarction; however, the predictive power of WmSI is greater.

关键词： Cox比例风险模型急性心肌梗死后左室射血分数评分指数室壁运动充血性心力衰竭心肌梗死患者独立预测指标超声心动图检查局部收缩功能

初发急性心肌梗死后以左室舒张期室壁运动异常作为左心室扩张的早期预测因素的作用

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世界核心医学期刊文摘(心脏病学分册) 2006年第3期 34-35页

作者： Husic m. Nφrager B. Egstrup K. mφller j.E. 柴大军 Department of Cardiology Odense University Hospital Odense Denmark Dr.

To determine the relation between regional diastolic wall motion abnormality and left ventricular remodeling after acute myocardial infarction(AmI), Doppler echocardiography and color kinesis with assessment of global and regional systolic and diastolic functions were performed in 84 patients who developed AmI within 24 hours of admission. In a multivariate logistic regression analysis, the percentage of left ventricular myocardial segments with diastolic wall motion abnormality(p=0.008), absence of myocardial viability(p=0.01), and overall diastolic function(p=0.001) were predictors of remodeling after AmI.

关键词：室壁运动异常舒张功能

心肌梗死后舒张期室壁运动异常与神经激素激活的相关性和预测意义

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 33-34页

作者： Husic m. Nφrager B. Egstrup K. mφller j. E. 韩瑞娟 Department of Cardiology Odense University Hospital Sdr Blvd 29 5000 Odense Denmark Dr.

Background: Systolic wall motion abnormality(WmA) after acute myocardial infarction(AmI) is a major determinant of outcome; the presence and importance of diastolic WmA after AmI are unknown. We therefore sought to detect diastolic WmA using color kinesis and to assess its relation to neurohormonal activation and its prognostic importance in a consecutive population with a first ***: Complete color-encoded color kinesis and 2-dimensional and Doppler echocardiography were performed in 149 consecutive patients with documented first AmI within 24 hours of their admission. N-terminal pro-brain natriuretic peptide was measured 3 days after AmI. Study end point was cardiac death or readmission for heart failure. Results: Diastolic area of WmA exceeded the systolic area in all but 5 patients(97% ) and was significantly correlated with brain natriuretic peptide(unadjusted β =.67, Pjusted for systolic function, age, Killip class, and overall diastolic function β =.27, P=.007). Diastolic WmA was also correlated with the number of diseased vessels on coronary angiography(β =.59, Pmitted because of recurrent heart failure. On univariate analysis, the area of diastolic WmA was a predictor of the composite end point(hazard ratio 1.07 95% CI 1.05-1.09 , Pmained a predictor on multivariate Cox analysis after adjustment of well-known risk factors, left ventricular systolic and overall diastolic functions(hazard ratio 1.09 95% CI 1.06-1.15 , PmA can be assessed early after AmI using color kinesis. Diastolic WmA is associated with neurohormonal activation and angiographic severity of coronary artery disease and provides independent prognostic information.

关键词：舒张期神经激素室壁运动异常相关性

多巴酚丁胺负荷超声心动图检查过程中多普勒超声心肌作功指数的变化与心肌梗死后神经激素激活及预后间的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 42-43页

作者： Nφager B. Husic m. mφller j.E. B. Nφrager 朱冰坡 3rd Apartment Springbanen 27 2820 Gentofte Denmark Dr.

Objectives: To test whether an increase in Doppler myocardial performance index(mPI) during dobutamine stress echocardiography, reflecting deterioration of overall left ventricular function, is associated with increased N-terminal pro-brain natriuretic peptide(NT-pro-BNP) concentration and provides prognostic information beyond conventional systolic wall motion analysis after acute myocardial infarction(AmI). Design: Prospective, observational study. methods: Dobutamine-atropine stress echocardiography(DASE) and NT-pro-BNP were assessed five days after AmI in 109 consecutive patients. mPI was measured at rest and at low-dose(10 μ/kg/min) and peak dobutamine infusion(≤40 μg/kg/min with or without atropine). main outcome measures: End point was a composite of cardiac death or readmission for heart failure or reinfarction. Results: In 35 patients(32%), mPI increased at low-dose DASE. This was associated with higher NT-pro-BNP concentrations(β=0.30, p=0.004). During a mean follow up of 27(SD 7) months, 8 patients died of cardiac causes and 15 patients were readmitted for heart failure or reinfarction. On Cox regression analysis, an increase in mPI at low-dose DASE(p=0.02) was an independent predictor of cardiac events. In contrast, traditional wall motion analysis during DASE provided no additional prognostic information. Conclusions: An increase in mPI at low-dose DASE, reflecting early deterioration of overall left ventricular function, is associated with raised NT-pro-BNP concentration and provides prognostic information beyond conventional stress echocardiographic data after AmI.

关键词：多巴酚丁胺负荷超声心动图预后信息室壁运动多普勒超声心肌作功指数

双色激光共振增强的气相C6H6分子的光电离谱

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光学学报 1987年第1期 1-10页

作者：范俊颖,G.müller,j.L.LYmAN,W.E.SOHmID,K.L.KOmPA 中国科学院上海光学精密机械研究所 max-Planck-Institut für Quantenoptik D-8046 Garching b.münchen FRG Los Alamos National Laboratory New mexico 87545 USA max-Planck-Institut für Quantenoptik D-8046 Garching b.münchen FRG max-Planck-Institut für Quantenoptik D-8046 Garching b.münchen FRG

本文给出了双色激光共振增强的气相苯的光电离谱结果。激发光子首先把分子从基态选择激发到s-1电子单态中一个确定的振动态,然后第二台激光器输出的离化光子把这个激发分子离化。实验证明离子的产额不但与中间电子能级1B2u的振动态有关... 详细信息

本文给出了双色激光共振增强的气相苯的光电离谱结果。激发光子首先把分子从基态选择激发到s-1电子单态中一个确定的振动态,然后第二台激光器输出的离化光子把这个激发分子离化。实验证明离子的产额不但与中间电子能级1B2u的振动态有关,且依赖于离化激光的波长。从所得到的离子谱的结构和强度可以求得离子的电子基态2E1g的振动频率及分子参数,精度较高。自离化里德堡能级对离化截面的贡献非常显著。某些自离化共振峰可以确认为是这些里德堡态的振动能级。

关键词：电子态跃迁 C6H6 激光双色共振增强气相