检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

hl-2m装置主机集成安装工程质量管理

核聚变与等离子体物理 2021年第S1期41卷 289-294页

作者：蔡立君宋斌斌李连才徐红兵杨泓林晨毛维成 hl-2m研制团队核工业西南物理研究院成都610041

基于hl-2m装置主机集成安装实践,以风险控制、过程管理为质量管理工作总体思路,对工程策划、实施、验收环节进行全面质量管理。通过实施质量管理活动,确保了hl-2m装置主机集成安装工程达到质量目标,并于2020年12月4日首次放电成功。通... 详细信息

基于hl-2m装置主机集成安装实践,以风险控制、过程管理为质量管理工作总体思路,对工程策划、实施、验收环节进行全面质量管理。通过实施质量管理活动,确保了hl-2m装置主机集成安装工程达到质量目标,并于2020年12月4日首次放电成功。通过本项目的实施积累了大科学工程的质量管理经验。

关键词： hl-2m装置主机安装质量管理

在线全文

学校读者我要写书评

暂无评论

hl-2m磁体系统安装中的定位与测量

核聚变与等离子体物理 2021年第S1期41卷 321-326页

作者：张龙刘健赖春林刘宽程查方正蔡立君卢勇黄文玉 hl-2m研制团队核工业西南物理研究院成都610041

为提高磁体系统安装精度,在hl-2m集成大厅建立63个基准点构成测量基准网,并利用激光跟踪仪等高精度测量设备建立每个磁体的局部坐标系,测量特征点的局部坐标;基于测量基准网和公共测量点,采用最佳拟合得到坐标转换矩阵,以此得到特征点... 详细信息

为提高磁体系统安装精度,在hl-2m集成大厅建立63个基准点构成测量基准网,并利用激光跟踪仪等高精度测量设备建立每个磁体的局部坐标系,测量特征点的局部坐标;基于测量基准网和公共测量点,采用最佳拟合得到坐标转换矩阵,以此得到特征点在测量基准网的位置,指导磁体安装。完成安装后的中心柱同支撑基础的同轴度为∅2.03mm;PF1~PF4线圈安装标高偏差为±0.5mm,与中心柱的同轴度为∅2.60mm;PF5/6/7/8线圈与中心柱的同轴度偏差小于∅3.00mm,标高偏差在[-1mm,1mm]区间内。基于以上方法所得到的线圈安装精度都满足设计需求。

关键词： hl-2m装置磁体系统安装集成基准网定位装配

在线全文

学校读者我要写书评

暂无评论

hl-2m装置环向场线圈的工程研制与调试

核聚变与等离子体物理 2021年第S1期41卷 312-315页

作者：刘晓龙李广生邹晖邱银单亚农蔡立君刘健 hl-2m研制团队核工业西南物理研究院成都610041

介绍了hl-2m装置环向场(TF)线圈的工程设计、关键制造工艺及其调试结果。目前,TF线圈最大通电电流达到42kA,对应TF线圈产生的磁场为0.66T,满足hl-2m装置初始放电需求。

关键词： hl-2m装置环向场线圈工程调试

Quantum chemical studies on antimalarial of artemisinin (qinghaosu) derivatives

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1995年第2期13卷 131-140页

作者： JIANG, hl CHEN, KX TANG, Y CHEN, JZ JI, RY CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

In this paper theoretical studies were performed on artemisinin (qinghaosu) derivatives with semiempirical quantum chemical methods Am1 and Pm3. The antimalarial activity -logC has an obvious correlation with the net charge of C(16) and bond orders of bonds O(1)-C(10), O(2)-C(6), O(1)-O(2) and O(5)-C(16). According to the calculation results, we derived structure-activity relationship, presented the probable pharmacophore of qinghaosu derivatives and the interaction fashion between the drugs and the plasmodium receptor.

关键词： ARTEmISININ (QINGHAOSU) ANTImALARIAL QUANTUm CHEmISTRY PHARmACOPHORE

The initial elevation of palaeokarst and planation surfaces on Tibet Plateau

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第11期42卷 934-939页

作者： Cui, ZJ Gao, QZ Liu, GN Pan, BT Chen, hl Department of Geography Peking University Beijing China Department of Geography Lanzhou University Lanzhou China

THE formation periods,properties and initial elevations of Tibetan planation surfaces are keysto the issues ot the plateau *** et *** that the study on planation surfaces hasfar-reaching *** et *** that the summit lev... 详细信息

关键词： Tibet Plateau planation surface period elevation.

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

在线全文

学校读者我要写书评

暂无评论

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU W.m.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

关键词：

Comparative studies on the mechanism of uridine phosphorolysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1997年第1期15卷 84-89页

作者： Zhao, SR Chen, KX Jiang, hl Wang, Qm Ji, RY Shanghai Institute of materia medica Chinese Academy of Sciences Shanghai 200031 China

We have used quantum mechanical method to study the transition states(TSs) of uridine phosphorolysis reaction. Comparing the four different reaction pathways and the five transition states obtained, we conclude that enzymatic uridine phosphorolysis takes place mainly according to acid-catalyzed S(N)2 mechanism. The proposed reaction pathway is consistent with many experimental results.

关键词： transition state uridine phosphorolysis reaction mechanism nucleophilic substitution intrinsic reaction coordinate

Insights from an academic endeavor into central nervous system drug discovery

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim Vanmierlo Rudy Schreiber BIOmED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University mS Center(UmSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(mazzucato,2013).

关键词： academic approval consequences

Neurocircuit regeneration by extracellular matrix reprogramming

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming