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In <i>Silico</i>Analysis of Cross Reactivity between Lipocalin of Domestic Animals

Open Journal of Immunology 2018年第4期8卷 97-106页

作者： múnera marlon Sanchez Andres Sanchez Jorge Emiliani Yuliana medical Research Group (GINUmED) Universitary Corporation Rafael Nu&ntilde ez Cartagena Colombia Group of Clinical and Experimental Allergy (GACE) IPS Universitaria University of Antioquia Medellín Colombia

Lipocalins are one of the groups of allergens derived from domestic animals with clinical importance for the development of allergic responses. They have been characterized in different animals. With allergenic capacity characterized, little is known about the epitopes involved in allergic responses. Here, potential antigenic regions involved in cross-reactivity among lipocalins were explored through bioinformatics tools. The amino acid sequences of several lipocalins from different domestic animals (mouse, dog, cat, bull, hamster, horse and pig) were used to determine the degree of kinship by phylogenetic studies. Groups with highest phylogenetic relation were obtained by using mEGA software. 3D models of lipocalins not reported in the protein data bank were modeled by homology to identify potential antigenic regions compromised in the cross-reactivity of this group of allergens. The alignment of the entire database of allergenic lipocalins and the inferred maximum likelihood tree segregate lipocalins into five monophyletic clades (referenced here as A, B, C, D and E). According to the multiple pairing analyzes, group C (Fel d 4, Rat n 1 and Equ c 1) showed the highest degree of identity among their amino acid sequences (58%). The analysis of conserved and exposed residues showed that group C shares three antigenic regions that could potentially contribute to its cross-reactivity. Potential antigenic sites were identified for the generation of cross-reactivity between the different lipocalins analyzed in this study. These studies support the need to carry out directed mutagenesis tests to confirm their relevance in the allergenic capacity of lipocalins.

关键词： Bioinformatics Immunology Prediction Epitope Allergen Antigen

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Visualization of real-time displacement time history superimposed with dynamic experiments using wireless smart sensors and augmented reality

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 573-588页

作者： marlon Aguero Derek Doyle David mascarenas Fernando moreu Department of Civil Construction and Environmental EngineeringUniversity of New MexicoCentennial Engineering Center 3056MSC011070210 University Blvd NEAlbuquerqueNM 87131USA Air Force Research Laboratory Space Vehicles DirectorateKirtland Air Force BaseAlbuquerqueNM 87117USA Engineering Institute Los Alamos National LaboratoryLos AlamosNM 8754USA

Wireless smart sensors(WSS)process field data and inform inspectors about the infrastructure health and *** bridge engineering,inspectors need reliable data about changes in displacements under loads to make correct decisions about repairs and *** to displacement information in the field and in real-time remains a challenge as inspectors do not see the data in real *** data from WSS in the field undergoes additional processing and is seen at a different *** inspectors were able to see structural displacements in real-time at the locations of interest,they could conduct additional observations,creating a new,information-based,decision-making reality in the *** paper develops a new,human-centered interface that provides inspectors with real-time access to actionable structural data during inspection and monitoring enhanced by augmented reality(AR).It summarizes and evaluates the development and validation of the new human-infrastructure interface in laboratory *** experiments demonstrate that the interface that processes all calculations in the AR device accurately estimates dynamic displacements in comparison with the *** this new AR interface tool,inspectors can observe and compare displacement data,share it across space and time,visualize displacements in time history,and understand structural deflection more accurately through a displacement time history visualization.

关键词： wireless smart sensor monitoring augmented reality displacement acceleration human-infrastructure interface

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An adaptive range-query optimization technique with distributed replicas

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Journal of Central South University 2014年第1期21卷 190-198页

作者： Sayar Ahmet Pierce marlon Fox C.Geoffrey Department of Computer Engineering Kocaeli University Department of Computer Science Indiana University Community Grids Lab Indiana University School of Informatics and Computing Indiana University

Replication is an approach often used to speed up the execution of queries submitted to a large dataset.A compile-time/run-time approach is presented for minimizing the response time of 2-dimensional range when a distributed replica of a dataset *** aim is to partition the query payload(and its range) into subsets and distribute those to the replica nodes in a way that minimizes a client's response ***,since query size and distribution characteristics of data(data dense/sparse regions) in varying ranges are not known a priori,performing efficient load balancing and parallel processing over the unpredictable workload is difficult.A technique based on the creation and manipulation of dynamic spatial indexes for query payload estimation in distributed queries was *** effectiveness of this technique was demonstrated on queries for analysis of archived earthquake-generated seismic data records.

关键词： distributed systems load balancing range query query optimization

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Quantum teleportation and information splitting via four-qubit cluster state and a Bell state

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Frontiers of physics 2017年第5期12卷 171-179页

作者： marlon David González Ramirez Babatunde James Falaye Guo-Hua Sun m. Cruz-Irisson Shi-Hai Dong ESImE-Culhuaean Instituto Politécnico Nacional Av. Santa Ana 1000 Mexico CDMX 04430 Mexico Departamento de Fisica Escuela Superior de Fisica y Matemdticas Instituto Politécnico Nacional Edificio 9 UPALM CDMX 07738 Mexico Applied Theoretical Physics Division Department of Physics Federal University Lafia P. M. B. 146 LafiaNigeria Catedrdtica CONACyT CIC Instituto Politéenico Nacional UPALM CDMX 07700 Mexico Laboratorio de Información Cudntica CIDETEC Instituto Politécnico Nacional UPALM CDMX 07700Mexico

Quantum teleportation provides a ＂bodiless＂ way of transmitting the quantum state from one object to another, at a distant location, using a classical communication channel and a previously shared entangled state. In this paper, we present a tripartite scheme for probabilistic teleportation of an arbitrary single qubit state, without losing the information of the state being teleported, via a fourqubit cluster state of the form ｜Ф） 1234 = α｜10000）＋β｜1010）＋ γ｜0101） - η｜1111）, as the quantum channel, where the nonzero real numbers α, β, γ, and η satisfy the relation ｜α｜^2 ＋｜β｜^2 ＋｜γ｜^2 ＋｜η｜^2 = 1. With the introduction of an auxiliary qubit with state ｜0}, using a suitable unitary transformation and a positive-operator valued measure （POVm）, the receiver can recreate the state of the original qubit. An important advantage of the teleportation scheme demonstrated here is that, if the teleportation fails, it can be repeated without teleporting copies of the unknown quantum state, if the concerned parties share another pair of entangled qubit. We also present a protocol for quantum information splitting of an arbitrary two-particle system via the aforementioned cluster state and a Bell-state as the quantum channel. Problems related to security attacks were examined for both the cases and it was found that this protocol is secure. This protocol is highly efficient and easy to implement.

关键词： teleportation positive-operator valued measure tripartite scheme security attacks

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COVID-19 and its effects upon orthopaedic surgery: The Trinidad and Tobago experience

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World Journal of Orthopedics 2021年第3期12卷 94-101页

作者： marlon meredith mencia Raakesh Goalan Department of Clinical Surgical Sciences University of the West IndiesSt.Joseph 0000Trinidad and Tobago Department of Surgery Sangre Grande HospitalSangre Grande 0000Trinidad and Tobago

The World Health Organisation(WHO)declared coronavirus disease 2019(COVID-19)a pandemic on march 11,***-19 is not the first infectious disease to affect Trinidad and *** country has faced outbreaks of both Chikungunya and Zika virus in 2014 and 2016 *** viral pandemic is predicted to have a significant impact upon all countries,but the healthcare services in a developing country are especially *** Government of Trinidad and Tobago swiftly established a parallel healthcare system to isolate and treat suspected and confirmed cases of ***‘lockdown’orders,office closures,social distancing and face mask usage recommendation were implemented following advice from the *** approach has seen Trinidad and Tobago emerge from the second wave of infections,with the most recent Oxford COVID-19 Government Response Tracker report indicating a favourable risk of openness index for the *** effects of the pandemic on the orthopaedic services in the public and private healthcare systems show significant *** by shortages in personal protective equipment and inadequate testing facilities,the public system moved into emergency mode prioritizing the care of urgent and critical *** healthcare driven more by economic considerations,quickly instituted widespread safety measures to ensure that the clinics remained open and elective surgery was not *** teaching at The University of the West Indies was quickly migrated to an online platform to facilitate both medical students and *** Caribbean Association of Orthopedic Surgeons through its frequent virtual meetings provided a forum for continuing education and social interaction amongst *** pandemic has disrupted our daily routines leading to unparalleled changes to our lives and *** of these changes will remain long after the pandemic is over,permanently transforming the practice of orthopaedics.

关键词： COVID-19 Coronavirus Orthopaedics Trinidad and Tobago University of the West Indies The Caribbean association of orthopaedic surgeons

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Assessing the inter-annual variability of separation distances around odour sources to protect the residents from odour annoyance

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Journal of Environmental Sciences 2019年第5期31卷 11-24页

作者： marlon Brancher martin Piringer Davide Franco Paulo Belli Filho Henrique De melo Lisboa Gunther Schauberger Postgraduate Program in Environmental Engineering (PPGEA) Federal University of Santa Catarina (UFSC) 88040900 Florianopolis Brazil.CAPES Foundation scholarship holder (main author) Brazilian Ministry of Education Brasilia Brazil WG Environmental Health Department of Biomedical Sciences University of Veterinary Medicine ViennaVeterinarplatz1 A-1210Vienna Austria Central Institute for meteorology and Geodynamics Hohe Warte 38 A-1190 Vienna Austria

In recent years, there has been a growing concern about potential impacts on public health and wellbeing due to exposure to environmental odour. Separation distances between odour-emitting sources and residential areas can be calculated using dispersion models, as a means of protecting the neighbourhood from odour annoyance. This study investigates the suitability of using one single year of meteorological input data to calculate reliable direction-dependent separation distances. Accordingly, we assessed and quantified the inter-annual variability of separation distances at two sites with different meteorological conditions, one in Brazil and the other in Austria. A 5-year dataset of hourly meteorological observations was used for each site. Two odour impact criteria set in current regulations were selected to explore their effect on the separation distances. The coefficient of variation was used as a statistical measure to characterise the amount of annual variation. Overall,for all scenarios, the separation distances had a low degree of inter-annual variability(mean coefficient of variation values from 8% to 21%). Reasonable agreements from year to year were therefore observed at the two sites under investigation, showing that one year of meteorological data is a good compromise to achieve reliable accuracy. This finding can provide a more cost-effective solution to calculate separation distances in the vicinity of odour sources.

关键词： Environmental odour Odour annoyance Impact assessment Dispersion modelling Regulatory criteria Separation distance

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Enabling affordances of blockchain in agri-food supply chains:A value-driver framework using Q-methodology

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International Journal of Innovation Studies 2023年第4期7卷 325-343页

作者： Pouyan Jahanbin Stephen C.Wingreen Ravishankar Sharma Behrang Ijadi marlon m.Reis College of Business University of CanterburyChristchurch8140New Zealand College of Technological Innovation Zayed UniversityAbu DhabiUnited Arab Emirates AgResearch Ltd Lincoln7674New Zealand

The application of blockchain beyond cryptocurrencies has received increasing attention from industry and scholars *** predicted looming food crises,some of the most impactful deployments of blockchains are likely to concern food supply *** study outlined how blockchain adoption can result in positive affordances in the food supply *** Q-methodology,this study explored the current status of the agri-food supply chain and how blockchain technology could be useful in addressing existing *** theorization leads to the proposition of the 3TIC value-driver framework for determining the enabling affordances of blockchain that would increase shared value for ***,we propose a framework based on the most promising features of blockchain technology to overcome current challenges in the agri-food *** value-driver framework is driven by the Q-study findings of respondents closely associated with the agri-food supply *** framework can provide supply chain stakeholders with a clear perception of blockchain affordances and serve as a guideline for utilizing appropriate features of technology that match organizations’capabilities,core competencies,goals,and ***,it could assist top-level decision-makers in systematically evaluating parts of the organization to focus on and improve the infrastructure for successful blockchain implementation along the agri-food supply *** conclude by noting certain significant challenges that must be carefully addressed to successfully adopt blockchain technology.

关键词： Blockchain technology Agricultural food supply chain Q-methodology Trustworthy platform

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Over-height truck collisions with railway bridges:attenuation of damage using crash beams

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Earthquake Engineering and Engineering Vibration 2022年第1期21卷 237-252页

作者： Dan Xu Xinxing Yuan Ali Irmak Ozdagli marlon Agüero Roya Nasimi Tao Wang Fernando moreu Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina EarthquakeAdministrationSanhe 065201China Department of Civil Construction and Environmental EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA Courtesy Appointment Department of Electrical and Computer EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA Courtesy Appointment Department of Mechanical EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA

Railway bridges are susceptible to over-height truck collisions and to address this issue,it is necessary to attenuate the effect of these impacts to ensure the safety of transportation *** study experimentally investigates the effectiveness of crash beams as a cushioning mechanism for railway bridges against ***-height truck and railway bridge impact events were simulated in a 1:5 scale *** design parameters such as the stiffness of the crash beam and the bridge supports were scaled to evaluate different levels of *** experiments were conducted with five configurations consisting of four different types of crash beams and one no-crash beam *** results show that crash beams attenuate bridge total peak dynamic displacement responses between 14.5%and 35.7%,depending on the intensity of the impact and crash beam *** addition,the results show that the average effectiveness in attenuating residual deformation for all four crash beams ranges from 43.03%to 83.40%.Finally,various designs and their effectiveness against lateral impacts with different speeds are *** overall scope of this research is to provide objective information about the design of crash beams for railway bridges based on their response to over-height truck collisions at various speeds.

关键词： railway bridge over-height truck impact attenuation crash beam dynamic displacement scaled model

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Lightweight in Automotive Components by Forming Technology

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Automotive Innovation 2020年第3期3卷 195-209页

作者： Stephan Rosenthal Fabian maaß mike Kamaliev marlon Hahn Soeren Gies A.Erman Tekkaya Institute of Forming Technology and Lightweight Components(IUL) TU Dortmund University44227 DortmundGermany

Lightweight design is one of the current key drivers to reduce the energy consumption of *** methodologies for lightweight components,strategies utilizing materials with favorable specific properties and hybrid materials are used to increase the performance of parts for automotive *** this paper,various forming processes to produce light parts are *** lightweight design is discussed,covering the manufacturing processes to produce hybrid components like fiber-metal,polymer-metal and metal-metal composites,which can be used in subsequent deep drawing or combined forming *** to increasing the specific strength and stiffness with thermomechanical forming processes as well as the in situ control of the microstructure of such components are *** lightweight design discusses possibilities to plastically form high-strength or high-performance materials like magnesium or titanium in sheet,profile and tube forming *** join those materials and/or dissimilar materials,new joining by forming technologies are *** economically produce lightweight parts with gears or functional elements,incremental sheet-bulk metal forming is *** an important part property,the damage evolution during the forming operations will be discussed to enable even lighter parts through a more reliable *** methods for predicting and tailoring the mechanical properties like strength and residual stresses will be *** possibilities of system lightweight design with forming technologies are presented.A combination of additive manufacturing and forming to produce highly complex parts with integrated functions will be *** integration of functions by a hot extrusion process for the manufacturing of shape memory alloys is *** in-depth understanding of the newly developed processes,methodologies and effects allows for a more accurate dimen-sioning of *** facilitates a reduction in th

关键词： Forming technology Lightweight design Energy efficiency manufacturing processes

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Tuberculous pericarditis-a silent and challenging disease:A case report

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World Journal of Clinical Cases 2022年第6期10卷 1869-1875页

作者： Oscar David Lucero marlon mauricio Bustos Darwin Jhoan Ariza Rodriguez Juan Camilo Perez Department of Internal medicine Hospital Universitario San IgnacioBogota 110231Colombia Internal medicine Resident Pontificia Universidad JaverianaBogota 110231Colombia

BACKGROUND Tuberculous pericarditis(TP)remains a challenge for endemic *** developing countries,one to two percent of patients with pulmonary tuberculosis develops *** SUmmARY A 49-year-old woman presented with dyspnea,chest pain and dry *** physical examination,veiled heart sounds were *** electrocardiogram showed low-voltage complexes and the transthoracic echocardiography revealed a large and free-looking pericardial *** patient was taken for an open *** pericardial fluid revealed high levels of adenosine deaminase and Ziehl-Neelsen stain showed acid-fast *** chain reaction study for mycobacterium tuberculosis in pericardial fluid was *** patient received tetra conjugate management with adequate clinical response after the first week of treatment and resolution of fever and chest *** In cases of TP,obtaining pericardial fluid and/or pericardial biopsy is the most efficient strategy to confirm the *** diagnosis of this entity will allow physicians to initiate timely treatment,avoid complications and improve the patient's clinical outcome,so we consider the description of this case pertinent and its review in the literature.

关键词： Tuberculosis Pericardial disease Tuberculous pericarditis Pericardial effusion mycobacterium tuberculosis Case report

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