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产前暴露于倍他米松与地塞米松的低体重新生儿近期不良结局的比较

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 44-44页

作者： Bar-Lev m.R.R. maayan-metzger A. matok I. J. Kuint 王伟华 Department of Neonatology Sheba Medical Center 52621 Ramat Gan Israel Dr.

OBJECTIVE: To assess the incidence of short-term outcomes of low birth weig ht infants (≤1,750 g) exposed prenattally to either dexamethasone or betamethaso ne. mETHODS: We retrospectively analyzed a cohort comprising 550 infants who wer e born alive at our center during the period January 1999 through December 2001, who weighed 1,750 g or less at birth, and who were exposed to prenatal steroid treatment. We compared brain ultrasound findings, such as intraventricular hemor rhage and cystic periventricular leukomalacia (PVL), as well as other clinical f indings, including respiratory distress syndrome (RDS), necrotizing enterocoliti s, retinopathy of prematurity, and bronchopulmonary dysplasia, for all premature infants whose mothers received either dexamethasone (from January 1, 1999 to Ju ne 30, 2000, n = 263) or beta-methasone (July 1, 2000 to December 31, 2001, n = 287). ResULTS: Patient characteristics (mothers and infants) were the same in b oth groups, with the exception of the number of steroid courses administered, th e number of women with premature rupture of membranes (defined as >24 hours), an d the number of women who had received tocolysis. No significant difference was found between the 2 groups with respect to intraventricular hemorrhage and cysti c PVL frequencies. No significant differences were found in the incidence of sho rt-term outcomes examined, despite the fact that the dexamethasone group was ex posed to a statistically significantly greater number of courses than the betame thasone group. CONCLUSION: There seem to be no advantages to maternal antenatal treatment with betamethasone compared with dexamethasone in reducing the risk of PVL in low birth weight (≤1,750 g) infants. Both drugs have the same effect on all short-term outcome parameters checked.

关键词：倍他米松呼吸窘迫综合征类固醇治疗视网膜病变胎膜早破无显著性差异保胎治疗超声结果发育不良日至

米诺环素诱导的皮肤色素沉着症:共聚焦激光扫描电子显微镜分析

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 10-10页

作者： Dodiuk-Gad R.P. de morentin H.m. Schafer J. S. Brenner 党倩丽 Department of Dermatology Tel Aviv Sourasky Medical Center 6Weizmann Street Tel Aviv 64239 Israel

Background: minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning microscope (CLSm). Results: A yellow-green fluorescencewas observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

关键词：共聚焦激光扫描皮肤色素沉着色素沉着症米诺环素电子显微镜分析扫描电子显微镜光学显微镜黄绿色荧光特征性

特种部队作战新兵胫骨应力变化:mR成像的模式和时机

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国际医学放射学杂志 2015年第1期 67-67页

作者： A.Hadid D.S.moran R.K.Evans Y.Fuks m.E.Schweitzer N.Shabshin Department of Imaging Assaf Harofeh University Medical CenterIsraelZerifiIsrael Department of Radiology Hospital of the University of Pennsylvania

目的描述基础训练前后4个月无症状新兵胫骨mRI表现的发生率、部位、分级和类型特征,探讨mR影像参数是否与训练前活动水平或未来有症状性损伤相关。材料与

关键词：新兵发生率 mR 应力变化特种部队

4种T1成像序列mOLLI、ShmOLLI、SASHA和SAPPHIRE准确性、精确性及可重复性的头对头对比研究

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国际医学放射学杂志 2014年第6期 573-573页

作者： S.Roujol S.Weingrtner m.Foppa K.Chow K.Kawaji R.Nezafat 杜明珊 Department of medicine(Cardiovascular Division) Beth Israel Deaconess Medical Center and Harvard Medical School300 Brookline AveBostonMA 02215

摘要目的就4种常用心肌T1mapping序列(mOLLI、Sh mOLLI、SASHA、SAPPHIRE)的准确性、精确性及可重复性进行比较。材料与方法本研究遵从HIPAA,并通过伦理委员会批准。受试者均签署知情同意书。首先在体外,利用人体体

关键词：可重复性 SASHA SAPPHIRE mOLLI

人体经皮下注入主动载人多囊脂质体内的大剂量布比卡因能够减缓药物释放同时避免达到全身中毒的血浆浓度

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麻醉与镇痛 2012年第1期8卷 89-95页

作者： Elyad m. Davidson, mD Yechezkel Barenholz, PhD Rivka Cohen, PhD simon Haroutiunian, mSc Leonid Kagan, PhD Yehuda Ginosar, BSc, mBBS 高超（译） Department of Anesthesiology and Critical Care medicine Hadassah-Hebrew University Medical Center Laboratory of membrane and Liposome Research Department of BiochemistryHebrew University Hadassah Medical School Department of Pharmaceutics School of PharmacyThe Hebrew University of Jerusalem Israel Departmentof Pharmaceutical Sciences University at Buffalo State University of New York Buffalo New York

背景缓释剂型能够延长局麻药的镇痛效果并降低其血浆峰浓度，这使我们可以更加安全地使用较大剂量的局麻药，延长镇痛的作用时间。之前我们报道了一种主动载入多囊大囊泡（1argemultivesicularvesicles，LmVVs）的布比卡因（多囊脂质体... 详细信息

背景缓释剂型能够延长局麻药的镇痛效果并降低其血浆峰浓度，这使我们可以更加安全地使用较大剂量的局麻药，延长镇痛的作用时间。之前我们报道了一种主动载入多囊大囊泡（1argemultivesicularvesicles，LmVVs）的布比卡因（多囊脂质体布比卡因），并证明在动物和人体内可以使镇痛作用时间延长5倍以上。本研究中，我们给出多囊脂质体布比卡因在人体内的药物代谢动力学数据。方法健康志愿者皮下注射0．5％单纯布比卡因20ml，1周后，注射2％的多囊脂质体布比卡因20ml，进行前瞻性非盲法交叉对照研究。结果8例受试者被纳入研究，未观察到局麻药的主观不良反应。通过血浆浓度一时间曲线模型获得血浆峰浓度及达峰时间。两组血浆峰浓度无显著差异（单纯布比卡因与脂质体布比卡因的浓度分别为0．87±0．45μg／ml和0．83±0．34μg／ml，P=0．83，无显著性差异）。这些数值远远低于被公认的中毒血浆浓度，即2-4μg／ml。达峰时间在脂质制剂中延长7倍（262±149分钟与37．5±16分钟，P〈0．01）。结论尽管以新的脂质制剂形式注入的布比卡因总剂量增加至4倍，两组的布比卡因血浆峰浓度并无差异。脂质体布比卡因消除和向血浆再分布的延迟与此前报道的长效制剂缓释效应导致的药代动力学效应的延长是相符的。

关键词：多囊脂质体布比卡因血浆浓度较大剂量全身中毒药物释放体内皮下注入

多层CT对健康志愿者用力呼气下支气管可塌陷性的评估

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国际医学放射学杂志 2011年第1期34卷 79-页

作者： D.Litmanovich C.R.O'Donnell A.A.Bankier A.Ernst m.E.millett S.H.Loring 杨荣荣 Center for Airway Imaging and Department of Radiology Beth Israel Deaconess Medical Center and Harvard Medical School

目的应用多层CT评估健康志愿者用力呼气下支气管的可塌陷性,并将这些结果与现行的支气管软化诊断标准进行比较。

关键词：健康志愿者主支气管百分数 CT

围手术期输注红细胞可降低心脏手术术后远期存活率

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麻醉与镇痛 2010年第5期6卷 81-88页

作者： Stephen D. Surgenor, mD Robert S. Kramer, mD Elaine m. Olmstead, BA Cathy S. Ross, mS Frank W. Sellke, mD Donald S. Likosky, PhD Charles A. S. martin, mBBS Robert E. Helm, Jr., mD Bruce J. Leavitt, mD Jeremy R. morton, mD David C. Charlesworth, mD Robert A. Clough, mD Felix Hernandez, mD Carmine Frumiento, mD Arnold Benak, CCP Christian DioData, CCP Gerald T. O'Connor, PhD, DSc 周全红(译) 江伟(校) Dartmouth-Hitchcock medical Center Lebanon New Hampshire maine medical Center Portland Maine Dartmouth medical School Hanover New Hampshire Beth israel Deaconess medical Center Boston Massachusetts Portsmouth Regional Hospital Portsmouth New Hampshire Fletcher Allen Health Care Burlington Vermont New England Heart Institute Catholic Medical Center Manchester New Hampshire Eastern maine medical Center Bangor Maine Central maine medical Center Lewiston Maine Concord Hospital Concord New Hampshire The Dartmouth Institute for Health Policy and Clinical Practice Dartmouth College Lebanon New Hampshire 不详

背景输注红细胞（RBC）与心脏手术后死亡率升高有关。我们分析了在住院期间接受了1或2个单位RBC输注的心脏手术患者的长期生存情况。方法将2001年至2004年期间9079例，在新英格兰北部地区8个医疗中心中接受了冠状动脉旁路移植术、瓣膜... 详细信息

背景输注红细胞（RBC）与心脏手术后死亡率升高有关。我们分析了在住院期间接受了1或2个单位RBC输注的心脏手术患者的长期生存情况。方法将2001年至2004年期间9079例，在新英格兰北部地区8个医疗中心中接受了冠状动脉旁路移植术、瓣膜手术或同时进行了冠状动脉旁路移植术和瓣膜手术的患者纳入本研究。研究将纳入地区与2006年6月30日社会保障署死亡档案确定的死亡率进行概率性配对。调整的风险比采用Cox比例风险和倾向评分法进行计算。结果36％的患者（n=3254）接受过1或2个单位的RBC。43％的RBCs是在手术中被输注的，分别有56％和1％的RBCs是在手术后和手术前输注的。输血的患者更可能是贫血、高龄、体表面积小、女性和同时患多种疾病的患者。那些在心脏手术住院期间接受了1或2个单位RBCs的患者的存活率显著低于未接受过RBCs的患者（P〈0．001）。调整了患者和疾病特征之后，接受1或2个单位RBCs仍使远期死亡风险提高16％（调整的风险比=1．16，95％CI：1．01—1．34，P=0．035）。结论输注1或2个单位的RBCs可使心脏手术术后存活率降低的风险提高16％。

关键词：术后死亡率心脏手术远期存活率红细胞输注围手术期冠状动脉旁路移植术 RBCs

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皮质下小血管病诊断的共识声明

国际脑血管病杂志 2016年第6期24卷 481-496页

作者： Gary A Rosenberg Anders Wallin Joanna m Wardlaw Hugh S markus Joan montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel martin Dichgans marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师张劼陈涵丰俞娅美徐子奇罗本燕 Department of Neurology University of New Mexico Albuquerque New Mexico USA Institute of Neuroscience and Physiology Sahlgrenska Academy Gothenburg University Gothenburg Sweden Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK Department of Clinical Neurosciences University of Cambridge Cambridge UK Neurovascular Research Laboratory Vail d'Hebron Research Institute Universitat Auto'noma de Barcelona Barcelona Spain Department of Neurology University of Connecticut Health Center Farmington Connecticut USA Feil Family Brain and mind Research Institute Weill Cornell Medical College New York New York USA Department of Physiology and Biophysics Zilkha Neurogenetic Institute Keck School of Medicine University of Southern Califomia Los Angeles California USA INSERm U1161 Paris France Institute for Stroke and Dementia Research Klinikum der Universitat Mtinchen Munich Germany Department of Neurology Medical University of Graz Graz Austria Tel-Aviv University medical School Ramat Aviv Israel Department of Neurology Memory and Aging Center and Department of Pathology University of Califomia San Francisco California USA University of Sao Paulo medical School Sao Paulo Brazil Department of Neurology University of Southern California Medical School Los Angeles California USA Department of Clinical Neurological Sciences University Hospital University of Western Ontario London Ontario Canada 浙江大学医学院附属第一医院杭州310003

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Binswanger＇s disease, BD）的进行性白质损害患者构成了从单纯血管性... 详细信息

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Binswanger＇s disease, BD）的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组，存在缺氧缺血、腔隙性梗死和炎症，它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物，这将有助于诊断以及将来协作性治疗试验的患者选择。

关键词：宾斯旺格病血脑屏障通透性脑脊液炎症白质疏松