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Celiac disease as potential obstacle to childbearing

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Open Journal of Obstetrics and Gynecology 2014年第2期4卷 75-80页

作者： mónika Kovács mária Szenes Tihamér Horváth Gyorgy Vajda Beáta Gasztonyi Gyorgy Bártfai Department of Internal medicine Zala County HospitalZalaegerszegHungary Department of Obstetrics and Gynecology Zala County HospitalZalaegerszegHungary Faculty of medicine Obstetrics and Gynecology Department Albert Szent-Gyorgyi Clinical Center of University SzegedSzegedHungary

AIm: The authors have aimed at confirming or excluding gluten sensitivity in infertile couples. PATIENTS AND mETHODS: Between 2004 and 2010, at our outpatient clinics of immunology, both partners of 223 couples, who had striven for having a child unsuccessfully, underwent history taking, physical examination, laboratory and immuno-serologic tests including anti-tissue-transglutaminase antibody (antitTG), as well as deep duodenal biopsy in antibody-carrying patients. RESULTS: Antibodies against tissue transglutaminase were positive in 6/223 female patients of whom the diagnosis of celiac disease was histologically confirmed in 3/223 cases (1.34%). Of the male patients 2/223 (0.9%) have proven to be carriers of the antibody;histology was pathognomonic in both of them. Curiously, one of the male patients with celiac disease has been the partner of a woman who also had celiac disease diagnosed by the authors. In the followup period, a female patient and the female member of the couple with celiac disease gave birth to healthy newborns after spontaneous conception, as the result of a strictly kept gluten-free diet, as well as occasional treatments of acetylsalicylate for antiphos-pholipid syndrome or levothyroxine for latent hypothyroidism due to autoimmune thyroiditis. CONCLUSION: The results underline that it is worth performing a screening for celiac disease in both partners of couples assessed due to the lack of success in having a child, as infertility can be ceased by an appropriate diet.

关键词： Celiac Disease Gluten-Free Diet Anti-Tissue-Transglutaminase Antibody Infertile Couples

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease

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World Journal of Gastrointestinal Surgery 2017年第7期9卷 167-173页

作者： Agnes milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár mónika Szucs Renáta Bor Anita Bálint mariann Rutka Zoltán Szepes Ferenc Nagy Klaudia Farkas Tamás molnár First Department of Internal medicine University of Szeged Department of Pathology University of Szeged Department of Surgery University of Szeged Department of medical Physics and Informatics University of Szeged

AIm To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative *** Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.

关键词： Submucosal plexitis Postoperative recurrence Crohn’s disease Stricturing disease behavior Isolated ileal disease

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开源之舞步为何如此沉重

计算机应用文摘 2004年第22期20卷 12-13页

作者： nika

开源(开放源代码)．其实并不是个热门的话题．至少它早已经风风火火地走入过业界的视线。经过媒体充分地“翻炒”，随着时间的推移，它也只是悄然地在自己的轨道七默默地舞动着属于它的舞姿。而“Sun抛弃OpenOffice事件”使开源又一次... 详细信息

开源(开放源代码)．其实并不是个热门的话题．至少它早已经风风火火地走入过业界的视线。经过媒体充分地“翻炒”，随着时间的推移，它也只是悄然地在自己的轨道七默默地舞动着属于它的舞姿。而“Sun抛弃OpenOffice事件”使开源又一次成为人们关注的焦点。

关键词： OpenOffice 开放源代码办公软件计算机

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宝宝成长的魔杖：模仿能力

母婴世界 2011年第12期 89-91页

作者： nika

宝宝出生后几个月模仿能力就开始萌芽并发展了，标志着他和周围的人有了一种关联，正是这种关联沟通了宝宝自我世界和外面世界。专家发现：越早懂得模仿的宝宝越聪明。也许模仿能力正是宝宝通往成长的魔杖呢!

关键词：模仿能力宝宝成长自我世界关联

Breeding for FHB Resistance via Fusarium Damaged Kernels and Deoxynivalenol Accumulation as Well as Inoculation methods in Winter Wheat

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Agricultural Sciences 2015年第9期6卷 970-1002页

作者： Akos mesterházy Szabolcs Lehoczki-Krsjak mónika Varga ágnes Szabó-Hevér Beata Tóth marc Lemmens Cereal Research Non-Profit Ltd Szeged Hungary University of Life Sciences-BOKU IFA Tulln Austria

FHB is one of the most destructive diseases of wheat. Resistance testing depends strongly on inoculation methods, and on measured traits. Therefore a four-year (2009-2012) study was performed using spray inoculation + polyethylene (PE) bag cover, spray inoculation + mist irrigation, and spawn method supported by mist irrigation on 40 genotypes, 20 from Hungary and 20 from IFA Tulln, Austria. Each year four isolates were used in artificial inoculations except the spawn method where stalk debris served the inoculum. Visual Fusarium head blight (FHB) scores, Fusarium damaged kernels (FDK) and deoxynivalenol (DON) contamination were checked. 7680 FHB and FDK, as well as 3840 DON analyses served as the background for the statistical evaluation. The most reliable method used was the spray + polyethylene (PE) bag;the other two were significantly poorer being valid for all traits. The FHB scores were the least reliable, whereas the FDK was much more consequent and the DON gave the best results. The FDK gave much better predictions for DON contamination than FHB. The cultivars responses correlated well at different epidemic severities. The presence of the kernel resistance was confirmed and a new trait as extra kernel susceptibility was described. Presence of DON resistance was confirmed again, and extra DON susceptibility was described as a new trait. DON performance varied on the most sensitive cultivar between 0.32 and 143 mg/kg (mean 17.52 mg/kg) and on the most resistant genotype between 0.00 and 18.19 mg/kg (mean 1.87 mg/kg). Correlations between stability and resistance level are r = 0.85 for FHB, 0.78 for FDK, and 0.88 for DON, all at a significance level of p = 0.001. The very close correlation between FDK and DON contamination (r = 0.81, p = 0.001) proves that control of DON contamination needs appropriate resistance. In the breeding program evaluation of FDK is the most important, and then DON will be decided. Variety registration must be updated;otherwise no impr

关键词： FHB Resistance Kernel Resistance Kernel Susceptibility DON Resistance DON Susceptibility Inoculation Techniques Breeding Aspects

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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挑战极限，运动无限

计算机应用文摘 2004年第20期20卷 123-125页

作者： nika

这是冒险与激情的舞台，这是年轻不服输的空间。激情出击，超越自我，正是青春的梦想。人类在自然的怀抱里创造文明，而文明却让人类远离自然，久处于建筑森林里，人们渴望一种全身心融人大自然的方式，渴望在挑战人类自身极限的过程中... 详细信息

这是冒险与激情的舞台，这是年轻不服输的空间。激情出击，超越自我，正是青春的梦想。人类在自然的怀抱里创造文明，而文明却让人类远离自然，久处于建筑森林里，人们渴望一种全身心融人大自然的方式，渴望在挑战人类自身极限的过程中，感受到一种快乐与激情。极限运动的兴起，正好满足了都市新新人类的需求。而2008年奥运会将新增设BmX小轮车越野赛项目，极限运动将跻身奥运项目。相信，在以后的日子里，极限运动将是地球上最动感的元素。

关键词：极限运动出击越野赛激情挑战 2008年奥运会奥运项目年轻人类全身