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Plasma Cell Neoplasms, Clinicopathological Characteristics and Immunophenotype of 21 Patients

Open Journal of Pathology 2012年第4期2卷 127-132页

作者： mónica belinda romero-guadarrama Cinthia Adriana meza medina Elvira Aguilar martínez Facultad de medicina Universidad Autónoma de Nayarit Tepic Mexico Unidad de Hematología del Hospital General de méxico Mexico City Mexico Unidad de Patología del Hospital General de méxico Mexico City Mexico

Introduction: Plasma cell neoplasms are monoclonal proliferations characterized by the secretion of an immunoglobulin product known as component "m" or monoclonal. The World Health Organization (WHO 2008) defines as plasma cell neoplasms the following: plasma cell myeloma, plasmacytoma and those syndromes defined by immunoglobulin deposits and primary amyloidosis, The objective of the present work was to correlate their clinical, morphological and phenotype characteristics in 21 patients. material and methods: A 2-year retrospective review was performed of the files of the surgical pathology laboratory and of the hematology service of the General Hospital of mexico, searching for patients with a diagnosis of plasma cell neoplasm. We analyzed the following variables: age, gender, clinical symptoms, evolution, localization, laboratory tests, morphology, and expression of immunohistochemical markers. Of the 21 patients, 12 (57.1%) corresponded to plasma cell myelomas and 9 (42.8%) were plasmacytomas (seven extraosseous and two solitary bone plasmacytoma);women predominated with 61.4% and age ranged between 22 and 84 years. mass and epistaxis were observed in the patients with plasmacytomas, and symptoms of medullary compression and anemia were observed in those patients with plasma cell myeloma. The time of symptomatology varied from 3 to 12 months. Laboratory tests revealed that lactate dehydrogenase (LDH), beta 2 microglobulin, C-reactive protein were altered and that hypercalcemia and anemia were present more in the systemic form of the disease. Treatment depended on the clinical staging and laboratory data. mature forms predominated morphologically. Immunohistochemical stain revealed a constant expression for CD 138, six patients expressed CD 56, and expression of the Kappa and Lambda light chains was while.

关键词： Plasma Cell Neoplasms

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Diffuse Large B-Cell Lymphoma with Anaplastic Clear Cells: A Rare Variant

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Open Journal of Pathology 2012年第4期2卷 150-154页

作者： mónica belinda romero-guadarrama Leslie Elizmara Aguilar-Ayala German Ott Jorge Pérez-Espinosa Department of Clinical Pathology Robert-Bosch-Hospital Stuttgart Germany Unit Pathology Hospital General de México OD and Medicine School Autonomous National University of Mexico Mexico City Mexico

Introduction: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous group conformed by morphological and clinical varieties of neoplasms;it originates from peripheral B-cells and is distinguished into three groups: germinal center (GC), activated B lymphocyte (ABL), and the third type. The existence of DLBCL with anaplastic morphology and expression of CD30 without t (2;5) translocation is rare. The aim of the present article is to describe this morphologic variant in a 54-year-old woman and a 74-year-old man, respectively. materials and methods: Patients diagnosed with DLBCL with anaplastic variant were identified from the surgical pathology records. Results: Out of 357 biopsies with this diagnosis, 11 (3%) corresponded to the anaplastic variant, 2 presented morphological clear cells;they became visible because of an increase in volume in the cervical area of 4 months of evolution, usually associated to diaphoresis and weight loss with clinical fulminating progression. An autopsy study was performed to one patient and it showed infiltration in supraclavicular lymph nodes, thyroid, and lung. The neoplastic cells presented abundant clear cytoplasm and pleomorphic nuclei that expressed CD20, CD30 and CD45. Conclusion: This variation is rare. The clinical presentation and prognosis are controversial;we present the morphological and immunophenotype changes of this variant. The differential diagnosis from other clear cell neoplasms should be made.

关键词： B-Cell Anaplastic Lymphoma with Clear Cells

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Diffuse Large B-Cell Lymphoma of the Central Nervous System. Immunophenotype, Clinicopathological Features and Differential Diagnosis

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Open Journal of Pathology 2012年第4期2卷 133-139页

作者： mónica belinda romero-guadarrama maría Esther Gutiérrez Díaz-Ceballos Fiacro Jiménez-Ponce Samantha Thingen-Velarde Hemathology Service Hospital General de México Mexico City Mexico mónica belinda romero-guadarrama Neurosurgery Unit Hospital General de méxico Mexico City Mexico Unit Pathology Hospital General de méxico Medicine School Autonomous University of Mexico Mexico City Mexico

Background: Diffuse large B-cell lymphomas of the central nervous system (DLBCL CNS) represent less than 1% of all lymphomas and between 2% and 3% of all cerebral tumors. They occur in adults of 60 years of age or more. The objective of this work is to describe the clinical-pathological characteristics, the immunophenotype and the differential diagnosis. Clinical Case: From the files of the surgical pathology unit we found four cases of primary diffuse large B cell lymphoma of the central nervous system in a 6-year period. Three corresponded to women over 47 years of age and the other to a 42-year-old man. The time of evolution was between 2 and 4 months. The symptoms were headache, blurred vision, hemiparesis, and seizures. Localization was in the pineal region, the frontal, parietal regions, and the right thalamus. morphologically, large lymphoid cells with a diffuse growth pattern and necrosis were observed. Immunohistochemical markers, such as CD 20 and bcl2 were positive, one was positive to CD3. Expression of bcl6 and CD 10 was positive in one case, and mUm-1 was positive in three cases. All the cases were negative for Epstein-Barr virus. Conclusions: The diffuse large-B cell lymphoma of the central nervous system is rare. Its average age of presentation is at 60 years or older. The localization is in the pineal, frontal, parietal and thalamic regions. Three cases were originated by activated B lymphocyte (mUm-1 expression) and other from the Germinal Center (GC) (CD 10 expression). The clinical course was bad. The four patients died shortly after the diagnosis.

关键词： Primary Lymphoma Central Nervous System

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Association of morphology and Immunophenotype in Diffuse Large B-Cell Lymphomas with Bone marrow Infiltration in a Sample mexican Population

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Open Journal of Pathology 2012年第2期2卷 29-37页

作者： mónica-belinda romero-guadarrama Fiacro Jiménez Ponce Armando medina Cruz Elsa Lorena Durán Ramírez Icela Palma Lara molecular and Celular morphology Laboratory Escuela Superior de Medicina Instituto Politécnico Nacional and Morphology Department Facultad de Medicina Veterinaria y Zootecnia (UNAM) México City México Unidad de Patología del Hospital General de méxico Facultad de Medicina Universidad Nacional Autónoma de México (UNAM) México City México

Introduction: Diffuse large B-cell lymphoma (DLBCL), not otherwise specified, is a large B-cell lymphoma with a diffuse growth pattern and aggressive clinical course. It is divided in subgroups according to its morphology, immunophenotype, and primary site. Dissemination to bone marrow occurs in 11% to 35% of cases and can be of concordant or discordant morphology. Objective: To examine the association, the type of bone marrow involvement in relation to the primary site, morphology, immunohistochemistry of DLBCLs and to determine the cases of Epstein-Barr virus positive DLBCLs. materials and methods: We reviewed lymph node and extranodal biopsies as well as the respective bone marrow biopsies in all cases of DLBCL diagnosed in the Hospital General de méxico during the period from 2002 to 2010. We used immunohystochemistry for immunophenotype identification (Hans’s algorithm) and an in-situ hybridization technique to detect presence of Epstein Barr encoded RNA (EBER). Results: We included 108 patients with a mean age of 51.9 years, 59 (55%) were men. DLBCL involved lymph nodes in 60% of cases and palatine tonsils in 13%. The centroblastic variant predominated (80%) and 58% originated from activated B-cells. Infiltration of bone marrow was present in 30% of cases and was discordant in 55% of these cases. Correlation between morphology and bone marrow infiltration was statistically significant (P = 0.0003). Presence of Epstein-Barr virus was demonstrated in 15% of patients older than 50 years. Conclusions: Dissemination to bone marrow occurred in 30% of cases and discordant involvement was most common. DLBCL originating from activated B-lymphocytes predominated and the most common extranodal sites were palatine tonsils, suggesting that our population has a clinical behavior similar to Asiatic populations.

关键词： Dissemination to Bone marrow Diffuse Large B-Cell Lymphoma Immunophenotype

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Kikuchi-Fujimoto Disease Associated to the Epstein-Barr Virus. A Type of Rare Necrotizing Lymphadenitis and Its Differential Diagnosis

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Open Journal of Pathology 2013年第4期3卷 186-192页

作者： mónica belinda romero guadarrama Oscar Daniel Guzmán-Aguilar Adriana Carolina López-Ugalde José Samuel Almeida Navarro Humberto Cruz-Ortíz Unidad de Patología Hospital General de México “Dr. Eduardo Liceaga” México D.F. México

Introduction: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a specific and self-limited disease;its etiology is unknown. Some causal microorganisms have been proposed. The objective of the present article is to emphasize the clinicopathological characteristics of this disease that has been associated to the Epstein-Barr virus and to compare the histological changes with other types of necrotizing lymphadenopathies. material and methods: We studied 32 patients of the Surgical Pathology Service with necrotizing lymphadenitis, diagnosed in the years from 2004 to 2012 to found more cases of this rare disease in our Institution. Patients were 18 women and 14 men with an average age of 37 years. Results: The lymph nodes were cervical and axillary ones, some were associated to autoimmune diseases and no cause was identified in others. One of the cases, was diagnosed as KFD, presented morphological changes characteristic of this disease, such as subcapsular lymphoid follicles, zones with cell debris, epithelioid macrophages, clear-cytoplasm histiocytes, and immunoblast-reactive lymphocytes. Immunohistochemical markers were determined, such as CD20, CD2, CD4, CD8, CD68, lysozyme, CD56, granzyme B and EBER, which demonstrated the presence of B, T lymphocytes, histiocytes and cells positive to EBER. Histological changes in KFD occurred in three stages: proliferative stage, necrotizing, and xanthomatous. It is important to identify the histological stages of the disease because a differential diagnosis must be performed in regard to lymphadenopathies with necrosis and diverse types of lymphomas. Conclusion: We present a case of necrotizing lymphadenitis (KFD) associated to the Epstein-Barr virus and in some cases it is not possible to render a specific diagnosis based on morphologic findings, alone, and a diagnosis of necrotizing lymphadenitis may be used.

关键词： Kikuchi-Fujimoto Disease Epstein Barr Virus

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Proteomic analysis of F_(1)hybrids and intermediate variants in a Littorina saxatilis hybrid zone

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Current Zoology 2022年第3期68卷 351-359页

作者： Angel P.DIZ mónica R.romero Juan GALINDO maría SAURA David O.F.SKIBINSKI Emilio ROLÁN-ALVAREZ Centro de Investigación mariña(CIm-UVIGO) Universidade de VigoVigo 36310Spain Departamento de mejora Genética Animal INIAMadrid 28040Spain Institute of Life Science Swansea University Medical SchoolSwansea SA28PPUK

Proteomic analysis was carried out on the Crab(upper-shore)and Wave(lower-shore)ecotypes of Littorina saxatilis from a hybrid zone at Silleiro Cape,*** profiles of individual snails were *** expression in F_(1)hybrid snails bred in the laboratory and snails with intermediate shell phenotypes collected from the mid-shore were compared with Crab and Wave ecotypes using analytical approaches used to study *** analysis over many protein spots showed that the F_(1)snails are distinct from both ecotypes but closer to the Wave *** intermediate snails are highly variable,some closer to the Crab and others to the Wave *** on a protein by protein basis,some proteins are significantly closer in expression to the Crab and others to the Wave ecotype for both F_(1)and intermediate ***,a significant majority of proteins were closer in expression to the Wave ecotype for the F_(1),consistent with the multivariate *** such significant majority toward either the Crab or Wave ecotype was observed for the intermediate *** closer similarity of F_(1)and Wave ecotype expression patterns could be the result of similar selective pressures in the similar mid-shore and low-shore *** a significantly larger number of proteins,intermediate snails were closer in expression to the ecotype having the lower expression,for both Crab and Wave *** is somewhat unexpected as lower expression might be expected to be an indication of impairment of function and lower *** analysis could be important for the identification of candidate proteins useful for gaining improved understanding of adaptation and barriers to gene flow in hybrid zones.

关键词： F_(1)hybrids gene expression marine invertebrates molecular phenotype reproductive isolation speciation

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Additive engineering for stable halide perovskite solar cells

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Journal of Energy Chemistry 2021年第9期30卷 599-634页

作者： Carlos Pereyra Haibing Xie mónica Lira-Cantu Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and the Barcelona Institute of Science and Technology(BIST).Building ICN2Campus UAB E-08193BellaterraBarcelonaSpain

Halide perovskite solar cells(PSCs)have already demonstrated power conversion efficiencies above 25%,which makes them one of the most attractive photovoltaic ***,one of the main bottlenecks towards their commercialization is their long-term stability,which should exceed the 20-year *** engineering is an effective pathway for the enhancement of device *** applied as organic or inorganic compounds,improve crystal grain growth enhancing power conversion *** interaction of their functional groups with the halide perovskite(HP)absorber,as well as with the transport layers,results in defect passivation and ion immobilization improving device performance and *** this review,we briefly summarize the different types of additives recently applied in PSC to enhance not only efficiency but also long-term *** discuss the different mechanism behind additive engineering and the role of the functional groups of these additives for defect *** emphasis is given to their effect on the stability of PSCs under environmental conditions such as humidity,atmosphere,light irradiation(UV,visible)or heat,taking into account the recently reported ISOS *** also discuss the relation between deep-defect passivation,non-radiative recombination and device efficiency,as well as the possible relation between shallow-defect passivation,ion immobilization and device operational ***,insights into the challenge and criteria for additive selection are provided for the further stability enhancement of PSCs.

关键词： Additives Additive engineering Perovskite solar cells Defect passivation Shallow defect Deep defect Stability

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Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach

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Neural Regeneration Research 2019年第5期14卷 762-766页

作者： mariano Bisbal mónica Sanchez Laboratory of Neurobiology Instituto Mercedes y Martín Ferreyra (INIMEC-CONICET) Universidad Nacional de Córdoba Instituto Universitario Ciencias Biomédicas Córdoba

Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal development and it is maintained by complex subcellular mechanisms throughout cell life. A well-defined and controlled spatio-temporal program of cellular and molecular events strictly regulates the formation of the axon and dendrites from a non-polarized cell. This event is critical for an adequate neuronal wiring and therefore for the normal functioning of the nervous system. Neuronal polarity is very sensitive to the harmful effects of different factors present in the environment. In this regard, rotenone is a crystalline, colorless and odorless isoflavone used as insecticide, piscicide and broad spectrum pesticide commonly used earlier in agriculture. In the present review we will summarize the toxicity mechanism caused by this pesticide in different neuronal cell types, focusing on a particular biological mechanism whereby rotenone could impair neuronal polarization in cultured hippocampal neurons. Recent advances suggest that the inhibition of axonogenesis produced by rotenone could be related with its effect on microtubule dynamics, the actin cytoskeleton and their regulatory pathways, particularly affecting the small RhoGTPase RhoA. Unveiling the mechanism by which rotenone produces neurotoxicity will be instrumental to understand the cellular mechanisms involved in neurodegenerative diseases influenced by this environmental pollutant, which may lead to research focused on the design of new therapeutic strategies.

关键词： rotenone environmental pollutants toxicity neuronal polarity RhoGTPase RhoA Lfc Arhgef1

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Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy

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World Journal of Gastroenterology 2021年第28期27卷 4639-4652页

作者： Alberto E muñoz Florencia D Pollarsky mónica marino mariano Cartier Horacio Vázquez Pablo Salgado Gustavo romero Sección Hepatología Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoFacultad de MedicinaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina Instituto de Investigaciones en Salud Pública Facultad de OdontologíaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1122Argentina Unidad Clínica Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoInvestigador Asociado del Gobierno de la Ciudad Autónoma de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina

This review summarizes the safety and efficacy of statins in patients with *** to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in *** most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver *** is the most serious and potentially life-threatening *** has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle ***,simvastatin should not be administered to patients with model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle *** to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something *** these effects,statins could prevent liver-related morbidity and mortality in cirrhotic *** studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and *** few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic *** large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival *** these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies ***,it is advisable to per

关键词： Cirrhosis Liver disease Statins Safety Efficiency

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Validation of kinetic modeling of progesterone release from polymeric membranes

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Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 54-62页

作者： Analia Irma romero mercedes Villegas Alicia Graciela Cid mónica Liliana Parentis Elio Emilio Gonzo José maría Bermúdez Instituto de Investigaciones para la Industria Química Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas Facultad de Ingeniería Universidad Nacional de Salta

mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone(Prg) controlled release from poly-3-hydroxybutyric acid(PHB) membranes. A statistical analysis was conducted to compare the fitting of our model with six different models and the Akaike information criterion(AIC) was used to find the equation with best-fit. A simple relation between mass and drug released rate was found,which allows predicting the effect of Prg loads on the release behavior. Our proposed model was the one with minimum AIC value, and therefore it was the one that statistically fitted better the experimental data obtained for all the Prg loads tested. Furthermore, the initial release rate was calculated and therefore, the interface mass transfer coefficient estimated and the equilibrium distribution constant of Prg between the PHB and the release medium was also determined. The results lead us to conclude that our proposed model is the one which best fits the experimental data and can be successfully used to describe Prg drug release in PHB membranes.

关键词： mathematical models model validation Drug delivery/release mass transfer coefficient Equilibrium distribution constant

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