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Efficacy of medium-chain fatty acid salts distilled from coconut oil against two enteric pathogen challenges in weanling piglets

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Journal of Animal Science and Biotechnology 2020年第1期11卷 251-267页

作者： Paola López-Colom Lorena Castillejos Agustina Rodríguez-Sorrento mónica puyalto Juan Josémallo Susana maría martín-Orúe Animal Nutrition and Welfare Service Animal and Food Science DepartmentFacultat de VeterinàriaUniversitat Autònoma de BarcelonaBellaterraSpain Norel S.A MadridSpain.

Background:The search for alternatives to antibiotics in pig production has increased the interest in natural resources with antimicrobial properties,such as medium-chain fatty acids(mCFA)as in-feed *** study evaluated the potential of a novel blend of mCFA salts(DIC)from distilled coconut oil with a lauric acid content to reduce enteropathogens and control intestinal diseases around *** experimental disease models were implemented in early-weaned piglets,consisting of two oral challenges:Salmonella Typhimurium(1.2×10~8 CFU)or enterotoxigenic Escherichia coli(ETEC)F4(1.5×10~9 CFU).The parameters assessed were:animal performance,clinical signs,pathogen excretion,intestinal fermentation,immune-inflammatory response,and intestinal ***:The Salmonella challenge promoted an acute course of diarrhea,with most of the parameters responding to the challenge,whereas the ETEC F4 challenge promoted a mild clinical course.A consistent antipathogenic effect of DIC was observed in both trials in the hindgut,with reductions in Salmonella *** counts in the cecum(P=0.03)on d 8 post-inoculation(PI)(Salmonella trial),and of enterobacteria and total coliform counts in the ileum and colon(Pmicrobiota(16 S rRNA gene sequencing),this additive tended(P=0.13)to reduce the Firmicutes/Bacteroidetes ratio and enriched Fibrobacteres after the Salmonella *** the ETEC F4 challenge,DIC prompted structural changes in the ecosystem with increases in Dialister,and a trend(P=0.14)to increase the Veillonellaceae *** parameters such as the intestinal fermentation products or serum pro-inflammatory mediators were not modified by DIC supplementation,nor were the histological *** the intraepithelial lymphocyte(IEL)counts were lowered by DIC in animals challenged with Salmonella(P=0.07).With ETEC F4,the IEL counts were higher with DIC on d 8 PI(P=0.08).Conclusions:This study c

关键词： Enteric pathogen Gut microbiota Intestinal immunity medium-chain fatty acids Weaning pig

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使用酸化液态饲料可提高猪的健康和生产性能

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国外畜牧学（猪与禽） 2016年第10期36卷 68-70页

作者：穆雅东(译) 陈建康韩浩月 Cinta Sol mónica puyalto Juan José mallo 不详 Norel公司技术部 Norel公司

以亚治疗剂量将抗生素用作生长促进剂在全世界的动物生产上已经行不通。欧盟在2006年禁止了将抗生素用作生长促进剂,每天还是有新的无抗动物生产情况的出现。这种情况对人类的健康有好处,因为这不太可能会导致细菌对治疗用抗生素产生耐... 详细信息

以亚治疗剂量将抗生素用作生长促进剂在全世界的动物生产上已经行不通。欧盟在2006年禁止了将抗生素用作生长促进剂,每天还是有新的无抗动物生产情况的出现。这种情况对人类的健康有好处,因为这不太可能会导致细菌对治疗用抗生素产生耐药性。然而,动物的生产性能达不到其最佳水平。目前人们越来越多地关注可提高猪生产性能的抗生素替代方法,主要是通过改善动物健康,随后是通过减少动物用于应对感染和健康问题的能量、蛋白质和其他营养素,或通过使用各种不同种类的功能性原料、添加剂甚至新的饲料管理方法。

关键词：液态饲料生产性能最佳水平替代方法饲料管理生长促进剂病原微生物隐窝深度采食行为仔猪小肠

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Renal elimination of organic anions in cholestasis

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World Journal of Gastroenterology 2008年第43期14卷 6616-6621页

作者： Adriana mónica Torres Facultad de Ciencias Bioquimicas y Farmacéuticas Universidad Nacional de RosarioCONICETSuipacha 5312000RosarioArgentina

The disposition of most drugs is highly dependent on specialized transporters. OAT1 and OAT3 are two organic anion transporters expressed in the basolateral membrane of renal proximal tubule cells, identified as contributors to xenobiotic and endogenous organic anion secretion. It is well known that cholestasis may cause renal damage. Impairment of kidney function produces modifications in the renal elimination of drugs. Recent studies have demonstrated that the renal abundance of OAT1 and OAT3 plays an important role in the renal elimination of organic anions in the presence of extrahepatic cholestasis. Time elapsed after obstructive cholestasis has an important impact on the regulation of both types of organic anion transporters. The renal expression of OAT1 and OAT3 should be taken into account in order to improve pharmacotherapeutic efficacy and to prevent drug toxicity during the onset of this hepatic disease.

关键词： Organic anions P-aminohippurate Furosemide OAT1 OAT3 Extrahepatic cholestasis

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Additive engineering for stable halide perovskite solar cells

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Journal of Energy Chemistry 2021年第9期30卷 599-634页

作者： Carlos Pereyra Haibing Xie mónica Lira-Cantu Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and the Barcelona Institute of Science and Technology(BIST).Building ICN2Campus UAB E-08193BellaterraBarcelonaSpain

Halide perovskite solar cells(PSCs)have already demonstrated power conversion efficiencies above 25%,which makes them one of the most attractive photovoltaic ***,one of the main bottlenecks towards their commercialization is their long-term stability,which should exceed the 20-year *** engineering is an effective pathway for the enhancement of device *** applied as organic or inorganic compounds,improve crystal grain growth enhancing power conversion *** interaction of their functional groups with the halide perovskite(HP)absorber,as well as with the transport layers,results in defect passivation and ion immobilization improving device performance and *** this review,we briefly summarize the different types of additives recently applied in PSC to enhance not only efficiency but also long-term *** discuss the different mechanism behind additive engineering and the role of the functional groups of these additives for defect *** emphasis is given to their effect on the stability of PSCs under environmental conditions such as humidity,atmosphere,light irradiation(UV,visible)or heat,taking into account the recently reported ISOS *** also discuss the relation between deep-defect passivation,non-radiative recombination and device efficiency,as well as the possible relation between shallow-defect passivation,ion immobilization and device operational ***,insights into the challenge and criteria for additive selection are provided for the further stability enhancement of PSCs.

关键词： Additives Additive engineering Perovskite solar cells Defect passivation Shallow defect Deep defect Stability

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Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach

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Neural Regeneration Research 2019年第5期14卷 762-766页

作者： mariano Bisbal mónica Sanchez Laboratory of Neurobiology Instituto Mercedes y Martín Ferreyra (INIMEC-CONICET) Universidad Nacional de Córdoba Instituto Universitario Ciencias Biomédicas Córdoba

Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal development and it is maintained by complex subcellular mechanisms throughout cell life. A well-defined and controlled spatio-temporal program of cellular and molecular events strictly regulates the formation of the axon and dendrites from a non-polarized cell. This event is critical for an adequate neuronal wiring and therefore for the normal functioning of the nervous system. Neuronal polarity is very sensitive to the harmful effects of different factors present in the environment. In this regard, rotenone is a crystalline, colorless and odorless isoflavone used as insecticide, piscicide and broad spectrum pesticide commonly used earlier in agriculture. In the present review we will summarize the toxicity mechanism caused by this pesticide in different neuronal cell types, focusing on a particular biological mechanism whereby rotenone could impair neuronal polarization in cultured hippocampal neurons. Recent advances suggest that the inhibition of axonogenesis produced by rotenone could be related with its effect on microtubule dynamics, the actin cytoskeleton and their regulatory pathways, particularly affecting the small RhoGTPase RhoA. Unveiling the mechanism by which rotenone produces neurotoxicity will be instrumental to understand the cellular mechanisms involved in neurodegenerative diseases influenced by this environmental pollutant, which may lead to research focused on the design of new therapeutic strategies.

关键词： rotenone environmental pollutants toxicity neuronal polarity RhoGTPase RhoA Lfc Arhgef1

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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Carbon capture for decarbonisation of energy-intensive industries:a comparative review of techno-economic feasibility of solid looping cycles

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Frontiers of Chemical Science and Engineering 2022年第9期16卷 1291-1317页

作者： mónica P.S.Santos Dawid P.Hanak Energy and Power School of WaterEnergy and EnvironmentCranfield UniversityBedfordshire MK430ALUK

Carbon capture and storage will play a crucial role in industrial ***,the current literature presents a large variability in the techno-economic feasibility of CO_(2)capture ***,reliable pathways for carbon capture deployment in energyintensive industries are still *** work provides a comprehensive review of the state-of-the-art CO_(2)capture technologies for decarbonisation of the iron and steel,cement,petroleum refining,and pulp and paper *** scrubbing was shown to be the least feasible option,resulting in the average avoided CO_(2)cost of between 62.7∈t_(CO_(2))^(-1)for the pulp and paper and 104.6∈t_(CO_(2))^(-1)for the iron and steel *** average equivalent energy requirement varied between 2.7(iron and steel)and 5.1mJ_(th)·kg_(CO_(2))^(-1)(cement).Retrofits of emerging calcium looping were shown to improve the overall viability of CO_(2)capture for industrial *** looping was shown to result in the average avoided CO_(2)cost of between 32.7(iron and steel)and 42.9(cement).Its average equivalent energy requirement varied between 2.0(iron and steel)and 3.7(pulp and paper).Such performance demonstrated the superiority of calcium looping for industrial *** work should focus on standardising the techno-economic assessment of technologies for industrial decarbonisation.

关键词： industrial CO_(2)emissions CCS deployment carbonate looping net-zero industry carbon capture benchmarks

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Pure and mixed plantations of Persian walnut (Juglans regia L.) for high quality timber production in Chile, South America

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Journal of Plant Ecology 2020年第1期13卷 12-19页

作者： Verónica Loewe-muñoz mónica Balzarini marta Ortega González Chilean Forest Institute(INFOR) Metropolitan OfficeSucre 2397ÑuñoaSantiagoChile CONICET Biometry Unit College of AgricultureUniversidad Nacional de CórdobaCiudad UniversitariaCC509CP 5000CórdobaArgentina Chilean Forest Institute(INFOR) Biobío OfficeCamino a Coronel Km 7.5San Pedro de la PazConcepciónChile

Aims Persian walnut(Juglans regia L.),an interesting forest species for the veneering industry,requires adequate management to produce valuable high-quality *** species associations and management level can improve stand productivity,the novelty of this work was to assess Persian walnut performance in different planting mixtures and in pure plantations conditioned to management *** Growth,straightness and survival measurements were taken annually for 7 years after planting pure and mixed plantations under two contrasting management *** were recorded at Age 7 in all *** each management intensity,besides the monoculture,three mixtures were tested:a mixture of only main forest species,main forest species plus one arboreal companion species,Black alder(Alnus glutinosa L.)and main species plus the shrub Russian olive(Elaeagnus angustifolia L.)as nurse species.A test of interaction between plantation type and management scenario was conducted using repeated growth *** Findings The interaction was significant,indicating the presence of different mechanisms underlying plantation effects under high and low management *** with pure plantations,Persian walnut associated with the nurse shrub exhibited 78%higher height and 53%higher diameter growth in plantations under low *** benefits(lower presence of walnut blight than in the monoculture)and better straightness were also found in the association including the shrub when the management intensity was not *** beneficial effects in the presence of Russian olive were not present under high management intensity(irrigation,fertilization,tutoring and frequent pruning).Site-specific designs for Persian walnut plantations would depend on the foreseen management intensity.

关键词： noble wood monoculture forest associations companion species Russian olive

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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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